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Article: [Research progress on anti-inflammatory effects of plant-derived cannabinoid type 2 receptor modulators].

Lian, Chen-Xia / Hu, Si-Jing / Zhang, Qiao-Yan / Zhao, Qi-Ming / Qin, Lu-Ping / Gong, Wan

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2024 Volume 48, Issue 23, Page(s) 6294–6306

Abstract: Excessive and persistent inflammatory responses are a potential pathological condition that can lead to diseases of various systems, including nervous, respiratory, digestive, circulatory, and endocrine systems. Cannabinoid type 2 receptor(CB2R) belongs ... ...

Abstract	Excessive and persistent inflammatory responses are a potential pathological condition that can lead to diseases of various systems, including nervous, respiratory, digestive, circulatory, and endocrine systems. Cannabinoid type 2 receptor(CB2R) belongs to the G protein-coupled receptor family and is widely distributed in immune cells, peripheral tissues, and the central nervous system. It plays a role in inflammatory responses under various pathological conditions. The down-regulation of CB2R activity is an important marker of inflammation and and CB2R modulators have been shown to have anti-inflammatory effects. This study explored the relationship between CB2R and inflammatory responses, delved into its regulatory mechanisms in inflammatory diseases, and summarized the research progress on CB2R modulators from plants other than cannabis, including plant extracts and monomeric compounds, in exerting anti-inflammatory effects. The aim is to provide new insights into the prevention and treatment of inflammatory diseases.
MeSH term(s)	Cannabinoid Receptor Modulators/pharmacology ; Cannabinoid Receptor Agonists/pharmacology ; Receptors, Cannabinoid ; Cannabinoids/pharmacology ; Anti-Inflammatory Agents/pharmacology
Chemical Substances	Cannabinoid Receptor Modulators ; Cannabinoid Receptor Agonists ; Receptors, Cannabinoid ; Cannabinoids ; Anti-Inflammatory Agents
Language	Chinese
Publishing date	2024-01-09
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20230927.601
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Article: [UPLC-Q-TOF-MS-based metabolomics reveals mechanism of Morinda officinalis iridoid glycosides in treating rheumatoid arthritis and bone loss].

Shen, Yi / Sun, Yi-Qi / Li, He-Ming / Zhang, Quan-Long / Zhao, Qi-Ming / Xu, Jin-Long / Qin, Lu-Ping / Zhang, Qiao-Yan

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2024 Volume 49, Issue 2, Page(s) 453–460

Abstract: This study aimed to investigate the therapeutic effects of Morinda officinalis iridoid glycosides(MOIG) on paw edema and bone loss of rheumatoid arthritis(RA) rats, and analyze its potential mechanism based on ultra-high performance liguid chromatography- ...

