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Article ; Online: Cinobufagin: a promising therapeutic agent for cancer.

Dai, Chun-Lan / Zhang, Run-Jing / An, Pei / Deng, Yi-Qing / Rahman, Khalid / Zhang, Hong

The Journal of pharmacy and pharmacology

2023 Volume 75, Issue 9, Page(s) 1141–1153

Abstract: Objectives: Cinobufagin is a natural active ingredient isolated from the traditional Chinese medicine Venenum Bufonis (Chinese: Chansu), which is the dried secretion of the postauricular gland or skin gland of the Bufo gargarizans Cantor or Bufo ... ...

Abstract	Objectives: Cinobufagin is a natural active ingredient isolated from the traditional Chinese medicine Venenum Bufonis (Chinese: Chansu), which is the dried secretion of the postauricular gland or skin gland of the Bufo gargarizans Cantor or Bufo melanostictus Schneider. There is increasing evidence indicating that cinobufagin plays an important role in the treatment of cancer. This article is to review and discuss the antitumor pharmacological effects and mechanisms of cinobufagin, along with a description of its toxicity and pharmacokinetics. Methods: The public databases including PubMed, China National Knowledge Infrastructure and Elsevier were referenced, and 'cinobufagin', 'Chansu', 'Venenum Bufonis', 'anticancer', 'cancer', 'carcinoma', and 'apoptosis' were used as keywords to summarize the comprehensive research and applications of cinobufagin published up to date. Key findings: Cinobufagin can induce tumour cell apoptosis and cycle arrest, inhibit tumour cell proliferation, migration, invasion and autophagy, reduce angiogenesis and reverse tumour cell multidrug resistance, through triggering DNA damage and activating the mitochondrial pathway and the death receptor pathway. Conclusions: Cinobufagin has the potential to be further developed as a new drug against cancer.
MeSH term(s)	Animals ; Humans ; Apoptosis ; Bufonidae ; Cell Proliferation ; China ; Neoplasms/drug therapy
Language	English
Publishing date	2023-05-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	3107-0
ISSN	2042-7158 ; 0022-3573 ; 0373-1022
ISSN (online)	2042-7158
ISSN	0022-3573 ; 0373-1022
DOI	10.1093/jpp/rgad059
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Article: Classical famous prescription of Jichuan decoction improved loperamide-induced slow transit constipation in rats through the cAMP/PKA/AQPs signaling pathway and maintained inflammatory/intestinal flora homeostasis.

Lin, Lina / Jiang, Yuanyuan / Lin, Pengfei / Ge, Lanlan / Wan, Haoqiang / Dai, Shuwen / Zhang, Runjing / Yao, Jie / Zeng, Xiaobin / Peng, Ying

Heliyon

2023 Volume 10, Issue 1, Page(s) e21870

Abstract: Introduction: Jichuan decoction (JCD) is a well-known traditional Chinese medicinal formula that moistens the intestines and is widely used for the treatment of constipation in China. However, its effects and mechanisms in alleviating slow transit ... ...

