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  1. Article ; Online: DRTerHGAT: A drug repurposing method based on the ternary heterogeneous graph attention network.

    He, Hongjian / Xie, Jiang / Huang, Dingkai / Zhang, Mengfei / Zhao, Xuyu / Ying, Yiwei / Wang, Jiao

    Journal of molecular graphics & modelling

    2024  Volume 130, Page(s) 108783

    Abstract: Drug repurposing is an effective method to reduce the time and cost of drug development. Computational drug repurposing can quickly screen out the most likely associations from large biological databases to achieve effective drug repurposing. However, ... ...

    Abstract Drug repurposing is an effective method to reduce the time and cost of drug development. Computational drug repurposing can quickly screen out the most likely associations from large biological databases to achieve effective drug repurposing. However, building a comprehensive model that integrates drugs, proteins, and diseases for drug repurposing remains challenging. This study proposes a drug repurposing method based on the ternary heterogeneous graph attention network (DRTerHGAT). DRTerHGAT designs a novel protein feature extraction process consisting of a large-scale protein language model and a multi-task autoencoder, so that protein features can be extracted accurately and efficiently from amino acid sequences. The ternary heterogeneous graph of drug-protein-disease comprehensively considering the relationships among the three types of nodes, including three homogeneous and three heterogeneous relationships. Based on the graph and the extracted protein features, the deep features of the drugs and the diseases are extracted by graph convolutional networks (GCN) and heterogeneous graph node attention networks (HGNA). In the experiments, DRTerHGAT is proven superior to existing advanced methods and DRTerHGAT variants. DRTerHGAT's powerful ability for drug repurposing is also demonstrated in Alzheimer's disease.
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1396450-1
    ISSN 1873-4243 ; 1093-3263
    ISSN (online) 1873-4243
    ISSN 1093-3263
    DOI 10.1016/j.jmgm.2024.108783
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Identification and characterization of novel genetic variants in the first Chinese family of mucopolysaccharidosis IIIC (Sanfilippo C syndrome).

    Zhao, Hongjun / Wang, Lijing / Zhang, Mengfei / Wang, Huakun / Zhang, Sizhe / Wu, Junjiao / Tang, Yu

    Journal of cellular and molecular medicine

    2024  Volume 28, Issue 8, Page(s) e18307

    Abstract: Mucopolysaccharidosis type IIIC (MPS IIIC) is one of inherited lysosomal storage disorders, caused by deficiencies in lysosomal hydrolases degrading acidic mucopolysaccharides. The gene responsible for MPS IIIC is HGSNAT, which encodes an enzyme that ... ...

    Abstract Mucopolysaccharidosis type IIIC (MPS IIIC) is one of inherited lysosomal storage disorders, caused by deficiencies in lysosomal hydrolases degrading acidic mucopolysaccharides. The gene responsible for MPS IIIC is HGSNAT, which encodes an enzyme that catalyses the acetylation of the terminal glucosamine residues of heparan sulfate. So far, few studies have focused on the genetic landscape of MPS IIIC in China, where IIIA and IIIB were the major subtypes. In this study, we utilized whole-exome sequencing (WES) to identify novel compound heterozygous variants in the HGSNAT gene from a Chinese patient with typical MPS IIIC symptoms: c.743G>A; p.Gly248Glu and c.1030C>T; p.Arg344Cys. We performed in silico analysis and experimental validation, which confirmed the deleterious pathogenic nature of both variants, as evidenced by the loss of HGSNAT activity and failure of lysosomal localization. To the best of our knowledge, the MPS IIIC is first confirmed by clinical, biochemical and molecular genetic findings in China. Our study thus expands the spectrum of MPS IIIC pathogenic variants, which is of importance to dissect the pathogenesis and to carry out clinical diagnosis of MPS IIIC. Moreover, this study helps to depict the natural history of Chinese MPS IIIC populations.
    MeSH term(s) Humans ; Mucopolysaccharidosis III/genetics ; Mucopolysaccharidoses/genetics ; Asian People/genetics ; Acetylation ; China ; Acetyltransferases
    Chemical Substances HGSNAT protein, human (EC 2.3.1.78) ; Acetyltransferases (EC 2.3.1.-)
    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2074559-X
    ISSN 1582-4934 ; 1582-4934 ; 1582-1838
    ISSN (online) 1582-4934
    ISSN 1582-4934 ; 1582-1838
    DOI 10.1111/jcmm.18307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5752: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: On four new species of the orb-weaver spider genus

    Wu, Yibei / Wang, Cheng / Wu, Nanfei / Zhang, Mengfei / Mi, Xiaoqi

    ZooKeys

    2023  Volume 1160, Page(s) 169–190

    Abstract: Four new species ... ...

