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Article ; Online: 1

Pu, Yue / Zhang, Juan / Peng, Nian / Li, Rui / Xie, Dao-Jun / Zhang, Rong-Xin / Sun, Lan-Ting / Wang, Jin-le / Ye, Hao

Journal of pharmaceutical and biomedical analysis

2023 Volume 229, Page(s) 115355

Abstract: Objective: To investigate the metabolic mechanisms of Chinese and Western medicines on the metabolic network of striatal injury in a copper-loaded rat model of Wilson disease (WD) from a metabolomic perspective.: Methods: We divided 60 rats into 4 ... ...

Abstract	Objective: To investigate the metabolic mechanisms of Chinese and Western medicines on the metabolic network of striatal injury in a copper-loaded rat model of Wilson disease (WD) from a metabolomic perspective. Methods: We divided 60 rats into 4 groups of 15 rats each according to a random number table, namely the control group, the model group, the Bushen Huoxue Huazhuo Recipe group, and the penicillamine group, and subsequently replicated the WD copper-loaded rat model according to the literature method for a total of 12 weeks. From the 7th week onwards, each intervention group was given an equivalent dose of the corresponding drug, and the control and model groups were given an equal volume of saline gavage until the end of the model replication. We used Results: Nerve cell damage was evident in the WD copper-loaded rat model and could be reduced to varying degrees by different methods of intervention in the striatal nerve cells. The content of glycine, serine metabolism, and valine metabolism decreased in WD copper-loaded rat model; aspartate content increased after penicillamine intervention; glycolytic metabolism, valine metabolism, taurine metabolism, and tyrosine metabolism increased in the group of Bushen Huoxue Huazhuo Recipe. Conclusion: Different intervention methods of Chinese and Western medicine affect aspartate, glycolysis, taurine, tyrosine, valine, and carbon metabolism in striatal tissues of WD copper-loaded rats, and can regulate the metabolism of small molecules, which in turn have certain repairing effects on nerve damage in WD copper-loaded rats.
MeSH term(s)	Rats ; Animals ; Hepatolenticular Degeneration/drug therapy ; Hepatolenticular Degeneration/metabolism ; Copper ; Proton Magnetic Resonance Spectroscopy ; Aspartic Acid ; Penicillamine/pharmacology ; Penicillamine/therapeutic use ; Metabolomics
Chemical Substances	Copper (789U1901C5) ; Aspartic Acid (30KYC7MIAI) ; Penicillamine (GNN1DV99GX)
Language	English
Publishing date	2023-03-25
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2023.115355
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Article ; Online: Responses of anammox to long-term p-nitrophenol stress: From apparent and microscopic phenomena to mechanism simulation

Luo, Di / Qian, Jie / Fu, Jin-xiang / Liu, Zhuang / Zhang, Rong-xin / Huang, Dian-nan / Zhang, Li

Bioresource technology. 2022 July, v. 355 p.127265-

2022

Abstract: p-Nitrophenol is usually present in ammonia-rich wastewaters produced by some chemical plants. In this work, the response of anammox process to long-term p-nitrophenol stress was investigated. The changes in the efficiency, sludge characteristics, and ... ...

Abstract	p-Nitrophenol is usually present in ammonia-rich wastewaters produced by some chemical plants. In this work, the response of anammox process to long-term p-nitrophenol stress was investigated. The changes in the efficiency, sludge characteristics, and microorganisms of the anammox system under different levels of p-nitrophenol stress were examined, and the potential stress mechanisms of p-nitrophenol on anammox were further speculated. The results showed that 10–50 mg/L p-nitrophenol had no obvious impact on nitrogen removal efficiency, but stimulated the secretion of more extracellular polymeric substances. 60 mg/L p-nitrophenol caused the nitrogen removal efficiency to decrease by 64.5% in 5 days. Long-term exposure to p-nitrophenol led to 8.6% reduction in Candidatus_Kuenenia abundance and 18.4%–35.9% decrease in the expression level of anammox bacterial functional genes. Molecular simulation indicated that p-nitrophenol could bind to key enzymes of anammox. This study provides new insights into the treatment of wastewater containing p-nitrophenol or phenol by anammox.
Keywords	anaerobic ammonium oxidation ; chronic exposure ; molecular dynamics ; nitrogen ; p-nitrophenol ; phenol ; polymers ; secretion ; sludge ; wastewater ; wastewater treatment ; Anammox ; Functional genes ; Key enzymes ; Nitrogen removal ; p-Nitrophenol
Language	English
Dates of publication	2022-07
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2022.127265
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Article ; Online: Responses of anammox to long-term p-nitrophenol stress: From apparent and microscopic phenomena to mechanism simulation.