Abstract	This study aimed to investigate the therapeutic effects of Morinda officinalis iridoid glycosides(MOIG) on paw edema and bone loss of rheumatoid arthritis(RA) rats, and analyze its potential mechanism based on ultra-high performance liguid chromatography-guadrupole time-of-flight tandem mass spectrometry(UPLC-Q-TOF-MS) serum metabolomics. RA rats were established by injecting bovin type Ⅱ collagen. The collagen-induced arthritis(CIA) rats were administered drug by gavage for 8 weeks, the arthritic score were used to evaluate the severity of paw edem, serum bone metabolism biochemical parameters were measured by ELISA kits, Masson staining was used to observe the bone microstructure of the femur in CIA rats. UPLC-Q-TOF-MS was used to analyze the alteration of serum metabolite of CIA rats, principal component analysis(PCA) and partial least squares-discriminant analysis(PLS-DA) were used to screen the potential biomarkers, KEGG database analysis were used to construct related metabolic pathways. The results demonstrated that the arthritic score, serum levels of IL-6 and parameters related with bone metabolism including OCN, CTX-Ⅰ, DPD and TRAP were significantly increased, and the ratio of OPG and RANKL was significantly decreased, the microstructure of bone tissue and cartilage were destructed in CIA rats, while MOIG treatments could significantly reduce arthritis score, mitigate the paw edema, reverse the changes of serum biochemical indicators related with bone metabolism, and improve the microstructure of bone tissue and cartilage of CIA rats. The non-targeted metabolomics results showed that 24 altered metabolites were identified in serum of CIA rats; compared with normal group, 13 significantly altered metabolites related to RA were identified in serum of CIA rats, mainly involving alanine, aspartate and glutamate metabolism; compared with CIA model group, MOIG treatment reversed the alteration of 15 differential metabolites, mainly involving into alanine, aspartate and glutamate metabolism, D-glutamine and D-glutamate metabolism, taurine and hypotaurine metabolism, valine, leucine and isoleucine biosynthesis. Therefore, MOIG significantly alleviated paw edema, improved the destruction of microstructure of bone and cartilage in CIA rats maybe through involving into the regulation of amino acid metabolism.
MeSH term(s)	Rats ; Animals ; Iridoid Glycosides/chemistry ; Morinda/chemistry ; Chromatography, High Pressure Liquid ; Aspartic Acid ; Metabolomics ; Arthritis, Rheumatoid/drug therapy ; Edema ; Alanine/therapeutic use ; Glutamates/therapeutic use ; Biomarkers
Chemical Substances	Iridoid Glycosides ; Aspartic Acid (30KYC7MIAI) ; Alanine (OF5P57N2ZX) ; Glutamates ; Biomarkers
Language	Chinese
Publishing date	2024-02-25
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20230914.705
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Article: [Analysis of Correlation between Interval Time of Chemotherapy and Prognosis in Patients with Acute Leukemia].

Zhang, Qiao-Yan / Lyu, Xia-Ye / Wang, Yan-Zhi / Li, Zi-Jian

Zhongguo shi yan xue ye xue za zhi

2021 Volume 29, Issue 3

Abstract: Objective: To investigate the relationship between average interval time of chemotherapy and prognosis in patients with acute leukemia (AL) during intensive treatment.: Methods: Data of 92 newly treated adult AL patients who received chemotherapy in ... ...

Abstract	Objective: To investigate the relationship between average interval time of chemotherapy and prognosis in patients with acute leukemia (AL) during intensive treatment. Methods: Data of 92 newly treated adult AL patients who received chemotherapy in The First Hospital of Lanzhou University from January 2010 to June 2019 were analyzed retrospectively. The patients were divided into groups according to the average interval time of chemotherapy during intensive treatment, and its influence on prognosis was analyzed. Results: The median interval of chemotherapy during intensive therapy was 38 (20-64) days. According to the average interval of chemotherapy, patients were divided into 4 groups, including < 30 days group, 30-39 days group, 40-49 days group and ≥ 50 days group. The 3-year overall survival (OS) rate of the four groups was (84.9±8.0)%, (73.5±8.7)%, (56.5±11.1)% and (41.8±13.6)%, respectively (P=0.008). The 3-year progression-free survival (PFS) rate of the four groups was (63.6±11.1)%, (52.8±10.2)%, (38.2±10.8)% and (14.0±9.0)%, respectively (P=0.001). After comparison between the 4 groups, it was found that OS and PFS in ≥ 50 days group were significantly shorter than those in < 30 days group (P<0.008). Multivariate analysis showed that risk stratification and average chemotherapy interval ≥ 50 days were the common adverse factors affecting OS and PFS. Conclusion: The average chemotherapy interval ≥ 50 days during intensive therapy is an independent risk factor affecting the prognosis and survival of patients with AL. When the bone marrow is completely relieved and the peripheral hemogram recovers to an acceptable level, the consolidation therapy should be started as soon as possible. The interval < 30 days can significantly improve the prognosis compared with the interval ≥ 50 days.
MeSH term(s)	Adult ; Antineoplastic Combined Chemotherapy Protocols ; Disease-Free Survival ; Humans ; Induction Chemotherapy ; Leukemia, Myeloid, Acute ; Prognosis ; Retrospective Studies
Language	Chinese
Publishing date	2021-06-09
Publishing country	China
Document type	Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2021.03.009
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Article ; Online: Phylogeography of cultivated and wild ophiopogon japonicus based on chloroplast DNA: exploration of the origin and sustainable cultivation.

