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  1. Article ; Online: Quantitation of Urine Nicotine, Cotinine, and 3-OH-Cotinine by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).

    Li, Wenbo / Zhang, Xiaochun Susan / Noguez, Jaime

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2737, Page(s) 337–345

    Abstract: Nicotine is a naturally occurring and highly addictive chemical used in e-cigarettes, cigarettes, chewing tobacco, and other tobacco products as well as in nicotine replacement therapies. The negative health consequences of using nicotine-containing ... ...

    Abstract Nicotine is a naturally occurring and highly addictive chemical used in e-cigarettes, cigarettes, chewing tobacco, and other tobacco products as well as in nicotine replacement therapies. The negative health consequences of using nicotine-containing products are well known. In fact, smoking remains the leading cause of preventable disease, disability, and death in the United States. Measurement of nicotine and its metabolites, cotinine and 3-OH-cotinine, offers an objective method to evaluate nicotine exposure and the associated health risks. In this chapter, we describe a quick and reliable isotope dilution LC-MS/MS method for the quantitation of these three compounds in 60 μL of human urine following a simple sample preparation procedure. Electrospray Ionization (ESI) in positive mode is used to introduce the analytes into the mass spectrometer and quantitation is achieved using Multiple Reaction Monitoring (MRM). The analytical measurable ranges for nicotine and cotinine are 10-2500 ng/mL and 20-5000 ng/mL for 3-OH-cotinine.
    MeSH term(s) Humans ; Nicotine ; Cotinine/urine ; Chromatography, Liquid/methods ; Tandem Mass Spectrometry/methods ; Smoking Cessation ; Electronic Nicotine Delivery Systems ; Tobacco Use Cessation Devices
    Chemical Substances Nicotine (6M3C89ZY6R) ; Cotinine (K5161X06LL)
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3541-4_31
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Positive Syphilis Serologies after Intravenous Immunoglobulin (IVIG) Treatment: A Diagnostic Confusion That Needs Emphasis.

    Yan, Mingfei / Zhang, Xiaochun Susan / Noguez, Jaime

    Clinical chemistry

    2023  Volume 69, Issue 12, Page(s) 1342–1346

    MeSH term(s) Humans ; Immunoglobulins, Intravenous/therapeutic use ; Syphilis/diagnosis ; Syphilis/drug therapy
    Chemical Substances Immunoglobulins, Intravenous
    Language English
    Publishing date 2023-11-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1093/clinchem/hvad160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.171: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: The humoral response to SARS-COV-2 vaccines in MS patients: A case series exploring the impact of DMT, lymphocyte count, immunoglobulins, and vaccine type.

    Jakubecz, Collin / Zhang, Xiaochun Susan / Woodson, Sophia / Serra, Alessandro / Abboud, Hesham

    Multiple sclerosis and related disorders

    2022  Volume 61, Page(s) 103785

    Abstract: Background & objectives: Certain disease modifying therapies may negatively impact the humoral response to SARS-CoV-2 vaccines. Many MS related clinical, demographic, and immunological characteristics can also affect vaccine response but those have not ... ...

