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  1. Article: Semi-supervised learning in diagnosis of infant hip dysplasia towards multisource ultrasound images.

    Li, Xuanpeng / Zhang, Ruixiang / Wang, Zhibo / Wang, Jiakuan

    Quantitative imaging in medicine and surgery

    2024  Volume 14, Issue 5, Page(s) 3707–3716

    Abstract: Background: Automated diagnosis of infant hip dysplasia is heavily affected by the individual differences among infants and ultrasound machines.: Methods: Hip sonographic images of 493 infants from various ultrasound machines were collected in the ... ...

    Abstract Background: Automated diagnosis of infant hip dysplasia is heavily affected by the individual differences among infants and ultrasound machines.
    Methods: Hip sonographic images of 493 infants from various ultrasound machines were collected in the Department of Orthopedics in Yangzhou Maternal and Child Health Care Service Centre. Herein, we propose a semi-supervised learning method based on a feature pyramid network (FPN) and a contrastive learning scheme based on a Siamese architecture. A large amount of unlabeled data of ultrasound images was used via the Siamese network in the pre-training step, and then a small amount of annotated data for anatomical structures was adopted to train the model for landmark identification and standard plane recognition. The method was evaluated on our collected dataset.
    Results: The method achieved a mean Dice similarity coefficient (DSC) of 0.7873 and a mean Hausdorff distance (HD) of 5.0102 in landmark identification, compared to the model without contrastive learning, which had a mean DSC of 0.7734 and a mean HD of 6.1586. The accuracy, precision, and recall of standard plane recognition were 95.4%, 91.64%, and 94.86%, respectively. The corresponding area under the curve (AUC) was 0.982.
    Conclusions: This study proposes a semi-supervised deep learning method following Graf's principle, which can better utilize a large volume of ultrasound images from various devices and infants. This method can identify the landmarks of infant hips more accurately than manual operators, thereby improving the efficiency of diagnosis of infant hip dysplasia.
    Language English
    Publishing date 2024-04-18
    Publishing country China
    Document type Journal Article
    ZDB-ID 2653586-5
    ISSN 2223-4306 ; 2223-4292
    ISSN (online) 2223-4306
    ISSN 2223-4292
    DOI 10.21037/qims-23-1384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Subcarinal lymphadenectomy during minimally invasive esophagectomy with 2 anomalous pulmonary veins.

    Chen, Xiankai / Li, Yin / Zhang, Ruixiang / Xu, Lei / Luo, Peng

    JTCVS techniques

    2023  Volume 20, Page(s) 173–175

    Language English
    Publishing date 2023-03-02
    Publishing country United States
    Document type Case Reports
    ISSN 2666-2507
    ISSN (online) 2666-2507
    DOI 10.1016/j.xjtc.2022.12.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Circular RNA hsa_circ_0000277 promotes tumor progression and DDP resistance in esophageal squamous cell carcinoma.

    Cheng, Jiwei / Zhang, Ruixiang / Yan, Ming / Li, Yin

    BMC cancer

    2022  Volume 22, Issue 1, Page(s) 238

    Abstract: Background: Circular RNAs (circRNAs) are well-known regulators of cancer progression and chemoresistance in various types of cancers. This study was performed to investigate the function of hsa_circ_0000277 in esophageal squamous cell carcinoma (ESCC).!# ...