Zhao, Lu-Ying / Liu, Yu-Ling / Shen, Yi / Zhang, Qiao-Yan / Liu, Sha / Ren, Qiu-Ru / Qin, Lu-Ping / Sun, Yi-Qi

BMC plant biology

2023 Volume 23, Issue 1, Page(s) 242

Abstract: Background: Ophiopogon japonicus, mainly planted in Sichuan (CMD) and Zhejiang (ZMD) province in China, has a lengthy cultivation history. During the long period of domestication, the genetic diversity of cultivated O. japonicus has substantially ... ...

Abstract	Background: Ophiopogon japonicus, mainly planted in Sichuan (CMD) and Zhejiang (ZMD) province in China, has a lengthy cultivation history. During the long period of domestication, the genetic diversity of cultivated O. japonicus has substantially declined, which will affect the population continuity and evolutionary potential of this species. Therefore, it is necessary to clarify the phylogeography of cultivated O. japonicus to establish a theoretical basis for the utilization and conservation of the genetic resources of O. japonicus. Result: The genetic diversity and population structure of 266 O. japonicus individual plants from 23 sampling sites were analyzed based on 4 chloroplast DNA sequences (atpB-rbcL, rpl16, psbA-trnH and rpl20-5'rps12) to identify the effects of domestication on genetic diversity of cultivars and determine their geographic origins. The results showed that cultivated O. japonicus and wild O. japonicus had 4 and 15 haplotypes respectively. The genetic diversity of two cultivars (H Conclusion: These results suggest that cultivated O. japonicus has experienced dramatic loss of genetic diversity under anthropogenic influence. The genetic differentiation between CMD and ZMD is likely to be influenced by founder effect and strong artificial selection for plant traits. It appears that wild populations in Sichuan area are involved in the origin of not only CMD but also ZMD. In addition, we also raise some suggestions for planning scientific strategies for resource conservation of O. japonicus based on its genetic diversity and population structure.
MeSH term(s)	DNA, Chloroplast/genetics ; Phylogeography ; Phylogeny ; Ophiopogon/chemistry ; Ophiopogon/genetics ; Haplotypes/genetics ; Genetic Variation
Chemical Substances	DNA, Chloroplast
Language	English
Publishing date	2023-05-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2059868-3
ISSN	1471-2229 ; 1471-2229
ISSN (online)	1471-2229
ISSN	1471-2229
DOI	10.1186/s12870-023-04247-2
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Article ; Online: Streptomyces gossypiisoli

Zhang, Qiao-Yan / Qin, Song / Luo, Xiao-Xia / Xia, Zhan-Feng

International journal of systematic and evolutionary microbiology

2020 Volume 71, Issue 1

Abstract: A novel actinobacterium, designated TRM ... ...

Abstract	A novel actinobacterium, designated TRM 44567
MeSH term(s)	Bacterial Typing Techniques ; Base Composition ; China ; DNA, Bacterial/genetics ; Diaminopimelic Acid/chemistry ; Fatty Acids/chemistry ; Gossypium ; Phospholipids/chemistry ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA ; Soil Microbiology ; Streptomyces/classification ; Streptomyces/isolation & purification ; Vitamin K 2/analogs & derivatives ; Vitamin K 2/chemistry
Chemical Substances	DNA, Bacterial ; Fatty Acids ; Phospholipids ; RNA, Ribosomal, 16S ; Vitamin K 2 (11032-49-8) ; menaquinone 9 (523-39-7) ; Diaminopimelic Acid (583-93-7)
Language	English
Publishing date	2020-12-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2002336-4
ISSN	1466-5034 ; 1466-5026
ISSN (online)	1466-5034
ISSN	1466-5026
DOI	10.1099/ijsem.0.004561
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Article: [Genetic diversity and genetic structures of original plants of Viticis Fructus:an SSR markers-based analysis].

Sun, Yi-Qi / Zhao, Lu-Ying / Zhu, Bo / Jia, Min / Zhang, Qiao-Yan / Qin, Lu-Ping

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2021 Volume 46, Issue 15, Page(s) 3824–3831

Abstract: The present study aimed to provide the protection strategies for wild germplasm resources of original plants of Viticis Fructus and a theoretical basis for the sustainable use of Viticis Fructus. The genetic diversity and genetic structures of the 232 ... ...

