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  1. Article ; Online: Effective enrichment of trace exosomes for the label-free SERS detection via low-cost thermophoretic profiling.

    Guo, Yu / Zhang, Ruiyuan / You, Hongjun / Fang, Jixiang

    Biosensors & bioelectronics

    2024  Volume 253, Page(s) 116164

    Abstract: Exosome-based liquid biopsies possess great potential in monitoring cancer development However, current exosome detection biosensors require large exosome volumes, showing the weak detection sensitivity. Besides, these methods pay little attention to in ... ...

    Abstract Exosome-based liquid biopsies possess great potential in monitoring cancer development However, current exosome detection biosensors require large exosome volumes, showing the weak detection sensitivity. Besides, these methods pay little attention to in situ analysis of exosomes, hence limiting the provision of more accurate clinically-relevant information. Herein, we develop an innovative label-free biosensor combining the low-cost thermophoretic enrichment method with the surface-enhanced Raman spectroscopy (SERS) detection. Based on the thermophoretic enrichment strategy, exosomes and gold nanoparticles can be enriched together into a small area with a scale of 500 μm within 10 min. The Raman signals of various exosomes derived from normal, cancerous cell lines and human serum are dynamically monitored in situ, with the limit of detection of 10
    MeSH term(s) Humans ; Exosomes ; Gold ; Biosensing Techniques ; Metal Nanoparticles ; Spectrum Analysis, Raman
    Chemical Substances Gold (7440-57-5)
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2024.116164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2275: Show issues Location:
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  2. Article ; Online: Synergistic Palladium/Copper-Catalyzed 1,4-Difunctionalization of 1,3-Dienes for Stereodivergent Construction of 1,5-Nonadjacent Stereocenters.

    Wang, Hongfa / Zhang, Ruiyuan / Zi, Weiwei

    Angewandte Chemie (International ed. in English)

    2024  , Page(s) e202402843

    Abstract: The construction of two distal stereocenters through a single catalytic process is of great interest in organic synthesis. While there are some successful reports regarding stereodivergent preparation of 1,3- or 1,4-stereocenters, the more challenged 1,5- ...

    Abstract The construction of two distal stereocenters through a single catalytic process is of great interest in organic synthesis. While there are some successful reports regarding stereodivergent preparation of 1,3- or 1,4-stereocenters, the more challenged 1,5-nonadjacent stereocenters have never been achieved in a stereodivergent fashion. Herein we describe a synergistic palladium/copper catalysis for 1,4-difunctionalization reactions of 1,3-dienes, providing access to 1,5-nonadjacent quaternary stereocenters. Because each of the two catalysts separately controlled one of the newly formed stereocenters, stereodivergent synthesis of all four diastereomers of the products could readily be achieved simply by choosing an appropriate combination of chiral catalysts. Experimental and computational studies supported a mechanism involving a Heck/Tsuji-Trost cascade reaction, and the origins of the stereoselectivity were elucidated.
    Language English
    Publishing date 2024-03-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202402843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Effect of Biochar on NO

    Bai, Yi-Ru / Liu, Xu / Zhang, Yu-Han / Zhang, Rui-Yuan / Ma, Yan / Wang, You-Qi

    Huan jing ke xue= Huanjing kexue

    2024  Volume 45, Issue 5, Page(s) 2905–2912

    Abstract: The objective of this study was to explore the effects of different amounts of biochar on the migration process and characteristics of ... ...

    Abstract The objective of this study was to explore the effects of different amounts of biochar on the migration process and characteristics of NO
    MeSH term(s) Soil ; Charcoal ; Nitrogen
    Chemical Substances biochar ; Soil ; Charcoal (16291-96-6) ; Nitrogen (N762921K75)
    Language Chinese
    Publishing date 2024-04-17
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 0250-3301
    ISSN 0250-3301
    DOI 10.13227/j.hjkx.202305075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Early life exposure to low-dose perfluorooctane sulfonate disturbs gut barrier homeostasis and increases the risk of intestinal inflammation in offspring.

