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Article: Reconciling disagreement on global river flood changes in a warming climate. See N&V p1090

Zhang, Shulei

2022 Volume 12, Issue 12, Page(s) 1160

Language	English
Document type	Article
ZDB-ID	2614383-5
ISSN	1758-678x
Database	Current Contents Nutrition, Environment, Agriculture

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Article ; Online: Ratiometric antifouling electrochemical biosensors based on designed Y-shaped peptide and MXene loaded with Au@ZIF-67 and methylene blue.

Ding, Yan / Zhang, Shulei / Zang, Xiuhui / Ding, Mengli / Ding, Caifeng

Mikrochimica acta

2023 Volume 191, Issue 1, Page(s) 5

Abstract: Based on the designed inverted Y-shaped peptide and MXene nanocomposite (MXene-Au@ZIF-67), a ratiometric anti-pollution electrochemical biosensor was designed and applied to the detection of biomarkers in serum. Au@ZIF-67 inserted into the interior of ... ...

Abstract	Based on the designed inverted Y-shaped peptide and MXene nanocomposite (MXene-Au@ZIF-67), a ratiometric anti-pollution electrochemical biosensor was designed and applied to the detection of biomarkers in serum. Au@ZIF-67 inserted into the interior of MXene can not only prevent the accumulation of MXene but also provide a large amounts of binding sites for capturing biomolecules. A designed multifunctional Y-shaped peptide containing anchoring, antifouling, and recognition sequences was anchored onto MXene-Au@ZIF-67 through Au-S bonds. Electrochemical signal molecules, ferrocenecarboxylic acid (Fc) and methylene blue (MB), were modified to another end of multifunctional peptide and interior of MXene-Au@ZIF-67, respectively, to produce a ratiometric electrochemical signal. We selected prostate specific antigen (PSA) as the model compound. PSA specifically recognizes and cleaves the recognition segment in the Y-shaped peptide, and the signal of Fc is reduced, while the signal of MB remains unchanged. The ratiometric strategy endows the present biosensor high accuracy and sensitivity with a detection limit of 0.85 pg/mL. In addition, the sensing surface has good antifouling ability due to the antifouling sequence of the two branching parts of the Y-shaped peptide. More importantly, by replacing the recognition segment of peptides also other targets are accessible, indicating the potential application of the universal detection strategy to the detection of various biomarkers in clinical diagnosis.
MeSH term(s)	Male ; Humans ; Methylene Blue/chemistry ; Prostate-Specific Antigen ; Biofouling/prevention & control ; Electrochemical Techniques ; Peptides/chemistry ; Biosensing Techniques
Chemical Substances	Methylene Blue (T42P99266K) ; Prostate-Specific Antigen (EC 3.4.21.77) ; MXene ; Peptides ; ferrocenecarboxylic acid (1271-42-7)
Language	English
Publishing date	2023-12-05
Publishing country	Austria
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	89-9
ISSN	1436-5073 ; 0026-3672
ISSN (online)	1436-5073
ISSN	0026-3672
DOI	10.1007/s00604-023-06079-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ultrasensitive Ratiometric Electrochemiluminescence Sensor with an Efficient Antifouling and Antibacterial Interface of PSBMA@SiO

Ding, Mengli / Zhang, Shulei / Wang, Jinge / Ding, Yan / Ding, Caifeng

Analytical chemistry

2023 Volume 95, Issue 44, Page(s) 16327–16334

Abstract: The sensitivity and accuracy of electrochemiluminescence (ECL) sensors for detecting small-molecule pollutants in environmental water are affected not only by nonspecific adsorption of proteins and other molecules but also by bacterial interference. ... ...

Abstract	The sensitivity and accuracy of electrochemiluminescence (ECL) sensors for detecting small-molecule pollutants in environmental water are affected not only by nonspecific adsorption of proteins and other molecules but also by bacterial interference. Therefore, there is an urgent need to develop an ECL sensor with antifouling and antibacterial functions for water environment monitoring. Herein, a highly efficient antifouling sensing interface (PSBMA@SiO
MeSH term(s)	Oxytetracycline ; Silicon Dioxide ; Biofouling/prevention & control ; Anti-Bacterial Agents ; Water ; Biosensing Techniques/methods ; Electrochemical Techniques/methods
Chemical Substances	Oxytetracycline (X20I9EN955) ; Silicon Dioxide (7631-86-9) ; MXene ; Anti-Bacterial Agents ; Water (059QF0KO0R)
Language	English
Publishing date	2023-10-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c03555
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Data-Driven Robust Optimization Based on Principle Component Analysis and Cutting Plane Methods

Zhang, Shulei / Jia, Runda / He, Dakuo / Chu, Fei

Industrial & engineering chemistry process design and development. 2022 Jan. 25, v. 61, no. 5

2022

Abstract: A data-driven robust optimization method is proposed by leveraging the merits of machine learning for decision-making under uncertainty. Robust optimization tends to result in performance loss due to its conservatism. To hedge against the conservational ... ...