Luo, Di / Qian, Jie / Fu, Jin-Xiang / Liu, Chuang / Zhang, Rong-Xin / Huang, Dian-Nan / Zhang, Li

Bioresource technology

2022 Volume 355, Page(s) 127265

Abstract	p-Nitrophenol is usually present in ammonia-rich wastewaters produced by some chemical plants. In this work, the response of anammox process to long-term p-nitrophenol stress was investigated. The changes in the efficiency, sludge characteristics, and microorganisms of the anammox system under different levels of p-nitrophenol stress were examined, and the potential stress mechanisms of p-nitrophenol on anammox were further speculated. The results showed that 10-50 mg/L p-nitrophenol had no obvious impact on nitrogen removal efficiency, but stimulated the secretion of more extracellular polymeric substances. 60 mg/L p-nitrophenol caused the nitrogen removal efficiency to decrease by 64.5% in 5 days. Long-term exposure to p-nitrophenol led to 8.6% reduction in Candidatus_Kuenenia abundance and 18.4%-35.9% decrease in the expression level of anammox bacterial functional genes. Molecular simulation indicated that p-nitrophenol could bind to key enzymes of anammox. This study provides new insights into the treatment of wastewater containing p-nitrophenol or phenol by anammox.
MeSH term(s)	Anaerobic Ammonia Oxidation ; Anaerobiosis ; Bioreactors/microbiology ; Denitrification ; Nitrogen/analysis ; Nitrophenols ; Oxidation-Reduction ; Sewage ; Waste Water
Chemical Substances	Nitrophenols ; Sewage ; Waste Water ; Nitrogen (N762921K75) ; 4-nitrophenol (Y92ZL45L4R)
Language	English
Publishing date	2022-05-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2022.127265
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Article ; Online: Long-term outcomes of intraoperative chemotherapy with 5-FU for colorectal cancer patients receiving curative resection (IOCCRC): a randomized, multicenter, prospective, phase III trial.

International journal of surgery (London, England)

2024

Abstract: Background: We aimed to compare combined intraoperative chemotherapy and surgical resection with curative surgical resection alone in colorectal cancer patients.: Methods: We performed a multicenter, open-label, randomized, phase III trial. All ... ...

Abstract	Background: We aimed to compare combined intraoperative chemotherapy and surgical resection with curative surgical resection alone in colorectal cancer patients. Methods: We performed a multicenter, open-label, randomized, phase III trial. All eligible patients were randomized and assigned to intraoperative chemotherapy and curative surgical resection or curative surgical resection alone (1:1). Survival actualization after long-term follow-up was performed in patients analyzed on an intention-to-treat basis. Results: From January 2011 to January 2016, 696 colorectal cancer patients were enrolled and randomly assigned to intraoperative chemotherapy and radical surgical resection (n=341) or curative surgical resection alone (n=344). Intraoperative chemotherapy with surgical resection showed no significant survival benefit over surgical resection alone in colorectal cancer patients (3-year DFS: 91.1% vs. 90.0%, P=0.328; 3-year OS: 94.4% vs. 95.9%, P=0.756). However, colon cancer patients benefitted from intraoperative chemotherapy, with a relative 4% reduction in liver and peritoneal metastasis (HR=0.336, 95% CI: 0.148-0.759, P=0.015) and a 6.5% improvement in 3-year DFS (HR=0.579, 95% CI: 0.353-0.949, P=0.032). Meanwhile, patients with colon cancer and abnormal pretreatment CEA levels achieved significant survival benefits from intraoperative chemotherapy (DFS: HR=0.464, 95% CI: 0.233-0.921, P=0.029 and OS: (HR=0.476, 95% CI: 0.223-1.017, P=0.049). Conclusions: Intraoperative chemotherapy showed no significant extra prognostic benefit in total colorectal cancer patients who underwent radical surgical resection; however, in colon cancer patients with abnormal pretreatment serum CEA levels (> 5 ng/ml), intraoperative chemotherapy could improve long-term survival.
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1097/JS9.0000000000001301
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Article ; Online: Machine Learning Models in Type 2 Diabetes Risk Prediction: Results from a Cross-sectional Retrospective Study in Chinese Adults.

