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Book ; Thesis: Stem cells derived from dental pulp and their application potential on tissue regeneration

Zhang, Weibo

2007

Author's details	by Weibo Zhang
Language	English ; Dutch
Size	208 S. : Ill., graph. Darst.
Publishing country	Netherlands
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Nijmegen, Univ., Diss., 2007
Note	Zsfassung in niederländ. Sprache
HBZ-ID	HT015377716
ISBN	978-90-9022156-4 ; 90-9022156-5
Database	Catalogue ZB MED Medicine, Health

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Article: TyroFill-Titanium Implant Constructs for the Coordinated Repair of Rabbit Mandible and Tooth Defects.

Zhang, Weibo / Kohn, Joachim / Yelick, Pamela C

Bioengineering (Basel, Switzerland)

2023 Volume 10, Issue 11

Abstract: Currently used methods to repair craniomaxillofacial (CMF) bone and tooth defects require a multi-staged surgical approach for bone repair followed by dental implant placement. Our previously published results demonstrated significant bioengineered bone ... ...

Abstract	Currently used methods to repair craniomaxillofacial (CMF) bone and tooth defects require a multi-staged surgical approach for bone repair followed by dental implant placement. Our previously published results demonstrated significant bioengineered bone formation using human dental pulp stem cell (hDPSC)-seeded tyrosine-derived polycarbonate scaffolds (E1001(1K)-bTCP). Here, we improved upon this approach using a modified TyroFill (E1001(1K)/dicalcium phosphate dihydrate (DCPD)) scaffold-supported titanium dental implant model for simultaneous bone-dental implant repair. TyroFill scaffolds containing an embedded titanium implant, with (
Language	English
Publishing date	2023-11-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2746191-9
ISSN	2306-5354
ISSN	2306-5354
DOI	10.3390/bioengineering10111277
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Article: IncRNA EPB41L4A-AS1 Mitigates the Proliferation of Non-Small-Cell Lung Cancer Cells through the miR-105-5p/GIMAP6 Axis.

Dong, Bingwei / Zhang, Fenjuan / Zhang, Weibo / Gao, Yingfang

Critical reviews in eukaryotic gene expression

2023 Volume 33, Issue 2, Page(s) 27–40

Abstract: Non-small-cell lung cancer (NSCLC) is the major subtype of lung cancer, with a series of long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and proteins involved in its pathogenesis. This study sought to investigate the functionality of lncRNA EPB41L4A ... ...

Abstract	Non-small-cell lung cancer (NSCLC) is the major subtype of lung cancer, with a series of long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and proteins involved in its pathogenesis. This study sought to investigate the functionality of lncRNA EPB41L4A antisense RNA 1 (lncRNA EPB41L4A-AS1) in the proliferation of NSCLC cells and provide a novel theoretical reference for NSCLC treatment. Levels of lncRNA EPB41L4A-AS1, miR-105-5p, and GTPase, IMAP family member 6 (GIMAP6) in tissues and cells were measured by RT-qPCR and the correlation between lncRNA EPB41L4A-AS1 and clinicopathological characteristics was analyzed. Cell proliferation was evaluated by cell counting kit-8 and colony formation assays. The subcellular localization of lncRNA EPB41L4A-AS1 was analyzed by the subcellular fractionation assay and the binding of miR-105-5p to lncRNA EPB41L4A-AS1 or GIMAP6 was analyzed by dual-luciferase and RNA pull-down assays. Functional rescue experiments were performed to analyze the role of miR-105-5p/GIMAP6 in NSCLC cell proliferation. lncRNA EPB41L4A-AS1 and GIMAP6 were downregulated while miR-105-5p was upregulated in NSCLC tissues and cells. lncRNA EPB41L4A-AS1 was correlated with tumor size and clinical staging and its overexpression reduced NSCLC cell proliferation. lncRNA EPB41L4A-AS1 was negatively correlated with miR-105-5p and positively correlated with GIMAP6 in NSCLC tissues, and lncRNA EPB41L4A-AS1 sponged miR-105-5p to promote GIMAP6 transcription in NSCLC cells. Overexpression of miR-105-5p or knockdown of GIMAP6 reversed the inhibition of lncRNA EPB41L4A-AS1 overexpression on NSCLC cell proliferation. lncRNA EPB41L4A-AS1 was downregulated in NSCLC and mitigated NSCLC cell proliferation through the miR-105-5p/GI-MAP6 axis.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/metabolism ; Lung Neoplasms/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Cell Line, Tumor ; Cell Movement/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic/genetics ; GTP Phosphohydrolases/genetics ; GTP Phosphohydrolases/metabolism
Chemical Substances	RNA, Long Noncoding ; MicroRNAs ; GIMAP6 protein, human (EC 3.6.1.-) ; GTP Phosphohydrolases (EC 3.6.1.-) ; MIRN105 microRNA, human
Language	English
Publishing date	2023-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1071345-1
ISSN	1045-4403
ISSN	1045-4403
DOI	10.1615/CritRevEukaryotGeneExpr.2022044323
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Article ; Online: Tooth Repair and Regeneration: Potential of Dental Stem Cells.

