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Article ; Online: Inhibiting L1CAM Reverses Cisplatin Resistance of Triple Negative Breast Cancer Cells by Blocking AKT Signaling Pathway.

Zhang, Lu-Yao / Shen, Zhi-Xin / Guo, Lu

2022 Volume 40, Issue 4, Page(s) 313–324

Abstract: DDP-resistant MDA-MB-231 cells (MDA-MB-231/DDP) cells had higher expression of L1CAM than their parental cells. L1CAM siRNA decreased the IC50 of MDA-MB-231/DDP cells to DDP. L1CAM inhibition down-regulated p-AKT/AKT in MDA-MB-231/DDP cells; meanwhile, ... ...

Abstract	DDP-resistant MDA-MB-231 cells (MDA-MB-231/DDP) cells had higher expression of L1CAM than their parental cells. L1CAM siRNA decreased the IC50 of MDA-MB-231/DDP cells to DDP. L1CAM inhibition down-regulated p-AKT/AKT in MDA-MB-231/DDP cells; meanwhile, it could promote MDA-MB-231/DDP cell apoptosis, inhibit cell EMT, invasion, and migration. Moreover, SC79 (an AKT activator) increased the DDP-resistance of MDA-MB-231/DDP cells, which was reversed by L1CAM inhibition. Furthermore, co-treatment of L1CAM shRNA and cisplatin injection had better anti-tumor effects
MeSH term(s)	Apoptosis ; Cell Line, Tumor ; Cell Proliferation ; Cisplatin/pharmacology ; Drug Resistance, Neoplasm ; Gene Expression Regulation, Neoplastic ; Humans ; Neural Cell Adhesion Molecule L1/antagonists & inhibitors ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/genetics
Chemical Substances	Neural Cell Adhesion Molecule L1 ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2022-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	604942-4
ISSN	1532-4192 ; 0735-7907
ISSN (online)	1532-4192
ISSN	0735-7907
DOI	10.1080/07357907.2021.2016801
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Article: [Spatial Distribution Characteristics and Risk Assessment of Cadmium Pollution in Soil-crops system of an E-waste Dismantling Area].

Zhang, Lu-Yao / Zhao, Ke-Li / Fu, Wei-Jun

Huan jing ke xue= Huanjing kexue

2021 Volume 42, Issue 9, Page(s) 4432–4440

Abstract: With the rapid development of electronic technology, soil heavy metal contamination caused by electronic waste dismantling activities has attracted the attention of many researchers. To investigate the contamination status and spatial distribution of Cd ... ...

Abstract	With the rapid development of electronic technology, soil heavy metal contamination caused by electronic waste dismantling activities has attracted the attention of many researchers. To investigate the contamination status and spatial distribution of Cd in soil-crop systems around an e-waste dismantling area, 171 pairs of soil and crop samples were collected for analysis. The concentrations of cadmium in root vegetable soil, leaf vegetable soil, solanaceous vegetable soil, and orchard soil were (1.292±0.647), (1.010±0.201), (0.921±0.125), and (0.861±0.135) mg·kg
MeSH term(s)	Cadmium ; Child ; Electronic Waste ; Environmental Monitoring ; Humans ; Risk Assessment ; Soil ; Soil Pollutants/analysis
Chemical Substances	Soil ; Soil Pollutants ; Cadmium (00BH33GNGH)
Language	Chinese
Publishing date	2021-08-14
Publishing country	China
Document type	Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.202101212
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Article: Ventricular tachycardia originating from the His bundle: A case report.

Zhang, Lu-Yao / Dong, Shu-Juan / Yu, Hai-Jia / Chu, Ying-Jie

World journal of clinical cases

2021 Volume 9, Issue 32, Page(s) 10040–10045

Abstract: Background: Ventricular tachycardia (VT) commonly occurs among patients with heart failure and can even cause sudden cardiac death. VT originating from the His bundle branch has been rarely reported. We present the case of a patient with VT from the His ...