    Abstract Four new species of
    Language English
    Publishing date 2023-05-09
    Publishing country Bulgaria
    Document type Journal Article
    ZDB-ID 2445640-8
    ISSN 1313-2970 ; 1313-2989
    ISSN (online) 1313-2970
    ISSN 1313-2989
    DOI 10.3897/zookeys.1160.101594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Recent Progress in Framework Materials for High-Performance Lithium-Sulfur Batteries.

    Chen, Changyun / Zhang, Mengfei / Chen, Quanzhan / Duan, Haibao / Liu, Suli

    Chemical record (New York, N.Y.)

    2023  Volume 23, Issue 6, Page(s) e202200278

    Abstract: Lithium-Sulfur batteries (LSBs) have been considered as a promising candidate for the next generation of energy storage systems due to their high theoretical capacity. However, there are still lots of pending scientific and technological issues to be ... ...

    Abstract Lithium-Sulfur batteries (LSBs) have been considered as a promising candidate for the next generation of energy storage systems due to their high theoretical capacity. However, there are still lots of pending scientific and technological issues to be solved. Framework materials show great potential to address the above-mentioned issues due to the highly ordered distribution of pore sizes, effective catalytic activity, and periodically arranged aperture. In addition, good tunability gives framework materials unlimited possibilities to achieve satisfying performance for LSBs. In this review, the recent advances in pristine framework materials, their derivatives, and composites have been summarized. And a short conclusion and outlook regard to future prospects for guiding the development of framework materials and LSBs.
    MeSH term(s) Lithium ; Electric Power Supplies ; Sulfur
    Chemical Substances Lithium (9FN79X2M3F) ; Sulfur (70FD1KFU70)
    Language English
    Publishing date 2023-02-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2044646-9
    ISSN 1528-0691 ; 1527-8999
    ISSN (online) 1528-0691
    ISSN 1527-8999
    DOI 10.1002/tcr.202200278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The efficient generation of knockout microglia cells using a dual-sgRNA strategy by CRISPR/Cas9.

    Zhang, Mengfei / Yi, Fang / Wu, Junjiao / Tang, Yu

    Frontiers in molecular neuroscience

    2022  Volume 15, Page(s) 1008827

    Abstract: Gene deletion in microglia has become an important and exciting approach for studying neuroinflammation, especially after the development of the CRISPR/Cas9 system for genome editing during the last decade. In this study, we described a protocol for the ... ...

    Abstract Gene deletion in microglia has become an important and exciting approach for studying neuroinflammation, especially after the development of the CRISPR/Cas9 system for genome editing during the last decade. In this study, we described a protocol for the highly efficient generation of knockout microglia cells using a dual-short guide RNA (sgRNA) strategy by CRISPR/Cas9.
    Language English
    Publishing date 2022-10-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2022.1008827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Surgical repair for left coronary artery-right atrium fistula with giant coronary aneurysm.

    Jin, Yan / Zhang, Mengfei / He, Juan

    Journal of cardiothoracic surgery

    2022  Volume 17, Issue 1, Page(s) 104

    Abstract: Background: Coronary artery fistula is a rare coronary anomaly which is defined as a communication between coronary artery and other heart chambers or vascular structures. The coronary artery which supply the fistula with blood can dilated, as a ... ...

    Abstract Background: Coronary artery fistula is a rare coronary anomaly which is defined as a communication between coronary artery and other heart chambers or vascular structures. The coronary artery which supply the fistula with blood can dilated, as a consequence, coronary aneurysm developed.
    Case introduction: Coronary artery fistula is frequently asymptomatic in its early stage, here we report a 26-year-old woman with left coronary artery fistula and left coronary artery aneurysm who presented in our hospital with dyspnea, fatigue and palpitation. The orifice of fistula was closed by continuous suture via right atriotomy. The wall of the aneurysm and enlarged LCA were partially resected along its longitudinal axis so that we can reduce the diameter of LCA to approximately normal.
    Conclusion: This technique provides a safe method for surgical repair of the giant coronary artery aneurysm with CAF.
    MeSH term(s) Adult ; Coronary Aneurysm/diagnosis ; Coronary Aneurysm/diagnostic imaging ; Coronary Artery Disease ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/surgery ; Female ; Fistula/diagnosis ; Fistula/diagnostic imaging ; Heart Atria/surgery ; Heart Defects, Congenital ; Humans ; Vascular Fistula/diagnosis ; Vascular Fistula/diagnostic imaging
    Language English
    Publishing date 2022-05-07
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2227224-0
    ISSN 1749-8090 ; 1749-8090
    ISSN (online) 1749-8090
    ISSN 1749-8090
    DOI 10.1186/s13019-022-01857-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [Research progress of ferroptosis in sepsis].