    Liu, Yongjie / Yu, Guoqi / Zhang, Ruiyuan / Feng, Liping / Zhang, Jun

    Environmental pollution (Barking, Essex : 1987)

    2023  Volume 329, Page(s) 121708

    Abstract: Perfluorooctane sulfonate (PFOS), one of the legacy per- and poly-fluoroalkyl substances (PFAS), is associated with multiple adverse health effects on children. However, much remains to be known about its potential impacts on intestinal immune ... ...

    Abstract Perfluorooctane sulfonate (PFOS), one of the legacy per- and poly-fluoroalkyl substances (PFAS), is associated with multiple adverse health effects on children. However, much remains to be known about its potential impacts on intestinal immune homeostasis during early life. Our study found that PFOS exposure during pregnancy in rats significantly increased the maternal serum levels of interleukin-6 (IL-6) and zonulin, a gut permeability biomarker, and decreased gene expressions of Tight junction protein 1 (Tjp1) and Claudin-4 (Cldn4), the tight junction proteins, in maternal colons on gestation day 20 (GD20). Being exposed to PFOS during pregnancy and lactation in rats significantly decreased the body weight of pups and increased the offspring's serum levels of IL-6 and tumor necrosis factor-α (TNF-α) on postnatal day 14 (PND14), and induced a disrupted gut tight junction, manifested by decreased expressions of Tjp1 in pup's colons on PND14 and increased pup's serum concentrations of zonulin on PND28. By integrating high-throughput 16S rRNA sequencing and metabolomics, we demonstrated that early-life PFOS exposure altered the diversity and composition of gut microbiota that were correlated with the changed metabolites in serum. The altered blood metabolome was associated with increased proinflammatory cytokines in offspring. These changes and correlations were divergent at each developmental stage, and pathways underlying immune homeostasis imbalance were significantly enriched in the PFOS-exposed gut. Our findings provide new evidence for the developmental toxicity of PFOS and its underlying mechanism and explain in part the epidemiological observation of its immunotoxicity.
    MeSH term(s) Pregnancy ; Female ; Rats ; Animals ; Interleukin-6 ; RNA, Ribosomal, 16S/genetics ; Fluorocarbons/toxicity ; Inflammation ; Homeostasis ; Alkanesulfonic Acids/toxicity
    Chemical Substances perfluorooctane (6P60ZBK0QL) ; Interleukin-6 ; RNA, Ribosomal, 16S ; Fluorocarbons ; Alkanesulfonic Acids
    Language English
    Publishing date 2023-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2023.121708
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2599: Show issues Location:
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  5. Article: Rapid and ultrasensitive solution-based SERS detection of drug additives in aquaculture by using polystyrene sulfonate modified gold nanobipyramids

    Amin, Muhammad Usman / Li, Lingwei / Zhang, Ruiyuan / Fang, Jixiang

    Talanta. 2023 Jan. 01, v. 251

    2023  

    Abstract: In recent years, surface-enhanced Raman spectroscopy (SERS) has been widely used in various fields for the rapid detection of trace-level molecular targets. In this study, we have developed a simple and effective solution-based SERS protocol to improve ... ...

