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  1. Article: [Research progress in the pathologic mechanism of temporomandibular joint osteoarthritis].

    Zhang, X Y / He, D M

    Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology

    2023  Volume 58, Issue 10, Page(s) 1077–1082

    Abstract: Temporomandibular joint osteoarthritis (TMJOA) is a kind of degenerative lesion in temporomandibular joint disorders. The pathogenesis of TMJOA is complex. Among them, excessive mechanical stress plays an important role, which can cause a series of ... ...

    Abstract Temporomandibular joint osteoarthritis (TMJOA) is a kind of degenerative lesion in temporomandibular joint disorders. The pathogenesis of TMJOA is complex. Among them, excessive mechanical stress plays an important role, which can cause a series of pathological changes, including synovial inflammation, chondrocyte death, osteogenic and adipogenic differentiation, degradation of extracellular matrix of cartilage, angiogenesis, osteochondral interface sclerosis, subchondral bone remodeling, degeneration of articular discs, etc. In the pathogenesis of TMJOA, it involves multiple signal pathways and epigenetic regulation, which may become potential therapeutic targets of TMJOA. In this paper, the research progress on the pathologic mechanism of TMJOA in recent years is reviewed to provide a basis for finding new therapeutic targets of TMJOA.
    MeSH term(s) Humans ; Epigenesis, Genetic ; Temporomandibular Joint/pathology ; Osteoarthritis/pathology ; Temporomandibular Joint Disorders ; Cartilage/metabolism ; Cartilage/pathology
    Language Chinese
    Publishing date 2023-09-08
    Publishing country China
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 1027950-7
    ISSN 1002-0098
    ISSN 1002-0098
    DOI 10.3760/cma.j.cn112144-20230817-00096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Research progress on pollution status and toxic effects of organophosphorus flame retardants 2-ethylhexyl diphenyl phosphate].

    Zhang, X Y / Zhang, T W / Li, J

    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases

    2024  Volume 42, Issue 3, Page(s) 224–231

    Abstract: The environmental pollution and health hazards caused by the extensive use of organophosphorus flame retardants (OPFRs) have become a problem of wide concern around the world. As a typical OPFR, 2-ethylhexyl diphenyl phosphate (EHDPP) can be detected in ... ...

    Abstract The environmental pollution and health hazards caused by the extensive use of organophosphorus flame retardants (OPFRs) have become a problem of wide concern around the world. As a typical OPFR, 2-ethylhexyl diphenyl phosphate (EHDPP) can be detected in water, atmosphere, soil and other environmental media. It widely exists in production and life and can accumulate in organisms, causing great risks the ecosystem and human health. This paper reviews the research of EHDPP domestically and abroad, and summarizes the physicochemical properties of EHDPP and the population situation of occupational exposure, environmental exposure, and population exposure in recent years. Besides, it summarizes the toxic effects and mechanisms of EHDPP, including acute toxicity, hepatotoxicity, neurotoxicity, reproductive and developmental toxicity, and carcinogenesis effects. This paper also proposes the future direction of toxicity and health risks of EHDPP, which provides a theoretical basis for further research on environmental hazards and safety evaluation of EHDPP.
    MeSH term(s) Humans ; Phosphates ; Organophosphates/toxicity ; Organophosphorus Compounds/toxicity ; Flame Retardants/toxicity ; Flame Retardants/analysis ; Ecosystem ; Occupational Exposure/adverse effects ; Biphenyl Compounds
    Chemical Substances Phosphates ; Organophosphates ; Organophosphorus Compounds ; Flame Retardants ; biphenyl (2L9GJK6MGN) ; Biphenyl Compounds
    Language Chinese
    Publishing date 2024-03-25
    Publishing country China
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 1050900-8
    ISSN 1001-9391
    ISSN 1001-9391
    DOI 10.3760/cma.j.cn121094-20230119-00019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [A case of primary carnitine deficiency presenting with cholestasis, hepatomegaly, and hyperketonemia].

    Zhang, X Y / Zhao, J / Lu, Y

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2023  Volume 31, Issue 8, Page(s) 877–879

    MeSH term(s) Humans ; Hepatomegaly ; Cholestasis
    Language Chinese
    Publishing date 2023-02-22
    Publishing country China
    Document type Case Reports ; Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.cn501113-20220915-00468
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Phosphoglycerate dehydrogenase deficiency in a child].

