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Article ; Online: Biostatistics in Clinical Decision Making What can We Get from a 2×2 Contingency Table

Zhang Shanshan

E3S Web of Conferences, Vol 233, p

2021 Volume 02014

Abstract: Biostatistics is an essential part when making clinical decisions. Applications of 2×2 contingency tables playing a key role in conducting analysis involving binary variables. When it comes to analysis based on 2×2 contingency tables, most people are ... ...

Abstract	Biostatistics is an essential part when making clinical decisions. Applications of 2×2 contingency tables playing a key role in conducting analysis involving binary variables. When it comes to analysis based on 2×2 contingency tables, most people are familiar with the concept of sensitivity and specificity for evaluating a new test, but predictive values and receiver operating characteristic (ROC) curves would also provide information. Besides, Odds Ratio (OR), Risk Ratio (RR), and Chi-square test are measures based on 2×2 tables and commonly applied in retrospective and prospective studies. This article will first review the two kinds of application of 2×2 contingency tables, evaluating a new test compared with a reference standard, and exploring the relationship of exposures and outcomes in retrospective or prospective studies. Two clinical examples are presented to demonstrate these basic biostatistical concepts: diagnostic accuracy of 64-slice multidetector computed tomography (64-MDCT) to identify periampullary duodenal diverticula, and a randomized clinical trial (RCT) to examine the effectiveness of Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery. Correctly understanding these concepts will assist clinicians and medical researchers to analyze the data and interpret the results, and therefore make accurate decisions in clinical practice.
Keywords	Environmental sciences ; GE1-350
Subject code	310 ; 610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Visible Light-Induced and ROS-Dependent Method for the Rapid Formation of a MOF Composite Membrane with Antibacterial Properties.

Zhang, Shanshan / Liu, Dongliang

International journal of molecular sciences

2023 Volume 24, Issue 2

Abstract: The diverse application potential of metal-organic framework (MOF) materials are currently limited by their challenging and complicated preparation processes. In this study, we successfully developed a novel strategy for the rapid synthesis of a ... ...

Abstract	The diverse application potential of metal-organic framework (MOF) materials are currently limited by their challenging and complicated preparation processes. In this study, we successfully developed a novel strategy for the rapid synthesis of a sustainable MOF composite membrane under neutral conditions with improved physicochemical and antibacterial properties. Our reaction pipeline comprised visible light that induced the production of reactive oxygen species (ROS) from ZIF-8 particles, which facilitated the rapid oxidative polymerization of dopamine to polydopamine. The physicochemical properties of the composite membrane were assessed using imaging methods, including scanning and transmission electron microscopy, X-ray photoelectron spectrometry, and nitrogen adsorption/desorption; its antibacterial effects against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa were measured using optical densitometry. The bactericidal potency of the synthesized membrane was >99% against all tested strains under the conditions of simulated sunlight. Moreover, the composite membrane retained its structural integrity and antibacterial effect after multiple cycles of use and recovery, showcasing remarkable stability. Overall, this study displays a ROS-mediated method for the rapid preparation of sustainable MOF composite membranes under neutral conditions with optimal physicochemical characteristics, antibacterial properties, and performance. Our study provides insights into the use of membrane materials as design platforms for a range of diverse practical applications.
MeSH term(s)	Reactive Oxygen Species ; Metal-Organic Frameworks/pharmacology ; Metal-Organic Frameworks/chemistry ; Light ; Sunlight ; Anti-Bacterial Agents/chemistry
Chemical Substances	Reactive Oxygen Species ; Metal-Organic Frameworks ; Anti-Bacterial Agents
Language	English
Publishing date	2023-01-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24021520
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Article ; Online: Safety and effectiveness of opioid-free anaesthesia in thoracoscopic surgery: a preliminary retrospective cohort study.

Zhang, Shanshan / Zhang, Jianmin / Zhang, Ran

BMC anesthesiology

2024 Volume 24, Issue 1, Page(s) 60

Abstract: Background: This study aimed to observe the effect of opioid-free anaesthesia (OFA) on intraoperative haemodynamic,postoperative analgesia and postoperative nausea and vomiting (PONV) in thoracoscopic surgery in order to provide more evidence for ... ...