    Abstract In recent years, surface-enhanced Raman spectroscopy (SERS) has been widely used in various fields for the rapid detection of trace-level molecular targets. In this study, we have developed a simple and effective solution-based SERS protocol to improve the activity for the detection of cationic dye molecules in aquaculture. The polystyrene sulfonate functionalized gold nanobipyramids (PSS–Au BPs) were synthesized from the cetyltrimethylammonium bromide (CTAB) reaction system followed by the ligand exchange process. The halide ions-induced aggregation of PSS-Au BPs was carried out by using four type of different salts such as NaCl, NaBr, MgCl₂ and MgSO₄ to investigate their influence on the SERS activity. The results demonstrate that the ionic strength of the solution has an important impact on the colloidal stability and SERS activity. The PSS-Au BPs show an improved SERS sensitivity at lower concentrations of the aggregating agents in solution-based SERS by detecting the crystal violet (CV) molecules with a limit of detection (LOD) to 3.28 × 10⁻¹¹ M. Furthermore, to demonstrate the generality of our proposed strategy, trace amounts of three more dyes such as malachite green (MG), methylene blue (MB), and rhodamine 6G (R-6G), as well as other molecules such as thiram and bisphenol-S were also detected. This protocol not only provides a method for rapid on-site detection of trace-level molecules but can also be applied to other SERS-based analysis.
    Keywords Raman spectroscopy ; aquaculture ; cetyltrimethylammonium bromide ; detection limit ; drugs ; gentian violet ; gold ; ionic strength ; ligands ; malachite green ; methylene blue ; polystyrenes ; rapid methods ; rhodamines ; sodium bromide ; sulfonates ; thiram
    Language English
    Dates of publication 2023-0101
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2022.123800
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  6. Article ; Online: A DNA tetrahedron docking assembly for imaging telomerase activity in cancerous cells.

    Zhang, Ruixue / Zhang, Ruiyuan / Zhao, Chunyan / Xu, Xiaowen

    Analytica chimica acta

    2021  Volume 1193, Page(s) 339395

    Abstract: The detection of telomerase activity inside cells is valuable for early cancer diagnosis and telomerase function study. However, besides cancerous cells, telomerase is also found to be expressed in few non-cancerous cells, which influences the assay ... ...

    Abstract The detection of telomerase activity inside cells is valuable for early cancer diagnosis and telomerase function study. However, besides cancerous cells, telomerase is also found to be expressed in few non-cancerous cells, which influences the assay reliability. By virtue of the extracellular pH, we design a DNA tetrahedron docking assembly (DTDA) for only responding telomerase activity in cancerous cells. The DTDA maintains structural integrity with extracellular acid pH of cancerous cells, but releases a telomerase substrate-containing strand after its cell internalization due to intracellular alkaline pH. The strand gets elongated by intracellular telomerase, docks to the vertex of tetrahedron, and returns to the DTDA after its separation, accompanied by fluorescence enhancement. For non-cancerous cells, the telomerase substrate-containing strand is already dissociated with extracellular alkaline pH and cannot enter into cells to achieve subsequent docking event. DTDA well distinguishes cancerous cells from non-cancerous cells in which telomerase are both expressed. The strategy can provide a more reliable way for telomerase-based cancer diagnosis and telomerase oncogenic study.
    MeSH term(s) DNA ; Reproducibility of Results ; Telomerase/metabolism
    Chemical Substances DNA (9007-49-2) ; Telomerase (EC 2.7.7.49)
    Language English
    Publishing date 2021-12-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2021.339395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Synergistic Pd/Amine-Catalyzed Stereodivergent Hydroalkylation of 1,3-Dienes with Aldehydes: Reaction Development, Mechanism, and Stereochemical Origins.

    Wang, Hongfa / Zhang, Ruiyuan / Zhang, Qinglong / Zi, Weiwei

    Journal of the American Chemical Society

    2021  Volume 143, Issue 29, Page(s) 10948–10962

    Abstract: Metal-hydride-catalyzed hydroalkylation of 1,3-dienes with enolizable carbonyl compounds is an atom- and step-economical method for preparing chiral molecules with allylic stereocenters. Although high diastereo- and enantioselectivities have been ... ...

    Abstract Metal-hydride-catalyzed hydroalkylation of 1,3-dienes with enolizable carbonyl compounds is an atom- and step-economical method for preparing chiral molecules with allylic stereocenters. Although high diastereo- and enantioselectivities have been achieved for many coupling partners, aldehydes have not yet been used for this purpose because they are less stable than other carbonyl compounds under basic conditions and they have the potential to rapidly epimerize at the α-position. Moreover, stereodivergent hydroalkylation reactions of 1,3-dienes to access complementary diastereomers with vicinal stereocenters is challenging. Herein, we describe a synergistic palladium/amine catalyst system that allowed us to achieve the first stereodivergent hydroalkylation reactions of 1,3-dienes with aldehydes. By choosing an appropriate combination of chiral palladium and amine catalysts, we could obtain either
    Language English
    Publishing date 2021-07-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.1c02220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A multicolor DNA tetrahedron nanoprobe for analyzing human telomerase in living cells.