Abstract	A data-driven robust optimization method is proposed by leveraging the merits of machine learning for decision-making under uncertainty. Robust optimization tends to result in performance loss due to its conservatism. To hedge against the conservational results, a data-driven general polyhedral uncertainty set is constructed by using the principal component analysis (PCA) and the cutting plane methods. By employing PCA to uncertainty data, correlations and distribution knowledge between uncertain variables are effectively captured. To remove redundant scenarios in the uncertainty set, cutting planes are introduced and an asymmetrical structure is generated. Besides, the statistic limits are utilized to construct a probability uncertainty set to realize the trade-off between the conservatism and protection level. The constructed uncertainty sets are incorporated into data-driven static and two-stage adaptive optimization models to induce robust counterparts. Finally, the efficiency of the proposed framework is verified by using a numerical experiment and the application of batch production scheduling.
Keywords	chemistry ; decision making ; principal component analysis ; process design ; system optimization ; uncertainty
Language	English
Dates of publication	2022-0125
Size	p. 2167-2182.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	1484436-9
ISSN	1520-5045 ; 0888-5885
ISSN (online)	1520-5045
ISSN	0888-5885
DOI	10.1021/acs.iecr.1c03886
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Ultrasensitive Ratiometric Electrochemiluminescence Sensor with an Efficient Antifouling and Antibacterial Interface of PSBMA@SiO₂‑MXene for Oxytetracycline Trace Detection in the Marine Environment

Ding, Mengli / Zhang, Shulei / Wang, Jinge / Ding, Yan / Ding, Caifeng

Analytical Chemistry. 2023 Oct. 27, v. 95, no. 44 p.16327-16334

2023

Abstract	The sensitivity and accuracy of electrochemiluminescence (ECL) sensors for detecting small-molecule pollutants in environmental water are affected not only by nonspecific adsorption of proteins and other molecules but also by bacterial interference. Therefore, there is an urgent need to develop an ECL sensor with antifouling and antibacterial functions for water environment monitoring. Herein, a highly efficient antifouling sensing interface (PSBMA@SiO₂-MXene) based on zwitterionic sulfobetaine methacrylate (SBMA) antifouling nanospheres (NPs) and two-dimensional MXene nanosheets was designed for the sensitive detection of oxytetracycline (OTC), an antibiotic small-molecule pollutant. Specifically, SBMA with good hydrophilicity and electrical neutrality was connected to SiO₂ NPs, thus effectively reducing protein and bacterial adsorption and improving stability. Second, MXene with a high specific surface area was selected as the carrier to load more antifouling NPs, which greatly improves the antifouling performance. Meanwhile, the introduction of MXene also enhances the conductivity of the antifouling interface. In addition, a ratio-based sensing strategy was designed to further improve the detection accuracy and sensitivity of the sensor by utilizing Au@luminol as an internal standard factor. Based on antifouling and antibacterial interfaces, as well as internal standard and ratiometric sensing strategies, the detection range of the proposed sensor was 0.1 ng/mL to 100 μg/mL, with a detection limit of 0.023 ng/mL, achieving trace dynamic monitoring of antibiotics in complex aqueous media.
Keywords	adsorption ; analytical chemistry ; antifouling activities ; detection limit ; electrochemiluminescence ; hydrophilicity ; marine environment ; nanosheets ; nanospheres ; oxytetracycline ; pollutants ; sulfobetaine ; surface area ; zwitterions
Language	English
Dates of publication	2023-1027
Size	p. 16327-16334.
Publishing place	American Chemical Society
Document type	Article ; Online
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c03555
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Lens Evaporation on Immiscible Liquid Surface with an Interfacial Cooling Effect.