    Zhang, Mengfei / Yu, Jiangquan / Zheng, Ruiqiang

    Zhonghua wei zhong bing ji jiu yi xue

    2022  Volume 34, Issue 9, Page(s) 985–990

    Abstract: Sepsis is a systemic disease with severe health consequences, and it was redefined in 2016 as a life-threatening organ dysfunction caused by an abnormal host response to infection and is a global public health priority. In recent years, there has been ... ...

    Abstract Sepsis is a systemic disease with severe health consequences, and it was redefined in 2016 as a life-threatening organ dysfunction caused by an abnormal host response to infection and is a global public health priority. In recent years, there has been increasing recognition of the role of dysregulated micronutrient iron metabolism in the pathogenesis of sepsis. The concept of ferroptosis, an iron-dependent, non-apoptotic mode of cell death characterized by the accumulation of lipid reactive oxygen species (ROS), was first proposed by Dixon et al. in 2012. As a novel mode of programmed cell death, ferroptosis differs in morphological and biochemical characteristics from various forms of cell death, such as apoptosis, autophagy, necrosis and lysis. Recent studies have shown that ferroptosis plays an important regulatory role in the development of sepsis and has become a research focus and highlight for the diagnosis and prognosis of related diseases. Therefore, this paper reviews the latest developments in ferroptosis in sepsis, in order to further understanding its pathogenesis and providing new therapeutic targets for sepsis-related organ dysfunction.
    MeSH term(s) Humans ; Ferroptosis ; Multiple Organ Failure ; Apoptosis ; Reactive Oxygen Species/metabolism ; Sepsis ; Iron/metabolism
    Chemical Substances Reactive Oxygen Species ; Iron (E1UOL152H7)
    Language Chinese
    Publishing date 2022-11-03
    Publishing country China
    Document type Review ; English Abstract ; Journal Article
    ISSN 2095-4352
    ISSN 2095-4352
    DOI 10.3760/cma.j.cn121430-20220329-00313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Optimization of a Perovskite Oxide-Based Cathode Catalyst Layer on Performance of Direct Ammonia Fuel Cells

    Jeerh, Georgina / Zou, Peimiao / Zhang, Mengfei / Tao, Shanwen

    ACS Applied Materials & Interfaces. 2022 Dec. 27, v. 15, no. 1 p.1029-1041

    2022  

    Abstract: To maximize fuel cell performance, transport pathways for electrons, ions, and reactants should be connected well. This demands a well-constructed microstructure in the catalyst layer (CL). Herein we design and optimize a cathode CL for a direct ammonia ... ...

    Abstract To maximize fuel cell performance, transport pathways for electrons, ions, and reactants should be connected well. This demands a well-constructed microstructure in the catalyst layer (CL). Herein we design and optimize a cathode CL for a direct ammonia fuel cell (DAFC) using a perovskite oxide as the catalyst to reduce reliance on platinum group metals (PGMs). The effects of tailoring carbon, ionomer, and polytetrafluoroethylene (PTFE) content in cathode CLs (CCLs) were explored, and several DAFCs were tested. Using the same catalyst and operating conditions, the lowest maximum current density and peak power density obtained were 85.3 mA cm-² and 5.92 mW cm-², respectively, which substantially increased to 317 mA cm-² and 30.1 mW cm-² through proper carbon, ionomer, and PTFE optimization, illustrating the importance of an effective three-phase interface. The findings reveal that despite employment of an active catalyst for oxygen reduction at the cathode site, the true performance of the catalyst cannot be reflected unless it is supported by proper design of the CCL. The study also reveals that by optimizing the CCL, similar performances to those of Pt/C-based CCLs in literature can be obtained at a cost reduction.
    Keywords ammonia ; carbon ; catalysts ; cathodes ; cost effectiveness ; fuel cells ; fuels ; microstructure ; oxygen ; platinum ; polytetrafluoroethylene ; direct ammonia fuel cell (DAFC) ; perovskite ; cathode ; catalyst layer ; optimization
    Language English
    Dates of publication 2022-1227
    Size p. 1029-1041.
    Publishing place American Chemical Society
    Document type Article ; Online
    ISSN 1944-8252
    DOI 10.1021/acsami.2c17253
    Database NAL-Catalogue (AGRICOLA)