    Zhang, X Y / Ding, C H / Ren, S S

    Zhonghua er ke za zhi = Chinese journal of pediatrics

    2023  Volume 61, Issue 7, Page(s) 653–655

    MeSH term(s) Child ; Humans ; Carbohydrate Metabolism, Inborn Errors ; Microcephaly ; Psychomotor Disorders ; Seizures
    Language Chinese
    Publishing date 2023-06-30
    Publishing country China
    Document type Case Reports ; Journal Article
    ZDB-ID 784523-6
    ISSN 0578-1310
    ISSN 0578-1310
    DOI 10.3760/cma.j.cn112140-20230219-00113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Silicosis complicated with rare bronchopulmonary cryptococcosis and meningitis: a case report].

    Zhang, X Y / Zhang, J L / Du, X X

    Zhonghua nei ke za zhi

    2023  Volume 62, Issue 3, Page(s) 320–323

    MeSH term(s) Humans ; Cryptococcosis ; Meningitis ; Silicosis
    Language Chinese
    Publishing date 2023-02-23
    Publishing country China
    Document type Case Reports ; Journal Article
    ZDB-ID 754223-9
    ISSN 0578-1426
    ISSN 0578-1426
    DOI 10.3760/cma.j.cn112138-20220307-00156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Progress and application of liver organoids in the study of liver cancer].

    Wang, M / Xu, Z Y / Yu, C / Zhang, X Y / Cao, H Y / Ma, Y

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2024  Volume 31, Issue 12, Page(s) 1332–1335

    Abstract: The incidence rate of liver cancer has been rising in recent years. Traditional cell line culture and human patient-derived tumor xenograft models, which are commonly used tools to simulate the occurrence of human liver cancer, have deepened the ... ...

    Abstract The incidence rate of liver cancer has been rising in recent years. Traditional cell line culture and human patient-derived tumor xenograft models, which are commonly used tools to simulate the occurrence of human liver cancer, have deepened the understanding of tumor occurrence, development, and drug resistance mechanisms. However, they cannot reflect the accurate state of cancer cells, the tumor microenvironment, or spatial structural characteristics. Recently, more in vitro-produced physiological liver organoids have been applied in the study of liver cancer. Liver organoid models have made breakthroughs in the occurrence and development mechanisms of liver cancer, personalized drug screening and biomarker identification, immunotherapy, and regenerative medicine applications. This paper mainly summarizes the progress and application of liver organoids processed in the study of liver cancer.
    MeSH term(s) Humans ; Animals ; Liver Neoplasms ; Cell Culture Techniques ; Cell Line ; Disease Models, Animal ; Organoids ; Tumor Microenvironment
    Language Chinese
    Publishing date 2024-01-22
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.cn501113-20231107-00178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [Inflammatory myopathy associated with anti-mitochondrial antibodies: a case report].

    Huo, J Y / Sun, A P / Zhang, X Y / Fu, Y / Fan, D S

    Zhonghua nei ke za zhi

    2024  Volume 63, Issue 4, Page(s) 415–418

    MeSH term(s) Humans ; Myositis ; Muscle, Skeletal ; Muscular Diseases ; Autoantibodies
    Chemical Substances Autoantibodies
    Language Chinese
    Publishing date 2024-04-01
    Publishing country China
    Document type Case Reports ; Journal Article
    ZDB-ID 754223-9
    ISSN 0578-1426
    ISSN 0578-1426
    DOI 10.3760/cma.j.cn112138-20231028-00258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: [The research progress of nervous system damage caused by diquat poisoning].

    Zhang, X Y / Li, G Q / Liu, B

    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases

    2022  Volume 40, Issue 8, Page(s) 636–640

    Abstract: In recent years, with the withdrawal of paraquat (PQ) pesticides from the market, the number of poisoning cases caused by its substitute diquat (DQ) has shown an increasing trend year by year. Among the clinical manifestations of DQ poisoning, the damage ...

