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  1. Article ; Online: Correlation analysis between peripheral blood dendritic cell subsets and PD-1 in patients with peritoneal adenocarcinoma.

    Hu, Huihui / Zhang, Man

    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

    2024  Volume 57, Page(s) e13192

    Abstract: The aim of this study was to explore the association between differential percentages of dendritic cell (DC) subsets in peripheral blood and malignancy (grade and lymph node metastasis) of peritoneal adenocarcinoma patients and the frequencies of ... ...

    Abstract The aim of this study was to explore the association between differential percentages of dendritic cell (DC) subsets in peripheral blood and malignancy (grade and lymph node metastasis) of peritoneal adenocarcinoma patients and the frequencies of dendritic cell subsets in the normal controls. The peripheral blood of 30 patients with peritoneal adenocarcinoma and 12 healthy controls were collected for multicolor flow cytometry analysis. Peritoneal adenocarcinoma patients were grouped according to the malignant degree (grade and lymph node metastasis). Percentages of myeloid DCs (mDCs) and its subsets MDC1 and MDC2 in DCs were lower in peripheral blood of patients with peritoneal adenocarcinoma than in normal controls. The percentages of plasmacytoid dendritic cells (pDCs) and CD16+mDCs in DCs were higher than in normal controls. Compared with poor differentiation grade, patients with well/moderate differentiation grade had an increased percentage of CD16+mDCs. Contrary to CD16+mDCs, the percentage of MDC1 was lower in the well/moderate differentiation grade group. In patients with no lymph node metastasis, pDCs and CD16+mDCs levels were higher compared with patients with lymph node metastasis. mDCs and MDC1 levels had opposite results. pDCs were positively correlated with CD16+mDCs in peripheral blood of peritoneal patients, as was mDCs and MDC1. CD16+mDCs were negatively correlated with MDC1. The percentages of pDCs and CD16+mDCs in DCs were positively correlated with CD3+CD8+T cells, and pDCs also positively correlated with CD8+PD-1+T cells. Our results revealed that DCs subsets correlated with peritoneal adenocarcinoma malignancy. Dendritic cells play an independent role in the immune function of peritoneal adenocarcinoma.
    MeSH term(s) Humans ; Programmed Cell Death 1 Receptor ; Lymphatic Metastasis/pathology ; Dendritic Cells ; Adenocarcinoma/pathology ; Lipid Metabolism, Inborn Errors ; Muscular Diseases ; Ichthyosiform Erythroderma, Congenital
    Chemical Substances Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2024-02-19
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 786234-9
    ISSN 1414-431X ; 0100-879X
    ISSN (online) 1414-431X
    ISSN 0100-879X
    DOI 10.1590/1414-431X2023e13192
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1359: Show issues Location:
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  2. Article ; Online: Preparation of gypsum with high purity and whiteness from phosphogypsum for CO

    Zhang, Man / Fan, Xing

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 4156

    Abstract: Phosphogypsum (PG) is a solid waste product generated during wet-process phosphoric acid production. Various impurities considerably reduce the purity, whiteness, and application range of PG. This article analyzes the physical properties of PG in detail ... ...

    Abstract Phosphogypsum (PG) is a solid waste product generated during wet-process phosphoric acid production. Various impurities considerably reduce the purity, whiteness, and application range of PG. This article analyzes the physical properties of PG in detail and systematically examines the content and distribution of impurities. Based on the obtained results, a simple process for the efficient removal of almost all impurities in the PG is proposed. The purity and whiteness of the purified gypsum (CaSO
    Language English
    Publishing date 2023-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-28251-6
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  3. Article ; Online: The experiences of patients with peritoneal dialysis: A systematic review of qualitative evidence protocol.

    Zhang, Man / Cai, Chunfeng

    PloS one

    2023  Volume 18, Issue 7, Page(s) e0288724

    Abstract: Background: The incidence of end-stage renal disease (ESRD) is on the rise, it has been a major public health problem and places a significant burden on healthcare systems. Peritoneal dialysis (PD) is an increasingly popular form of renal replacement ... ...