    Abstract Background: Circular RNAs (circRNAs) are well-known regulators of cancer progression and chemoresistance in various types of cancers. This study was performed to investigate the function of hsa_circ_0000277 in esophageal squamous cell carcinoma (ESCC).
    Methods: RNA levels were analyzed via the reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Cell Counting Kit-8 (CCK-8) assay was applied to determine cell proliferation and half maximal inhibitory concentration (IC50) of cisplatin (DDP). Colony formation ability was evaluated by colony formation assay. Cell cycle and apoptosis were measured using flow cytometry. RNA immunoprecipitation (RIP), pull-down assay and dual-luciferase reporter assays were performed for target interaction analysis. The protein levels were determined through western blot. Xenograft models were established for researching hsa_circ_0000277 function in vivo.
    Results: Hsa_circ_0000277 expression was increased in ESCC cells and tissues, and it had important clinical significance. Downregulation of hsa_circ_0000277 repressed ESCC cell proliferation, colony formation, cell cycle, and DDP resistance. Hsa_circ_0000277 acted as a microRNA-873-5p (miR-873-5p) sponge and Sry-related high-mobility group box 4 (SOX4) was validated as a target of miR-873-5p. Moreover, hsa_circ_0000277/miR-873-5p axis and miR-873-5p/SOX4 axis regulated ESCC cell progression and DDP resistance. Hsa_circ_0000277/miR-873-5p axis activated SOX4/Wnt/β-catenin signaling pathway. Hsa_circ_0000277 facilitated tumorigenesis and DDP resistance by miR-873-5p/SOX4 axis in vivo.
    Conclusion: These findings unraveled that hsa_circ_0000277 promoted ESCC progression and DDP resistance via miR-873-5p/SOX4/Wnt/β-catenin axis, showing a specific molecular mechanism of carcinogenesis and chemoresistance in ESCC.
    MeSH term(s) Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Apoptosis/genetics ; Carcinogenesis/drug effects ; Carcinogenesis/genetics ; Cell Cycle/drug effects ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Cisplatin/pharmacology ; Down-Regulation/drug effects ; Drug Resistance, Neoplasm/genetics ; Esophageal Neoplasms/drug therapy ; Esophageal Neoplasms/genetics ; Esophageal Squamous Cell Carcinoma/drug therapy ; Esophageal Squamous Cell Carcinoma/genetics ; Humans ; MicroRNAs/drug effects ; RNA, Circular/genetics ; SOXC Transcription Factors/drug effects ; Wnt Proteins/drug effects ; Xenograft Model Antitumor Assays ; beta Catenin/drug effects
    Chemical Substances Antineoplastic Agents ; CTNNB1 protein, human ; MIRN873 microRNA, human ; MicroRNAs ; RNA, Circular ; SOX4 protein, human ; SOXC Transcription Factors ; Wnt Proteins ; beta Catenin ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2022-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-022-09241-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: An improved multi-timescale coordinated control strategy for an integrated energy system with a hybrid energy storage system

    Pan, Chenyun / Fan, Hongtao / Zhang, Ruixiang / Sun, Jie / Wang, Yu / Sun, Yaojie

    Applied Energy. 2023 Aug., v. 343 p.121137-

    2023  

    Abstract: In view of the complex energy coupling and fluctuation of renewable energy sources in the integrated energy system, this paper proposes an improved multi-timescale coordinated control strategy for an integrated energy system (IES) with a hybrid energy ... ...

    Abstract In view of the complex energy coupling and fluctuation of renewable energy sources in the integrated energy system, this paper proposes an improved multi-timescale coordinated control strategy for an integrated energy system (IES) with a hybrid energy storage system (HESS). The power response characteristics of various devices in IES at different time scales are analyzed which shows that the multi-timescale coordinated control method can be well coupled with the IES including HESS. The advantages of HESS over single energy storage system in stabilizing power fluctuation and extending energy storage life are compared and analyzed while the control method of supercapacitor under multi-time scale coordinated control strategy is proposed. The primary energy consumption, operating costs, carbon dioxide emissions and load shedding costs are considered the optimization objectives in the day-ahead rolling optimization stage according to the day-ahead forecast renewable energy (RE) data. In the intraday rolling adjusting stage, the proposed method can reduce the effect of the RE day-ahead forecasting errors to achieve the intraday energy scheduling balance and ensure the safe operation of the devices of IES. Considering the background of IES with a high proportion of renewable energy, this paper makes innovative use of the advantages of HESS to improve the power response characteristic of the system. The high-frequency part of RE is balanced by HESS in the real-time coordinated control stage. A typical structure of IES is applied and the simulation results are analyzed to show the performance of the proposed method in this paper. Moreover, general rules for sizing of HESS are also proposed. The influence of the hybrid energy storage capacity allocation ratio on battery capacity loss and carbon emission reduction is discussed. The Pareto front including the configuration and cost of supercapacitor has been obtained. As shown in the case, the application of HESS in the IES can improve the power response characteristic, extend the lithium-ion battery (LiB) life and has more benefits in reducing carbon emissions.
    Keywords carbon ; carbon dioxide ; control methods ; electrochemical capacitors ; lithium batteries ; primary energy ; renewable energy sources ; shelf life ; Integrated energy system ; Hybrid energy storage system ; Multi-timescale coordinated control ; Approach for sizing hybrid energy storage system
    Language English
    Dates of publication 2023-08
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2000772-3
    ISSN 0306-2619
    ISSN 0306-2619
    DOI 10.1016/j.apenergy.2023.121137
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Lymph node metastases in middle and upper mediastinum of Siewert type II adenocarcinoma: A real-world retrospective study.

