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Article: Penetrating canaloplasty in corticosteroid-induced glaucoma: a report of two cases.

Liu, Fang / Zhou, Liu-Shan / Zhang, Wei-Wei

2024 Volume 17, Issue 4, Page(s) 770–772

Language	English
Publishing date	2024-04-18
Publishing country	China
Document type	Journal Article
ZDB-ID	2663246-9
ISSN	2227-4898 ; 2222-3959
ISSN (online)	2227-4898
ISSN	2222-3959
DOI	10.18240/ijo.2024.04.23
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Article ; Online: Guillain-Barré syndrome: immunopathogenesis and therapeutic targets.

Liu, Shan / Zhang, Wei Wei / Jia, Linpei / Zhang, Hong-Liang

Expert opinion on therapeutic targets

2024 , Page(s) 1–13

Abstract: Introduction: Guillain-Barré syndrome (GBS) is a group of acute immune-mediated disorders in the peripheral nervous system. Both infectious and noninfectious factors are associated with GBS, which may act as triggers of autoimmune responses leading to ... ...

Abstract	Introduction: Guillain-Barré syndrome (GBS) is a group of acute immune-mediated disorders in the peripheral nervous system. Both infectious and noninfectious factors are associated with GBS, which may act as triggers of autoimmune responses leading to neural damage and dysfunction. Areas covered: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its vaccines as well as flaviviruses have been associated with GBS, although a robust conclusion has yet to be reached. Immunomodulatory treatments, including intravenous immunoglobulins (IVIg) and plasma exchange (PE), have long been the first-line therapies for GBS. Depending on GBS subtype and severity at initial presentation, the efficacy of IVIg and PE can be variable. Several new therapies showing benefits to experimental animals merit further investigation before translation into clinical practice. We review the state-of-the-art knowledge on the immunopathogenesis of GBS in the context of coronavirus disease 2019 (COVID-19). Immunomodulatory therapies in GBS, including IVIg, PE, corticosteroids, and potential therapies, are summarized. Expert opinion: The association with SARS-CoV-2 remains uncertain, with geographical differences that are difficult to explain. Evidence and guidelines are lacking for the decision-making of initiating immunomodulatory therapies in mildly affected patients or patients with regional subtypes of GBS.
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2055208-7
ISSN	1744-7631 ; 1472-8222
ISSN (online)	1744-7631
ISSN	1472-8222
DOI	10.1080/14728222.2024.2330435
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Article: Risk factors associated with false negative rate of sentinel lymph node biopsy in endometrial cancer: a systematic review and meta-analysis.

Fan, Meng-Si / Qiu, Ke-Xin / Wang, Dong-Yue / Wang, Hao / Zhang, Wei-Wei / Yan, Li

Frontiers in oncology

2024 Volume 14, Page(s) 1391267

Abstract: Objective: Currently, sentinel lymph node biopsy (SLNB) is increasingly used in endometrial cancer, but the rate of missed metastatic lymph nodes compared to systemic lymph node dissection has been a concern. We conducted a systematic review and meta- ... ...

Abstract	Objective: Currently, sentinel lymph node biopsy (SLNB) is increasingly used in endometrial cancer, but the rate of missed metastatic lymph nodes compared to systemic lymph node dissection has been a concern. We conducted a systematic review and meta-analysis to evaluate the false negative rate (FNR) of SLNB in patients with endometrial cancer and to explore the risk factors associated with this FNR. Data sources: Three databases (PubMed, Embase, Web of Science) were searched from initial database build to January 2023 by two independent reviewers. Research eligibility criteria: Studies were included if they included 10 or more women diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage I or higher endometrial cancer, the study technique used sentinel lymph node localization biopsy, and the reported outcome metrics included false negative and/or FNR. Study appraisal and synthesis methods: Two authors independently reviewed the abstracts and full articles. The FNR and factors associated with FNR were synthesized through random-effects meta-analyses and meta-regression. The results: We identified 62 eligible studies. The overall FNR for the 62 articles was 4% (95% CL 3-5).There was no significant difference in the FNR in patients with high-risk endometrial cancer compared to patients with low-risk endometrial cancer. There was no difference in the FNR for whether frozen sections were used intraoperatively. The type of dye used intraoperatively (indocyanine green/blue dye) were not significantly associated with the false negative rate. Cervical injection reduced the FNR compared with alternative injection techniques. Indocyanine green reduced the FNR compared with alternative Tc-99m. Postoperative pathologic ultrastaging reduced the FNR. Conclusions: Alternative injection techniques (other than the cervix), Tc-99m dye tracer, and the absence of postoperative pathologic ultrastaging are risk factors for a high FNR in endometrial cancer patients who undergo SLNB; therefore, we should be vigilant for missed diagnosis of metastatic lymph nodes after SLNB in such populations. Systematic review registration: http://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023433637.
Language	English
Publishing date	2024-04-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2024.1391267
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Article: 壳聚糖对NaCl胁迫下菜用大豆叶绿体蛋白的影响.