Xiong, Xiao-Lu / Zhang, Rong-Xin / Bi, Yan / Zhou, Wei-Hong / Yu, Yun / Zhu, Da-Long

Current medical science

2019 Volume 39, Issue 4, Page(s) 582–588

Abstract: Type 2 diabetes mellitus (T2DM) has become a prevalent health problem in China, especially in urban areas. Early prevention strategies are needed to reduce the associated mortality and morbidity. We applied the combination of rules and different machine ... ...

Abstract	Type 2 diabetes mellitus (T2DM) has become a prevalent health problem in China, especially in urban areas. Early prevention strategies are needed to reduce the associated mortality and morbidity. We applied the combination of rules and different machine learning techniques to assess the risk of development of T2DM in an urban Chinese adult population. A retrospective analysis was performed on 8000 people with non-diabetes and 3845 people with T2DM in Nanjing. Multilayer Perceptron (MLP), AdaBoost (AD), Trees Random Forest (TRF), Support Vector Machine (SVM), and Gradient Tree Boosting (GTB) machine learning techniques with 10 cross validation methods were used with the proposed model for the prediction of the risk of development of T2DM. The performance of these models was evaluated with accuracy, precision, sensitivity, specificity, and area under receiver operating characteristic (ROC) curve (AUC). After comparison, the prediction accuracy of the different five machine models was 0.87, 0.86, 0.86, 0.86 and 0.86 respectively. The combination model using the same voting weight of each component was built on T2DM, which was performed better than individual models. The findings indicate that, combining machine learning models could provide an accurate assessment model for T2DM risk prediction.
MeSH term(s)	Adult ; China/epidemiology ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/pathology ; Female ; Humans ; Machine Learning ; Male ; Retrospective Studies ; Risk Assessment
Language	English
Publishing date	2019-07-25
Publishing country	China
Document type	Journal Article
ZDB-ID	2931065-9
ISSN	2523-899X ; 2096-5230
ISSN (online)	2523-899X
ISSN	2096-5230
DOI	10.1007/s11596-019-2077-4
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Article ; Online: Neoadjuvant PD-1 blockade with sintilimab in mismatch-repair deficient, locally advanced rectal cancer: an open-label, single-centre phase 2 study.

Chen, Gong / Jin, Ying / Guan, Wen-Long / Zhang, Rong-Xin / Xiao, Wei-Wei / Cai, Pei-Qiang / Liu, Min / Lin, Jun-Zhong / Wang, Fu-Long / Li, Cong / Quan, Ting-Ting / Xi, Shao-Yan / Zhang, Hui-Zhong / Pan, Zhi-Zhong / Wang, Feng / Xu, Rui-Hua

The lancet. Gastroenterology & hepatology

2023 Volume 8, Issue 5, Page(s) 422–431

Abstract: Background: The current standard treatment for locally advanced rectal cancer is neoadjuvant chemoradiotherapy followed by radical surgery, but this approach can lead to multiple complications. We aimed to investigate the clinical activity and safety of ...