    Abstract Background: The incidence of end-stage renal disease (ESRD) is on the rise, it has been a major public health problem and places a significant burden on healthcare systems. Peritoneal dialysis (PD) is an increasingly popular form of renal replacement therapy. Patients undergoing dialysis treatment undergo specific pathophysiological and psychological changes. The aim of this systematic review is to investigate the experiences of ESRD patients receiving PD in order to gain deeper insights into their attitudes and beliefs towards this treatment. This will help researchers and health professionals to target interventions to improve the quality of life of PD patients.
    Design: Protocol for a qualitative systematic review.
    Methods: This systematic review protocol will follow the Joanna Briggs Institute (JBI) meta-analysis methodology. We will conduct a comprehensive search, including English and Chinese databases. It will include all published qualitative studies of patients' experiences with PD. Both English and Chinese literature will be covered. Two reviewers will independently participate in the literature selection, document selection, and data extraction process. Synthesis will be carried out through in-depth reading of the original text and subsequent creation of similar categories.
    Results: Experiencing is a complex dimension that includes physical, psychological and social aspects. This review will enable nurses to gain a deeper understanding of the feelings and beliefs of patients with PD. Our findings will provide healthcare professionals and policy makers with evidence to provide better care for patients with PD.
    MeSH term(s) Humans ; Quality of Life ; Renal Dialysis ; Qualitative Research ; Kidney Failure, Chronic/therapy ; Peritoneal Dialysis ; Systematic Reviews as Topic ; Meta-Analysis as Topic
    Language English
    Publishing date 2023-07-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0288724
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  4. Article ; Online: Detection of SARS-CoV-2 receptor binding domain using fluorescence probe and DNA flowers enabled by rolling circle amplification.

    Zhang, Man / Ye, Lei

    Mikrochimica acta

    2023  Volume 190, Issue 4, Page(s) 163

    Abstract: Using rolling circle amplification (RCA) and two different ways of signal readout, we developed analytical methods to detect the receptor-binding domain (RBD) of SARS-CoV-2 spike protein (S protein). We modified streptavidin-coated magnetic beads with an ...

    Abstract Using rolling circle amplification (RCA) and two different ways of signal readout, we developed analytical methods to detect the receptor-binding domain (RBD) of SARS-CoV-2 spike protein (S protein). We modified streptavidin-coated magnetic beads with an aptamer of RBD through a biotin-tagged complementary DNA strand (biotin-cDNA). Binding of RBD caused the aptamer to dissociate from the biotin-cDNA, making the cDNA available to initiate RCA on the magnetic beads. Detection of RBD was achieved using a dual signal output. For fluorescence signaling, the RCA products were mixed with a dsDNA probe labeled with fluorophore and quencher. Hybridization of the RCA products caused the dsDNA to separate and to emit fluorescence (λ
    MeSH term(s) Humans ; Fluorescent Dyes ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism ; Biotin/chemistry ; DNA, Complementary ; Hydrogen Peroxide/chemistry ; COVID-19 ; DNA/chemistry ; Horseradish Peroxidase/metabolism
    Chemical Substances spike protein, SARS-CoV-2 ; Fluorescent Dyes ; Biotin (6SO6U10H04) ; DNA, Complementary ; Hydrogen Peroxide (BBX060AN9V) ; DNA (9007-49-2) ; Horseradish Peroxidase (EC 1.11.1.-)
    Language English
    Publishing date 2023-03-29
    Publishing country Austria
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 89-9
    ISSN 1436-5073 ; 0026-3672
    ISSN (online) 1436-5073
    ISSN 0026-3672
    DOI 10.1007/s00604-023-05747-6
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    In stock of ZB MED Bonn / Germany

    Z 56/171: Show issues
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  5. Article ; Online: High-grade B-cell lymphoma with

    Zhang, Man / Yang, Yu

    EJHaem

    2023  Volume 4, Issue 2, Page(s) 503–504

    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Journal Article
    ISSN 2688-6146
    ISSN (online) 2688-6146
    DOI 10.1002/jha2.653
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  6. Article: Seasonal dynamics of phyllosphere epiphytic microbial communities of medicinal plants in farmland environment.

    He, Chao / Zhang, Man / Li, Xianen / He, Xueli

    Frontiers in plant science

    2024  Volume 14, Page(s) 1328586

    Abstract: Introduction: The phyllosphere of plants is inhabited by various microorganisms, which play a crucial role in plant physiological metabolism. Currently, there is limited research on the dynamic effects of species and seasons on plant phyllosphere ... ...

    Abstract Introduction: The phyllosphere of plants is inhabited by various microorganisms, which play a crucial role in plant physiological metabolism. Currently, there is limited research on the dynamic effects of species and seasons on plant phyllosphere microbial community diversity and microbial interactions.
    Methods: In this study, high-throughput sequencing technology was used to sequence the leaf surface parasitic microorganisms of five medicinal plants (
    Results: The results showed that bacteria and fungi clustered into 3,898 and 1,572 operational taxonomic units (OTUs), respectively. Compared to host species, seasons had a more significant impact on the a diversity of bacteria and fungi. The heterogeneity of phyllosphere microbial communities was greater in winter compared to summer. Key species analysis at the OTU level and Spearman correlation analysis demonstrated significant preferences in microbial interactions under plant and seasonal backgrounds. The network connections between bacterial and fungal communities significantly increased during seasonal transitions compared to connections with plants.
    Discussion: This study enhances our understanding of the composition and ecological roles of plant-associated microbial communities in small-scale agricultural environments. Additionally, it provides valuable insights for assessing the biodiversity of medicinal plants.
    Language English
    Publishing date 2024-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1328586
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  7. Article ; Online: Imaging Biomarkers for Nonalcoholic Fatty Liver Disease.