Abstract	Background: Ventricular tachycardia (VT) commonly occurs among patients with heart failure and can even cause sudden cardiac death. VT originating from the His bundle branch has been rarely reported. We present the case of a patient with VT from the His bundle branch. Case summary: A 58-year-old female complained of paroxysmal palpitations and dizziness for approximately 6 mo. She had a history of fatty liver and cholecystitis, and carotid atherosclerosis could not be excluded from the ultrasound results. An evaluation of the electrocardiogram obtained after admission showed spontaneous conversion between two different morphologies. The possible electrophysiologic mechanism suggested that the dual-source VT originated from the same source, the His bundle branch. Finally, the His bundle branch was ablated, and a dual-chamber pacemaker was inserted into the patient's heart. No further VT occurred during the 3-year follow-up after hospital discharge. Conclusion: The diagnosis of VT originating from the His bundle is rare and difficult to establish. The results of this study showed VT originating from the His bundle based on a careful evaluation of the electrocardiogram, and the diagnosis was confirmed by an intracardiac electrophysiologic examination.
Language	English
Publishing date	2021-11-30
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v9.i32.10040
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Article: The Effect of Temperature and Moisture on Colonization of Apple Fruit and Branches by Botryosphaeria dothidea

Liu, Jing / Zhang, Lu-yao / Wang, Hua-yu / Liu, Na / Lian, Sen / Xu, Xiang-ming / Li, Bao-hua

Phytopathology. 2022 Aug., v. 112, no. 8

2022

Abstract: Botryosphaeria dothidea causes severe disease of apple trees in China. The process of conidium germination, colonization, and infection of apple fruit and branches was examined on ‘Fuji’ apple and the effect of temperature, surface wetness and relative ... ...

Abstract	Botryosphaeria dothidea causes severe disease of apple trees in China. The process of conidium germination, colonization, and infection of apple fruit and branches was examined on ‘Fuji’ apple and the effect of temperature, surface wetness and relative humidity (RH), and host surface washates on these processes was studied in controlled environments. Initial germ tube development and hyphal growth resulted in the colonization of the host surface without forming an infection structure. Hyphae expanded radially across the host surface and, after entering lenticels, developed into a dense mycelium mass or differentiated pseudoparenchyma. Hyphae from the bottom of the pseudoparenchyma either directly penetrated the lenticel surface intercellularly through the cell layer, or formed an undifferentiated hypha that invaded the lenticel through cracks formed during the lenticel development. Conidial germination and hyphal colonization occurred at 10 to 40°C, with an optimum of approximately 28°C. Conidial germination required an RH > 95% or surface wetness but, for hyphal colonization, an RH > 90% was sufficient. Conidia germinated and formed germ tubes within 1 h under optimum conditions. However, the pathogen required a longer period at RH > 90% or surface wetness for hyphae to colonize and form pseudoparenchyma or dense mycelia on the host surface. Hyphal colonization is a crucial stage for infection of apple tissues by B. dothidea.
Keywords	Botryosphaeria dothidea ; apples ; conidia ; disease severity ; germ tube ; germination ; mycelium ; pathogens ; plant pathology ; relative humidity ; temperature ; China
Language	English
Dates of publication	2022-08
Size	p. 1698-1709.
Publishing place	The American Phytopathological Society
Document type	Article
ZDB-ID	208889-7
ISSN	1943-7684 ; 0031-949X
ISSN (online)	1943-7684
ISSN	0031-949X
DOI	10.1094/PHYTO-11-21-0487-R
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Article: The Effect of Temperature and Moisture on Colonization of Apple Fruit and Branches by

Liu, Jing / Zhang, Lu-Yao / Wang, Hua-Yu / Liu, Na / Lian, Sen / Xu, Xiang-Ming / Li, Bao-Hua

Phytopathology

2022 Volume 112, Issue 8, Page(s) 1698–1709

Abstract: Botryosphaeria ... ...

