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  1. Article: Acute combined effects of concurrent physical activities on autonomic nervous activation during cognitive tasks.

    Cheng, Shan / Li, Wenbin / Hui, Duoduo / Ma, Jin / Zhang, Taihui / Teng, Chaolin / Dang, Weitao / Xiong, Kaiwen / Hu, Wendong / Cong, Lin

    Frontiers in physiology

    2024  Volume 15, Page(s) 1340061

    Abstract: Backgrounds: ...

    Abstract Backgrounds:
    Language English
    Publishing date 2024-02-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2024.1340061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Bioequivalence study of dacomitinib and Vizimpro® in healthy Chinese volunteers under fasting and fed conditions: A randomized, open-label, single-dose, crossover trial.

    Yang, Xiaojia / Li, Jinfang / Zhang, Taihui / Xia, Qinping / Zhang, Wei / Cui, Yike / He, Wen

    Clinical and translational science

    2023  Volume 16, Issue 12, Page(s) 2591–2603

    Abstract: This study aimed to evaluate the bioequivalence between test tablet dacomitinib and reference product Vizimpro® under fasting and fed conditions and assess their pharmacokinetic (PK) and safety profiles for gaining marketing approval of the new generic ... ...

    Abstract This study aimed to evaluate the bioequivalence between test tablet dacomitinib and reference product Vizimpro® under fasting and fed conditions and assess their pharmacokinetic (PK) and safety profiles for gaining marketing approval of the new generic drug. A single-center, randomized, open-label, single-dose, two-treatment, two-period, crossover bioequivalence study was conducted in healthy Chinese subjects. Eligible healthy subjects randomly received a single 45 mg dose of test or reference formulations with an administration sequence of test tablet (T), reference tablet (R), or (RT), under both fasting and fed conditions, and each single administration was followed by a 21-day washout period. Plasma concentrations and corresponding non-compartmental PK parameters of dacomitinib were determined. The 90% confidence intervals of the geometric mean ratio (GMR) (test/reference) for C
    MeSH term(s) Humans ; Therapeutic Equivalency ; Cross-Over Studies ; Healthy Volunteers ; Fasting ; Tablets ; China
    Chemical Substances dacomitinib (5092U85G58) ; Tablets
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2433157-0
    ISSN 1752-8062 ; 1752-8054
    ISSN (online) 1752-8062
    ISSN 1752-8054
    DOI 10.1111/cts.13653
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Enhancing emotion regulation: investigating the efficacy of transcutaneous electrical acupoint stimulation at PC6 in reducing fear of heights.

    Cong, Lin / Yu, Xiao / Huang, Meiqing / Sun, Jicheng / Lv, Hao / Zhang, Taihui / Dang, Weitao / Teng, Chaolin / Xiong, Kaiwen / Ma, Jin / Hu, Wendong / Wang, Jianqi / Cheng, Shan

    Frontiers in psychology

    2024  Volume 15, Page(s) 1371014

    Abstract: This study investigated the impact of transcutaneous electrical acupoint stimulation (TEAS) at Neiguan acupoint (PC6) on the physiological and behavioral responses of participants exposed in virtual height. 40 participants were included in the study and ... ...

    Abstract This study investigated the impact of transcutaneous electrical acupoint stimulation (TEAS) at Neiguan acupoint (PC6) on the physiological and behavioral responses of participants exposed in virtual height. 40 participants were included in the study and were randomly assigned to either a control group or an intervention group. Participants had an immersive experience with a VR interactive platform that provided somatosensory interaction in height stimulation scenes. Psychological scores, behavioral and cognitive performance, and physiological responses were recorded and analyzed. The results indicated that the intervention group had significantly lower fear scores compared to the control group. Analysis of heart rate variability revealed that the intervention group exhibited improved heart rate variability, indicating enhanced cardiovascular function and emotion regulation. The behavioral and cognitive results demonstrated that the intervention group exhibited higher left eye openness, faster reaction times, and greater movement distance, suggesting enhanced attentional focus, cognitive processing, and reduced avoidance behaviors. These findings suggest that TEAS at PC6 can effectively reduce fear and improve the regulation of physiological and behavioral responses to negative emotional stimuli.
    Language English
    Publishing date 2024-04-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2024.1371014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The neuroelectrophysiological and behavioral effects of transcranial direct current stimulation on executive vigilance under a continuous monotonous condition.

    Dai, Jing / Wang, Hang / Yang, Lin / Wang, Chunchen / Cheng, Shan / Zhang, Taihui / Ma, Jin / Wen, Zhihong / Cao, Xinsheng / Hu, Wendong

    Frontiers in neuroscience

    2022  Volume 16, Page(s) 910457

    Abstract: A prolonged period of vigilance task will lead to vigilance decrement and a drop in cognitive efficiency. Although transcranial direct current stimulation (tDCS) can be used to improve cognitive performance following vigilance decrement, the findings in ... ...