    Luo, Peng / Chen, Xiankai / Yang, Yafan / Zhang, Ruixiang / Kang, Xiaozheng / Qin, Jianjun / Qi, Xiuzhu / Li, Yin

    Cancer medicine

    2024  Volume 13, Issue 4, Page(s) e6919

    Abstract: Objective: To explore whether the upper and/or middle mediastinal nodes (UMMN) should be dissected in Siewert type II adenocarcinoma (AC) according to the incidence of lymph node metastasis. Additionally, to investigate the association between the ... ...

    Abstract Objective: To explore whether the upper and/or middle mediastinal nodes (UMMN) should be dissected in Siewert type II adenocarcinoma (AC) according to the incidence of lymph node metastasis. Additionally, to investigate the association between the length of esophageal involvement (LEI) and the UMMN metastases.
    Methods: A cohort with Siewert type II AC who were operated on by a surgical team that routinely treated esophagogastric junction (EGJ) tumors with esophagectomy and extended lymphadenectomy were assessed retrospectively. The primary endpoint of the research was the metastasis rate of UMMN.
    Results: A total of 94 patients with EGJ tumor from July 2018 to September 2022 were enrolled. Station 106recR (6.4%, 6/94) was the only station among upper mediastinal nodes (UMN) that presented positive nodes. Middle mediastinal nodes (MMN) metastases of station 107, 109 and station 108 were 2.1% (2/94) and 5.0% (4/80), respectively. Among the 11 patients with MMN or UMN metastases, 63.6% (7/11) had lesser than seven metastatic nodes, and 54.5% (6/11) had a pathological N stage ≤2. LEI >3 cm (p = 0.042) showed a higher risk for MMN metastases in univariable logistic analysis. However, no independent risk factor for mediastinal node metastases was detected.
    Conclusion: This study demonstrated that the incidence of positive MMN and UMN is relatively low in resectable Siewert type II AC, which indicated that it is not necessary to perform a routine dissection upon these stations. LEI >3 cm might be associated with higher risk for mediastinal node metastasis. Certain patients could benefit from extended lymphadenectomy since most of the patients with positive MMN or UMN have a limited number of metastatic nodes.
    MeSH term(s) Humans ; Mediastinum ; Lymphatic Metastasis ; Retrospective Studies ; Adenocarcinoma/surgery ; Mediastinal Neoplasms
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.6919
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Identification and Analysis of Key Barriers of BIM Application for Small- and Medium-Sized Fire Protection Enterprises.

    Liu, Hui / Zhang, Ruixiang / Zhang, Hang / Jiang, Hongbing / Ju, Qianqian

    Journal of environmental and public health

    2022  Volume 2022, Page(s) 9240224

    Abstract: The application of Building Information Modeling (BIM) in fire protection discipline has been sufficiently proved to be useful, but has encountered many barriers in China. Among which, small- and medium-sized enterprises (SMEs), which are considered ... ...