    Zhang, Man

    Academic radiology

    2019  Volume 26, Issue 7, Page(s) 869–871

    MeSH term(s) Biomarkers ; Diabetes Mellitus ; Humans ; Liver ; Non-alcoholic Fatty Liver Disease ; Ultrasonography
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-05-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1355509-1
    ISSN 1878-4046 ; 1076-6332
    ISSN (online) 1878-4046
    ISSN 1076-6332
    DOI 10.1016/j.acra.2019.04.001
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4594: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Phosphorus release from the sediment of a drinking water reservoir under the influence of seasonal hypoxia.

    Lv, Yaobin / Zhang, Man / Yin, Hongbin

    The Science of the total environment

    2024  Volume 917, Page(s) 170490

    Abstract: Seasonal sediment internal phosphorus (P) release may cause water eutrophication and impair water quality in drinking water reservoir. During a year-long field investigation, the effects of the microenvironment on the release of internal phosphorus were ... ...

    Abstract Seasonal sediment internal phosphorus (P) release may cause water eutrophication and impair water quality in drinking water reservoir. During a year-long field investigation, the effects of the microenvironment on the release of internal phosphorus were meticulously analyzed using high-resolution peepers technique and microelectrode system. The release mechanisms of P fractions from the reservoir sediments were also explored. The results showed that seasonal fluctuations in temperature, dissolved oxygen, redox potential, and pH at the sediment-water interface impacted the release of P fractions from the studied reservoir sediment. Higher diffusive fluxes of soluble reactive PO
    Language English
    Publishing date 2024-02-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.170490
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
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  9. Article ; Online: Effect of combining intrauterine cerebral blood flow changes with electrical activity on prognostic evaluation of brain injury.

    Yao, Juan / Zhang, Man / Qiu, Yu

    World neurosurgery

    2024  

    Abstract: Objectives: We sought to investigate the value of combining intrauterine cerebral blood flow changes with brain electrical activity examination in evaluating the prognosis of brain injury.: Methods: A total of 90 preterm infants were enrolled and ... ...

    Abstract Objectives: We sought to investigate the value of combining intrauterine cerebral blood flow changes with brain electrical activity examination in evaluating the prognosis of brain injury.
    Methods: A total of 90 preterm infants were enrolled and divided into two groups: the brain damaged preterm infants group (n=55) and the non-brain damaged preterm infants group (n=35).The diagnostic efficacy of combining intrauterine cerebral blood flow changes with EEG activity examination in predicting the prognosis of preterm infants with brain injury was evaluated usingT-test. Pearson linear correlation was applied to analyze the relationship between fetal intrauterine cerebral blood flow changes combined with electrical activity examination and the prognosis of brain injury.
    Results: Significant differences were seen in pulse index, S/D ratio, and other indexes between the two groups (P<0.05). The combined approach of intrauterine cerebral blood flow changes with EEG activity examination demonstrated significantly higher values for area under the curve (AUC), sensitivityand negative predictive value compared to using intrauterine cerebral blood flow changes or EEG activity examination alone (P<0.05). A positive correlation was found between fetal intrauterine cerebral blood flow and electrical activity examination (P<0.05).
    Summary: Combining the assessment of intrauterine cerebral blood flow changes with cerebral electrical activity examination proved beneficial in diagnosing the prognosis of brain injury and provided an important reference for early clinical intervention.
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2024.04.042
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    In stock of ZB MED Cologne/Königswinter

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  10. Article: Application and perspective of CRISPR/Cas9 genome editing technology in human diseases modeling and gene therapy.

    Zhang, Man-Ling / Li, Hong-Bin / Jin, Yong

    Frontiers in genetics

    2024  Volume 15, Page(s) 1364742

    Abstract: The Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) mediated Cas9 nuclease system has been extensively used for genome editing and gene modification in eukaryotic cells. CRISPR/Cas9 technology holds great potential for various ... ...

    Abstract The Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) mediated Cas9 nuclease system has been extensively used for genome editing and gene modification in eukaryotic cells. CRISPR/Cas9 technology holds great potential for various applications, including the correction of genetic defects or mutations within the human genome. The application of CRISPR/Cas9 genome editing system in human disease research is anticipated to solve a multitude of intricate molecular biology challenges encountered in life science research. Here, we review the fundamental principles underlying CRISPR/Cas9 technology and its recent application in neurodegenerative diseases, cardiovascular diseases, autoimmune related diseases, and cancer, focusing on the disease modeling and gene therapy potential of CRISPR/Cas9 in these diseases. Finally, we provide an overview of the limitations and future prospects associated with employing CRISPR/Cas9 technology for diseases study and treatment.
    Language English
    Publishing date 2024-04-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2024.1364742
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