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Article ; Online: A patient with myeloid sarcoma with multisystemic involvement in complete remission with chemotherapy:A case report.

Zhang, Shuang-Shuang / Chen, Xiao-Yi / Wang, Zi-Yi / Xu, Na

2024

Language	English
Publishing date	2024-04-23
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2024.04.060
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Zs.B 2831: Show issues

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Article ; Online: Non-peptidic inhibitors targeting SARS-CoV-2 main protease: A review.

Xiao, Ya-Qi / Long, Jiao / Zhang, Shuang-Shuang / Zhu, Yuan-Yuan / Gu, Shuang-Xi

Bioorganic chemistry

2024 Volume 147, Page(s) 107380

Abstract: The COVID-19 pandemic continues to pose a threat to global health, and sounds the alarm for research & development of effective anti-coronavirus drugs, which are crucial for the patients and urgently needed for the current epidemic and future crisis. The ...

Abstract	The COVID-19 pandemic continues to pose a threat to global health, and sounds the alarm for research & development of effective anti-coronavirus drugs, which are crucial for the patients and urgently needed for the current epidemic and future crisis. The main protease (M
MeSH term(s)	SARS-CoV-2/drug effects ; SARS-CoV-2/enzymology ; Humans ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry ; Coronavirus 3C Proteases/antagonists & inhibitors ; Coronavirus 3C Proteases/metabolism ; Protease Inhibitors/pharmacology ; Protease Inhibitors/chemistry ; Structure-Activity Relationship ; COVID-19 Drug Treatment ; Molecular Structure ; COVID-19/virology
Chemical Substances	3C-like proteinase, SARS-CoV-2
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2024.107380
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Zs.A 4207: Show issues

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Article ; Online: A scoping review of the contralateral effects of unilateral peripheral stimulation on neuromuscular function.

Zhou, Shi / Zhang, Shuang-Shuang / Crowley-McHattan, Zachary J

PloS one

2022 Volume 17, Issue 2, Page(s) e0263662

Abstract: It is known that resistance exercise using one limb can affect motor function of both the exercised limb and the unexercised contralateral limb, a phenomenon termed cross-education. It has been suggested that cross-education has clinical implications, e ... ...

Abstract	It is known that resistance exercise using one limb can affect motor function of both the exercised limb and the unexercised contralateral limb, a phenomenon termed cross-education. It has been suggested that cross-education has clinical implications, e.g. in rehabilitation for orthopaedic conditions or post-stroke paresis. Much of the research on the contralateral effect of unilateral intervention on motor output is based on voluntary exercise. This scoping review aimed to map the characteristics of current literature on the cross-education caused by three most frequently utilised peripheral neuromuscular stimulation modalities in this context: electrical stimulation, mechanical vibration and percutaneous needling, that may direct future research and translate to clinical practice. A systematic search of relevant databases (Ebsco, ProQuest, PubMed, Scopus, Web of Science) through to the end of 2020 was conducted following the PRISMA Extension for Scoping Review. Empirical studies on human participants that applied a unilateral peripheral neuromuscular stimulation and assessed neuromuscular function of the stimulated and/or the unstimulated side were selected. By reading the full text, the demographic characteristics, context, design, methods and major findings of the studies were synthesised. The results found that 83 studies were eligible for the review, with the majority (53) utilised electrical stimulation whilst those applied vibration (18) or needling (12) were emerging. Although the contralateral effects appeared to be robust, only 31 studies claimed to be in the context of cross-education, and 25 investigated on clinical patients. The underlying mechanism for the contralateral effects induced by unilateral peripheral stimulation remains unclear. The findings suggest a need to enhance the awareness of cross-education caused by peripheral stimulation, to help improve the translation of theoretical concepts to clinical practice, and aid in developing well-designed clinical trials to determine the efficacy of cross-education therapies.
MeSH term(s)	Electric Stimulation Therapy/methods ; Humans ; Musculoskeletal Physiological Phenomena ; Neuromuscular Diseases/etiology ; Neuromuscular Diseases/physiopathology ; Neuromuscular Diseases/therapy ; Paresis/etiology ; Paresis/physiopathology ; Paresis/therapy ; Peripheral Nerves/physiopathology ; Physical Therapy Modalities ; Stroke/complications ; Stroke/physiopathology ; Stroke/therapy ; Stroke Rehabilitation/methods
Language	English
Publishing date	2022-02-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0263662
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Article ; Online: Quinolines and isoquinolines as HIV-1 inhibitors: Chemical structures, action targets, and biological activities.