Zhang, Weibo / Yelick, Pamela C

Trends in molecular medicine

2021 Volume 27, Issue 5, Page(s) 501–511

Abstract: Tooth defects are an extremely common health condition that affects millions of individuals. Currently used dental repair treatments include fillings for caries, endodontic treatment for pulp necrosis, and dental implants to replace missing teeth, all of ...

Abstract	Tooth defects are an extremely common health condition that affects millions of individuals. Currently used dental repair treatments include fillings for caries, endodontic treatment for pulp necrosis, and dental implants to replace missing teeth, all of which rely on the use of synthetic materials. By contrast, the fields of tissue engineering and regenerative medicine and dentistry (TERMD) use biologically based therapeutic strategies for vital tissue regeneration, and thus have the potential to regenerate living tissues. Methods to create bioengineered replacement teeth benefit from a detailed understanding of the molecular signaling networks regulating natural tooth development. We discuss how key signaling pathways regulating natural tooth development are being exploited for applications in TERMD approaches for vital tooth regeneration.
MeSH term(s)	Humans ; Odontogenesis/physiology ; Regenerative Medicine/methods ; Signal Transduction ; Stem Cells/metabolism ; Tissue Engineering ; Tissue Scaffolds ; Tooth/embryology ; Tooth/growth & development ; Tooth/pathology ; Tooth Germ/growth & development ; Tooth Germ/metabolism
Language	English
Publishing date	2021-03-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2036490-8
ISSN	1471-499X ; 1471-4914
ISSN (online)	1471-499X
ISSN	1471-4914
DOI	10.1016/j.molmed.2021.02.005
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Article: A Novel Strategy to Enhance the pH Stability of Zein Particles through Octenyl Succinic Anhydride-Modified Starch: The Role of Preparation pH.

Wang, Linlin / Wang, Pengjie / Li, Yi / Liu, Siyuan / Wu, Lida / Zhang, Weibo / Chen, Chong

Foods (Basel, Switzerland)

2024 Volume 13, Issue 2

Abstract: Ensuring the stability of zein nanoparticles at different pH levels is crucial for their application as nanocarriers. In this study, octenyl succinic anhydride-modified starch (OSA-modified starch) was employed to enhance the stability of zein ... ...

Abstract	Ensuring the stability of zein nanoparticles at different pH levels is crucial for their application as nanocarriers. In this study, octenyl succinic anhydride-modified starch (OSA-modified starch) was employed to enhance the stability of zein nanoparticles against different pH levels by forming complex nanoparticles with OSA-modified starch. The effect of preparation pH on the stability of the zein/OSA-modified starch nanoparticles was investigated. Sedimentation occurred in zein nanoparticles as the pH reached the isoelectric point. However, the stability of zein nanoparticles at various pH levels significantly improved after adding OSA-modified starch to form zein/OSA-modified starch nanoparticles regardless of whether they were prepared under acidic or alkaline pH conditions. Notably, the stability of zein/OSA-modified starch nanoparticles prepared at an acidic pH was higher than that of those prepared at an alkaline pH, thereby highlighting the critical role of the preparation pH for zein/OSA-modified starch in maintaining the stability of zein. The stable zein/OSA-modified starch nanoparticles developed in this study exhibit significant potential for use in delivery systems across various pH environments.
Language	English
Publishing date	2024-01-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods13020303
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Article ; Online: Leaching behaviors of dissolved organic matter from face masks revealed by fluorescence EEM combined with FRI and PARAFAC.

