LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Zhang, Lingye"
  2. AU="Venko, Katja"
  3. AU="Kasthuri, Thirupathi"
  4. AU="Pirtskhalava, Tamar"
  5. AU="Saridakis, E N"
  6. AU="Vithana, Eranga N"
  7. AU="Suárez-Lledó, M"
  8. AU="Olivo-Marston, Susan"
  9. AU="Denise P Momesso"
  10. AU="Obrecht-Sturm, Denise"

Suchergebnis

Treffer 1 - 9 von insgesamt 9

Suchoptionen

  1. Artikel ; Online: Optimizing oil spill emergency logistics: a time-varying multi-resource collaborative scheduling model.

    Zhang, Lingye / Lu, Jing

    Environmental science and pollution research international

    2023  Band 31, Heft 2, Seite(n) 2773–2801

    Abstract: Emergency resource scheduling is at the heart of the response to an oil spill, as it lays the foundation for all other emergency operations. Extant studies address the dynamicity inherent to these operations primarily by modeling a dynamic network flow ... ...

    Abstract Emergency resource scheduling is at the heart of the response to an oil spill, as it lays the foundation for all other emergency operations. Extant studies address the dynamicity inherent to these operations primarily by modeling a dynamic network flow with static data, which is not applicable to continuously changing conditions resulting from oil film movement. To enhance the responsiveness and cost-efficiency of the response to oil spills, this paper takes a novel approach and formulates a multi-objective location-routing model for multi-resource collaborative scheduling, namely, harnessing time-varying parameters rather than static data to model real-time changes in the demand for emergency resources and the transportation network. Additionally, the model considers various operational factors, including the transportation of multiple resources in the order of operating procedures; the coordination of split delivery with the consumption of emergency resources; and the matching of multiple resources with suitable vehicles. To solve the proposed model, a hybrid heuristic algorithm of PSO-PGSA is developed, which utilizes particle swarm optimization (PSO) to search widely for non-dominated solutions. The algorithm then makes use of the plant growth simulation algorithm (PGSA) to find the more effective vehicle routes based on the obtained solutions. Finally, a numerical analysis is used to illustrate the practical capabilities of the developed model and solution strategies. Most significantly, our work not only validates the methodology proposed here but also underlines the importance of incorporating the features of an oil spill emergency response into emergency logistics in general.
    Mesh-Begriff(e) Petroleum Pollution ; Models, Theoretical ; Algorithms ; Transportation ; Computer Simulation
    Sprache Englisch
    Erscheinungsdatum 2023-12-08
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-30987-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  2. Artikel ; Online: Lysine Methyltransferase 5A Promotes the Progression of Growth hormone Pituitary Neuroendocrine Tumors Through the Wnt/β-catenin Signaling Pathway.

    Li, Junjun / Song, Hao / Chen, Ting / Zhang, Sixi / Zhang, Chao / Ma, Chen / Zhang, Lingye / Wang, Tengfei / Qian, Yuan / Deng, Xingli

    Neuroendocrinology

    2024  

    Abstract: Introduction: Growth hormone (GH) secreting pituitary adenoma is considered one of the most harmful types of Pituitary Neuroendocrine Tumors (PitNETs). Our previous research has found that high expression of Lysine Methyltransferase 5A (KMT5A) is ... ...