    Abstract In recent years, with the withdrawal of paraquat (PQ) pesticides from the market, the number of poisoning cases caused by its substitute diquat (DQ) has shown an increasing trend year by year. Among the clinical manifestations of DQ poisoning, the damage to the central nervous system is relatively common and serious, but the specific toxicity mechanism is not clear, and there is no clear treatment. This article reviews the nervous system damage caused by DQ poisoning in order to improve the understanding systen of DQ poisoning.
    MeSH term(s) Diquat ; Herbicides ; Humans ; Nervous System ; Paraquat ; Poisoning
    Chemical Substances Herbicides ; Diquat (A9A615U4MP) ; Paraquat (PLG39H7695)
    Language Chinese
    Publishing date 2022-09-02
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 1050900-8
    ISSN 1001-9391
    ISSN 1001-9391
    DOI 10.3760/cma.j.cn121094-20210713-00350
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Estimating ground-level CH₄ concentrations inferred from Sentinel-5P

    Qin, J. Y. / Zhang, X. Y. / Liu, L. / Qin, K. / Xing, X. W.

    International Journal of Remote Sensing. 2023 Aug. 03, v. 44, no. 15 p.4796-4814

    2023  

    Abstract: Methane (CH₄) is an important greenhouse gas; however, there is a lack of large-scale studies on ground-level CH₄ concentrations. We estimated global ground-level CH₄ concentrations based on the CH₄ columns from the Copernicus Sentinel-5 precursor ... ...

    Abstract Methane (CH₄) is an important greenhouse gas; however, there is a lack of large-scale studies on ground-level CH₄ concentrations. We estimated global ground-level CH₄ concentrations based on the CH₄ columns from the Copernicus Sentinel-5 precursor satellite (S5P) and vertical profiles of CH₄ concentrations simulated from the Atmospheric Chemical Transport Model (GEOS-Chem). The proposed approach had achieved a high predictive accuracy for monthly ground-level CH₄ concentrations, with a correlation coefficient of 0.93 (p < 0.01) and RMSE of 29.93 ppb between the estimated CH₄ concentrations and those of ground measurements from the World Data Centre for Greenhouse Gases (WDCGG). Compared with the S5P CH₄ columns, the estimated ground-level CH₄ concentration has a close spatial relationship with emissions. The high CH₄ concentrations occurred in eastern China, northern India, western Russia, eastern U.S., and central Europe. Furthermore, the estimated ground-level CH₄ concentrations could reflect the seasonal variations of the observations, with correlation coefficients from 0.14 to 0.92. Our findings highlight the importance of satellite observations on atmospheric CH₄ in understanding the spatial and temporal emissions.
    Keywords Russia ; greenhouse gases ; greenhouses ; methane ; models ; satellites ; Central European region ; China ; Eastern United States ; India ; Ground-levelCH4 concentration ; S5P CH4 columns ; GEOS-Chem model
    Language English
    Dates of publication 2023-0803
    Size p. 4796-4814.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 1497529-4
    ISSN 1366-5901 ; 0143-1161
    ISSN (online) 1366-5901
    ISSN 0143-1161
    DOI 10.1080/01431161.2023.2240028
    Database NAL-Catalogue (AGRICOLA)

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  10. Book ; Online: Distributed sequential federated learning

    Wang, Z. F. / Zhang, X. Y. / Chang, Y-c I.

    2023  

    Abstract: The analysis of data stored in multiple sites has become more popular, raising new concerns about the security of data storage and communication. Federated learning, which does not require centralizing data, is a common approach to preventing heavy data ... ...

    Abstract The analysis of data stored in multiple sites has become more popular, raising new concerns about the security of data storage and communication. Federated learning, which does not require centralizing data, is a common approach to preventing heavy data transportation, securing valued data, and protecting personal information protection. Therefore, determining how to aggregate the information obtained from the analysis of data in separate local sites has become an important statistical issue. The commonly used averaging methods may not be suitable due to data nonhomogeneity and incomparable results among individual sites, and applying them may result in the loss of information obtained from the individual analyses. Using a sequential method in federated learning with distributed computing can facilitate the integration and accelerate the analysis process. We develop a data-driven method for efficiently and effectively aggregating valued information by analyzing local data without encountering potential issues such as information security and heavy transportation due to data communication. In addition, the proposed method can preserve the properties of classical sequential adaptive design, such as data-driven sample size and estimation precision when applied to generalized linear models. We use numerical studies of simulated data and an application to COVID-19 data collected from 32 hospitals in Mexico, to illustrate the proposed method.

    Comment: 22 pages
    Keywords Statistics - Machine Learning ; Computer Science - Machine Learning ; Statistics - Methodology ; 62L10 ; 62L12
    Subject code 310
    Publishing date 2023-01-31
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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