Abstract	The present study aimed to provide the protection strategies for wild germplasm resources of original plants of Viticis Fructus and a theoretical basis for the sustainable use of Viticis Fructus. The genetic diversity and genetic structures of the 232 indivi-duals in 19 populations of Vitex rotundifolia and V. trifolia were analyzed by eight SSR markers with tools such as Popgene32, GenAlex 6.502, and STRUCTURE. Bottleneck effect was detected for the population with more than 10 individuals. The results indicated that 42 and 26 alleles were detected from the populations of V. rotundifolia and V. trifolia, respectively, with average expected heterozygo-sities of 0.448 6 and 0.583 9, which are indicative of low genetic diversity. AMOVA revealed the obvious genetic variation of V. rotundifolia and V. trifolia within population(84.43%, P<0.01; 60.37%, P<0.01). Furthermore, in eight SSR loci, six from V. rotundifolia populations and two from V. trifolia populations failed to meet Hardy-Weinberg equilibrium expectations(P<0.05), which confirmed that the populations experienced bottleneck effect. As assessed by Mantel test, geographical distance posed slight impacts on the genetic variation between the populations of V. rotundifolia and V. trifolia. Principal component analysis(PCA) and STRUCTURE analysis demonstrated evident introgression of genes among various populations. The original plants of Viticis Fructus were confirmed low in genetic diversity and genetic differentiation level. Therefore, the protection of wild resources of original plants of Viticis Fructus should be strengthened to ensure its sustainable use.
MeSH term(s)	Alleles ; Fruit/genetics ; Genetic Variation ; Geography ; Microsatellite Repeats ; Vitex/genetics
Language	Chinese
Publishing date	2021-09-15
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20210522.101
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Article ; Online: Chinese herbal formula Tongxie Yaofang for diarrhea-predominant irritable bowel syndrome: study protocol for a randomized, multiple-blind, placebo-controlled trial.

Liang, Shi-Bing / Han, Mei / Cheng, Hong-Jie / Zhang, Qiao-Yan / Zhang, Nai-Wei / Jia, Bo-Yi / Robinson, Nicola / Liu, Jian-Ping

Trials

2022 Volume 23, Issue 1, Page(s) 226

Abstract: Introduction: Diarrhea-predominant irritable bowel syndrome (IBS-D) is a bowel disease with a high incidence. It significantly reduces the quality of life of patients and affects the patient's daily activities and mental health. No specific therapeutic ... ...

Abstract	Introduction: Diarrhea-predominant irritable bowel syndrome (IBS-D) is a bowel disease with a high incidence. It significantly reduces the quality of life of patients and affects the patient's daily activities and mental health. No specific therapeutic medications for IBS-D have been found. Published clinical trials suggest that Chinese herbal formula Tongxie Yaofang (TXYF) for IBS-D may be effective. However, high-quality clinical evidence supporting its use in IBS-D is still lacking. This trial aims to evaluate the therapeutic effects and safety of TXYF for IBS-D in adults. Methods/design: A randomized, multiple-blind, placebo-controlled trial will be conducted. It will consist of an 8-week intervention followed by a 3-month follow-up period. The target sample size is 96 IBS-D patients aged 18 to 65 years. The eligible participants will be randomly allocated to either TXYF or placebo group in a ratio of 1:1. Participants in the experimental group will take TXYF granules, while participants in the control group will be given TXYF placebo granules. The primary outcome will be the degree of IBS symptom severity measured using the scale of IBS symptom severity score. The secondary outcomes include: (a) stool frequency, and (b) stool consistency measured using the Bristol stool scale, (c) quality of life measured using the scale of IBS-quality of life, (d) anxiety measured using the self-rating anxiety scale, (e) depression measured by the self-rating depression scale, and (f) the safety of using TXYF and placebo. Safety monitoring and assessment will be undertaken throughout treatment. Discussion: Chinese herbal formula TXYF consists of four Chinese herbs: Atractylodes macrocephala Koidz., Paeonia lactiflora Pall ., Citrus × aurantium L ., and Radix saposhnikoviae. It has been used for diarrhea for hundreds of years and may have a potential benefit in treating adults with IBS-D, but due to lack of high-quality evidence, we designed a randomized, multiple-blind, placebo-controlled trial to evaluate its therapeutic effects and safety. This trial will provide important data to guide the clinical practice of TXYF for the treatment of IBS-D in adults. Trial registration: ISRCTN registry ISRCTN12453166 . Registered on 23 March 2021.
MeSH term(s)	China ; Diarrhea/diagnosis ; Diarrhea/drug therapy ; Feces ; Humans ; Irritable Bowel Syndrome/complications ; Irritable Bowel Syndrome/diagnosis ; Irritable Bowel Syndrome/drug therapy ; Quality of Life ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2022-03-21
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-022-06142-x
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Article ; Online: Streptomyces griseicoloratus sp. nov., isolated from soil in cotton fields in Xinjiang, China.