Abstract	Introduction: Jichuan decoction (JCD) is a well-known traditional Chinese medicinal formula that moistens the intestines and is widely used for the treatment of constipation in China. However, its effects and mechanisms in alleviating slow transit constipation (STC) in vivo remain unclear. We attempted to demonstrate the effect of JCD, with and without essential oil (VO), on intestinal transit and its underlying molecular mechanisms in rats with loperamide-induced STC. Materials and methods: Water consumption, body weight, fecal water content, time to first melena excretion, and intestinal transit ratio of the animals were measured. 5-Hydroxytryptamine (5-HT), substance P (SP), vasoactive intestinal peptide (VIP), and interleukin-6 (IL-6) levels in the sera of rats were evaluated using ELISA. Hematoxylin and eosin and Periodic Acid-Schiff staining were used to determine intestinal tissue histology, while quantitative real-time PCR, western blotting, and immunohistochemical analysis were used to assess the relative expression levels of cAMP/PKA/AQPs pathway- and inflammation-related proteins. 16 S rDNA sequence analysis of rat feces was used to determine the diversity and abundance of the intestinal flora. Results: The JCD groups showed reduced time to first melena excretion and expression of VIP and IL-6. The JCD groups, specifically JCD + VO groups, showed increased fecal water content, intestinal transit rate, and SP expression. Further, these groups showed improved histological characteristics of the colon, with no significant change in the index of immune organs or morphological characteristics of other organs. In addition, a significant decrease in the activation of the cAMP/PKA/AQPs signaling pathway in the colon tissue was observed in these groups, specifically the JCD + VO groups. Moreover, treatment with JCD, with or without VO, downregulated the expression of inflammatory factors and enriched the diversity of intestinal flora as evidenced by polymorphism analysis and the contents of Conclusion: JCD improved loperamide-induced STC, and co-administration with VO exhibited better activity than sole JCD therapy. JCD may improve STC by inhibiting the cAMP/PKA/AQPs signaling pathway and maintaining inflammatory/intestinal flora homeostasis.
Language	English
Publishing date	2023-11-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e21870
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Article: Network pharmacology-based mechanism prediction and pharmacological validation of Xiaoyan Lidan formula on attenuating alpha-naphthylisothiocyanate induced cholestatic hepatic injury in rats

Wang, Meiqi / Liu, Fangle / Yao, Yufeng / Zhang, Qiuyu / Lu, Zenghui / Zhang, Runjing / Liu, Changhui / Lin, Chaozhan / Zhu, Chenchen

Journal of ethnopharmacology. 2021 Apr. 24, v. 270

2021

Abstract: The well-known Chinese prescription, Xiaoyan Lidan Formula (XYLDF), possesses efficiency of heat-clearing, dampness-eliminating and jaundice-removing. It has long been used clinically for the treatment of hepatobiliary diseases due to intrahepatic ... ...

Abstract	The well-known Chinese prescription, Xiaoyan Lidan Formula (XYLDF), possesses efficiency of heat-clearing, dampness-eliminating and jaundice-removing. It has long been used clinically for the treatment of hepatobiliary diseases due to intrahepatic cholestasis (IHC). However, the mechanism of XYLDF for its therapeutic effects remains elusive.The study aimed to explore the potential targets for liver protective mechanism of XYLDF based on network pharmacology and experimental assays in ANIT-induced cholestatic hepatic injury (CHI) in rats.On the basis of the 29 serum migrant compounds of XYLDF elucidated by UPLC-TOF-MS/MS, a network pharmacology approach was applied for the mechanism prediction. Systematic networks were constructed to identify potential molecular targets, biological processes, and signaling pathways. And the interactions between significantly potential targets and active compounds were simulated by molecular docking. For the mechanism validation, an ANIT-induced rat model was used to evaluate the effects of XYLDF on CHI according to serum biochemistry, bile flow rates, histopathological examination, and the gene and protein expression including enzymes related to synthesis, export, and import of bile acid in liver and ileum, and those of inflammatory cytokines, analyzed by RT-qPCR and WB.The results of network pharmacology research indicated TNF (TNF-α), RELA (NF-κB), NR1H4 (FXR), and ICAM1 (ICAM-1) to be the important potential targets of XYLDF for cholestatic liver injury, which are related to bile metabolism and NF-κB-mediated inflammatory signaling. And the molecular docking had pre-validated the prediction of network pharmacology, as the core active compounds of XYLDF had shown strong simulation binding affinity with FXR, followed by NF-κB, TNF-α, and ICAM-1. Meanwhile, the effects of XYLDF after oral administration on ANIT-induced CHI in rats exhibited the decreased levels of transaminases (ALT and AST), TBA, and TBIL in serum, raised bile flow rates, and markedly improved hepatic histopathology. Furthermore, consistent to the above targets prediction and molecular docking, XYLDF significantly up-regulated the expression of FXR, SHP, BSEP, and MRP2, and down-regulated CYP7A1 and NTCP in liver, and promoted expression of IBABP and OSTα/β in ileum, suggesting the activation of FXR-mediated pathway referring to bile acid synthesis, transportation, and reabsorption. Moreover, the lower levels of TNF-α in plasma and liver, as well as the reduced hepatic gene and protein expression of NF-κB, TNF-α, and ICAM-1 after XYLDF treatment revealed the suppression of NF-κB-mediated inflammatory signaling pathway, as evidenced by the inhibition of nuclear translocation of NF-κB.XYLDF exhibited an ameliorative liver protective effect on ANIT-induced cholestatic hepatic injury. The present study has confirmed its mechanism as activating the FXR-regulated bile acid pathway and inhibiting inflammation via the NF-κB signaling pathway.
Keywords	animal models ; bile ; bile acids ; blood chemistry ; blood serum ; genes ; hepatoprotective effect ; histopathology ; ileum ; inflammation ; intercellular adhesion molecule-1 ; intrahepatic cholestasis ; liver ; oral administration ; prediction ; protein synthesis ; resorption ; traditional medicine ; transportation
Language	English
Dates of publication	2021-0424
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2021.113816
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Article ; Online: A Biocompatible, Stimuli-Responsive, and Injectable Hydrogel with Triple Dynamic Bonds.