    Abstract Introduction: Growth hormone (GH) secreting pituitary adenoma is considered one of the most harmful types of Pituitary Neuroendocrine Tumors (PitNETs). Our previous research has found that high expression of Lysine Methyltransferase 5A (KMT5A) is closely related to the proliferation of PitNETs. The aim of this study was to investigate the role and molecular mechanism of KMT5A in the progression of GH PitNETs.
    Methods: Immunohistochemistry, qRT-PCR and Western blot (WB) were used to assess the expression levels of KMT5A in human normal pituitary and GH PitNETs, as well as in rat normal pituitary and GH3 cells. Additionally, we utilized RNA interference technology and treatment with a selective KMT5A inhibitor to decrease the expression of KMT5A in GH3 cells. CCK-8, EdU, Flow cytometry (FCM), clone formation, and WB assay were further employed to evaluate the impact of KMT5A on the proliferation of GH3 cells in vitro. A xenograft model was established to evaluate the role of KMT5A in GH PitNETs progression in vivo.
    Results: KMT5A was highly expressed in GH PitNETs and GH3 cells. Moreover, the reduction of KMT5A expression led to inhibited growth of GH PitNETs and increased apoptosis of tumor cells, as indicated by the findings from CCK-8, EdU, clone formation and FCM assays. Additionally, WB analysis identified the Wnt/β-catenin signaling pathway as a potential mechanism through which KMT5A promotes GH PitNETs progression.
    Conclusion: Our research suggests that KMT5A may facilitate the progression of GH PitNETs via the Wnt/β-catenin signaling pathway. Therefore, KMT5A may serve as a potential therapeutic target and molecular biomarker for GH PitNETs.
    Sprache Englisch
    Erscheinungsdatum 2024-04-02
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 123303-8
    ISSN 1423-0194 ; 0028-3835
    ISSN (online) 1423-0194
    ISSN 0028-3835
    DOI 10.1159/000538560
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  3. Artikel: Individual risk and prognostic value prediction by machine learning for distant metastasis in pulmonary sarcomatoid carcinoma: a large cohort study based on the SEER database and the Chinese population.

    Yi, Xinglin / Xu, Wenhao / Tang, Guihua / Zhang, Lingye / Wang, Kaishan / Luo, Hu / Zhou, Xiangdong

    Frontiers in oncology

    2023  Band 13, Seite(n) 1105224

    Abstract: Background: This study aimed to develop diagnostic and prognostic models for patients with pulmonary sarcomatoid carcinoma (PSC) and distant metastasis (DM).: Methods: Patients from the Surveillance, Epidemiology, and End Results (SEER) database were ...

    Abstract Background: This study aimed to develop diagnostic and prognostic models for patients with pulmonary sarcomatoid carcinoma (PSC) and distant metastasis (DM).
    Methods: Patients from the Surveillance, Epidemiology, and End Results (SEER) database were divided into a training set and internal test set at a ratio of 7 to 3, while those from the Chinese hospital were assigned to the external test set, to develop the diagnostic model for DM. Univariate logistic regression was employed in the training set to screen for DM-related risk factors, which were included into six machine learning (ML) models. Furthermore, patients from the SEER database were randomly divided into a training set and validation set at a ratio of 7 to 3 to develop the prognostic model which predicts survival of patients PSC with DM. Univariate and multivariate Cox regression analyses have also been performed in the training set to identify independent factors, and a prognostic nomogram for cancer-specific survival (CSS) for PSC patients with DM.
    Results: For the diagnostic model for DM, 589 patients with PSC in the training set, 255 patients in the internal and 94 patients in the external test set were eventually enrolled. The extreme gradient boosting (XGB) algorithm performed best on the external test set with an area under the curve (AUC) of 0.821. For the prognostic model, 270 PSC patients with DM in the training and 117 patients in the test set were enrolled. The nomogram displayed precise accuracy with AUC of 0.803 for 3-month CSS and 0.869 for 6-month CSS in the test set.
    Conclusion: The ML model accurately identified individuals at high risk for DM who needed more careful follow-up, including appropriate preventative therapeutic strategies. The prognostic nomogram accurately predicted CSS in PSC patients with DM.
    Sprache Englisch
    Erscheinungsdatum 2023-06-26
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1105224
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  4. Artikel ; Online: The role of GTPase-activating protein ARHGAP26 in human cancers.