Abstract	Background: The current standard treatment for locally advanced rectal cancer is neoadjuvant chemoradiotherapy followed by radical surgery, but this approach can lead to multiple complications. We aimed to investigate the clinical activity and safety of neoadjuvant therapy with sintilimab, a single-agent PD-1 antibody, in patients with mismatch-repair deficient locally advanced rectal cancer. Methods: This open-label, single-arm, phase 2 study was done at the Sun Yat-sen University Cancer Center, Guangzhou, China. Patients aged 18-75 years with mismatch-repair deficient or microsatellite instability-high locally advanced rectal cancer were enrolled and received neoadjuvant sintilimab monotherapy (200 mg by intravenous infusion) every 21 days. After an initial four cycles of treatment, patients and clinicians could choose one of the following options: total mesorectal excision surgery, followed by four cycles of adjuvant sintilimab with or without CapeOX chemotherapy (capecitabine 1000 mg/m Findings: Between Oct 19, 2019, and June 18, 2022, 17 patients were enrolled and received at least one dose of sintilimab. The median age was 50 years (IQR 35-59) and 11 (65%) of 17 patients were male. One patient was excluded from efficacy analyses because they were lost to follow-up after the first sintilimab cycle. Of the remaining 16 patients, six underwent surgery, of whom three had a pathological complete response. Nine other patients had a clinical complete response and chose the watch and wait strategy. One patient had a serious adverse event and discontinued treatment; this patient did not have a complete clinical response and refused to undergo surgery. A complete response was thus noted for 12 (75%; 95% CI 47-92) of 16 patients. One of the three patients who underwent surgery but did not have a pathological complete response showed an increase in tumour volume after the initial four cycles of sintilimab (at which point they underwent surgery); this patient was deemed to have primary resistance to immune checkpoint inhibitors. After a median follow-up of 17·2 (IQR 8·2-28·5) months, all patients were alive and none had disease recurrence. Only one (6%) patient had a grade 3-4 adverse event, which was deemed a serious adverse event (grade 3 encephalitis). Interpretation: The preliminary results of this study suggest that anti-PD-1 monotherapy is effective and tolerable for patients with mismatch-repair deficient locally advanced rectal cancer and could potentially spare some patients from radical surgery. Longer treatment courses might be needed to achieve maximum effects in some patients. Longer follow-up is also needed to observe the duration of response. Funding: The National Natural Science Foundation of China, CAMS Innovation Fund for Medical Sciences, Science and Technology Program of Guangzhou, and Innovent Biologics.
MeSH term(s)	Female ; Humans ; Male ; Middle Aged ; Neoadjuvant Therapy/adverse effects ; Neoplasm Recurrence, Local/pathology ; Neoplasm Staging ; Rectal Neoplasms/drug therapy ; Treatment Outcome
Chemical Substances	sintilimab (8FU7FQ8UPK) ; PDCD1 protein, human
Language	English
Publishing date	2023-03-01
Publishing country	Netherlands
Document type	Clinical Trial, Phase II ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2468-1253
ISSN (online)	2468-1253
DOI	10.1016/S2468-1253(22)00439-3
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Article ; Online: Stage IV colon cancer patients without DENND2D expression benefit more from neoadjuvant chemotherapy.

Ma, Wen-Juan / Chen, Yukun / Peng, Jian-Hong / Tang, Chaoming / Zhang, Ling / Liu, Min / Hu, Shanshan / Xu, Haineng / Tan, Hua / Gu, Yangkui / Pan, Zhi-Zhong / Chen, Gong / Zhou, Zhong-Guo / Zhang, Rong-Xin

Cell death & disease

2022 Volume 13, Issue 5, Page(s) 439

Abstract: According to the EPOC study, chemotherapy could improve 5-year disease-free survival of stage IV colon cancer patients by 8.1%. However, more molecular biomarkers are required to identify patients who need neoadjuvant chemotherapy. DENND2D expression was ...

Abstract	According to the EPOC study, chemotherapy could improve 5-year disease-free survival of stage IV colon cancer patients by 8.1%. However, more molecular biomarkers are required to identify patients who need neoadjuvant chemotherapy. DENND2D expression was evaluated by immunohistochemistry in 181 stage IV colon cancer patients. The prognosis was better for patients with DENND2D expression than patients without DENND2D expression (5-year overall survival [OS]: 42% vs. 12%, p = 0.038; 5-year disease-free survival: 20% vs. 10%, p = 0.001). Subgroup analysis of the DENND2D-negative group showed that patients treated with neoadjuvant chemotherapy achieved longer OS than patients without neoadjuvant chemotherapy (RR = 0.179; 95% CI = 0.054-0.598; p = 0.003). DENND2D suppressed CRC proliferation in vitro and in vivo. Downregulation of DENND2D also promoted metastasis to distant organs in vivo. Mechanistically, DENND2D suppressed the MAPK pathway in CRC. Colon cancer patients who were DENND2D negative always showed a worse prognosis and were more likely to benefit from neoadjuvant chemotherapy. DENND2D may be a new prognostic factor and a predictor of the need for neoadjuvant chemotherapy in stage IV colon cancer.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemotherapy, Adjuvant ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/genetics ; Disease-Free Survival ; Humans ; Immunohistochemistry ; Neoadjuvant Therapy ; Neoplasm Staging ; Retrospective Studies
Language	English
Publishing date	2022-05-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-022-04885-8
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Article ; Online: Case report: Reproductive organ preservation and subsequent pregnancy for an infertility patient with lynch syndrome-associated synchronous endometrial cancer and colon cancer after treatment with a PD-1 checkpoint inhibitor.