Abstract	Background: This study aimed to observe the effect of opioid-free anaesthesia (OFA) on intraoperative haemodynamic,postoperative analgesia and postoperative nausea and vomiting (PONV) in thoracoscopic surgery in order to provide more evidence for evaluating the safety and effectiveness of OFA technology. Methods: This was a single-centre retrospective observational study.Adult patients who underwent thoracoscopic surgery with the preoperative thoracic paravertebral block between January 2017 and June 2020 were included.A cohort of 101 thoracoscopic surgery patients who received the OFA technique were matched with 101 thoracoscopic surgery patients who received standard opioid-containing anaesthesia(SOA). Heart rate (HR) and mean arterial blood pressure (MAP) were measured before anaesthesia induction, immediately after endotracheal intubation, at the beginning of surgery, and 10, 20, and 30 min after surgery began.The total amount of intraoperative infusion, frequency of vasoactive drugs use, morphine ingested via the patient-controlled intravenous analgesia (PCIA) 24 h post-surgery,visual analogue scale (VAS) scores at rest and activity on the first day post-surgery, and frequency of nausea and vomiting within 24 h post-surgery were analysed. Results: There was no significant difference in intraoperative HR between the two groups (F = 0.889, P = 0.347); however, there was significant difference in intraoperative MAP (F = 16.709, P < 0.001), which was lower in SOA patients than in OFA patients. The frequency of vasoactive drug use and amount of infusion was less in OFA patients (P = 0.001). The consumption of morphine used by the PCIA 24 h post-surgery was significantly lower in OFA patients (OFA, 1.8 [0, 4.8] mg vs. SOA, 3.6 [0.6, 23] mg, P < 0.001). There was no significant difference in VAS scores at rest (P = 0.745) or during activity (P = 0.792) on the first day post-surgery. There was also no statistically significant difference in nausea and vomiting within 24 h post-surgery (P = 0.651). Conclusions: This case-control study demonstrated that compared with SOA, OFA can effectively maintain the stability of intraoperative MAP, reduce the incidence of hypotension. Although OFA reduced morphine consumption via the PCIA pump 24 h post-surgery, postoperative pain scores and nausea and vomiting within 24 h post-surgery were similar between the groups.But this study was only a preliminary study and needed to confirm in a larger, more robust trial.
MeSH term(s)	Adult ; Humans ; Analgesics, Opioid/therapeutic use ; Retrospective Studies ; Case-Control Studies ; Morphine/therapeutic use ; Pain, Postoperative/drug therapy ; Pain, Postoperative/prevention & control ; Postoperative Nausea and Vomiting/epidemiology ; Postoperative Nausea and Vomiting/drug therapy ; Nerve Block/methods ; Thoracoscopy
Chemical Substances	Analgesics, Opioid ; Morphine (76I7G6D29C)
Language	English
Publishing date	2024-02-09
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2091252-3
ISSN	1471-2253 ; 1471-2253
ISSN (online)	1471-2253
ISSN	1471-2253
DOI	10.1186/s12871-024-02441-9
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Article ; Online: Recombinase polymerase amplification-lateral flow dipstick (RPA-LFD) designed for rapid detection of canine distemper virus.

Zhang, Shanshan / Wang, Chengyu / Meng, Keyin / Liu, Jun

The Journal of veterinary medical science

2024

Abstract: In the present study, recombinase polymerase amplification (RPA) was combined with the colloidal gold lateral flow dipstick (LFD) method to establish a new, stable, and efficient assay for the detection of canine distemper virus (CDV). We designed a set ... ...

Abstract	In the present study, recombinase polymerase amplification (RPA) was combined with the colloidal gold lateral flow dipstick (LFD) method to establish a new, stable, and efficient assay for the detection of canine distemper virus (CDV). We designed a set of specific primers labeled with biotin and a specific probe labeled with dSpacer and C3 spacer, according to the conserved region in the N-terminal gene sequence of CDV. The reaction conditions and systems were then optimized, and the sensitivity and specificity were analyzed for potential clinical application. The results showed that the RPA-LFD assay for CDV detection was successfully established. We also found that the temperature in a closed fist (35°C) is optimal for the RPA reaction. The optimal ratio of primer to probe was 2:1. The minimum detection limit of the RPA-LFD assay was 1 × 10
Language	English
Publishing date	2024-03-11
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1071753-5
ISSN	1347-7439 ; 0916-7250
ISSN (online)	1347-7439
ISSN	0916-7250
DOI	10.1292/jvms.23-0389
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Article ; Online: Duke Infective Endocarditis Criteria 3.0 for the Clinician: Defining What Is Possible.