Chen, Yujie / Zhang, Runjing / Zheng, Baiqin / Cai, Chao / Chen, Zhen / Li, Hua / Liu, Hezhou

Molecules (Basel, Switzerland)

2020 Volume 25, Issue 13

Abstract: Injectable hydrogels have attracted growing interests as promising biomaterials for clinical applications, due to their minimum invasive implanting approach and easy-handling performance. Nevertheless, natural biomaterials-based injectable hydrogels with ...

Abstract	Injectable hydrogels have attracted growing interests as promising biomaterials for clinical applications, due to their minimum invasive implanting approach and easy-handling performance. Nevertheless, natural biomaterials-based injectable hydrogels with desirable nontoxicity are suffering from limited functions, failing to fulfill the requirements of clinical biomaterials. The development of novel injectable biomaterials with a combination of biocompatibility and adequate functional properties is a growing urgency toward biomedical applications. In this contribution, we report a simple and effective approach to fabricate multi-functional CMC-OSA-DTP hydrogels. Two kinds of natural polysaccharide derived polymers, carboxymethyl chitosan (CMC) and oxidized alginate (OSA) along with 3,3'-dithiopropionic acid dihydrazide (DTP) were utilized to introduce three dynamic covalent bonds. Owing to the existence of triple dynamic bonds, this unique CMC-OSA-DTP hydrogel possessed smart redox and pH stimuli-responsive property, injectability as well as self-healing ability. In addition, the CCK-8 and live/dead assays demonstrated satisfying cytocompatibility of the CMC-OSA-DTP hydrogel in vitro. Based on its attractive properties, this easy-fabricated and multi-functional hydrogel demonstrated the great potential as an injectable biomaterial in a variety of biomedical applications.
MeSH term(s)	Alginates/chemistry ; Biocompatible Materials ; Bone Neoplasms/drug therapy ; Bone Neoplasms/pathology ; Cell Proliferation ; Chitosan/analogs & derivatives ; Chitosan/chemistry ; Humans ; Hydrogels/administration & dosage ; Hydrogels/chemistry ; Osteosarcoma/drug therapy ; Osteosarcoma/pathology ; Polymers/chemistry ; Polysaccharides/administration & dosage ; Polysaccharides/chemistry ; Tissue Engineering ; Tumor Cells, Cultured
Chemical Substances	Alginates ; Biocompatible Materials ; Hydrogels ; Polymers ; Polysaccharides ; carboxymethyl-chitosan ; Chitosan (9012-76-4)
Language	English
Publishing date	2020-07-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules25133050
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Article ; Online: Compound-composed Chinese medicine of Huachansu triggers apoptosis of gastric cancer cells through increase of reactive oxygen species levels and suppression of proteasome activities.