    Abstract Background & objectives: Certain disease modifying therapies may negatively impact the humoral response to SARS-CoV-2 vaccines. Many MS related clinical, demographic, and immunological characteristics can also affect vaccine response but those have not been fully explored. This study aimed to investigate potential correlations between clinical, demographic, and immunological variables in MS patients to post-vaccination spike protein antibody positivity rates and levels.
    Methods: Patients with MS and related neuroimmunological disorders who requested verification of the immune response to the SARS-COV-2 vaccine were tested for the spike protein antibody from January to October 2021. We performed an exploratory analysis to compare patients with positive versus negative spike protein antibody.
    Results: Fifty patients (mean age 53 ±12, 78% females) were included. There were 29 patients with positive post-vaccination spike protein antibody (58%) and 21 with negative antibody (42%). Patients with negative antibody were more likely to have been on B-cell therapy (86% vs 31%, P=.001) while positive patients were more likely to have been on a fumarate (31% vs 4.8%, P=.03). Thirty percent of positive patients on fumarate therapy had mild lymphopenia. No differences existed between groups in gender, age, race, disease phenotype, vaccine brand, and lymphocyte counts. Among patients on B-cell therapy, 33% had a positive spike protein antibody. There was an association between detectable CD19 cells at time of vaccination and positive humoral response to vaccination (P=0.049). There was no relationship between subgroups in terms of vaccine timing relative to B-cell therapy dose. Hypogammaglobulinemia was not associated with seroconversion rates, however it was associated with decreased quantitative spike protein antibody levels (p=0.045).
    Discussion: B-cell therapy is associated with a negative humoral response to SARS-COV-2 vaccines. Patients on B-cell depleting therapy with detectable CD19 counts at the time of vaccination were associated with a positive humoral response. There was no relationship between hypogammaglobinemia and seroconversion rate, however it was associated with decreased spike protein antibody levels. The fumarates are associated with positive humoral response even in the presence of mild lymphopenia.
    MeSH term(s) Antibodies, Viral ; COVID-19/prevention & control ; COVID-19 Vaccines ; Female ; Fumarates ; Humans ; Lymphocyte Count ; Lymphopenia ; Male ; Multiple Sclerosis/drug therapy ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/therapeutic use ; Vaccination
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines ; Fumarates ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-03-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2645330-7
    ISSN 2211-0356 ; 2211-0348
    ISSN (online) 2211-0356
    ISSN 2211-0348
    DOI 10.1016/j.msard.2022.103785
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Discouraging Non-ELISA antiphospholipid antibody assays in antiphospholipid syndrome classification may hinder clinical research.

    Zhang, Xiaochun Susan / Bizzaro, Nicola / Tebo, Anne E / Nandakumar, Vijayalakshmi / Infantino, Maria / Carbone, Teresa / Bossuyt, Xavier / Damoiseaux, Jan

    Immunologic research

    2023  

    Language English
    Publishing date 2023-12-12
    Publishing country United States
    Document type Letter
    ZDB-ID 632857-x
    ISSN 1559-0755 ; 0257-277X
    ISSN (online) 1559-0755
    ISSN 0257-277X
    DOI 10.1007/s12026-023-09443-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1755: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Pediatric Case of Severe COVID-19 With Shock and Multisystem Inflammation.

    Nguyen, David C / Haydar, Hanan / Pace, Elizabeth R / Zhang, Xiaochun Susan / Dobbs, Katherine R

    Cureus

    2020  Volume 12, Issue 6, Page(s) e8915

    Abstract: While the majority of pediatric coronavirus disease 2019 (COVID-19) cases have not been critical, occurrences of a multisystem inflammatory syndrome in children (MIS-C) have been emerging as the pandemic progresses. Herein, we report our experience with ... ...

    Abstract While the majority of pediatric coronavirus disease 2019 (COVID-19) cases have not been critical, occurrences of a multisystem inflammatory syndrome in children (MIS-C) have been emerging as the pandemic progresses. Herein, we report our experience with a pediatric COVID-19 case that presented with shock and multisystem inflammation. Our patient notably had multiple negative severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription polymerase chain reaction (RT-PCR) assays but tested positive for SARS-CoV-2 IgG antibody. This case not only highlights the utility of SARS-CoV-2 IgG in the diagnosis of COVID-19 when RT-PCR is negative but suggests MIS-C may be a post-infectious immune-mediated process.
    Keywords covid19
    Language English
    Publishing date 2020-06-29
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.8915
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Pediatric Case of Severe COVID-19 With Shock and Multisystem Inflammation

    Nguyen, David C. / Haydar, Hanan / Pace, Elizabeth R. / Zhang, Xiaochun Susan / Dobbs, Katherine R.

    Cureus

    Abstract: While the majority of pediatric coronavirus disease 2019 (COVID-19) cases have not been critical, occurrences of a multisystem inflammatory syndrome in children (MIS-C) have been emerging as the pandemic progresses Herein, we report our experience with a ...

    Abstract While the majority of pediatric coronavirus disease 2019 (COVID-19) cases have not been critical, occurrences of a multisystem inflammatory syndrome in children (MIS-C) have been emerging as the pandemic progresses Herein, we report our experience with a pediatric COVID-19 case that presented with shock and multisystem inflammation Our patient notably had multiple negative severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription polymerase chain reaction (RT-PCR) assays but tested positive for SARS-CoV-2 IgG antibody This case not only highlights the utility of SARS-CoV-2 IgG in the diagnosis of COVID-19 when RT-PCR is negative but suggests MIS-C may be a post-infectious immune-mediated process
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #693652
    Database COVID19

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