Hu, Sha / Chen, Jiong / Cao, Jin-Xu / Zhang, Shuang-Shuang / Gu, Shuang-Xi / Chen, Fen-Er

Bioorganic chemistry

2023 Volume 136, Page(s) 106549

Abstract: Human immunodeficiency virus type 1 (HIV-1), a lentivirus that causes acquired immunodeficiency syndrome (AIDS), poses a serious threat to global public health. Since the advent of the first drug zidovudine, a number of anti-HIV agents acting on ... ...

Abstract	Human immunodeficiency virus type 1 (HIV-1), a lentivirus that causes acquired immunodeficiency syndrome (AIDS), poses a serious threat to global public health. Since the advent of the first drug zidovudine, a number of anti-HIV agents acting on different targets have been approved to combat HIV/AIDS. Among the abundant heterocyclic families, quinoline and isoquinoline moieties are recognized as promising scaffolds for HIV inhibition. This review intends to highlight the advances in diverse chemical structures and abundant biological activity of quinolines and isoquinolines as anti-HIV agents acting on different targets, which aims to provide useful references and inspirations to design and develop novel HIV inhibitors for medicinal chemists.
MeSH term(s)	Humans ; HIV-1 ; Saquinavir/therapeutic use ; Acquired Immunodeficiency Syndrome/drug therapy ; HIV Protease Inhibitors/pharmacology ; HIV Protease Inhibitors/therapeutic use ; Quinolines/pharmacology ; Quinolines/therapeutic use ; Isoquinolines/pharmacology ; Anti-HIV Agents/pharmacology ; Anti-HIV Agents/therapeutic use
Chemical Substances	Saquinavir (L3JE09KZ2F) ; HIV Protease Inhibitors ; Quinolines ; Isoquinolines ; Anti-HIV Agents
Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2023.106549
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Article ; Online: T7 peptide-mediated co-delivery platform overcoming multidrug-resistant breast cancer: In vitro and in vivo evaluation.

Zhang, Shuang-Shuang / Yu, Jia-Hui / Jiang, Si-Si / Wang, Lun / Chen, Jiong / Long, Jiao / Gu, Shuang-Xi / Li, Hui

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

2024 , Page(s) 114327

Abstract: P-glycoprotein (P-gp) overexpressed mutidrug resistance (MDR) is currently a key factor limiting the effectiveness of breast cancer chemotherapy. Systemic administration based on P-gp-associated mechanism leads to severe toxic side effects. Here, we ... ...

Abstract	P-glycoprotein (P-gp) overexpressed mutidrug resistance (MDR) is currently a key factor limiting the effectiveness of breast cancer chemotherapy. Systemic administration based on P-gp-associated mechanism leads to severe toxic side effects. Here, we designed a T7 peptide-modified mixed liposome (T7-MLP@DTX/SchB) that, by active targeting co-delivering chemotherapeutic agents and P-gp inhibitors, harnessed synergistic effects to improve the treatment of MDR breast cancer. This study established drug-resistant cell models and animal models. Subsequently, comprehensive evaluations involving cell uptake, cell apoptosis, cellular toxicity assays, in vivo tumor-targeting capability, and anti-tumor activity assays were conducted to assess the drug resistance reversal effects of T7-MLP@DTX/SchB. Additionally, a systematic assessment of the biosafety profile of T7-MLP@DTX/SchB was executed, including blood profiles, biochemical markers, and histopathological examination. It was found that this co-delivery strategy successfully exerted the synergistic effects, since there was a significant tumor growth inhibitory effect on multidrug-resistant breast cancer. Targeted modification with T7 peptide enhanced the therapeutic efficacy remarkably, while vastly ameliorating the biocompatibility compared to free drugs. The intriguing results supported the promising potential use of T7-MLP@DTX/SchB in overcoming MDR breast cancer treatment.
Language	English
Publishing date	2024-05-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1065368-5
ISSN	1873-3441 ; 0939-6411
ISSN (online)	1873-3441
ISSN	0939-6411
DOI	10.1016/j.ejpb.2024.114327
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Article: Phosphorus recovery in the alternating aerobic/anaerobic biofilm system: Performance and mechanism

Zhang, Hao / Zhang, Shuang-Shuang / Zhu, Liang / Li, Yi-Ping / Chen, Lin

Science of the total environment. 2022 Mar. 01, v. 810

2022

Abstract: To balance the high phosphorus concentration in recirculated solution and the stability of biofilm system, this study explored the performance and mechanism of phosphorus uptake/release for recovering phosphorus from sewage when the phosphorus content in ...

