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  1. Article: The Representation of Decision Variables in Orbitofrontal Cortex is Longitudinally Stable.

    Zhang, Manning / Livi, Alessandro / Carter, Mary / Schoknecht, Heide / Burkhalter, Andreas / Holy, Timothy E / Padoa-Schioppa, Camillo

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The computation and comparison of subjective values underlying economic choices rely on the orbitofrontal cortex (OFC). In this area, distinct groups of neurons encode the value of individual options, the binary choice outcome, and the chosen value. ... ...

    Abstract The computation and comparison of subjective values underlying economic choices rely on the orbitofrontal cortex (OFC). In this area, distinct groups of neurons encode the value of individual options, the binary choice outcome, and the chosen value. These variables capture both the input and the output of the choice process, suggesting that the cell groups found in OFC constitute the building blocks of a decision circuit. Here we show that this neural circuit is longitudinally stable. Using two-photon calcium imaging, we recorded from mice choosing between different juice flavors. Recordings of individual cells continued for up to 20 weeks. For each cell and each pair of sessions, we compared the activity profiles using cosine similarity, and we assessed whether the cell encoded the same variable in both sessions. These analyses revealed a high degree of stability and a modest representational drift. A quantitative estimate indicated this drift would not randomize the circuit within the animal's lifetime.
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.16.580715
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Ternary catalyst Mn-Fe-Ce/Al2O3 for the ozonation of phenol pollutant: performance and mechanism

    Zhang, Manning / Yin, Dulin / Guo, Jinjin / Wu, Huanghe / Gong, Meiling / Feng, Xiangdong

    Environmental science and pollution research. 2021 July, v. 28, no. 25

    2021  

    Abstract: In this study, a novel ternary catalyst Mn-Fe-Ce/Al₂O₃ was synthesized by co-impregnation method, and was characterized by XRD, SEM, XPS, and FTIR. The catalytic performance of this ternary catalyst was evaluated in the heterogeneous catalytic ozonation ... ...

    Abstract In this study, a novel ternary catalyst Mn-Fe-Ce/Al₂O₃ was synthesized by co-impregnation method, and was characterized by XRD, SEM, XPS, and FTIR. The catalytic performance of this ternary catalyst was evaluated in the heterogeneous catalytic ozonation of phenol pollutants and it improved the removal rate and mineralization degree of phenol pollutants. The changes of dissolved ozone in water and the TBA experiment proved that the ternary catalyst could accelerate the decomposition of ozone into hydroxyl radicals, thus accelerating the oxidation of phenol. Phosphate experiments and surface hydroxyl density measurements proved that surface hydroxyl was the active site of the catalyst. XPS analysis showed that the ternary catalysts accelerated electron transfer through the redox cycles of Mn²⁺-Mn³⁺-Mn⁴⁺, Fe²⁺-Fe³⁺, and Ce³⁺-Ce⁴⁺, which also contributed to the high catalytic activity. Moreover, the catalyst maintained high catalytic activity after five cycles of use. Therefore, the ternary catalyst was considered an efficient and promising catalyst for catalytic ozonation system.
    Keywords active sites ; catalysts ; catalytic activity ; electron transfer ; mineralization ; oxidation ; ozonation ; ozone ; phenol ; phosphates ; pollutants ; pollution ; research
    Language English
    Dates of publication 2021-07
    Size p. 32921-32932.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-021-13006-5
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Ternary catalyst Mn-Fe-Ce/Al

    Zhang, Manning / Yin, Dulin / Guo, Jinjin / Wu, Huanghe / Gong, Meiling / Feng, Xiangdong

    Environmental science and pollution research international

    2021  

    Abstract: In this study, a novel ternary catalyst Mn-Fe-Ce/ ... ...

    Abstract In this study, a novel ternary catalyst Mn-Fe-Ce/Al
    Language English
    Publishing date 2021-02-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-021-13006-5
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  4. Article ; Online: Spectral hallmark of auditory-tactile interactions in the mouse somatosensory cortex.