Wang, Cong / Guo, Yuan / Zhang, Wei-Wei

Ying yong sheng tai xue bao = The journal of applied ecology

2022 Volume 33, Issue 1, Page(s) 111–118

Abstract: Chitosan (CTS) can effectively enhance the tolerance of plants to salt stress, but its role in driving the responses of vegetable soybean seedlings to salt stress at proteomic level is still unclear. Here, both 200 mmol· ... ...

Title translation	Effects of chitosan on chloroplast protein of vegetable soybean under NaCl stress.
Abstract	Chitosan (CTS) can effectively enhance the tolerance of plants to salt stress, but its role in driving the responses of vegetable soybean seedlings to salt stress at proteomic level is still unclear. Here, both 200 mmol·L
MeSH term(s)	Chitosan/metabolism ; Chitosan/pharmacology ; Chloroplast Proteins/metabolism ; Chloroplast Proteins/pharmacology ; Photosynthesis ; Plant Leaves/physiology ; Proteomics ; Seedlings ; Sodium Chloride/pharmacology ; Glycine max/metabolism ; Stress, Physiological ; Vegetables
Chemical Substances	Chloroplast Proteins ; Sodium Chloride (451W47IQ8X) ; Chitosan (9012-76-4)
Language	Chinese
Publishing date	2022-02-28
Publishing country	China
Document type	Journal Article
ZDB-ID	2881809-X
ISSN	1001-9332
ISSN	1001-9332
DOI	10.13287/j.1001-9332.202201.029
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Article ; Online: Intussusception after injury to the small intestine during emergent cesarean delivery of a premature triplet pregnancy: A case report.

Star, Allen / Ripa, Valeria / Sheikh, Fariha / Zhang, Wei Wei

Case reports in women's health

2022 Volume 36, Page(s) e00468

Abstract: Intussusception is a rare cause of intestinal obstruction in the postoperative setting. This report describes a rare case of intussusception in the early postoperative period following an emergent cesarean delivery of a premature triplet pregnancy, where ...

Abstract	Intussusception is a rare cause of intestinal obstruction in the postoperative setting. This report describes a rare case of intussusception in the early postoperative period following an emergent cesarean delivery of a premature triplet pregnancy, where the small intestine was fully transected. The intestine was repaired with a stapled primary side-to-side functional end-to-end anastomosis. Five days after being discharged, the patient was readmitted due to a small bowel obstruction due to intussusception. The anastomotic site was acting as the lead point, and it required resection. Bowel continuity was reestablished with a hand-sewn anastomosis in end-to-end fashion. The patient had an uneventful recovery and was discharged home. All three neonates were eventually discharged home and the patient was able to start breast feeding. This is believed to be the first case in the obstetric literature where intussusception occurred after intestinal repair of transected bowel during an obstetric emergency.
Language	English
Publishing date	2022-11-15
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2800286-6
ISSN	2214-9112 ; 2214-9112
ISSN (online)	2214-9112
ISSN	2214-9112
DOI	10.1016/j.crwh.2022.e00468
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Article: [Down-regulation of MDR1 gene expression by CRISPRi to enhance the sensitivity of lung adenocarcinoma A549/DDP cells to cisplatin].

Liu, Kai / Sun, Xin-di / Zhang, Wei-Wei / Yang, Qing-Zhu / Huang, Xin / Shao, Shu-Li

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology

2023 Volume 38, Issue 5, Page(s) 590–594

Abstract: Objective: To investigate the effects of down-regulating MDR1 gene expression by CRISPRi on enhancing the sensitivity of lung adenocarcinoma A549/DDP cells to cisplatin.: Methods: The potential CRISPRi interference sites on the MDR1 gene promoter ... ...