Abstract	Botryosphaeria dothidea
MeSH term(s)	Ascomycota/pathogenicity ; Fruit/microbiology ; Humidity ; Malus/microbiology ; Plant Diseases/microbiology ; Temperature
Language	English
Publishing date	2022-07-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	208889-7
ISSN	1943-7684 ; 0031-949X
ISSN (online)	1943-7684
ISSN	0031-949X
DOI	10.1094/PHYTO-11-21-0487-R
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Article: TiO2-supported Au-Ag plasmonic nanocatalysts achieved by plasma restructuring and activation

Zhu, Bin / Zhang, Lu-Yao / Liu, Jing-Lin / Zhang, Xiao-Min / Li, Xiao-Song / Zhu, Ai-Min

Journal of hazardous materials. 2021 Jan. 15, v. 402

2021

Abstract: Plasmonic Au-Ag/TiO₂ bimetallic nanocatalyst is regarded as a promising visible-light (VL) photocatalyst due to its wide light absorption and potentially enhanced activity. For its preparation, Au precursors usually contain Cl and co-impregnation/co- ... ...

Abstract	Plasmonic Au-Ag/TiO₂ bimetallic nanocatalyst is regarded as a promising visible-light (VL) photocatalyst due to its wide light absorption and potentially enhanced activity. For its preparation, Au precursors usually contain Cl and co-impregnation/co-deposition suffers from AgCl precipitation, and consequently Au and Ag have to be sequentially supported. However, Au and Ag species of the sequential preparation are individually isolated and difficult to be homogeneously mixed. Here we report an Au-Ag plasmonic nanocatalyst achieved by plasma restructuring and activation from the sequential preparation. The isolated cationic Au and Ag species on the sequentially-prepared Au-Ag/TiO₂ sample are restructured to be homogeneously mixed and highly activated by O₂ plasma, which can be partially auto-reduced to Au-Ag bimetallic nanoparticles within the induction period of a few minutes in VL photocatalytic oxidation of CO. The Au-Ag plasmonic nanocatalyst exhibits a strongly enhanced activity in the VL photocatalytic reaction. The contribution of O₂ plasma treatment and the enhancement mechanism for the Au-Ag plasmonic nanocatalyst are disclosed.
Keywords	absorption ; light ; nanocatalysts ; oxidation ; photocatalysis ; photocatalysts
Language	English
Dates of publication	2021-0115
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2020.123508
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Article: Effects of preoperative current smoking on chronic postsurgical pain in thoracic surgery: a retrospective cohort study.

Liu, Xin-Min / Zhao, Ying / Zhang, Lu-Yao / Li, Bing / Wang, Shi-Chao / Zhu, Hai-Peng / Zhi, Hui / Zhang, Jia-Qiang / Zhang, Wei

American journal of translational research

2023 Volume 15, Issue 3, Page(s) 2256–2267

Abstract: Objective: This study aimed to investigate the effect of preoperative current smoking on chronic postsurgical pain in patients who underwent thoracic surgery.: Methods: A total of 5,395 patients aged over 18 years old who underwent thoracic surgery ... ...

Abstract	Objective: This study aimed to investigate the effect of preoperative current smoking on chronic postsurgical pain in patients who underwent thoracic surgery. Methods: A total of 5,395 patients aged over 18 years old who underwent thoracic surgery from January 2016 to March 2020 in Henan Provincial People's Hospital were enrolled. Patients were divided into two groups: the smoking group (SG group) and the nonsmoking group (NSG group). Propensity score matching was utilized to eliminate the influence of confounding factors, and a multivariable logistic regression model was established to determine the effect of preoperative current smoking on chronic postsurgical pain. The dose-response relationship between the smoking index (SI) and chronic postsurgical pain at rest was analyzed using a restricted cubic spline curve. Results: In a matched cohort of 1028 patients, the incidence of chronic pain at rest was 13.2% in the smoking group and 19.0% in the nonsmoking group (P = 0.011). Three different models were used to verify the stability of the model between preoperative current smoking and chronic postsurgical pain. A regression model was established to determine the influence of different smoking indexes (SIs) on chronic postsurgical pain. The incidence of chronic pain at rest was lower in patients with SI ≥400 before thoracic surgery than in patients whose SI was less than 400. Conclusions: A relationship between the preoperative current smoking index and chronic postsurgical pain at rest was observed. The incidence of chronic postsurgical pain at rest was lower in patients whose SI was greater than 400.
Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
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Article: Sex and age differences in chronic postoperative pain among patients undergoing thoracic surgery: a retrospective cohort study.