    Abstract The application of Building Information Modeling (BIM) in fire protection discipline has been sufficiently proved to be useful, but has encountered many barriers in China. Among which, small- and medium-sized enterprises (SMEs), which are considered sensitive to adoption costs and external funding support, play a critical role in the BIM adoption process in fire protection discipline. Therefore, identifying and analyzing the barriers of BIM application are essential to help small- and medium-sized fire protection enterprises to overcome these barriers. In this study, semantic analysis, which includes word frequency analysis and coword analysis, based on literature review was utilized to identify the main barriers. 20 main barriers, which were classified into software, people, organization, and environment group, were obtained. Then, Interpretive Structural Modelling (ISM) approach and Cross-Impact Matrix Multiplication Applied to Classification (MICMAC) analysis were utilized to hierarchically analyze and categorize the main barriers of BIM application in Chinese SMFEs. The findings revealed that the lack of external support and the lack of BIM laws and regulations applicable to fire protection discipline are the key barriers in general for the application of BIM in SMFEs. For the barriers at the enterprise level, through further analysis and discussion based on barriers in the people and organization clusters, the lack of funding support for proper BIM training and the lack of organization culture support were concluded as the key barriers of BIM application inside the scope of SMFEs. According to 80-20 principle, more effort should be focused on the key barriers to gain maximum management effect. The research result categorizes the barriers for easy intervention of fire protection enterprises' managers and policymakers. It contributes to the nascent studies of BIM application and provides guidance for the application of BIM in fire protection discipline.
    MeSH term(s) Building Codes ; China ; Fires/prevention & control ; Humans
    Language English
    Publishing date 2022-09-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2526611-1
    ISSN 1687-9813 ; 1687-9813
    ISSN (online) 1687-9813
    ISSN 1687-9813
    DOI 10.1155/2022/9240224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A population-based investigation: How to identify high-risk T1-2N0 esophageal cancer patients?

    Luo, Peng / Wu, Jie / Chen, Xiankai / Yang, Yafan / Zhang, Ruixiang / Qi, Xiuzhu / Li, Yin

    Frontiers in surgery

    2023  Volume 9, Page(s) 1003487

    Abstract: Purpose: Newly diagnosed T1-2N0 esophageal cancer (EC) is generally deemed as early local disease, with distant metastases (DM) easily overlooked. This retrospective study aimed to describe the metastatic patterns, identify risk factors and established ... ...

    Abstract Purpose: Newly diagnosed T1-2N0 esophageal cancer (EC) is generally deemed as early local disease, with distant metastases (DM) easily overlooked. This retrospective study aimed to describe the metastatic patterns, identify risk factors and established a risk prediction model for DM in T1-2N0 EC patients.
    Methods: A total of 4623 T1-2N0 EC patients were identified in the Surveillance, Epidemiology and End Results (SEER) database from 2004 to 2018. Multivariable logistic regression was used to identify risk factors for DM. A nomogram was developed for presentation of the final model.
    Results: Of 4623 T1-2N0 patients, 4062 (87.9%) had M0 disease and 561 (12.1%) had M1 disease. The most common metastatic site was liver (
    Conclusions: We identified independent predictive factors for DM, as well as for BoM, BrM, LiM and LuM. Above all, a practical and convenient nomogram with a great accuracy to predict DM probability for T1-2N0 EC patients was established.
    Language English
    Publishing date 2023-01-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.1003487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online: Robust Tiny Object Detection in Aerial Images amidst Label Noise

    Zhu, Haoran / Xu, Chang / Yang, Wen / Zhang, Ruixiang / Zhang, Yan / Xia, Gui-Song

    2024  

    Abstract: Precise detection of tiny objects in remote sensing imagery remains a significant challenge due to their limited visual information and frequent occurrence within scenes. This challenge is further exacerbated by the practical burden and inherent errors ... ...

    Abstract Precise detection of tiny objects in remote sensing imagery remains a significant challenge due to their limited visual information and frequent occurrence within scenes. This challenge is further exacerbated by the practical burden and inherent errors associated with manual annotation: annotating tiny objects is laborious and prone to errors (i.e., label noise). Training detectors for such objects using noisy labels often leads to suboptimal performance, with networks tending to overfit on noisy labels. In this study, we address the intricate issue of tiny object detection under noisy label supervision. We systematically investigate the impact of various types of noise on network training, revealing the vulnerability of object detectors to class shifts and inaccurate bounding boxes for tiny objects. To mitigate these challenges, we propose a DeNoising Tiny Object Detector (DN-TOD), which incorporates a Class-aware Label Correction (CLC) scheme to address class shifts and a Trend-guided Learning Strategy (TLS) to handle bounding box noise. CLC mitigates inaccurate class supervision by identifying and filtering out class-shifted positive samples, while TLS reduces noisy box-induced erroneous supervision through sample reweighting and bounding box regeneration. Additionally, Our method can be seamlessly integrated into both one-stage and two-stage object detection pipelines. Comprehensive experiments conducted on synthetic (i.e., noisy AI-TOD-v2.0 and DOTA-v2.0) and real-world (i.e., AI-TOD) noisy datasets demonstrate the robustness of DN-TOD under various types of label noise. Notably, when applied to the strong baseline RFLA, DN-TOD exhibits a noteworthy performance improvement of 4.9 points under 40% mixed noise. Datasets, codes, and models will be made publicly available.
    Keywords Computer Science - Computer Vision and Pattern Recognition
    Subject code 006
    Publishing date 2024-01-15
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Book ; Online: Analog Bits