Cao, Di / Gao, Yu / Zhang, Rong-Xin / Wang, Fu-Long / Li, Cong / Wu, Miao-Qing / Liu, Yi-Fan / Li, Dan-Dan / Chen, Gong

Frontiers in immunology

2022 Volume 13, Page(s) 1010490

Abstract: Currently, immune checkpoint inhibitors (ICIs) are the mainstay of treatment for Lynch syndrome patients. However, the tumor regression features in radiology and pathology are inconsistent for patients who are treated with ICIs, which sometimes confuses ... ...

Abstract	Currently, immune checkpoint inhibitors (ICIs) are the mainstay of treatment for Lynch syndrome patients. However, the tumor regression features in radiology and pathology are inconsistent for patients who are treated with ICIs, which sometimes confuses surgical decision-making. Here, we report a case in which a 36-year-old patient suffering from infertility was diagnosed with Lynch syndrome-associated synchronous endometrial cancer and colon cancer, and persistently enlarged left iliac paravascular lymph nodes were detected after receiving sintilimab treatment, a programmed cell death 1 (PD-1) receptor inhibitor. Fortunately, when she was about to undergo hysterectomy and bilateral salpingo-oophorectomy, intraoperative pathology examination did not reveal any cancer cells in these lymph nodes, and therefore, her reproductive organs were preserved. Later, the patient successfully conceived and gave birth to a healthy male neonate with no immune-related adverse events (irAEs) during an 11-month follow-up. This case indicates that surgeons should carefully inspect the imaging characteristics after immunotherapy and that organ preservation is possible even for patients who fail to achieve complete clinical regression, which is especially important for female patients of childbearing age.
MeSH term(s)	Humans ; Infant, Newborn ; Male ; Female ; Pregnancy ; Adult ; Colorectal Neoplasms, Hereditary Nonpolyposis/complications ; Programmed Cell Death 1 Receptor ; Organ Preservation ; Endometrial Neoplasms/complications ; Endometrial Neoplasms/pathology ; Colonic Neoplasms/complications ; Infertility ; Genitalia
Chemical Substances	Programmed Cell Death 1 Receptor
Language	English
Publishing date	2022-10-17
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.1010490
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Article: [Features of Syndrome Patterns of Chinese Medicine in Elderly AIDS Patients in Guangxi Zhuang Autonomous Region].

Jiang, Feng / Zhang, Rong-Xin / Zhang, Ya-Ping / Liu, Zhen-Wei / Li, Xuan / Wu, Wei-Qun / Wen, Bin / Deng, Xin

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine

2019 Volume 36, Issue 10, Page(s) 1175–1179

Abstract: Objective To observe the features of syndrome patterns of Chinese medicine (CM) in elderly human immunodeficiency virus/acquired immune deficiency syndrome ( HIV/AIDS) patients in Guangxi Zhuang Autonomous Region. Methods According to a case-control ... ...