Abstract	To balance the high phosphorus concentration in recirculated solution and the stability of biofilm system, this study explored the performance and mechanism of phosphorus uptake/release for recovering phosphorus from sewage when the phosphorus content in biofilm (Pbᵢₒfᵢₗₘ) changed. The results showed that the maximum phosphorus concentration in the concentrated solution reached 171.2 ± 2.5 mg·L⁻¹ in harvest 1st-5th stages. Polyphosphate accumulating organisms (PAOs) performed a metabolic shift from glycogen accumulation metabolism (GAM) to polyphosphate accumulation metabolism (PAM) when Pbᵢₒfᵢₗₘ increased at each phosphorus enrichment stage, and more phosphorus was absorbed/released by PAOs. Nevertheless, the release of poly-phosphate from PAOs was inhibited after phosphorus concentration stabilized, and PAOs were unable to absorb phosphorus from wastewater as it reached the phosphorus saturation stage. To maintain the stability of the system, phosphorus had to be harvested so that the saturated phosphorus in PAOs was easily released in a new recirculated solution, resulting in adequate storage space for PAOs to absorb phosphorus. Meanwhile, the ³¹P NMR analysis demonstrated that phosphorus was stored in EPS and cell of PAOs, whereas EPS played a significant role than cell at the anaerobic phase. Particularly, ortho-phosphate was the major component of phosphorus release by EPS and poly-phosphate was the major part of phosphorus release by cell. Furthermore, the change of Pbᵢₒfᵢₗₘ had no impact on biofilm characteristics and microbial communities, whereas some PAOs would be enriched, and others that were not suitable for this process would be inhibited with repeated cycles of alternating aerobic/anaerobic operation.
Keywords	biofilm ; environment ; glycogen ; metabolism ; phosphorus ; phosphorus content ; sewage ; wastewater
Language	English
Dates of publication	2022-0301
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2021.152297
Database	NAL-Catalogue (AGRICOLA)

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Article: [Exploration of practice of acupuncture-moxibustion scientization by

Mao, Jin-Feng / Shen, Tian-Yi / Xie, Tao / Zhang, Shuang-Shuang / Zhang, Jian-Bin

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

2022 Volume 42, Issue 4, Page(s) 447–450

Abstract: HUANG Xue- ... ...

Abstract	HUANG Xue-long
MeSH term(s)	Acupuncture ; Acupuncture Points ; Acupuncture Therapy ; China ; Humans ; Male ; Moxibustion ; Schools
Language	Chinese
Publishing date	2022-04-10
Publishing country	China
Document type	Journal Article
ISSN	0255-2930
ISSN	0255-2930
DOI	10.13703/j.0255-2930.20210209-k0001
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Article: [Exercise preconditioning reduces exercise-induced risks of cardiovascular events in obese population].

Wang, Chuan-Zhi / Wang, Wei / Zhang, Shuang-Shuang / Liang, Zhi-De / Yuan, Yang

Sheng li xue bao : [Acta physiologica Sinica

2022 Volume 74, Issue 5, Page(s) 792–804

Abstract: Obesity is an independent risk factor of cardiovascular diseases. Epidemiological studies have shown that obesity induces the production of inflammatory factors and changes in cardiac hemodynamics, remodeling and function, leading to myocardial damage ... ...

Abstract	Obesity is an independent risk factor of cardiovascular diseases. Epidemiological studies have shown that obesity induces the production of inflammatory factors and changes in cardiac hemodynamics, remodeling and function, leading to myocardial damage and heart diseases. The positive effect of exercise on the cardiovascular system has been widely confirmed, while the acute cardiovascular stress caused by exercise cannot be ignored. Compared with the general population, obese people were more prone to arrhythmia and have a higher risk of cardiovascular events during exercise, due to their abnormal cardiac function, myocardial pathological remodeling and low tolerance to corresponding stress. Studies have shown that the intervention of exercise preconditioning (EP) can effectively reduce such risks. EP increases myocardial oxygen consumption through short-term exercise, resulting in relative or absolute myocardial ischemia, inducing the intrinsic myocardial protective effect and reducing the continuous ischemia caused by subsequent long-term exercise. This article reviews the obesity-induced abnormal changes of cardiac function and structure, possible exercise- induced risks of cardiovascular events in obese people and the role of EP in reducing exercise-induced risks of cardiovascular events. We summarize the progress on EP models in obese people, EP prevention against adverse cardiovascular events in obese people, with the aim to provide a theoretical basis for the application of EP in obese people.
MeSH term(s)	Humans ; Exercise ; Obesity ; Myocardium/pathology ; Myocardial Ischemia ; Cardiovascular Diseases
Language	Chinese
Publishing date	2022-11-01
Publishing country	China
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	604308-2
ISSN	0371-0874
ISSN	0371-0874
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Zs.A 386: Show issues