    Abstract A prolonged period of vigilance task will lead to vigilance decrement and a drop in cognitive efficiency. Although transcranial direct current stimulation (tDCS) can be used to improve cognitive performance following vigilance decrement, the findings in this area of study are inconsistent. This study aims to identify the neuroelectrophysiological and behavioral effects of tDCS over the left dorsolateral prefrontal cortex (DLPFC) on executive vigilance under a continuous monotonous condition. We recruited 29 participants who randomly received 30 min active or sham tDCS before the vigilance task (anode electrode at the left DLPFC, cathode electrode at the right supraorbital area). Participants completed four sessions of vigilance task and five sessions of self-report sleepiness, Oddball task, and Go/Nogo task, for a total of about 5 h. EEG was acquired in real-time throughout the experiment. Repeated measures of ANOVA were utilized to analyze the evolution of each metric with task-on-time. The results demonstrated that subjective arousal state, vigilance performance, event-related potentials (ERPs), and EEG power were significantly affected by time on task. Brain stimulation did not significantly affect the evolution of subjective and objective executive vigilance performance, but significantly modulated spontaneous activity in the alpha and beta bands across the entire brain. The continuous enhancement of the prefrontal cortex increased P2 amplitude for the Oddball task, which was associated with the enhancement of the early stage of information processing. P3 amplitude had a temporary enhancement effect, which significantly decreased following a cognitive fatigue. tDCS had a continuous enhancement effect on N2 amplitude for the Go/Nogo task, which was associated with the enhanced inhibition of distracting stimuli. Together, the current data suggest that anodal tDCS over left DLPFC possibly enhances the early stage of relevant information processing and the inhibitory control of distracting stimuli during a continuous and monotonous vigilance task.
    Language English
    Publishing date 2022-09-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2022.910457
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Standard low-resolution electromagnetic tomography imaging of brain for the analysis of mental fatigue during a simulated air traffic control task.

    Cong, Lin / Huang, Meiqing / Yang, Jinghua / Cheng, Shan / Teng, Chaolin / Xiong, Kaiwen / Zhang, Taihui / Dang, Weitao / Liu, Cui / Ma, Jin / Hu, Wendong

    Neuro endocrinology letters

    2023  Volume 44, Issue 8, Page(s) 491–499

    Abstract: Background: Standard low-resolution electromagnetic tomography (sLORETA) was used to accurately detect EEG changes in mental fatigue of air traffic controllers (ATCo) under a simulated air traffic control (ATC) task. We explored the changes in standard ... ...

    Abstract Background: Standard low-resolution electromagnetic tomography (sLORETA) was used to accurately detect EEG changes in mental fatigue of air traffic controllers (ATCo) under a simulated air traffic control (ATC) task. We explored the changes in standard current density, activated cortical intensity, and brain source location.
    Methods: The participants were instructed to use the tower flight command simulation training system for three hours of uninterrupted ATC task. The 3-hour EEG signal was divided into four stages: task start, 1st hour, 2nd hour, and task end. Each stage was preprocessed for 3 minutes to explore the EEG changes and then processed by sLORETA in a statistical non-parametric mapping analysis.
    Results: The current density distribution of δ and α oscillations differed significantly during the four tasks, while θ, β and γ oscillations did not. Changes in δ oscillations of the brain during mental fatigue were detected mainly in the postcentral gyrus (BA2 and BA3), precentral gyrus (BA4 and BA6), inferior temporal gyrus (BA20), and superior temporal gyrus (BA38). The α oscillations were found mainly decreased in the postcentral gyrus (BA2) and inferior parietal lobule (BA40) when the task was in progress compared with the end of the task.
    Conclusion: The superior temporal gyrus and somatosensory cortex were the main activated cortical regions during the simulated ATC task. The α and δ oscillations showed contrasting activity during simulated ATC task, which might reflect the release of task-relevant brain's areas from inhibition and enhance the neural activity.
    MeSH term(s) Humans ; Electroencephalography/methods ; Brain/diagnostic imaging ; Tomography/methods ; Brain Mapping ; Electromagnetic Phenomena ; Mental Fatigue ; Magnetic Resonance Imaging
    Language English
    Publishing date 2023-12-22
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 135951-4
    ISSN 2354-4716 ; 0172-780X
    ISSN (online) 2354-4716
    ISSN 0172-780X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2384: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Development and validation of an assessment index for quantifying cognitive task load in pilots under simulated flight conditions using heart rate variability and principal component analysis.

    Yang, Jinghua / Tang, Mengjun / Cong, Lin / Sun, Jicheng / Guo, Dalong / Zhang, Taihui / Xiong, Kaiwen / Wang, Li / Cheng, Shan / Ma, Jin / Hu, Wendong

    Ergonomics

    2023  Volume 67, Issue 4, Page(s) 515–525

    Abstract: To investigate whether high cognitive task load (CTL) for aircraft pilots can be identified by analysing heart-rate variability, electrocardiograms were recorded while cadet pilots ( ...

    Abstract To investigate whether high cognitive task load (CTL) for aircraft pilots can be identified by analysing heart-rate variability, electrocardiograms were recorded while cadet pilots (
    MeSH term(s) Humans ; Heart Rate/physiology ; Principal Component Analysis ; Electrocardiography ; Cognition
    Language English
    Publishing date 2023-07-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1920-3
    ISSN 1366-5847 ; 0014-0139
    ISSN (online) 1366-5847
    ISSN 0014-0139
    DOI 10.1080/00140139.2023.2229075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.365: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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