Deng, Yi-Qing / Gao, Min / Lu, Dong / Liu, Qiu-Ping / Zhang, Run-Jing / Ye, Ji / Zhao, Jing / Feng, Zhi-Hui / Li, Qi-Zhang / Zhang, Hong

Phytomedicine : international journal of phytotherapy and phytopharmacology

2023 Volume 123, Page(s) 155169

Abstract: Background: Huachansu (HCS), a known Chinese patent drug extracted from the Chinese toad skin, is frequently used for the treatment of various advanced cancers, especially gastric cancer, due to the good therapeutic effect. However, it is rather ... ...

Abstract	Background: Huachansu (HCS), a known Chinese patent drug extracted from the Chinese toad skin, is frequently used for the treatment of various advanced cancers, especially gastric cancer, due to the good therapeutic effect. However, it is rather difficult to clarify the active substances and molecular mechanisms involved owing to the lack of appropriate research strategies. We recently proposed the concept and research ideas of compound-composed Chinese medicine formula. Purpose: To discover compound-composed Chinese medicine from Huachansu and to explore its mechanism of action in inducing apoptosis of gastric cancer cells. Method: Network pharmacology combined with serum pharmacochemistry was utilized to screen the predominant active constituents from HCS against gastric cancer. Then, the compound-composed Chinese medicine of HCS (CCMH) was prepared according to their relative contents in serum. The pharmacological effects and potential mechanisms for CCMH were investigated by assays for cell viability, cell cycle, apoptosis, mitochondrial membrane potential (MMP), proteomics, reactive oxygen species (ROS), N-Acetylcysteine (NAC) antagonism, proteasome activity, and western blot. Results: CCMH was comprised of arenobufagin (11.14%), bufalin (18.67%), bufotalin (7.33%), cinobufagin (16.67%), cinobufotalin (16.74%), gamabufotalin (8.45%), resibufogenin (12.03%), and telocinobufagin (8.97%). CCMH evidently induced proliferation inhibition, cell cycle arrest, apoptosis, and MMP collapse in gastric cancer cells, possessing the better activities than HCS. Proteomic analysis showed that CCMH influenced ROS pathway, ubiquitin proteasome system, and PI3K/Akt and MAPK signaling pathways. CCMH markedly enhanced intracellular ROS levels in gastric cancer cells, which was reversed by NAC. Accordingly, NAC antagonized the apoptosis-inducing effect of CCMH. Significantly decreased proteasome 20S activity by CCMH was observed in gastric cancer cells. CCMH also regulated the expression of key proteins in PI3K/Akt and MAPK signaling pathways. Conclusion: CCMH possesses more significant apoptotic induction effects on gastric cancer cells than HCS, which is achieved primarily through suppression of proteasome activities and increase of ROS levels, followed by regulating PI3K/Akt and MAPK signaling pathways. Network pharmacology combined with serum pharmacochemistry is an effective strategy for discovering compound-composed Chinese medicine from traditional Chinese medicine, which can help clarify the pharmacological substances and mechanisms of action for traditional Chinese medicine.
MeSH term(s)	Humans ; Reactive Oxygen Species/metabolism ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/metabolism ; Proteasome Endopeptidase Complex ; Proto-Oncogene Proteins c-akt/metabolism ; Medicine, Chinese Traditional ; Phosphatidylinositol 3-Kinases/metabolism ; Proteomics ; Cell Line, Tumor ; Apoptosis ; Amphibian Venoms
Chemical Substances	Reactive Oxygen Species ; huachansu ; Proteasome Endopeptidase Complex (EC 3.4.25.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Amphibian Venoms
Language	English
Publishing date	2023-10-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.155169
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Article ; Online: Network pharmacology-based mechanism prediction and pharmacological validation of Xiaoyan Lidan formula on attenuating alpha-naphthylisothiocyanate induced cholestatic hepatic injury in rats.