Xing, Li / Xia, Ying-Ying / Zhang, Qiao-Yan / Xia, Zhan-Feng / Wan, Chuan-Xing / Zhang, Li-Li / Luo, Xiao-Xia

Archives of microbiology

2022 Volume 204, Issue 5, Page(s) 254

Abstract: A novel bacterium of the genus Streptomyces, designated TRM S81- ... ...

Abstract	A novel bacterium of the genus Streptomyces, designated TRM S81-3
MeSH term(s)	DNA, Bacterial/genetics ; Fatty Acids/chemistry ; Gossypium ; Phospholipids/chemistry ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA ; Soil ; Soil Microbiology ; Streptomyces
Chemical Substances	DNA, Bacterial ; Fatty Acids ; Phospholipids ; RNA, Ribosomal, 16S ; Soil
Language	English
Publishing date	2022-04-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124824-8
ISSN	1432-072X ; 0302-8933
ISSN (online)	1432-072X
ISSN	0302-8933
DOI	10.1007/s00203-022-02818-9
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Article: Streptomyces griseicoloratus sp. nov., isolated from soil in cotton fields in Xinjiang, China

Xing, Li / Xia, Ying-ying / Zhang, Qiao-Yan / Xia, Zhan-Feng / Wan, Chuan-xing / Zhang, Li-li / Luo, Xiao-Xia

Archives of microbiology. 2022 May, v. 204, no. 5

2022

Abstract: A novel bacterium of the genus Streptomyces, designated TRM S81-3ᵀ, was isolated from soil in cotton fields of Xinjiang, China. Comparative 16S rRNA gene sequence analysis indicated that strain TRM S81-3ᵀ is most closely related to Streptomyces ... ...

Abstract	A novel bacterium of the genus Streptomyces, designated TRM S81-3ᵀ, was isolated from soil in cotton fields of Xinjiang, China. Comparative 16S rRNA gene sequence analysis indicated that strain TRM S81-3ᵀ is most closely related to Streptomyces viridiviolaceus NBRC 13359ᵀ (98.9% sequence similarity); however, the average nucleotide identity (ANI) between strains TRM S81-3ᵀ and S. viridiviolaceus NBRC 13359ᵀ is relatively low (91.6%). Strain TRM S81-3ᵀ possesses LL-diaminopimelic acid as the diagnostic cell-wall diamino acid, MK-9(H₄), MK-9(H₆), and MK-9(H₁₀) as the major menaquinones, and polar lipids including diphosphatidylglycerol (DPG), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylmethyl ethanolamine (PME), phosphotidylinositolone (PI), phospholipid of unknown structure containing glucosamine (NPG), and two unidentified phospholipids (PLs).The major fatty acids are iso-C₁₆:₀, anteiso-C₁₅:₀, anteiso-C₁₇:₁ ω9c, anteiso-C₁₇:₀, iso-C₁₅:₀, and C₁₄:₀. The genomic DNA G + C content is 72.1%. Based on the evidence from this polyphasic study, strain TRM S81-3ᵀ represents a novel species of Streptomyces, for which the name Streptomyces grisecoloratus is proposed. The type strain is TRM S81-3ᵀ (= CCTCC AA 2020002ᵀ = LMG 31942ᵀ).
Keywords	Streptomyces viridiviolaceus ; bacteria ; cotton ; ethanolamine ; glucosamine ; menaquinones ; nucleotide sequences ; phosphatidylcholines ; phosphatidylethanolamines ; sequence homology ; soil ; China
Language	English
Dates of publication	2022-05
Size	p. 254.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	124824-8
ISSN	1432-072X ; 0302-8933
ISSN (online)	1432-072X
ISSN	0302-8933
DOI	10.1007/s00203-022-02818-9
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Article ; Online: Orcinol glucoside targeted p38 as an agonist to promote osteogenesis and protect glucocorticoid-induced osteoporosis.