Zhao, Ying / Liu, Xin-Min / Zhang, Lu-Yao / Li, Bing / Wang, Ruo-Han / Yuan, Qin-Yue / Wang, Shi-Chao / Zhu, Hai-Peng / Zhi, Hui / Zhang, Jia-Qiang / Zhang, Wei

Frontiers in medicine

2023 Volume 10, Page(s) 1180845

Abstract: Background: The effect of sex and age on chronic post-thoracic surgical pain (CPTP) at rest and with activity remains unclear. The main purpose of this study was to investigate the relationship between the incidence of chronic postoperative pain (at ... ...

Abstract	Background: The effect of sex and age on chronic post-thoracic surgical pain (CPTP) at rest and with activity remains unclear. The main purpose of this study was to investigate the relationship between the incidence of chronic postoperative pain (at rest and with activity) and sex/age differences. Methods: This was a single-center retrospective study that included adult patients who had undergone elective thoracic surgery. Patients were divided into two groups based on sex. Demographic and perioperative data were collected, including age, sex, education level, Body Mass Index (BMI), American Society of Anesthesiologists (ASA) physical status, and medical history (hypertension, diabetes mellitus). Chronic postoperative pain data were collected by telephone follow-up. Results: Among the 3,159 patients enrolled, 1,762 were male, and 1,397 were female. After creating a matched-pairs cohort, 1,856 patients were analyzed. The incidence of CPTP at rest was 14.9% among males and 17.8% among females ( Conclusion: Females have a higher incidence of chronic postoperative pain with activity after thoracic surgery. Females in the 45-55-year-old age group are more prone to develop CPTP than females in other age groups.
Language	English
Publishing date	2023-06-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1180845
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Article: Babao Dan decreases hepatocarcinogenesis by inhibiting hepatic progenitor cells malignant transformation via down-regulating toll-like receptor 4.

Liang, Lei / Zhang, Lu-Yao / Liu, Wen-Ting / Zong, Chen / Gao, Lu / Li, Rong / Zhao, Qiu-Dong / Zhao, Na-Ping / Wei, Li-Xin / Zhang, Li / Han, Zhi-Peng

Frontiers in oncology

2023 Volume 13, Page(s) 1073859

Abstract: Background: Babao Dan (BBD) is a traditional Chinese medicine that has been widely used as a complementary and alternative medicine to treat chronic liver diseases. In this study, we aimed to observe the effect of BBD on the incidence of ... ...