    Chen, Ting / Zhang, Ruixiang / Hinton, Geoffrey

    Generating Discrete Data using Diffusion Models with Self-Conditioning

    2022  

    Abstract: We present Bit Diffusion: a simple and generic approach for generating discrete data with continuous state and continuous time diffusion models. The main idea behind our approach is to first represent the discrete data as binary bits, and then train a ... ...

    Abstract We present Bit Diffusion: a simple and generic approach for generating discrete data with continuous state and continuous time diffusion models. The main idea behind our approach is to first represent the discrete data as binary bits, and then train a continuous diffusion model to model these bits as real numbers which we call analog bits. To generate samples, the model first generates the analog bits, which are then thresholded to obtain the bits that represent the discrete variables. We further propose two simple techniques, namely Self-Conditioning and Asymmetric Time Intervals, which lead to a significant improvement in sample quality. Despite its simplicity, the proposed approach can achieve strong performance in both discrete image generation and image captioning tasks. For discrete image generation, we significantly improve previous state-of-the-art on both CIFAR-10 (which has 3K discrete 8-bit tokens) and ImageNet-64x64 (which has 12K discrete 8-bit tokens), outperforming the best autoregressive model in both sample quality (measured by FID) and efficiency. For image captioning on MS-COCO dataset, our approach achieves competitive results compared to autoregressive models.

    Comment: ICLR'23
    Keywords Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Artificial Intelligence ; Computer Science - Computation and Language ; Computer Science - Machine Learning
    Subject code 006
    Publishing date 2022-08-08
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Book ; Online: Meta-RangeSeg

    Wang, Song / Zhu, Jianke / Zhang, Ruixiang

    LiDAR Sequence Semantic Segmentation Using Multiple Feature Aggregation

    2022  

    Abstract: LiDAR sensor is essential to the perception system in autonomous vehicles and intelligent robots. To fulfill the real-time requirements in real-world applications, it is necessary to efficiently segment the LiDAR scans. Most of previous approaches ... ...

    Abstract LiDAR sensor is essential to the perception system in autonomous vehicles and intelligent robots. To fulfill the real-time requirements in real-world applications, it is necessary to efficiently segment the LiDAR scans. Most of previous approaches directly project 3D point cloud onto the 2D spherical range image so that they can make use of the efficient 2D convolutional operations for image segmentation. Although having achieved the encouraging results, the neighborhood information is not well-preserved in the spherical projection. Moreover, the temporal information is not taken into consideration in the single scan segmentation task. To tackle these problems, we propose a novel approach to semantic segmentation for LiDAR sequences named Meta-RangeSeg, where a novel range residual image representation is introduced to capture the spatial-temporal information. Specifically, Meta-Kernel is employed to extract the meta features, which reduces the inconsistency between the 2D range image coordinates input and Cartesian coordinates output. An efficient U-Net backbone is used to obtain the multi-scale features. Furthermore, Feature Aggregation Module (FAM) aggregates the meta features and multi-scale features, which tends to strengthen the role of range channel. We have conducted extensive experiments for performance evaluation on SemanticKITTI, which is the de-facto dataset for LiDAR semantic segmentation. The promising results show that our proposed Meta-RangeSeg method is more efficient and effective than the existing approaches. Our full implementation is publicly available at https://github.com/songw-zju/Meta-RangeSeg .

    Comment: 8 pages, 6 figures
    Keywords Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Robotics
    Subject code 004
    Publishing date 2022-02-27
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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