Abstract	Objective To observe the features of syndrome patterns of Chinese medicine (CM) in elderly human immunodeficiency virus/acquired immune deficiency syndrome ( HIV/AIDS) patients in Guangxi Zhuang Autonomous Region. Methods According to a case-control study, a clinical question- naire was designated in elderly HIV/AIDS patients older than 50 years and healthy examinees with age and sex match. Their syndrome information of CM were collected from designated medical institutions in Guangxi Zhuang Autonomous Region from October 2013 to April 2014. Analyses of syndrome factors were conducted using WF-I[A Diagnosis and Treatment System of Traditional Chinese Medicine (Auxilia- ry). The disease location of CM and nature of diseases were compared between elderly HIV/AIDS patients and the controls. The features of syndrome patterns of CM in elderly HIV/AIDS patients were summarized. Results A total of 417 elderly HIV/AIDS patients and 362 examinees were enrolled. In elderly patients with HIV/AIDS, established syndrome factors of disease nature were qi deficiency, yang deficiency, yin deficiency, blood deficiency, dampness, and phlegm , and established syndrome factors of disease loca- tion included Shen, Fei, Pi, and Gan. There were statistical differences in established syndrome factors of disease location or nature between elderly patients with HIV/AIDS and the controls (P <0. 05). Conclu- sions Elderly HIV/AIDS patients were characterized by deficiency of qi, yang, yin, and blood in Shen, Fei, Pi, and Gan, as well as endogenous production of pathogenic factors such as dampness and phlegm. Intermingled deficiency and excess was dominated in elderly HIV/AIDS patients, and mainly man- ifested as deficiency syndrome.
MeSH term(s)	Acquired Immunodeficiency Syndrome/complications ; Aged ; Case-Control Studies ; China ; Humans ; Medicine, Chinese Traditional ; Syndrome ; Yang Deficiency ; Yin Deficiency
Language	Chinese
Publishing date	2019-01-14
Publishing country	China
Document type	Journal Article
ZDB-ID	1195456-5
ISSN	1003-5370
ISSN	1003-5370
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Article ; Online: Indoleamine-2,3-dioxygenase 1/cyclooxygenase 2 expression prediction for adverse prognosis in colorectal cancer.

Ma, Wen-Juan / Wang, Xing / Yan, Wen-Ting / Zhou, Zhong-Guo / Pan, Zhi-Zhong / Chen, Gong / Zhang, Rong-Xin

World journal of gastroenterology

2018 Volume 24, Issue 20, Page(s) 2181–2190

Abstract: Aim: To evaluate indoleamine-2,3-dioxygenase 1/cyclooxygenase 2 (IDO1/COX2) expression as an independent prognostic biomarker for colorectal cancer (CRC) patients.: Methods: We retrospectively studied the medical records of 95 patients who received ... ...

Abstract	Aim: To evaluate indoleamine-2,3-dioxygenase 1/cyclooxygenase 2 (IDO1/COX2) expression as an independent prognostic biomarker for colorectal cancer (CRC) patients. Methods: We retrospectively studied the medical records of 95 patients who received surgical resection from August 2008 to January 2010. All patients were randomly assigned to adjuvant treatment with or without celecoxib groups after surgery. We performed standard immunohistochemistry to assess the expression levels of IDO1/COX2 and evaluated the correlation of IDO1/COX2 with clinicopathological factors and overall survival (OS) outcomes. Results: The expression of nuclear IDO1 was significantly correlated with body mass index ( Conclusion: Our results showed that cytoplasmic IDO1/COX2 coexpression could be used as an independent poor predictor for OS in CRC.
MeSH term(s)	Biomarkers, Tumor/metabolism ; Celecoxib/therapeutic use ; Cell Nucleus/metabolism ; Chemotherapy, Adjuvant/methods ; China/epidemiology ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/therapy ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2 Inhibitors/therapeutic use ; Cytoplasm/metabolism ; Epithelial Cells/pathology ; Female ; Follow-Up Studies ; Humans ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Intestinal Mucosa/cytology ; Intestinal Mucosa/pathology ; Lymphocytes, Tumor-Infiltrating ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Survival Analysis
Chemical Substances	Biomarkers, Tumor ; Cyclooxygenase 2 Inhibitors ; IDO1 protein, human ; Indoleamine-Pyrrole 2,3,-Dioxygenase ; Cyclooxygenase 2 (EC 1.14.99.1) ; PTGS2 protein, human (EC 1.14.99.1) ; Celecoxib (JCX84Q7J1L)
Language	English
Publishing date	2018-06-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v24.i20.2181
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