Mi, Menglong / Jiang, Jian / Zhang, Shulei / Dong, Xinyu / Liu, Lu

ACS omega

2022 Volume 7, Issue 16, Page(s) 14113–14120

Abstract: A theoretical heat and mass transfer model of volatile liquid lens evaporation on the surface of an immiscible liquid substrate is established in toroidal coordinates. According to the coupled boundary conditions of heat and mass transfer at the lens ... ...

Abstract	A theoretical heat and mass transfer model of volatile liquid lens evaporation on the surface of an immiscible liquid substrate is established in toroidal coordinates. According to the coupled boundary conditions of heat and mass transfer at the lens surface as well as the interfacial cooling effect, the analytical solutions of the temperature field inside the lens and the vapor concentration field around the lens are derived for the first time. Compared with the isothermal model, the change of contact radius calculated by the present model agrees well with the experimental data, especially when the liquid substrate reaches a relatively high temperature. It also reveals that the temperature distribution inside the lens is not uniform, which is similar to the sessile droplet evaporation on a solid substrate surface. In addition, the excess temperature, heat flux, and evaporation flux of the lens-air interface increase monotonically from the lens center to the contact line. Finally, the influences of density ratio and evaporative cooling number
Language	English
Publishing date	2022-04-12
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c00691
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Organocatalytic diastereo- and atroposelective construction of N-N axially chiral pyrroles and indoles.

Wang, Shao-Jie / Wang, Xia / Xin, Xiaolan / Zhang, Shulei / Yang, Hui / Wong, Ming Wah / Lu, Shenci

Nature communications

2024 Volume 15, Issue 1, Page(s) 518

Abstract: The construction of N-N axially chiral motifs is an important research topic, owing to their wide occurrence in natural products, pharmaceuticals and chiral ligands. One efficient method is the atroposelective dihydropyrimidin-4-one formation. We present ...

Abstract	The construction of N-N axially chiral motifs is an important research topic, owing to their wide occurrence in natural products, pharmaceuticals and chiral ligands. One efficient method is the atroposelective dihydropyrimidin-4-one formation. We present herein a direct catalytic synthesis of N-N atropisomers with simultaneous creation of contiguous axial and central chirality by oxidative NHC (N-heterocyclic carbenes) catalyzed (3 + 3) cycloaddition. Using our method, we are able to synthesize structurally diverse N-N axially chiral pyrroles and indoles with vicinal central chirality or bearing a 2,3-dihydropyrimidin-4-one moiety in moderate to good yields and excellent enantioselectivities. Further synthetic transformations of the obtained axially chiral pyrroles and indoles derivative products are demonstrated. The reaction mechanism and the origin of enantioselectivity are understood through DFT calculations.
Language	English
Publishing date	2024-01-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-44743-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Tumor-derived microvesicles for cancer therapy.

Yang, Shiqi / Zheng, Bo / Raza, Faisal / Zhang, Shulei / Yuan, Wei-En / Su, Jing / Qiu, Mingfeng

Biomaterials science

2024 Volume 12, Issue 5, Page(s) 1131–1150

Abstract: Extracellular vesicles (EVs) are vesicles with lipid bilayer structures shed from the plasma membrane of cells. Microvesicles (MVs) are a subset of EVs containing proteins, lipids, nucleic acids, and other metabolites. MVs can be produced under specific ... ...

Abstract	Extracellular vesicles (EVs) are vesicles with lipid bilayer structures shed from the plasma membrane of cells. Microvesicles (MVs) are a subset of EVs containing proteins, lipids, nucleic acids, and other metabolites. MVs can be produced under specific cell stimulation conditions and isolated by modern separation technology. Due to their tumor homing and large volume, tumor cell-derived microvesicles (TMVs) have attracted interest recently and become excellent delivery carriers for therapeutic vaccines, imaging agents or antitumor drugs. However, preparing sufficient and high-purity TMVs and conducting clinical transformation has become a challenge in this field. In this review, the recent research achievements in the generation, isolation, characterization, modification, and application of TMVs in cancer therapy are reviewed, and the challenges facing therapeutic applications are also highlighted.
MeSH term(s)	Humans ; Cell-Derived Microparticles/chemistry ; Cell-Derived Microparticles/metabolism ; Cell-Derived Microparticles/pathology ; Extracellular Vesicles/chemistry ; Neoplasms/drug therapy ; Cell Membrane
Language	English
Publishing date	2024-02-27
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2693928-9
ISSN	2047-4849 ; 2047-4830
ISSN (online)	2047-4849
ISSN	2047-4830
DOI	10.1039/d3bm01980b
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bioinspired ginsenoside Rg3 PLGA nanoparticles coated with tumor-derived microvesicles to improve chemotherapy efficacy and alleviate toxicity.