    Zhang, Lingye / Zhou, Anni / Zhu, Shengtao / Min, Li / Liu, Si / Li, Peng / Zhang, Shutian

    Molecular and cellular biochemistry

    2021  Band 477, Heft 1, Seite(n) 319–326

    Abstract: Rho GTPases are molecular switches that play an important role in regulating the behavior of a variety of tumor cells. RhoA GTPase-activating protein 26 (ARHGAP26) is a GTPase-activating protein and inhibits the activity of Rho GTPases by promoting the ... ...

    Abstract Rho GTPases are molecular switches that play an important role in regulating the behavior of a variety of tumor cells. RhoA GTPase-activating protein 26 (ARHGAP26) is a GTPase-activating protein and inhibits the activity of Rho GTPases by promoting the hydrolytic ability of Rho GTPases. It also affects tumorigenesis and progression of various tumors through several methods, including formation of abnormal fusion genes and circular RNA. This review summarizes the biological functions and molecular mechanisms of ARHGAP26 in different tumors, proposes the potential clinical value of ARHGAP26 in cancer treatment, and discusses current issues that need to be addressed.
    Mesh-Begriff(e) Animals ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; GTPase-Activating Proteins/genetics ; GTPase-Activating Proteins/metabolism ; Humans ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Neoplasms/genetics ; Neoplasms/metabolism
    Chemische Substanzen ARHGAP26 protein, human ; GTPase-Activating Proteins ; Neoplasm Proteins
    Sprache Englisch
    Erscheinungsdatum 2021-10-30
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 184833-1
    ISSN 1573-4919 ; 0300-8177
    ISSN (online) 1573-4919
    ISSN 0300-8177
    DOI 10.1007/s11010-021-04274-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  5. Artikel: Pharmacokinetics of Bismuth following Oral Administration of Wei Bi Mei in Healthy Chinese Volunteers.

    Zhang, Lingye / Liu, Juan / Meng, Fandong / Guan, Yingying / Wang, Yongjun / Zhu, Shengtao / Liu, Yaqiong / Xie, Qing / Yu, Junxian / Zhang, Shutian

    Evidence-based complementary and alternative medicine : eCAM

    2020  Band 2020, Seite(n) 2679034

    Abstract: Background: Bismuth-containing quadruple therapy achieves higher eradication rate of : Results: For single-dose Wei Bi Mei granules administration, the mean time to peak concentration (: Conclusion: Bismuth has a washout period of approximately ... ...

    Abstract Background: Bismuth-containing quadruple therapy achieves higher eradication rate of
    Results: For single-dose Wei Bi Mei granules administration, the mean time to peak concentration (
    Conclusion: Bismuth has a washout period of approximately two months. The concentration of bismuth in blood was far less than the "safe level." Thus, Wei Bi Mei is a highly safe therapeutic medicine, with a good clinical application value. Wei Bi Mei should be recommended more widely for use in bismuth-containing quadruple therapy for the treatment of
    Sprache Englisch
    Erscheinungsdatum 2020-08-13
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2020/2679034
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  6. Artikel ; Online: The effect of quality of segmental bowel preparation on adenoma detection rate.

    Guo, Rui / Wang, Yong-Jun / Liu, Mo / Ge, Jun / Zhang, Ling-Ye / Ma, Ling / Huang, Wen-Yu / Zhai, Hui-Hong

    BMC gastroenterology

    2019  Band 19, Heft 1, Seite(n) 119

    Abstract: Background: The effectiveness in surveillance colonoscopy largely depends on the quality of bowel preparation. We aimed to investigate the quality of bowel preparation segmentally and its effect on Adenoma Detection Rate (ADR) and Advanced Adenoma ... ...

