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  1. Book: Natural products

    Zhang, Lixin

    drug discovery and therapeutic medicine

    2005  

    Author's details ed. by Lixin Zhang
    Keywords Pharmacognosy ; Drug Design ; Biological Products / therapeutic use ; Biological Factors / therapeutic use ; Pharmacogenetics
    Language English
    Size XIV, 382 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT014237672
    ISBN 1-58829-383-1 ; 978-1-58829-383-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2005 A 2371 order for loan Magazin

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  2. Article ; Online: Discovering the next decade's synthetic biology research trends with ChatGPT.

    Tong, Yaojun / Zhang, Lixin

    Synthetic and systems biotechnology

    2023  Volume 8, Issue 2, Page(s) 220–223

    Language English
    Publishing date 2023-02-22
    Publishing country China
    Document type Editorial
    ISSN 2405-805X
    ISSN (online) 2405-805X
    DOI 10.1016/j.synbio.2023.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: First report of root rot in

    Fu, Min / Yin, Canhong / Xia, Zhijie / Zhang, Lixin

    Plant disease

    2024  

    Abstract: Trichosanthes ... ...

    Abstract Trichosanthes kirilowii
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 754182-x
    ISSN 0191-2917
    ISSN 0191-2917
    DOI 10.1094/PDIS-11-23-2403-PDN
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 2043: Show issues

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  4. Article ; Online: Lowly expressed LNC01136 fails to aid HIF-1α to induce BTG2 expression resulting in increased proliferation of retinal microvascular endothelial cells.

    Zhang, Lixin / Wang, Xilang

    Microvascular research

    2022  Volume 141, Page(s) 104315

    Abstract: Background: Retinal neovascularization (RN), a major cause of blindness occurring in multiple types of ophthalmic diseases, is closely associated with hypoxic conditions. However, the underlying pathological mechanisms of RN have not been fully ... ...

    Abstract Background: Retinal neovascularization (RN), a major cause of blindness occurring in multiple types of ophthalmic diseases, is closely associated with hypoxic conditions. However, the underlying pathological mechanisms of RN have not been fully elucidated. BTG2 is anti-proliferative factor. The up-stream of BTG2 gene within 3000 bp expresses a long non-coding RNA, LNC01136.
    Methods: we initially compared the expression of BTG2 and LNC01136 in human retinal microvascular endothelial cells (hRMECs) with other eye-associated cells, including Muller cells, ARPE19 cells and RGC-5, in response to a hypoxia mimetic agent (CoCl
    Results: After the treatment with CoCl
    Conclusions: This study revealed that LNC01136 is a cell growth suppressor by recruiting HIF-1α to induce BTG2 expression. However the low expression of LNC01136 in hRMECs compared to other eye-associated cells promoted hRMECs' proliferation, which is probably a cause of RN under hypoxia.
    MeSH term(s) Cell Hypoxia/physiology ; Cell Proliferation ; Endothelial Cells/metabolism ; Humans ; Hypoxia/pathology ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Immediate-Early Proteins/genetics ; Immediate-Early Proteins/metabolism ; Retina/metabolism ; Retinal Neovascularization/metabolism ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism
    Chemical Substances Hypoxia-Inducible Factor 1, alpha Subunit ; Immediate-Early Proteins ; Tumor Suppressor Proteins ; BTG2 protein, human (141490-22-4)
    Language English
    Publishing date 2022-01-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80307-8
    ISSN 1095-9319 ; 0026-2862
    ISSN (online) 1095-9319
    ISSN 0026-2862
    DOI 10.1016/j.mvr.2022.104315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 746: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Asymmetric synthesis of (

    Wang, Bingfu / Liu, Jian / Li, Tianxing / Jin, Hui / Zhang, Lixin

    Organic & biomolecular chemistry

    2024  Volume 22, Issue 6, Page(s) 1146–1151

    Abstract: This work demonstrates asymmetric synthesis of the GABA derivative ( ...

    Abstract This work demonstrates asymmetric synthesis of the GABA derivative (
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d3ob02009f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Doubly adaptive biased coin design to improve Bayesian clinical trials with time-to-event endpoints.

    Cao, Wenhao / Zhu, Hongjian / Wang, Li / Zhang, Lixin / Yu, Jun

    Statistics in medicine

    2024  Volume 43, Issue 9, Page(s) 1743–1758

    Abstract: Clinical trialists often face the challenge of balancing scientific questions with other design features, such as improving efficiency, minimizing exposure to inferior treatments, and simultaneously comparing multiple treatments. While Bayesian response ... ...