Abstract	Background: Babao Dan (BBD) is a traditional Chinese medicine that has been widely used as a complementary and alternative medicine to treat chronic liver diseases. In this study, we aimed to observe the effect of BBD on the incidence of diethylnitrosamine (DEN)-initiated hepatocellular carcinoma formation in rats and explored its possible mechanism. Methods: To verify this hypothesis, BBD was administrated to rats at a dose of 0.5g/kg body weight per two days from the 9th to 12th week in HCC-induced by DEN. Liver injury biomarkers and hepatic inflammatory parameters were evaluated by histopathology as well as serum and hepatic content analysis. We applied immunohistochemical analysis to investigate the expression of CK-19 and SOX-9 in liver tissues. The expression of TLR4 was determined by immunohistochemical, RT-PCR, and western blot analysis. Furthermore, we also detected the efficacy of BBD against primary HPCs neoplastic transformation induced by LPS. Results: We observed that DEN could induce hepatocarcinogenesis, and BBD could obviously decrease the incidence. The biochemical and histopathological examination results confirmed that BBD could protect against liver injury and decrease inflammatory infiltration. Immunohistochemistry staining results showed that BBD could effectively inhibit the ductal reaction and the expression of TLR4. The results showed that BBD-serumcould obviously inhibit primary HPCs neoplastic transformation induced by regulating the TLR4/Ras/ERK signaling pathway. Conclusion: In summary, our results indicate that BBD has potential applications in the prevention and treatment of HCC, which may be related to its effect on hepatic progenitor cells malignant transformation via inhibiting the TLR4/Ras/ERK signaling pathway.
Language	English
Publishing date	2023-05-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1073859
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Article ; Online: Risk model for predicting mortality in patients with necrotizing soft tissue infections in the intensive care unit.

Zhang, Lu-Yao / Zheng, Wei-Jie / Li, Ke / JianPing-Ye / Qiu, Zhi-Min / Zhao, Guang-Ju / Jin, Pin-Pin / Chen, Long-Wang / Tang, Ya-Hui / Hong, Guang-Liang / Lu, Zhong-Qiu

Burns : journal of the International Society for Burn Injuries

2023 Volume 50, Issue 3, Page(s) 578–584

Abstract: Background: The goal of this study is to look into the factors that lead to death in patients with necrotizing soft tissue infections（NSTIs） in the intensive care unit and create a mortality risk model.: Methods: The clinical data of 106 patients ... ...

Abstract	Background: The goal of this study is to look into the factors that lead to death in patients with necrotizing soft tissue infections（NSTIs） in the intensive care unit and create a mortality risk model. Methods: The clinical data of 106 patients with necrotizing soft tissue infections admitted to intensive care unit(ICU) of the First Affiliated Hospital of Wenzhou Medical University between January 2008 and December 2021 were retrospectively analyzed. Univariate analysis and multivariate analysis were performed to evaluate the risk factors impacting patient mortality. The regression coefficient in binary logistic regression analysis was converted into the item score in the model, and then the model score of each patient was calculated. Finally, an ROC curve was constructed to evaluate the efficiency of the model for predicting mortality. Thirteen patients with NSTIs admitted to ICU between January 2022 and November 2022 were used to validate the model. Results: The death group had 44 patients, while the survival group had 62 patients. The overall mortality was 41.5%. Binary logistic regression analysis showed that risk factors for mortality were age≥ 60 years(OR:4.419; 95%CI:1.093-17.862; P = 0.037), creatinine ≥ 132μmol/L(OR:11.166; 95%CI:2.234-55.816; P = 0.003), creatine kinase ≥ 1104 U/L(OR:4.019; 95%CI:1.134-14.250; P = 0.031), prothrombin time ≥ 24.4 s(OR:11.589; 95%CI:2.510-53.506; P = 0.002), and invasive mechanical ventilation (OR:17.404; 95%CI:4.586-66.052; P＜0.000). The AUC of the model for predicting mortality was 0.940 (95% CI:0.894-0.986). When the cut-off value for the model was 4 points, the sensitivity was 95.5% and the specificity was 83.9%. Conclusion: The death risk model in this study for NSTIs patients in the intensive care unit shows high sensitivity and specificity. Patients with a score of ≥ 4 points have a higher risk of mortality.
MeSH term(s)	Humans ; Middle Aged ; Soft Tissue Infections/epidemiology ; Retrospective Studies ; Sepsis ; Prognosis ; Burns ; Intensive Care Units ; ROC Curve
Language	English
Publishing date	2023-12-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	197308-3
ISSN	1879-1409 ; 0305-4179
ISSN (online)	1879-1409
ISSN	0305-4179
DOI	10.1016/j.burns.2023.11.008
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