Article ; Online: Nanodisc-Based Proteomics Identify Caj1 as an Hsp40 with Affinity for Phosphatidic Acid Lipids.
2021 Volume 20, Issue 10, Page(s) 4831–4839
Abstract: Many soluble proteins interact with membranes to perform important biological functions, including signal transduction, regulation, transport, trafficking, and biogenesis. Despite their importance, these protein-membrane interactions are difficult to ... ...
Abstract | Many soluble proteins interact with membranes to perform important biological functions, including signal transduction, regulation, transport, trafficking, and biogenesis. Despite their importance, these protein-membrane interactions are difficult to characterize due to their often-transient nature as well as phospholipids' poor solubility in aqueous solution. Here, we employ nanodiscs-small, water-soluble patches of a lipid bilayer encircled with amphipathic scaffold proteins-along with quantitative proteomics to identify lipid-binding proteins in |
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MeSH term(s) | Calmodulin-Binding Proteins ; HSP40 Heat-Shock Proteins ; Lipid Bilayers ; Membrane Proteins ; Nanostructures ; Phosphatidic Acids ; Proteomics ; Saccharomyces cerevisiae Proteins |
Chemical Substances | CAJ1 protein, S cerevisiae ; Calmodulin-Binding Proteins ; HSP40 Heat-Shock Proteins ; Lipid Bilayers ; Membrane Proteins ; Phosphatidic Acids ; Saccharomyces cerevisiae Proteins |
Language | English |
Publishing date | 2021-09-14 |
Publishing country | United States |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 2078618-9 |
ISSN | 1535-3907 ; 1535-3893 |
ISSN (online) | 1535-3907 |
ISSN | 1535-3893 |
DOI | 10.1021/acs.jproteome.1c00503 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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