    Zhang, Manning / Kwon, Sung Eun / Ben-Johny, Manu / O'Connor, Daniel H / Issa, John B

    Communications biology

    2020  Volume 3, Issue 1, Page(s) 64

    Abstract: To synthesize a coherent representation of the external world, the brain must integrate inputs across different types of stimuli. Yet the mechanistic basis of this computation at the level of neuronal populations remains obscure. Here, we investigate ... ...

    Abstract To synthesize a coherent representation of the external world, the brain must integrate inputs across different types of stimuli. Yet the mechanistic basis of this computation at the level of neuronal populations remains obscure. Here, we investigate tactile-auditory integration using two-photon Ca
    MeSH term(s) Animals ; Auditory Perception/physiology ; Calcium/metabolism ; Evoked Potentials ; Mice ; Molecular Imaging/methods ; Motor Activity ; Neurons/physiology ; Physical Stimulation ; Psychomotor Performance ; Somatosensory Cortex/physiology ; Touch/physiology
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2020-02-11
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-020-0788-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Eating disorders treatment experiences and social support: Perspectives from service seekers in mainland China.

    Ma, Ruofan / Zhang, Manning / Oakman, Jonathan M / Wang, Jiping / Zhu, Siqi / Zhao, Chendi / Hu, Zhiyuan / Buchanan, NiCole T

    The International journal of eating disorders

    2021  Volume 54, Issue 8, Page(s) 1537–1548

    Abstract: Objective: This study explored treatment experiences and social support among individuals with eating disorders (EDs) in mainland China.: Method: Subscribers of a Chinese online social media platform (WeChat) focused on EDs were invited to complete a ...

    Abstract Objective: This study explored treatment experiences and social support among individuals with eating disorders (EDs) in mainland China.
    Method: Subscribers of a Chinese online social media platform (WeChat) focused on EDs were invited to complete a screening questionnaire that included the Eating Disorder Diagnostic Scale for the DSM-5. Of the 116 questionnaire responses, 31 met inclusion criteria for follow-up interviews. Individuals who never sought treatment were not eligible for follow-up interviews, but provided brief explanations about why they did not seek treatment. All eligible participants (n = 31) completed a semi-structured interview about their experiences with ED treatment and social support. Qualitative data from the interviews and survey responses regarding not seeking treatment were subjected to inductive data-driven thematic analysis with deductive coding to illuminate treatment and social support experiences or reasons for not seeking treatment.
    Results: Themes emerged from interviews revealed positive inpatient treatment experiences for anorexia nervosa, but negative outpatient treatment experiences, unaffordable care, and ineffective psychopharmacological treatments. Parents, friends, and partners were sources of social support, but participants largely felt misunderstood or blamed by these same entities. Shame, not recognizing ED as an illness, and financial constraints were listed as the primary reasons for not seeking treatment.
    Discussion: The importance of hearing patients' perspectives, improving ED literacy in China, increasing knowledge of culturally specific manifestations of EDs, and developing culturally responsive services and dissemination of treatment resources are emphasized.
    MeSH term(s) Ambulatory Care ; Anorexia Nervosa ; Bulimia Nervosa ; China ; Feeding and Eating Disorders/diagnosis ; Feeding and Eating Disorders/therapy ; Friends ; Humans ; Parents
    Language English
    Publishing date 2021-06-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603170-5
    ISSN 1098-108X ; 0276-3478
    ISSN (online) 1098-108X
    ISSN 0276-3478
    DOI 10.1002/eat.23565
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1749: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: A rendezvous with the queen of ion channels: Three decades of ion channel research by David T Yue and his Calcium Signals Laboratory.

    Dick, Ivy E / Limpitikul, Worawan B / Niu, Jacqueline / Banerjee, Rahul / Issa, John B / Ben-Johny, Manu / Adams, Paul J / Kang, Po Wei / Lee, Shin Rong / Sang, Lingjie / Yang, Wanjun / Babich, Jennifer / Zhang, Manning / Bazazzi, Hojjat / Yue, Nancy C / Tomaselli, Gordon F

    Channels (Austin, Tex.)