Wang, Meiqi / Liu, Fangle / Yao, Yufeng / Zhang, Qiuyu / Lu, Zenghui / Zhang, Runjing / Liu, Changhui / Lin, Chaozhan / Zhu, Chenchen

Journal of ethnopharmacology

2021 Volume 270, Page(s) 113816

Abstract: Ethnopharmacological relevance: The well-known Chinese prescription, Xiaoyan Lidan Formula (XYLDF), possesses efficiency of heat-clearing, dampness-eliminating and jaundice-removing. It has long been used clinically for the treatment of hepatobiliary ... ...

Abstract	Ethnopharmacological relevance: The well-known Chinese prescription, Xiaoyan Lidan Formula (XYLDF), possesses efficiency of heat-clearing, dampness-eliminating and jaundice-removing. It has long been used clinically for the treatment of hepatobiliary diseases due to intrahepatic cholestasis (IHC). However, the mechanism of XYLDF for its therapeutic effects remains elusive. Aim of the study: The study aimed to explore the potential targets for liver protective mechanism of XYLDF based on network pharmacology and experimental assays in ANIT-induced cholestatic hepatic injury (CHI) in rats. Materials and methods: On the basis of the 29 serum migrant compounds of XYLDF elucidated by UPLC-TOF-MS/MS, a network pharmacology approach was applied for the mechanism prediction. Systematic networks were constructed to identify potential molecular targets, biological processes, and signaling pathways. And the interactions between significantly potential targets and active compounds were simulated by molecular docking. For the mechanism validation, an ANIT-induced rat model was used to evaluate the effects of XYLDF on CHI according to serum biochemistry, bile flow rates, histopathological examination, and the gene and protein expression including enzymes related to synthesis, export, and import of bile acid in liver and ileum, and those of inflammatory cytokines, analyzed by RT-qPCR and WB. Results: The results of network pharmacology research indicated TNF (TNF-α), RELA (NF-κB), NR1H4 (FXR), and ICAM1 (ICAM-1) to be the important potential targets of XYLDF for cholestatic liver injury, which are related to bile metabolism and NF-κB-mediated inflammatory signaling. And the molecular docking had pre-validated the prediction of network pharmacology, as the core active compounds of XYLDF had shown strong simulation binding affinity with FXR, followed by NF-κB, TNF-α, and ICAM-1. Meanwhile, the effects of XYLDF after oral administration on ANIT-induced CHI in rats exhibited the decreased levels of transaminases (ALT and AST), TBA, and TBIL in serum, raised bile flow rates, and markedly improved hepatic histopathology. Furthermore, consistent to the above targets prediction and molecular docking, XYLDF significantly up-regulated the expression of FXR, SHP, BSEP, and MRP2, and down-regulated CYP7A1 and NTCP in liver, and promoted expression of IBABP and OSTα/β in ileum, suggesting the activation of FXR-mediated pathway referring to bile acid synthesis, transportation, and reabsorption. Moreover, the lower levels of TNF-α in plasma and liver, as well as the reduced hepatic gene and protein expression of NF-κB, TNF-α, and ICAM-1 after XYLDF treatment revealed the suppression of NF-κB-mediated inflammatory signaling pathway, as evidenced by the inhibition of nuclear translocation of NF-κB. Conclusions: XYLDF exhibited an ameliorative liver protective effect on ANIT-induced cholestatic hepatic injury. The present study has confirmed its mechanism as activating the FXR-regulated bile acid pathway and inhibiting inflammation via the NF-κB signaling pathway.
MeSH term(s)	1-Naphthylisothiocyanate/toxicity ; Animals ; Bile Acids and Salts/metabolism ; Chemical and Drug Induced Liver Injury/blood ; Chemical and Drug Induced Liver Injury/drug therapy ; Chemical and Drug Induced Liver Injury/pathology ; Cholestasis, Intrahepatic/blood ; Cholestasis, Intrahepatic/chemically induced ; Cholestasis, Intrahepatic/drug therapy ; Cholestasis, Intrahepatic/pathology ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Inflammation/drug therapy ; Inflammation/metabolism ; Male ; Metabolic Networks and Pathways/drug effects ; Molecular Docking Simulation ; NF-kappa B/metabolism ; Protective Agents/pharmacology ; Protective Agents/therapeutic use ; Protein Interaction Maps/drug effects ; Rats, Sprague-Dawley ; Receptors, Cytoplasmic and Nuclear/chemistry ; Receptors, Cytoplasmic and Nuclear/metabolism ; Signal Transduction/drug effects ; Rats
Chemical Substances	Bile Acids and Salts ; Drugs, Chinese Herbal ; NF-kappa B ; Protective Agents ; Receptors, Cytoplasmic and Nuclear ; xiaoyanlidan ; farnesoid X-activated receptor (0C5V0MRU6P) ; 1-Naphthylisothiocyanate (551-06-4)
Language	English
Publishing date	2021-01-12
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2021.113816
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Article ; Online: Xiaoyan lidan formula ameliorates α-naphthylisothiocyanate-induced intrahepatic cholestatic liver injury in rats as revealed by non-targeted and targeted metabolomics.