He, Xin-Yun-Xi / Zhao, Wan-Lu / Yao, Li-Ping / Sun, Peng / Cheng, Gang / Liu, Yu-Ling / Yu, Yang / Liu, Yan / Wang, Teng-Jian / Zhang, Qiao-Yan / Qin, Lu-Ping / Zhang, Quan-Long

Phytomedicine : international journal of phytotherapy and phytopharmacology

2023 Volume 119, Page(s) 154953

Abstract: Background: Glucocorticoids (GC)-induced osteoporosis (GIOP) is the most common cause of secondary osteoporosis, which leads to an increased risk of fracture in patients. The inhibition of the osteoblast effect is one of the main pathological ... ...

Abstract	Background: Glucocorticoids (GC)-induced osteoporosis (GIOP) is the most common cause of secondary osteoporosis, which leads to an increased risk of fracture in patients. The inhibition of the osteoblast effect is one of the main pathological characteristics of GIOP, but without effective drugs on treatment. Purpose: The aim of this study was to investigate the potential effects of orcinol glucoside (OG) on osteoblast cells and GIOP mice, as well as the mechanism of the underlying molecular target protein of OG both in vitro osteoblast cell and in vivo GIOP mice model. Methods: GIOP mice were used to determine the effect of OG on bone density and bone formation. Then, a cellular thermal shift assay coupled with mass spectrometry (CETSA-MS) method was used to identify the target of OG. Surface plasmon resonance (SPR), enzyme activity assay, molecular docking, and molecular dynamics were used to detect the affinity, activity, and binding site between OG and its target, respectively. Finally, the anti-osteoporosis effect of OG through the target signal pathway was investigated in vitro osteoblast cell and in vivo GIOP mice model. Results: OG treatment increased bone mineral density (BMD) in GIOP mice and effectively promoted osteoblast proliferation, osteogenic differentiation, and mineralization in vitro. The CETSA-MS result showed that the target of OG acting on the osteoblast is the p38 protein. SPR, molecular docking assay and enzyme activity assay showed that OG could direct bind to the p38 protein and is a p38 agonist. The cellular study found that OG could promote p38 phosphorylation and upregulate the proteins expression of its downstream osteogenic (Runx2, Osx, Collagen Ⅰ, Dlx5). Meanwhile, it could also inhibit the nuclear transport of GR by increasing the phosphorylation site at GR226 in osteoblast cell. In vivo GIOP mice experiment further confirmed that OG could prevent bone loss in the GIOP mice model through promoting p38 activity as well as its downstream proteins expression and activity. Conclusions: This study has established that OG could promote osteoblast activity and revise the bone loss in GIOP mice by direct binding to the p38 protein and is a p38 agonist to improve its downstream signaling, which has great potential in GIOP treatment for targeting p38. This is the first report to identify OG anti-osteoporosis targets using a label-free strategy (CETSA-MS).
MeSH term(s)	Animals ; Mice ; Glucocorticoids/adverse effects ; Osteogenesis ; Glucosides/therapeutic use ; Molecular Docking Simulation ; Osteoporosis/chemically induced ; Osteoporosis/drug therapy ; Osteoporosis/metabolism
Chemical Substances	Glucocorticoids ; orcinol (534PMB3438) ; Glucosides
Language	English
Publishing date	2023-07-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.154953
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