    2016  Volume 10, Issue 1, Page(s) 20–32

    Abstract: David T. Yue was a renowned biophysicist who dedicated his life to the study of Ca(2+) signaling in cells. In the wake of his passing, we are left not only with a feeling of great loss, but with a tremendous and impactful body of work contributed by a ... ...

    Abstract David T. Yue was a renowned biophysicist who dedicated his life to the study of Ca(2+) signaling in cells. In the wake of his passing, we are left not only with a feeling of great loss, but with a tremendous and impactful body of work contributed by a remarkable man. David's research spanned the spectrum from atomic structure to organ systems, with a quantitative rigor aimed at understanding the fundamental mechanisms underlying biological function. Along the way he developed new tools and approaches, enabling not only his own research but that of his contemporaries and those who will come after him. While we cannot hope to replicate the eloquence and style we are accustomed to in David's writing, we nonetheless undertake a review of David's chosen field of study with a focus on many of his contributions to the calcium channel field.
    MeSH term(s) Animals ; Biophysics/history ; Calcium Channels/metabolism ; Calcium Signaling ; History, 20th Century ; History, 21st Century ; United States
    Chemical Substances Calcium Channels
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Autobiography ; Biography ; Historical Article ; Journal Article ; Portraits ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1933-6969
    ISSN (online) 1933-6969
    DOI 10.1080/19336950.2015.1051272
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  7. Article ; Online: Towards a Unified Theory of Calmodulin Regulation (Calmodulation) of Voltage-Gated Calcium and Sodium Channels.

    Ben-Johny, Manu / Dick, Ivy E / Sang, Lingjie / Limpitikul, Worawan B / Kang, Po Wei / Niu, Jacqueline / Banerjee, Rahul / Yang, Wanjun / Babich, Jennifer S / Issa, John B / Lee, Shin Rong / Namkung, Ho / Li, Jiangyu / Zhang, Manning / Yang, Philemon S / Bazzazi, Hojjat / Adams, Paul J / Joshi-Mukherjee, Rosy / Yue, Daniel N /
    Yue, David T

    Current molecular pharmacology

    2015  Volume 8, Issue 2, Page(s) 188–205

    Abstract: Voltage-gated Na and Ca(2+) channels represent two major ion channel families that enable myriad biological functions including the generation of action potentials and the coupling of electrical and chemical signaling in cells. Calmodulin regulation ( ... ...

    Abstract Voltage-gated Na and Ca(2+) channels represent two major ion channel families that enable myriad biological functions including the generation of action potentials and the coupling of electrical and chemical signaling in cells. Calmodulin regulation (calmodulation) of these ion channels comprises a vital feedback mechanism with distinct physiological implications. Though long-sought, a shared understanding of the channel families remained elusive for two decades as the functional manifestations and the structural underpinnings of this modulation often appeared to diverge. Here, we review recent advancements in the understanding of calmodulation of Ca(2+) and Na channels that suggest a remarkable similarity in their regulatory scheme. This interrelation between the two channel families now paves the way towards a unified mechanistic framework to understand vital calmodulin-dependent feedback and offers shared principles to approach related channelopathic diseases. An exciting era of synergistic study now looms.
    MeSH term(s) Animals ; Calcium/metabolism ; Calcium Channels/metabolism ; Calmodulin/metabolism ; Feedback, Physiological/physiology ; Humans ; Ion Channel Gating/physiology ; Models, Biological ; Voltage-Gated Sodium Channels/metabolism
    Chemical Substances Calcium Channels ; Calmodulin ; Voltage-Gated Sodium Channels ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2015-07-14
    Publishing country United Arab Emirates
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1874-4702
    ISSN (online) 1874-4702
    DOI 10.2174/1874467208666150507110359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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