Chambers, Henry F / Zhang, ShanShan / Evans, Scott

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2024 Volume 78, Issue 4, Page(s) 964–967

MeSH term(s)	Humans ; Endocarditis, Bacterial/diagnosis ; Endocarditis/diagnosis ; Heart ; Communicable Diseases
Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciae037
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Article ; Online: Comment on 'effects of multicomponent exercise on the muscle strength, muscle endurance and balance of frail older adults: A meta-analysis of randomised controlled trials'.

Han, Lina / Hu, Pei / Kuang, Wen / Zhang, Shanshan

Journal of clinical nursing

2024

Language	English
Publishing date	2024-04-25
Publishing country	England
Document type	Letter
ZDB-ID	1159483-4
ISSN	1365-2702 ; 0962-1067 ; 1752-9816
ISSN (online)	1365-2702
ISSN	0962-1067 ; 1752-9816
DOI	10.1111/jocn.17177
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Article ; Online: Comparison of different adjuvants for immune efficacy of recombinant PKF protein of Acinetobacter baumannii

ZHANG Shanshan / LI Guocheng / FENG Rang / XUE Ruoyi

陆军军医大学学报, Vol 45, Iss 9, Pp 957-

2023 Volume 963

Abstract: Objective To compare the immune effects of recombinant PKF protein of Acinetobacter baumannii with different immune modes and different adjuvants. Methods After recombinant PKF protein was obtained by plasmid expression and purification, the protein was ... ...

Abstract	Objective To compare the immune effects of recombinant PKF protein of Acinetobacter baumannii with different immune modes and different adjuvants. Methods After recombinant PKF protein was obtained by plasmid expression and purification, the protein was then combined with aluminum hydroxide (Al) or with AS03 to immunize mice by intramuscular (im) injection.In another experiment, the combination of PKF and LTK63 or PKF and LP1-34 was adopted to intranasally (in) immunize mice, respectively.The total animals were thus divided into 7 groups: PBS group; PKF group (im), PKF+Al group (im), PKF+AS03 group (im), PKF group (in), PKF+LTK63 group (in), and PKF+LP1-34 group (in).The levels of serum specific IgG and mucosal sIgA in the immunized mice were detected by ELISA.Moreover, the sublethal model of Acinetobacter baumannii pulmonary infection was established, and then the bacterial colonization amount in blood and lung of mice after challenge was measured to evaluate the protective immune efficacy of the recombinant vaccine. Results In the intramuscular immunization group, AS03-assisted PKF produced the highest specific IgG antibody level (P < 0.01), and in the nasal immunization group, LTK63 significantly increased the level of specific sIgA in the alveolar lavage fluid (P < 0.01).Bacterial challenge test showed that the bacterial colonization amount was similar in the PKF+AS03(im) group and PKF (im) alone group, while the PKF+LTK63 group (in) obtained remarkably reduced bacterial colonization amount (P < 0.01). Conclusion LTK63 assists PKF to better protect against Acinetobacter baumannii pulmonary infection, suggesting that vaccine-mediated mucosal immune response may play a more important role in the infection protection.
Keywords	acinetobacter baumannii ; adjuvant ; pkf ; immun efficacy ; Medicine (General) ; R5-920
Subject code	630
Language	Chinese
Publishing date	2023-05-01T00:00:00Z
Publisher	Editorial Office of Journal of Army Medical University
Document type	Article ; Online
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Article ; Online: Computed tomography with clinical scoring to differentiate phytobezoar from feces in childhood small bowel obstruction.

Wang, Ning / Wu, Xuedong / Lin, Xiaodong / Zhang, Shanshan / Shen, Wei

The Turkish journal of pediatrics

2024 Volume 65, Issue 6, Page(s) 1002–1011

Abstract: Background: Identification of phytobezoar in childhood small bowel obstruction (SBO) characterized by smallbowel feces sign (SBFS) is still challenging. The aim of our study was to assess the diagnostic performance of quantitative computed tomography ( ... ...