Zhang, Shulei / Zheng, Bo / Wei, Yiqi / Liu, Yuhao / Yang, Lan / Qiu, Yujiao / Su, Jing / Qiu, Mingfeng

Biomaterials science

2024

Abstract: Breast cancer, a pervasive malignancy affecting women, demands a diverse treatment approach including chemotherapy, radiotherapy, and surgical interventions. However, the effectiveness of doxorubicin (DOX), a cornerstone in breast cancer therapy, is ... ...

Abstract	Breast cancer, a pervasive malignancy affecting women, demands a diverse treatment approach including chemotherapy, radiotherapy, and surgical interventions. However, the effectiveness of doxorubicin (DOX), a cornerstone in breast cancer therapy, is limited when used as a monotherapy, and concerns about cardiotoxicity persist. Ginsenoside Rg3, a classic compound of traditional Chinese medicine found in
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2693928-9
ISSN	2047-4849 ; 2047-4830
ISSN (online)	2047-4849
ISSN	2047-4830
DOI	10.1039/d4bm00159a
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dynamic RGD ligands derived from highly mobile cyclodextrins regulate spreading and proliferation of endothelial cells to promote vasculogenesis.

Zhong, Xuanshu / Zhang, Shulei / Wang, Han / Wang, Mengjie / Feng, Zengguo / Su, Wei / Wang, Jin / Liu, Zongjian / Ye, Lin

International journal of biological macromolecules

2024 Volume 267, Issue Pt 2, Page(s) 131667

Abstract: A thiolated RGD was incorporated into the threaded allyl-β-cyclodextrins (Allyl-β-CDs) of the polyrotaxane (PR) through a thiol-ene click reaction, resulting in the formation of dynamic RGD ligands on the PR surface (dRGD-PR). When maintaining consistent ...

Abstract	A thiolated RGD was incorporated into the threaded allyl-β-cyclodextrins (Allyl-β-CDs) of the polyrotaxane (PR) through a thiol-ene click reaction, resulting in the formation of dynamic RGD ligands on the PR surface (dRGD-PR). When maintaining consistent RGD density and other physical properties, endothelial cells (ECs) cultured on dRGD-PR exhibited significantly increased cell proliferation and a larger cell spreading area compared to those on the non-dynamic RGD (nRGD-PCL). Furthermore, ECs on dRGD-PR demonstrated elevated expression levels of FAK, p-FAK, and p-AKT, along with a larger population of cells in the G2/M stage during cell cycle analysis, in contrast to cells on nRGD-PCL. These findings suggest that the movement of the RGD ligands may exert additional beneficial effects in promoting EC spreading and proliferation, beyond their essential adhesion and proliferation-promoting capabilities, possibly mediated by the RGD-integrin-FAK-AKT pathway. Moreover, in vitro vasculogenesis tests were conducted using two methods, revealing that ECs cultured on dRGD-PR exhibited much better vasculogenesis than nRGD-PCL in vitro. In vivo testing further demonstrated an increased presence of CD31-positive tissues on dRGD-PR. In conclusion, the enhanced EC spreading and proliferation resulting from the dynamic RGD ligands may contribute to improved in vitro vasculogenesis and in vivo vascularization.
MeSH term(s)	Cell Proliferation/drug effects ; Oligopeptides/pharmacology ; Oligopeptides/chemistry ; Ligands ; Cyclodextrins/chemistry ; Cyclodextrins/pharmacology ; Humans ; Neovascularization, Physiologic/drug effects ; Endothelial Cells/metabolism ; Endothelial Cells/drug effects ; Endothelial Cells/cytology ; Cell Adhesion/drug effects ; Human Umbilical Vein Endothelial Cells/metabolism ; Human Umbilical Vein Endothelial Cells/drug effects ; Proto-Oncogene Proteins c-akt/metabolism ; Poloxamer/chemistry ; Poloxamer/pharmacology ; Cell Movement/drug effects ; Animals ; Rotaxanes
Chemical Substances	Oligopeptides ; arginyl-glycyl-aspartic acid (78VO7F77PN) ; Ligands ; Cyclodextrins ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; polyrotaxane ; Poloxamer (106392-12-5) ; Rotaxanes
Language	English
Publishing date	2024-04-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.131667
Database	MEDical Literature Analysis and Retrieval System OnLINE

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