Zhang, Runjing / Huang, Tao / Zhang, Qiuyu / Yao, Yufeng / Liu, Changhui / Lin, Chaozhan / Zhu, Chenchen

Journal of pharmaceutical and biomedical analysis

2019 Volume 179, Page(s) 112966

Abstract: Intrahepatic cholestasis is a clinical syndrome of liver damage with systemic circulation and intrahepatic accumulation of excessive toxic bile acids without effective therapeutic methods so far. Xiaoyan Lidan Formula (XYLDF), a traditional Chinese ... ...

Abstract	Intrahepatic cholestasis is a clinical syndrome of liver damage with systemic circulation and intrahepatic accumulation of excessive toxic bile acids without effective therapeutic methods so far. Xiaoyan Lidan Formula (XYLDF), a traditional Chinese prescription, has long been clinically applied for hepatobiliary disorders due to cholestasis. But its mechanism remains unknown. In this study, a non-targeted metabolomics approach based on UHPLC-Q-TOF-MS/MS combined with a bile acids (BAs) - targeted metabolomics approach based on UHPLC-MS/MS were performed to elucidate the functional mechanisms of XYLDF on α-naphthylisothiocyanate(ANIT)-induced intrahepatic cholestasis rats. The results showed that a total of 39 endogenous metabolites with significant difference (VIP > 1.00, P < 0.05) were identified as biomarkers of ANIT-induced intrahepatic cholestasis in rats. After treatment by XYLDF, 22 biomarkers were reversed to the control-like levels, which involved in primary BA biosynthesis, bile acid metabolism and excretion, steroids metabolism, retinol metabolism, starch and sucrose metabolism, inter conversions between pentose and glucoronate as well as arachidonic acid metabolism. Meanwhile, the results of contents variation of BAs in liver and serum showed that both hydrophilic and hydrophobic BAs were markedly increased in the model rats, while XYLDF treatment could restore the increase induced by ANIT, which suggested that one of the mechanisms of XYLDF on cholestasis referred to regulation of metabolic homeostasis of cholic acid.
MeSH term(s)	1-Naphthylisothiocyanate/toxicity ; Animals ; Bile Acids and Salts/metabolism ; Cholestasis, Intrahepatic/pathology ; Cholestasis, Intrahepatic/prevention & control ; Chromatography, High Pressure Liquid ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Male ; Metabolomics ; Rats ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry
Chemical Substances	Bile Acids and Salts ; Drugs, Chinese Herbal ; xiaoyanlidan ; 1-Naphthylisothiocyanate (551-06-4)
Language	English
Publishing date	2019-11-09
Publishing country	England
Document type	Journal Article ; Validation Study
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2019.112966
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Article ; Online: High-Performance Thin-Layer Chromatographic Fingerprints of Triterpenoids for Distinguishing Between

Lin, Chaozhan / Liu, Fangle / Zhang, Runjing / Liu, Meiting / Zhu, Chenchen / Zhao, Jing / Li, Shaoping