    Abstract Background: The effectiveness in surveillance colonoscopy largely depends on the quality of bowel preparation. We aimed to investigate the quality of bowel preparation segmentally and its effect on Adenoma Detection Rate (ADR) and Advanced Adenoma Detection Rate (AADR) at corresponding bowel segments.
    Methods: This is a single-centered and cross-sectional study. A consecutive of 5798 patients who underwent colonoscopy examination were included. Bowel preparation was evaluated based on Bowel Bubble Scale (BBS) in general and Boston Bowel Preparation Scale (BBPS) in each segment (right side, transverse and left side of colon) and total BBPS scores. The quality of bowel preparation was correlated with ADR and AADR.
    Results: Four thousand nine hundred forty colonoscopies (14,820 bowel segments) were included in the final analysis. In which 30.9% scored 3, 57.5% scored 2, 11.2% scored 1 and 0.4% scored 0 on basis of BBPS. For each score, ADR were 10.8, 7.7, 4.9 and 3.2%, respectively; whereas AADR were 4.5, 2.8,1.8 and 1.6% (P < 0.05). 36.9% of the colonoscopies showed presence of minimal bubbles and 34.3% with no bubble. For bowels without bubbles and with a large amount of bubbles, ADR were 28.3 and 20.0% respectively; and AADR were 13.3 and 7.1% respectively.
    Conclusions: Segmental bowels' cleanliness and the amount of bubbles in bowels significantly affect ADR and AADR. The better the bowel preparation at each segment is and the less bubbles in the bowel there are, the higher ADR and AADR we got. We suggest repeating colonoscopy if any segment of the bowel preparation is poor, or if there is more bubbles, even if the total score of BBPS indicates good or fair bowel preparation.
    Mesh-Begriff(e) Adenoma/diagnosis ; Aged ; Cathartics/standards ; Cathartics/therapeutic use ; Colon/drug effects ; Colonoscopy/statistics & numerical data ; Colorectal Neoplasms/diagnosis ; Cross-Sectional Studies ; Early Detection of Cancer/statistics & numerical data ; Female ; Humans ; Male ; Middle Aged ; Population Surveillance/methods
    Chemische Substanzen Cathartics
    Sprache Englisch
    Erscheinungsdatum 2019-07-08
    Erscheinungsland England
    Dokumenttyp Evaluation Study ; Journal Article
    ZDB-ID 2041351-8
    ISSN 1471-230X ; 1471-230X
    ISSN (online) 1471-230X
    ISSN 1471-230X
    DOI 10.1186/s12876-019-1019-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  7. Artikel: Efficacy of a Novel Exoskeletal Robot for Locomotor Rehabilitation in Stroke Patients: A Multi-center, Non-inferiority, Randomized Controlled Trial.

    Li, Yongqiang / Fan, Tao / Qi, Qi / Wang, Jun / Qiu, Huaide / Zhang, Lingye / Wu, Xixi / Ye, Jing / Chen, Gong / Long, Jianjun / Wang, Yulong / Huang, Guozhi / Li, Jianan

    Frontiers in aging neuroscience

    2021  Band 13, Seite(n) 706569

    Abstract: ... ...

    Abstract Objective
    Sprache Englisch
    Erscheinungsdatum 2021-08-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2021.706569
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  8. Artikel ; Online: A Simple, Time-Saving Dye Staining of Proteins in Sodium Dodecyl Sulfate-Polyacrylamide Gel Using Coomassie Blue.

    Dong, Wei-Hua / Wang, Fang / Zhang, Jun-He / Zhou, Yan-Sheng / Zhang, Ling-Ye / Wang, Tian-Yun

    Methods in molecular biology (Clifton, N.J.)

    2018  Band 1853, Seite(n) 31–35

    Abstract: Most traditional post-electrophoretic processes need several hours to several days to finish the whole staining process and traditional staining solutions all contain methanol, acetic acid, or phosphoric acid, which not only produce the unpleasant smell ... ...