Abstract	Background: Identification of phytobezoar in childhood small bowel obstruction (SBO) characterized by smallbowel feces sign (SBFS) is still challenging. The aim of our study was to assess the diagnostic performance of quantitative computed tomography (CT) analysis combined with the Acute General Emergency Surgical Severity-Small Bowel Obstruction (AGESS-SBO) scoring system in determining phytobezoar-related SBO. Methods: Sixteen phytobezoar-related SBO were categorized as the phytobezoar group and the other 19 SBFSpositive SBO was categorized as the control group. Demographic data, clinical presentation, and laboratory and CT findings were collected and analyzed. Each patient`s AGESS-SBO score was determined according to the individual medical record. Multivariate logistic regression analyses were used to identify significant variables associated with phytobezoar-related SBO. Diagnostic performance of key variables was assessed using receiver operating characteristic (ROC) curve analysis. Results: Compared to the control group, the phytobezoar group showed a significantly shorter debris maximal length (3.0 ± 0.5 cm vs. 3.5 ± 0.7 cm, P < 0.05), stronger attenuation (12.6 ± 5.9 HU vs. 8.2 ± 4.0 HU, P < 0.05) in CT, and higher AGESS-SBO scores (4.5 [interquartile (IQR): 4-5]) vs. (2 [IQR: 1-4]). With the combination of debris attenuation (with a cut-off of > 9.0 HU) and AGESS-SBO score (with a cut-off of > 3 points), the positive predictive value (PPV) and negative predictive value (NPV) to diagnose phytobezoar-related SBO were 80% (12/15) and 84% (16/19), respectively. Conclusions: The diagnostic method of integrating quantitative CT analysis and the AGESS-SBO scoring system can improve the identification accuracy of phytobezoar in SBFS-positive childhood SBO.
MeSH term(s)	Humans ; Feces ; ROC Curve ; Tomography, X-Ray Computed
Language	English
Publishing date	2024-01-10
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	123487-0
ISSN	2791-6421 ; 0041-4301
ISSN (online)	2791-6421
ISSN	0041-4301
DOI	10.24953/turkjped.2023.338
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Article: Impact of Incorporating Shiitake Mushrooms (

Geng, Jingzhang / He, Siqiao / Zhang, Shanshan / Tian, Honglei / Jin, Wengang

Foods (Basel, Switzerland)

2024 Volume 13, Issue 7

Abstract: Jiuqu is one of the important raw materials for brewing Chinese rice wine (Huangjiu), often known as the "bone of wine". In this study, the microbial community and flavor substances of Jiuqu made with different amounts of shiitake mushroom ( ...

Abstract	Jiuqu is one of the important raw materials for brewing Chinese rice wine (Huangjiu), often known as the "bone of wine". In this study, the microbial community and flavor substances of Jiuqu made with different amounts of shiitake mushroom (
Language	English
Publishing date	2024-03-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods13071019
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Article ; Online: Targeting reprogrammed metabolism as a therapeutic approach for respiratory diseases.

Gan, Phyllis X L / Zhang, Shanshan / Fred Wong, W S

Biochemical pharmacology

2024 , Page(s) 116187

Abstract: Metabolic reprogramming underlies the etiology and pathophysiology of respiratory diseases such as asthma, idiopathic pulmonary fibrosis (IPF), and chronic obstructive pulmonary disease (COPD). The dysregulated cellular activities driving airway ... ...

Abstract	Metabolic reprogramming underlies the etiology and pathophysiology of respiratory diseases such as asthma, idiopathic pulmonary fibrosis (IPF), and chronic obstructive pulmonary disease (COPD). The dysregulated cellular activities driving airway inflammation and remodelling in these diseases have reportedly been linked to aberrant shifts in energy-producing metabolic pathways: glycolysis and oxidative phosphorylation (OXPHOS). The rewiring of glycolysis and OXPHOS accompanying the therapeutic effects of many clinical compounds and natural products in asthma, IPF, and COPD, supports targeting metabolism as a therapeutic approach for respiratory diseases. Correspondingly, inhibiting glycolysis has largely attested effective against experimental asthma, IPF, and COPD. However, modulating OXPHOS and its supporting catabolic pathways like mitochondrial pyruvate catabolism, fatty acid β-oxidation (FAO), and glutaminolysis for these respiratory diseases remain inconclusive. An emerging repertoire of metabolic enzymes are also interconnected to these canonical metabolic pathways that similarly possess therapeutic potential for respiratory diseases. Taken together, this review highlights the urgent demand for future studies to ascertain the role of OXPHOS in different respiratory diseases, under different stimulatory conditions, and in different cell types. While this review provides strong experimental evidence in support of the inhibition of glycolysis for asthma, IPF, and COPD, further verification by clinical trials is definitely required.
Language	English
Publishing date	2024-03-30
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/j.bcp.2024.116187
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