Abstract	Objective: To investigate the effects of down-regulating MDR1 gene expression by CRISPRi on enhancing the sensitivity of lung adenocarcinoma A549/DDP cells to cisplatin. Methods: The potential CRISPRi interference sites on the MDR1 gene promoter were predicted by bioinformatics software, and the interference fragments were designed and constructed. The mRNA and protein expression levels of MDR1 gene in each group of cells were detected by qRT-PCR and Western blot methods, and the recombinant vectors with high interference efficiency were screened. Human lung cancer A549/DDP cells were divided into three groups: A549/DDP, Scrambed and sgRNA-MDR1-1, with three multiple holes in each group. After each vector was transfected into the cells for 48 h, the efflux of cells in each group was detected by flow cytometry, the IC Results: After sequencing and comparison, two kinds of CRISPRi recombinant vectors interfering with MDR1 gene transcription were constructed successfully. After transfection of A549/DDP cells, the mRNA and protein levels of MDR1 gene in all transfection groups were decreased significantly ( Conclusion: CRISPRi interference with MDR1 gene in drug-resistant A549/DDP cells can significantly enhance the sensitivity to cisplatin.
MeSH term(s)	Humans ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Antineoplastic Agents/pharmacology ; Down-Regulation ; Drug Resistance, Neoplasm/genetics ; Cell Line, Tumor ; Apoptosis ; Adenocarcinoma of Lung/genetics ; Lung Neoplasms/genetics ; Lung Neoplasms/drug therapy ; RNA, Messenger ; Gene Expression
Chemical Substances	Cisplatin (Q20Q21Q62J) ; Antineoplastic Agents ; RNA, Messenger
Language	Chinese
Publishing date	2023-04-23
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1000-6834
ISSN	1000-6834
DOI	10.12047/j.cjap.6342.2022.109
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Article: [Chicken-claw needling at Xiaguan (ST 7) combined with intradermal needling on negative emotions in primary trigeminal neuralgia of phlegm obstruction and blood stasis: a randomized controlled trial].

Zhang, Wei-Wei / Tian, Shu-Yi / Tang, Tian-Tian / Li, Ya-Xue

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

2022 Volume 42, Issue 9, Page(s) 999–1003

Abstract: Objective: To observe the clinical effect of chicken-claw needling at Xiaguan (ST 7) combined with intradermal needling on negative emotion in primary trigeminal neuralgia (PTN) of phlegm obstruction and blood stasis.: Methods: Sixty cases of ... ...

Abstract	Objective: To observe the clinical effect of chicken-claw needling at Xiaguan (ST 7) combined with intradermal needling on negative emotion in primary trigeminal neuralgia (PTN) of phlegm obstruction and blood stasis. Methods: Sixty cases of patients with PTN of phlegm obstruction and blood stasis were randomly divided into an observation group and a control group, 30 cases in each group. The observation group was treated with chicken-claw needling at Xiaguan (ST 7) combined with intradermal needling (acupoints Sibai [ST 2], Yuyao [EX-HN 4], Hegu [LI 4], Taichong [LR 3] and auricular points Xin [CO Results: After treatment, the VAS, SAS, TCM syndrome scores and the contents of serum SP in the two groups were lower than those before treatment ( Conclusion: Chicken-claw needling at Xiaguan (ST 7) combined with intradermal needling can relieve pain symptoms and negative emotions in patients with primary trigeminal neuralgia of phlegm obstruction and blood stasis, which may be related to the regulation of serum neurotransmitter levels.
MeSH term(s)	Acupuncture Points ; Acupuncture Therapy ; Emotions ; Humans ; Pain ; Serotonin ; Syndrome ; Treatment Outcome ; Trigeminal Neuralgia/therapy
Chemical Substances	Serotonin (333DO1RDJY)
Language	Chinese
Publishing date	2022-09-08
Publishing country	China
Document type	Journal Article ; Randomized Controlled Trial
ISSN	0255-2930
ISSN	0255-2930
DOI	10.13703/j.0255-2930.20220314-0004
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Article ; Online: Curcumin hybrid molecules for the treatment of Alzheimer's disease: Structure and pharmacological activities.

Zang, Wei-Biao / Wei, Hui-Ling / Zhang, Wei-Wei / Ma, Wei / Li, Juan / Yao, Yao

European journal of medicinal chemistry

2023 Volume 265, Page(s) 116070

Abstract: Alzheimer's disease (AD) is the most common neurodegenerative disease among the elderly. Contemporary treatments can only relieve symptoms but fail to delay disease progression. Curcumin is a naturally derived compound that has demonstrated significant ... ...