    Abstract Most traditional post-electrophoretic processes need several hours to several days to finish the whole staining process and traditional staining solutions all contain methanol, acetic acid, or phosphoric acid, which not only produce the unpleasant smell but also cause environmental pollution. Here a fixation-free, fast protein staining method in sodium dodecyl sulfate-polyacrylamide gel electrophoresis using Coomassie blue is described. The protocol includes only staining and quick washing steps, can be completed in 0.5 h. It has a sensitivity of 10 ng. In addition, the dye stain does not contain any acid or methanol.
    Mesh-Begriff(e) Acrylic Resins ; Electrophoresis, Polyacrylamide Gel/methods ; Proteins/chemistry ; Rosaniline Dyes ; Staining and Labeling/methods
    Chemische Substanzen Acrylic Resins ; Proteins ; Rosaniline Dyes ; polyacrylamide gels ; Coomassie blue (78642-64-5)
    Sprache Englisch
    Erscheinungsdatum 2018-07-26
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-8745-0_5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  9. Artikel ; Online: Efficacy and safety of using premedication with simethicone/Pronase during upper gastrointestinal endoscopy examination with sedation: A single center, prospective, single blinded, randomized controlled trial.

    Zhang, Ling-Ye / Li, Wen-Yan / Ji, Ming / Liu, Fu-Kun / Chen, Guang-Yong / Wu, Shan-Shan / Hao, Qian / Zhai, Hui-Hong / Zhang, Shu-Tian

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

    2017  Band 30, Heft 1, Seite(n) 57–64

    Abstract: Background and aim: To investigate the efficacy and safety of premedication with simethicone/Pronase during esophagogastroduodenoscopy (EGD) with sedation.: Methods: Six hundred and ten patients were randomly allocated to two groups based on type of ... ...

    Abstract Background and aim: To investigate the efficacy and safety of premedication with simethicone/Pronase during esophagogastroduodenoscopy (EGD) with sedation.
    Methods: Six hundred and ten patients were randomly allocated to two groups based on type of premedication given. Premedication used in the control group was 10 mL lidocaine hydrochloride mucilage (LHM, N = 314) and premedication used in the intervention group was 80 mL simethicone/Pronase solution plus 10 mL lidocaine hydrochloride mucilage (SP/LHM, N = 296). EGD was done under sedation. Visibility scores, number of mucosal areas that needed cleansing, water consumption for cleansing, time taken for examination, diminutive lesions, pathological diagnosis, patients' gag reflex and oxygenation (pulse oximetry) were recorded.
    Results: SP/LHM has significantly lower total visibility score than LHM (7.978 ± 1.526 vs 6.348 ± 1.097, P < 0.01). During the procedure, number of intragastric areas that needed cleansing and amount of water consumed were significantly less in the SP/LHM than in the LHM group (P < 0.01). In SP/LHM (P = 0.01), endoscopy procedure duration was significantly longer. Although there was no significant difference in rate of detection of diminutive lesions between LHM and SP/LHM, the endoscopist carried out more biopsies in SP/LHM. This led to a higher rate of diagnosis of atrophic gastritis (P = 0.014) and intestinal metaplasia (P = 0.024). There was no significant difference in gag reflex (P = 0.604) and oxygenation during the endoscopy procedure for either group of patients.
    Conclusion: Routine use of premedication with simethicone/Pronase should be recommended during EGD with sedation.
    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; Antifoaming Agents/pharmacology ; Conscious Sedation/methods ; Early Detection of Cancer/methods ; Endoscopy, Gastrointestinal/methods ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Premedication/methods ; Pronase/pharmacology ; Prospective Studies ; Simethicone/pharmacology ; Single-Blind Method ; Stomach Neoplasms/diagnosis ; Young Adult
    Chemische Substanzen Antifoaming Agents ; Simethicone (8050-81-5) ; Pronase (EC 3.4.24.-)
    Sprache Englisch
    Erscheinungsdatum 2017-10-12
    Erscheinungsland Australia
    Dokumenttyp Journal Article ; Randomized Controlled Trial
    ZDB-ID 1171589-3
    ISSN 1443-1661 ; 0915-5635
    ISSN (online) 1443-1661
    ISSN 0915-5635
    DOI 10.1111/den.12952
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

Zum Seitenanfang