Jin, Zhong / Zhang, Weibo / Wang, Xihuan / Liu, Ang / Li, Zhongyu / Bai, Yingchen / Wu, Fengchang

Water research

2024 Volume 254, Page(s) 121399

Abstract: Despite numerous studies investigating the occurrence and fate of microplastics, no effort has been devoted toward exploring the characteristics of dissolved organic matter (DOM) leached from face masks mainly made of plastics and additives used in large ...

Abstract	Despite numerous studies investigating the occurrence and fate of microplastics, no effort has been devoted toward exploring the characteristics of dissolved organic matter (DOM) leached from face masks mainly made of plastics and additives used in large quantities during the COVID-19 pandemic. By using FTIR, UV-vis, fluorescence EEM coupling with FRI and PARAFAC, and kinetic models of leaching experiments, we explored the leaching behaviors of face mask-derived DOM (FM-DOM) from commonly used face masks including N95, KN95, medical surgical masks, etc. The concentration of FM-DOM increased quickly at early 0-48 h and reached equilibrium at about 48 h measured in terms of dissolved organic carbon and fluorescence intensity. The protein-like materials ranged from 80.32 % to 89.40 % of percentage fluorescence response (P
MeSH term(s)	Humans ; Dissolved Organic Matter ; Plastics ; Ecosystem ; Masks ; Pandemics ; Tryptophan ; Spectrometry, Fluorescence ; Tyrosine ; Humic Substances/analysis ; Factor Analysis, Statistical
Chemical Substances	Dissolved Organic Matter ; Plastics ; Tryptophan (8DUH1N11BX) ; Tyrosine (42HK56048U) ; Humic Substances
Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Journal Article
ZDB-ID	202613-2
ISSN	1879-2448 ; 0043-1354
ISSN (online)	1879-2448
ISSN	0043-1354
DOI	10.1016/j.watres.2024.121399
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Article ; Online: Explaining how childhood physical abuse and physical neglect influence adult depression: An analysis with multiple sequential mediators.

Zhang, Wei-Bo / Jia, Fei-Fei / Liu, Bao-Peng / Li, Qi / Jia, Cun-Xian

Child abuse & neglect

2024 Volume 152, Page(s) 106771

Abstract: Background: Substantial evidence indicates that experiencing physical abuse and neglect during childhood significantly elevates the likelihood of developing depression in adulthood. Nevertheless, there remains a dearth of understanding regarding the ... ...

Abstract	Background: Substantial evidence indicates that experiencing physical abuse and neglect during childhood significantly elevates the likelihood of developing depression in adulthood. Nevertheless, there remains a dearth of understanding regarding the mechanisms underpinning this correlation. Objective: In this study, we aimed to examine the associations of childhood physical abuse and physical neglect with depression using follow-up data from UK Biobank and quantified the contribution of smoking, insomnia, and BMI in these associations. Participants and settings: This study included 144,704 participants (64,168 men and 80,536 women) from UK Biobank, most of whom were white (97 %). Methods: Physical abuse and physical neglect were measured using two items of Childhood Trauma Screener (CTS). Data on the incidence of depression were obtained from primary care, hospital inpatient records, self-reported medical conditions, and death registries. We used a sequential mediation analysis based on the "g-formula" approach to explore the individual and joint effects of potential mediators. Results: The depression incidence rate was 1.85 per 1000 person-years for men and 2.83 per 1000 person-years for women, respectively. Results of Cox proportional risk regression showed that physical abuse (HRs: 1.39-1.53, P < 0.001) and physical neglect (HRs: 1.43-1.60, P < 0.001) are associated with depression. Smoking, insomnia, and BMI together mediated 3 %-26 % of the associations. Conclusions: These findings contribute to our understanding of how physical abuse and physical neglect influence depression. Furthermore, a more effective reduction in the burden of depression can be achieved by managing modifiable mediators.
Language	English
Publishing date	2024-04-05
Publishing country	England
Document type	Journal Article
ZDB-ID	799143-5
ISSN	1873-7757 ; 0145-2134
ISSN (online)	1873-7757
ISSN	0145-2134
DOI	10.1016/j.chiabu.2024.106771
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Article ; Online: Enhancing psychiatric rehabilitation outcomes through a multimodal multitask learning model based on BERT and TabNet: An approach for personalized treatment and improved decision-making.