Abstract	Alzheimer's disease (AD) is the most common neurodegenerative disease among the elderly. Contemporary treatments can only relieve symptoms but fail to delay disease progression. Curcumin is a naturally derived compound that has demonstrated significant therapeutic effects in AD treatment. Recently, molecular hybridization has been utilized to combine the pharmacophoric groups present in curcumin with those of other AD drugs, resulting in a series of novel compounds that enhance the therapeutic efficacy through multiple mechanisms. In this review, we firstly provide a concise summary of various pathogenetic hypotheses of AD and the mechanism of action of curcumin in AD, as well as the concept of molecular hybridization. Subsequently, we focus on the recent development of hybrid molecules derived from curcumin, summarizing their structures and pharmacological activities, including cholinesterase inhibitory activity, Aβ aggregation inhibitory activity, antioxidant activity, and other activities. The structure-activity relationships were further discussed.
MeSH term(s)	Humans ; Aged ; Alzheimer Disease/drug therapy ; Curcumin/pharmacology ; Curcumin/therapeutic use ; Curcumin/chemistry ; Neurodegenerative Diseases/drug therapy ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Structure-Activity Relationship ; Amyloid beta-Peptides
Chemical Substances	Curcumin (IT942ZTH98) ; Antioxidants ; Amyloid beta-Peptides
Language	English
Publishing date	2023-12-18
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2023.116070
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Article: Prevotella oris

Zhang, Wei-Wei / Ai, Chao / Mao, Chien-Tai / Liu, Dong-Kang / Guo, Yi

World journal of clinical cases

2023 Volume 11, Issue 16, Page(s) 3830–3836

Abstract: Background: Prevotella oris: Case summary: We report a case of a 9-year-old boy suffering from meningitis and spinal canal infection. The patient presented to the neurosurgery department with lumbosacral pain for 1 mo and headache and vomiting for 1 ... ...

Abstract	Background: Prevotella oris Case summary: We report a case of a 9-year-old boy suffering from meningitis and spinal canal infection. The patient presented to the neurosurgery department with lumbosacral pain for 1 mo and headache and vomiting for 1 d. He had been treated with cephalosporin and nonsteroidal anti-inflammatory drugs for fever, otalgia and pharyngalgia in a local hospital 2 mo prior to this admission. During hospitalization, magnetic resonance imaging suggested meningitis and L3-S1 lumbosacral dural sac infection. The cerebrospinal fluid and blood cultures were negative, but the cerebrospinal fluid specimen indicated the presence of Conclusion: This report shed light on the characteristics of
Language	English
Publishing date	2023-06-27
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v11.i16.3830
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Article: Effect of different interventions on the treatment of high-risk human papillomavirus infection: a systematic review and network meta-analysis.

Wang, Dong-Yue / Cui, Ying-Ying / Zhang, Wei-Wei / Fan, Meng-Si / Qiu, Ke-Xin / Yan, Li

Frontiers in medicine

2024 Volume 11, Page(s) 1274568

Abstract: Background: Persistent infection with high-risk human papillomavirus (HR-HPV) can lead to cervical intraepithelial neoplasia and cancer. At present, there is no medication that specifically targets HR-HPV infection.: Objective: This study aimed to ... ...

Abstract	Background: Persistent infection with high-risk human papillomavirus (HR-HPV) can lead to cervical intraepithelial neoplasia and cancer. At present, there is no medication that specifically targets HR-HPV infection. Objective: This study aimed to evaluate the effectiveness of different interventions in promoting HR-HPV regression using a MeSH meta-analysis method. Methods: A search for randomized controlled trials (RCTs) reporting different interventions for the treatment of HR-HPV infection included PubMed, Web of Science, Embase and Cochrane Library from the inception of the databases to March 8, 2023. Two researchers independently screened the articles, extracted data, and evaluated the quality. The literature that met the inclusion criteria was selected, the quality and risk of bias of the included studies were assessed according to the Cochrane 5.1 manual, and NMA was performed using Stata 16.0. The area under the cumulative ranking probability graph (SUCRA) represented the probability that each treatment would be the best intervention. Results: Nine studies involving 961 patients and 7 treatment options were included in the analysis. The results of the network meta-analysis indicated the following rank order in terms of promoting HR-HPV conversion: Anti-HPV biological dressing > vaginal gel > imiquimod > REBACIN® > interferon > probiotics > observation/placebo > Polyphenon E. Conclusion: Anti-HPV biological dressing treatment was found to be significantly effective in promoting HR-HPV conversion. However, further validation of the findings is necessary due to the limited number and quality of studies included in the analysis. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42023413917.
Language	English
Publishing date	2024-02-14
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2024.1274568
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