    Abstract Clinical trialists often face the challenge of balancing scientific questions with other design features, such as improving efficiency, minimizing exposure to inferior treatments, and simultaneously comparing multiple treatments. While Bayesian response adaptive randomization (RAR) is a popular and effective method for achieving these objectives, it is known to have large variability and a lack of explicit theoretical results, making its use in clinical trials a subject of concern. It is desirable to propose a design that targets the same allocation proportion as Bayesian RAR and achieves the above objectives but addresses the concerns over Bayesian RAR. We propose the frequentist doubly adaptive biased coin designs (DBCD) targeting ethical allocation proportions from the Bayesian framework to satisfy different objectives in clinical trials with time-to-event endpoints. We derive the theoretical properties of the proposed adaptive randomization design and show through comprehensive numerical simulations that it can achieve ethical objectives without sacrificing efficiency. Our combined theoretical and numerical results offer a strong foundation for the practical use of RAR in real clinical trials.
    MeSH term(s) Humans ; Bayes Theorem ; Research Design ; Random Allocation
    Language English
    Publishing date 2024-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 843037-8
    ISSN 1097-0258 ; 0277-6715
    ISSN (online) 1097-0258
    ISSN 0277-6715
    DOI 10.1002/sim.10047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1756: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Book ; Online: Mechanisms of antibiotic resistance

    Zhang, Lixin / Aminov, Rustam I. / Tolmasky, Marcelo / Roberts, Marilyn C. / Nishino, Kunihiko / Lin, Jun

    2015  

    Abstract: Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and ... ...

    Abstract Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens
    Keywords Microbiology ; Science (General)
    Size 1 electronic resource (224 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020090194
    ISBN 9782889195268 ; 2889195260
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: Application of New COF Materials in Secondary Battery Anode Materials.

    Jia, Miao / Zhang, Lixin / Yuan, Qiong

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 16

    Abstract: Covalent organic framework materials (COFs), as a new type of organic porous material, not only have the characteristics of flexible structure, abundant resources, environmental friendliness, etc., but also have the characteristics of a regular structure ...

    Abstract Covalent organic framework materials (COFs), as a new type of organic porous material, not only have the characteristics of flexible structure, abundant resources, environmental friendliness, etc., but also have the characteristics of a regular structure and uniform pore channels, so they have broad application prospects in secondary batteries. Their functional group structure, type, and number of active sites play a crucial role in the performance of different kinds of batteries. Therefore, this article starts from these aspects, summarizes the application and research progress of the COF anode materials used in lithium-ion batteries, sodium-ion batteries, and potassium-ion batteries in recent years, discusses the energy storage mechanism of COF materials, and expounds the application prospects of COF electrodes in the field of energy storage.
    Language English
    Publishing date 2023-08-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28165953
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  9. Article ; Online: HPTLC + SRES screening of pesticide for point-of-care application as shown with thiram in juice.

    Wang, Zhijian / Zhang, Lixin / Chen, Yisheng

    Food chemistry: X

    2023  Volume 18, Page(s) 100670

    Abstract: In this study, a HPTLC-platformed SERS detection was established for screening thiram in juice. After a simple extraction, the sample liquid was separated on HPTLC plates, which resulted in a specific zone for the analyte. Following infiltration with ... ...

    Abstract In this study, a HPTLC-platformed SERS detection was established for screening thiram in juice. After a simple extraction, the sample liquid was separated on HPTLC plates, which resulted in a specific zone for the analyte. Following infiltration with atomize water, the band of interest was easily scraped off and eluted. In parallel, a flexible and SERS-active substrate was fabricated by the
    Language English
    Publishing date 2023-04-01
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-1575
    ISSN (online) 2590-1575
    DOI 10.1016/j.fochx.2023.100670
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The creep model based on nonlinear Newton body under different temperature conditions.

    Zhang, Lixin / Wei, Xiujie / Zhang, Yin

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 4822

    Abstract: Mastering the creep deformation characteristics of rock under different temperature conditions is of great significance for studying the long-term stability and deformation mechanism of geotechnical engineering. Based on the classical Burgers model, the ... ...

    Abstract Mastering the creep deformation characteristics of rock under different temperature conditions is of great significance for studying the long-term stability and deformation mechanism of geotechnical engineering. Based on the classical Burgers model, the creep model under different temperature conditions is established by introducing a nonlinear Newton body. The parameters of the creep model are identified and the influence law of different parameters on rock creep deformation is analyzed. The relationship between model parameters and temperature is quantitatively expressed. The results show that the newly established model can describe the characteristics of the rock in the decay creep stage and the constant creep stage, especially can quantitatively characterize the relationship between the strain and the time of the rock in the tertiary creep under different temperatures conditions. The model fitting curve is highly consistent with the test data, and the correlation coefficient R
    Language English
    Publishing date 2023-03-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-31983-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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