Yang, Hongyi / Zhu, Dian / He, Siyuan / Xu, Zhiqi / Liu, Zhao / Zhang, Weibo / Cai, Jun

Psychiatry research

2024 Volume 336, Page(s) 115896

Abstract: Evaluating the rehabilitation status of individuals with serious mental illnesses (SMI) necessitates a comprehensive analysis of multimodal data, including unstructured text records and structured diagnostic data. However, progress in the effective ... ...

Abstract	Evaluating the rehabilitation status of individuals with serious mental illnesses (SMI) necessitates a comprehensive analysis of multimodal data, including unstructured text records and structured diagnostic data. However, progress in the effective assessment of rehabilitation status remains limited. Our study develops a deep learning model integrating Bidirectional Encoder Representations from Transformers (BERT) and TabNet through a late fusion strategy to enhance rehabilitation prediction, including referral risk, dangerous behaviors, self-awareness, and medication adherence, in patients with SMI. BERT processes unstructured textual data, such as doctor's notes, whereas TabNet manages structured diagnostic information. The model's interpretability function serves to assist healthcare professionals in understanding the model's predictive decisions, improving patient care. Our model exhibited excellent predictive performance for all four tasks, with an accuracy exceeding 0.78 and an area under the curve of 0.70. In addition, a series of tests proved the model's robustness, fairness, and interpretability. This study combines multimodal and multitask learning strategies into a model and applies it to rehabilitation assessment tasks, offering a promising new tool that can be seamlessly integrated with the clinical workflow to support the provision of optimized patient care.
Language	English
Publishing date	2024-04-06
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2024.115896
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Article: [Modified acupuncture at sphenopalatine ganglion for allergic rhinitis: a randomized controlled trial].

Bao, Jia-Ying / Li, Xin-Wei / Zhang, Wei-Bo / Du, Jia

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

2023 Volume 43, Issue 5, Page(s) 522–526

Abstract: Objective: To observe the effect of modified acupuncture at sphenopalatine ganglion for allergic rhinitis (AR).: Methods: A total of 80 patients with AR were randomly divided into an observation group and a control group, 40 cases in each group. In ... ...

Abstract	Objective: To observe the effect of modified acupuncture at sphenopalatine ganglion for allergic rhinitis (AR). Methods: A total of 80 patients with AR were randomly divided into an observation group and a control group, 40 cases in each group. In the observation group, modified acupuncture at sphenopalatine ganglion was given, 30 min each time, 2 times a week and with an interval of 3-4 days. In the control group, budesonide nasal spray was given. Both groups were treated for 4 weeks. The total nasal symptom score (TNSS) and total non-nasal symptom score (TNNSS) were observed before treatment, after first treatment, after last treatment and 4 weeks after treatment; the scores of visual analogue scale (VAS) and rhinoconjunctivitis quality of life questionnaire (RQLQ) were observed before treatment, after last treatment and 4 weeks after treatment; the recurrence condition was evaluated 4 weeks after treatment; the clinical efficacy was evaluated after last treatment in the two groups. Results: Compared with before treatment, the total scores and each score of TNSS, TNNSS scores after first treatment, after last treatment and 4 weeks after treatment were decreased in both groups ( Conclusion: Modified acupuncture at sphenopalatine ganglion could effectively improve symptoms and quality of life in patients with AR, and the recurrence rate is lower.
MeSH term(s)	Humans ; Quality of Life ; Acupuncture Therapy ; Rhinitis, Allergic/therapy ; Pain Measurement
Language	Chinese
Publishing date	2023-05-10
Publishing country	China
Document type	Randomized Controlled Trial ; English Abstract ; Journal Article
ISSN	0255-2930
ISSN	0255-2930
DOI	DOI：10.13703/j.0255-2930.20220807-0002
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Article ; Online: In vivo visualization of meridians with fluorescent dyes.

Hu, Qingchuan / Li, Tongju / Zhang, Wei-Bo / Tang, Bruce Qing

Asian journal of surgery

2023 Volume 46, Issue 6, Page(s) 2599–2600

MeSH term(s)	Humans ; Meridians ; Fluorescent Dyes
Chemical Substances	Fluorescent Dyes
Language	English
Publishing date	2023-01-12
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2022.12.129
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