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Article: [Effect of electroacupuncture at "Tianshu" (ST25) on the regulation of nitrergic neurons in different intestinal segments in streptozotocin induced type 2 diabetic rats].

Zhang, Shuang-Shuang / Xu, Tian-Cheng / Yu, Zhi / Mao, Jin-Feng / Xu, Bin

Zhen ci yan jiu = Acupuncture research

2022 Volume 47, Issue 9, Page(s) 785–792

Abstract: Objective: To observe the effect of electroacupuncture (EA) at "Tianshu" (ST25) on nitrergic neurons in jejunum and distal colon in type 2 diabetic rats, so as to explore its mechanism of regulating different intestinal segments.: Methods: Twenty- ... ...

Abstract	Objective: To observe the effect of electroacupuncture (EA) at "Tianshu" (ST25) on nitrergic neurons in jejunum and distal colon in type 2 diabetic rats, so as to explore its mechanism of regulating different intestinal segments. Methods: Twenty-four SD rats were randomly divided into control, model and EA groups ( Results: After modeling, the blood glucose was significantly increased ( Conclusion: EA can effectively improve the intestinal mucosal damage and restore intestinal motor function in type 2 diabetic rats, which may be related to its function in regulating the number of nitrergic neurons in the intestinal nervous system.
MeSH term(s)	Acupuncture Points ; Animals ; Blood Glucose ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/therapy ; Diabetes Mellitus, Type 2/chemically induced ; Diabetes Mellitus, Type 2/therapy ; Electroacupuncture ; Nitrergic Neurons ; Nitric Oxide Synthase Type I/metabolism ; Rats ; Rats, Sprague-Dawley ; Streptozocin
Chemical Substances	Blood Glucose ; Streptozocin (5W494URQ81) ; Nitric Oxide Synthase Type I (EC 1.14.13.39)
Language	Chinese
Publishing date	2022-09-24
Publishing country	China
Document type	Journal Article
ZDB-ID	1283179-7
ISSN	1000-0607
ISSN	1000-0607
DOI	10.13702/j.1000-0607.20210628
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Zs.A 4364: Show issues

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Article ; Online: Biomineralization and AHLs-guided quorum sensing enhanced phosphorus recovery in the alternating aerobic/anaerobic biofilm system under metal ion stress.

Zhang, Hao / Zhang, Shuang-Shuang / Zhang, Wei / Zhu, Liang / Li, Yi-Ping / Pan, Yang

Journal of environmental management

2022 Volume 325, Issue Pt B, Page(s) 116583

Abstract: The alternating aerobic/anaerobic biofilm system had been applied for phosphorus (P) enrichment and recovery because of the advantage of low energy consumption and high efficiency. The metal ions and N-acyl-L-homoserine lactones (AHLs) in system were ... ...

Abstract	The alternating aerobic/anaerobic biofilm system had been applied for phosphorus (P) enrichment and recovery because of the advantage of low energy consumption and high efficiency. The metal ions and N-acyl-L-homoserine lactones (AHLs) in system were studied to better clarify the mechanism of P uptake/release under metal ion stress. The results indicated that the increase of metal ions stimulated the release of AHLs, and AHLs-guided quorum sensing (QS) enhanced P uptake. Moreover, biomineralization could stimulate the increase of P content in biofilm (P
MeSH term(s)	Acyl-Butyrolactones/metabolism ; Quorum Sensing ; Phosphorus ; Anaerobiosis ; Biomineralization ; Biofilms ; Polyphosphates ; Metals
Chemical Substances	Acyl-Butyrolactones ; Phosphorus (27YLU75U4W) ; Polyphosphates ; Metals
Language	English
Publishing date	2022-10-26
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2022.116583
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