Journal of AOAC International

2018 Volume 102, Issue 3, Page(s) 714–719

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Chromatography, Thin Layer/methods ; Isodon/classification ; Plant Components, Aerial/chemistry ; Plant Extracts/analysis ; Software ; Triterpenes/analysis
Chemical Substances	Plant Extracts ; Triterpenes
Language	English
Publishing date	2018-11-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1103149-9
ISSN	1944-7922 ; 1060-3271
ISSN (online)	1944-7922
ISSN	1060-3271
DOI	10.5740/jaoacint.18-0305
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Article ; Online: The complete chloroplast genome sequence of the medicinal plant Morinda officinalis (Rubiaceae), an endemic to China.

Zhang, Runjing / Li, Qian / Gao, Junli / Qu, Minhong / Ding, Ping

Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis

2016 Volume 27, Issue 6, Page(s) 4324–4325

Abstract: The complete chloroplast genome of Morinda officinalis, an endangered and important Chinese medicine with great economic value, has been sequenced in this article. The genome size is 153 398 bp in length, with 38.05% GC content. A pair of inverted ... ...

Abstract	The complete chloroplast genome of Morinda officinalis, an endangered and important Chinese medicine with great economic value, has been sequenced in this article. The genome size is 153 398 bp in length, with 38.05% GC content. A pair of inverted repeats (IRs, 51 834 bp) are separated by a large single copy region (LSC, 83 996 bp) and a small single copy region (SSC, 17 566 bp). The chloroplast genome contains 103 unique genes, 80 protein-coding genes, 19 tRNA genes, and 4 rRNA genes. In these genes, 8 genes contained 1 intron, and 2 genes comprised of 2 introns.
Language	English
Publishing date	2016-11
Publishing country	England
Document type	Journal Article
ISSN	2470-1408
ISSN (online)	2470-1408
DOI	10.3109/19401736.2015.1089484
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Article ; Online: Qualitative and Quantitative Analysis of the Major Constituents in WLJ Herbal Tea Using Multiple Chromatographic Techniques.

Lin, Chao-Zhan / Zhang, Run-Jing / Yao, Yu-Feng / Huang, Xiao-Dan / Zheng, Rong-Bo / Wu, Bo-Jian / Zhu, Chen-Chen

Molecules (Basel, Switzerland)

2018 Volume 23, Issue 10

Abstract: Quality control of Chinese herbal tea remains a challenge due to our poor knowledge of their complex chemical profile. This study aims to investigate the chemical composition of one of the best-selling and famous brand of beverage in China, Wanglaoji ... ...

Abstract	Quality control of Chinese herbal tea remains a challenge due to our poor knowledge of their complex chemical profile. This study aims to investigate the chemical composition of one of the best-selling and famous brand of beverage in China, Wanglaoji Herbal Tea (WLJHT), via a full component quantitative analysis. In this paper, a total of thirty-two representative constituents were identified or tentatively characterized using ultra-high performance liquid chromatography coupled with quadrupole tandem time-of-flight mass spectrometry (UPLC-Q-TOF-MS). Moreover, the quantitative analyses of fourteen constituents were performed by high performance liquid chromatography with a triple quadruple tandem mass spectrometry (HPLC-MS/MS) method and saccharide compositions of WLJHT were also quantitatively determined by high performance liquid chromatography (HPLC) with evaporative light scattering detector (ELSD) on a Hilic column, separately. Using multiple chromatographic techniques presented a good precision, sensitivity, repeatability and stability, and was successfully applied to analyze 16 batches of WLJHT samples. Therefore, it would be a reliable and useful approach for the quality control of WLJHT.
MeSH term(s)	Chromatography, High Pressure Liquid/methods ; Drugs, Chinese Herbal/analysis ; Dynamic Light Scattering ; Molecular Structure ; Quality Control ; Tandem Mass Spectrometry/methods ; Teas, Herbal/analysis
Chemical Substances	Drugs, Chinese Herbal ; Teas, Herbal
Language	English
Publishing date	2018-10-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules23102623
Database	MEDical Literature Analysis and Retrieval System OnLINE

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