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  9. Book ; Online: Distributed pressure matching strategy using diffusion adaptation

    Zhang, Mengfei / Zhang, Junqing / Chen, Jie / Richard, Cédric

    2023  

    Abstract: Personal sound zone (PSZ) systems, which aim to create listening (bright) and silent (dark) zones in neighboring regions of space, are often based on time-varying acoustics. Conventional adaptive-based methods for handling PSZ tasks suffer from the ... ...

    Abstract Personal sound zone (PSZ) systems, which aim to create listening (bright) and silent (dark) zones in neighboring regions of space, are often based on time-varying acoustics. Conventional adaptive-based methods for handling PSZ tasks suffer from the collection and processing of acoustic transfer functions~(ATFs) between all the matching microphones and all the loudspeakers in a centralized manner, resulting in high calculation complexity and costly accuracy requirements. This paper presents a distributed pressure-matching (PM) method relying on diffusion adaptation (DPM-D) to spread the computational load amongst nodes in order to overcome these issues. The global PM problem is defined as a sum of local costs, and the diffusion adaption approach is then used to create a distributed solution that just needs local information exchanges. Simulations over multi-frequency bins and a computational complexity analysis are conducted to evaluate the properties of the algorithm and to compare it with centralized counterparts.
    Keywords Computer Science - Sound ; Electrical Engineering and Systems Science - Audio and Speech Processing ; Physics - Applied Physics
    Subject code 005
    Publishing date 2023-11-13
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Macrolactin R from Bacillus siamensis and its antifungal activity against Botrytis cinerea

    Ni, Jie / Yu, Lian / Li, Fei / Li, Yulin / Zhang, Mengfei / Deng, Yuping / Liu, Xiaoling

    World J Microbiol Biotechnol. 2023 May, v. 39, no. 5, p. 117

    2023  , Page(s) 117

    Abstract: Botrytis cinerea is listed among the most important fungal pathogens infecting strawberries. The use of biological control agents, such as Bacillus species, offers an alternative and effective way to reduce airborne pathogens. The aim of this research ... ...

    Abstract Botrytis cinerea is listed among the most important fungal pathogens infecting strawberries. The use of biological control agents, such as Bacillus species, offers an alternative and effective way to reduce airborne pathogens. The aim of this research was to select the macrolactin R produced by Bacillus siamensis with potential for using as biological agents against the pathogenetic fungi (Botrytis cinerea) of strawberries, and to assess the mechanisms involved. Macrolactin R had significant inhibitory effects on spore germination, germ tube elongation, and mycelial growth of Botrytis cinerea. The MICs of macrolactin R inhibitions in vitro was 12.5 mg/L and The EC₅₀ value of NJ08-3 to Botrytis cinerea spores and mycelial was 1.93 and 2.88 mg/L, respectively. Macrolactin R impacted the membrane structure of Botrytis cinerea, resulting in changes in membrane permeability and leakage of proteins and nucleic acids, then cell death. The application of the macrolactin R of Bacillus siamensis reduced the disease severity index of gray mold on strawberries. This study demonstrated that the production of macrolactin R produced by Bacillus siamensis are involved in the antifungal activity against Botrytis cinerea.
    Keywords Bacillus siamensis ; Botrytis cinerea ; antifungal properties ; biological control ; cell death ; disease severity ; fungi ; germ tube ; gray mold ; membrane permeability ; mycelium ; spore germination
    Language English
    Dates of publication 2023-05
    Size p. 117
    Publishing place Springer Netherlands
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 1499109-3
    ISSN 1573-0972 ; 0959-3993
    ISSN (online) 1573-0972
    ISSN 0959-3993
    DOI 10.1007/s11274-023-03563-x
    Database NAL-Catalogue (AGRICOLA)

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