    Zhang, Ruiyuan / Zhang, Ruixue / Jiang, Wei / Xu, Xiaowen

    Chemical communications (Cambridge, England)

    2021  Volume 57, Issue 17, Page(s) 2188–2191

    Abstract: Herein, we report the in situ analysis of human telomerase by a multicolor DNA tetrahedron nanoprobe. The elongated telomeric repeats can hybridize with settled molecular beacons in order, accompanied by sequentially lighted up fluorescence. Imaging ... ...

    Abstract Herein, we report the in situ analysis of human telomerase by a multicolor DNA tetrahedron nanoprobe. The elongated telomeric repeats can hybridize with settled molecular beacons in order, accompanied by sequentially lighted up fluorescence. Imaging telomerase activity, real-time monitoring telomerase action and determining product length distribution in living cells are realized. It detects multiple information of intracellular telomerase and provides deeper insights into the function of telomerase.
    MeSH term(s) DNA/chemistry ; DNA Probes/chemistry ; Fluorescent Dyes ; HeLa Cells ; Humans ; Optical Imaging/methods
    Chemical Substances DNA Probes ; Fluorescent Dyes ; DNA (9007-49-2)
    Language English
    Publishing date 2021-02-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d0cc07893j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Rapid and ultrasensitive solution-based SERS detection of drug additives in aquaculture by using polystyrene sulfonate modified gold nanobipyramids.

    Amin, Muhammad Usman / Li, Lingwei / Zhang, Ruiyuan / Fang, Jixiang

    Talanta

    2022  Volume 251, Page(s) 123800

    Abstract: In recent years, surface-enhanced Raman spectroscopy (SERS) has been widely used in various fields for the rapid detection of trace-level molecular targets. In this study, we have developed a simple and effective solution-based SERS protocol to improve ... ...

    Abstract In recent years, surface-enhanced Raman spectroscopy (SERS) has been widely used in various fields for the rapid detection of trace-level molecular targets. In this study, we have developed a simple and effective solution-based SERS protocol to improve the activity for the detection of cationic dye molecules in aquaculture. The polystyrene sulfonate functionalized gold nanobipyramids (PSS-Au BPs) were synthesized from the cetyltrimethylammonium bromide (CTAB) reaction system followed by the ligand exchange process. The halide ions-induced aggregation of PSS-Au BPs was carried out by using four type of different salts such as NaCl, NaBr, MgCl
    MeSH term(s) Aquaculture ; Cetrimonium ; Coloring Agents ; Gentian Violet/analysis ; Gold/chemistry ; Ligands ; Metal Nanoparticles/chemistry ; Methylene Blue ; Polystyrenes ; Salts ; Sodium Chloride ; Spectrum Analysis, Raman/methods ; Thiram/analysis
    Chemical Substances Coloring Agents ; Ligands ; Polystyrenes ; Salts ; Thiram (0D771IS0FH) ; Sodium Chloride (451W47IQ8X) ; polystyrene sulfonic acid (70KO0R01RY) ; Gold (7440-57-5) ; Gentian Violet (J4Z741D6O5) ; Methylene Blue (T42P99266K) ; Cetrimonium (Z7FF1XKL7A)
    Language English
    Publishing date 2022-08-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2022.123800
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Impact of Oat (

    Li, Lin / Zhang, Ruiyuan / Hu, Yichen / Deng, Hongdan / Pei, Xu / Liu, Fang / Chen, Chen

    Journal of agricultural and food chemistry

    2023  Volume 71, Issue 41, Page(s) 14838–14852

    Abstract: Oat ( ...

    Abstract Oat (
    MeSH term(s) Avena/metabolism ; Metabolic Syndrome/drug therapy ; Edible Grain ; Australia ; Canada
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c02304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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