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Article: Pulmonary infection with

Wang, Chaoyang / Wei, Nan / Zhang, Moyuan / Zhang, Xiaoju

2024 Volume 11, Page(s) 1357714

Abstract: Background: Aeromonas dhakensis: Case presentation: A patient with acute T lymphoblastic leukemia experienced myelosuppression after chemotherapy, developed a secondary pulmonary infection with : Discussion: Among pulmonary infectious pathogens, ...

Abstract	Background: Aeromonas dhakensis Case presentation: A patient with acute T lymphoblastic leukemia experienced myelosuppression after chemotherapy, developed a secondary pulmonary infection with Discussion: Among pulmonary infectious pathogens,
Language	English
Publishing date	2024-04-17
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2024.1357714
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Article ; Online: Study on the Track and Degree of Pb Content Transportation

Yang Dongfang / Zhang Xiaoju / Manickam Sivakumar

E3S Web of Conferences, Vol 406, p

2023 Volume 02023

Abstract: Heavy Pb pollution has been noted in many developed countries. This study examined Pb pollution in Jiaozhou Bay for human security. We used the survey data on the Jiaozhou Bay waters of May, September and October 1994, the results examines Pb content and ...

Abstract	Heavy Pb pollution has been noted in many developed countries. This study examined Pb pollution in Jiaozhou Bay for human security. We used the survey data on the Jiaozhou Bay waters of May, September and October 1994, the results examines Pb content and its horizontal distribution in the surface water bodies, which showed that the in the waters of Jiaozhou Bay Pb content expresses the range of 0.12-2.48 μg/L, agreeing with the seawater standards of Class I and II. Moreover, it has been noted that by the view of Pb content, Pb content in May, September and October polluted the Jiaozhou Bay water bodies softly. In May, September and October, the Pb content in the waters of Jiaozhou Bay ranged from 0.12 to 1μg/L, 0.84 to 1.34 μg/L, and 0.92 to 2.48 μg/L. These results show that Pb content in May did not pollute the Jiaozhou Bay water bodies. While Pb content during September and October slightly polluted. Three sources transported mainly Pb content into Jiaozhou bay. These sources are rivers, land surface runoff and offshore ocean currents. The rivers transported the Pb content 0.47-2.48 μg/L, the land surface runoff 2μg/L and the offshore ocean currents 1.34 μg/L. It demonstrates that Pb slightly polluted rivers, land surface runoff and offshore ocean currents in the transportation of Pb. From May to October, rivers transported Pb content which varied significantly. In September, land surface runoff transported Pb content during the rainy season. In addition, the offshore currents also transported Pb content to the waters of Jiaozhou Bay. Human activities discharged Pb content to land and transported it to the ocean, relying on the land surface runoff and rivers. Thus, two channels were transporting Pb content on land to the ocean, increasing Pb content. Through ocean currents, Pb content was transported from the high-content water area to the low-content water area. Therefore, the Pb content transported by rivers and land surface runoff could raise concerns from humans.
Keywords	Environmental sciences ; GE1-350
Subject code	551
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
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Article ; Online: Influence of Human Activity on Hg Transportation

Yang Dongfang / Manickam Sivakumar / Zhang Xiaoju

E3S Web of Conferences, Vol 406, p

2023 Volume 04029

Abstract: Hg pollutes the environment, living organisms, and humans; hence, studying Hg content is essential for human health security. Using the dataset in May, September, and October, the Hg content, horizontal distribution, sources and transportation paths in ... ...

Abstract	Hg pollutes the environment, living organisms, and humans; hence, studying Hg content is essential for human health security. Using the dataset in May, September, and October, the Hg content, horizontal distribution, sources and transportation paths in the waters of Jiaozhou Bay were easily determined. These results indicate that the Hg content changing range in the waters in May, September and October was 0.015-0.150 μg/L, corresponding to the national seawater quality standards of Class I and Class II. The Hg content in the water body mainly arises from two sources, the transportation of rivers and offshore ocean currents. It from rivers' offshore ocean currents was 0.019-0.150 μg/L and 0.020 μg/L, respectively. Among them, the transportation of rivers includes the transportation of Haibo River, Licun River and Loushan River. So, a model block diagram has been built to unveil Hg contents and its different paths during the transportation to Jiaozhou Bay. Thus, it becomes easy to quantitively determine the migration process of Hg content through human activities to the ocean and rivers. Hg's different paths and contents reveal four rules for entering Jiaozhou Bay. In May, the offshore ocean currents and Haibo River did not affect by Hg pollution. In September, the Laoshan River was not polluted by it. In October, the Licun River was not, while the Haibo River exhibited light Hg pollution. When the Hg content transported by rivers was relatively low, it by offshore ocean currents became visible. From May to October, three rivers were transporting Hg content. Hg mildly polluted only one river in October, depicting that human activity is a key concern for environmental protection. It discharged by humans to land was relatively low, meanwhile only once was river transportation slightly polluted by it.
Keywords	Environmental sciences ; GE1-350
Subject code	910
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
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Article ; Online: The XPO1 inhibitor selinexor ameliorates bleomycin-induced pulmonary fibrosis in mice via GBP5/NLRP3 inflammasome signaling.

Zhang, Jia / Zhang, Yihua / Chen, Qi / Qi, Yong / Zhang, Xiaoju

International immunopharmacology

2024 Volume 130, Page(s) 111734

Abstract: Pulmonary fibrosis is an irreversible and progressive lung disease with limited treatments available. Selinexor (Sel), an orally available, small-molecule, selective inhibitor of XPO1, exhibits notable antitumor, anti-inflammatory and antiviral ... ...

Abstract	Pulmonary fibrosis is an irreversible and progressive lung disease with limited treatments available. Selinexor (Sel), an orally available, small-molecule, selective inhibitor of XPO1, exhibits notable antitumor, anti-inflammatory and antiviral activities. However, its potential role in treating pulmonary fibrosis is unknown. C57BL/6J mice were used to establish a pulmonary fibrosis model by intratracheal administration of bleomycin (BLM). Subsequently, Sel was administered intraperitoneally. Our data demonstrated that Sel administration ameliorated BLM-induced pulmonary fibrosis by increasing mouse body weights; reducing H&E staining, Masson staining scores, and shadows in mouse lung computed tomography (CT) images, decreasing the total cell and neutrophil counts in the lung and bronchoalveolar lavage fluid (BALF); and decreasing the levels of TGF-β1. We next confirmed that Sel reduced the deposition of extracellular matrix (ECM) components in the lungs of BLM-induced pulmonary fibrosis mice. We showed that collagen I, alpha-smooth muscle actin (α-SMA), and hydroxyproline levels and the mRNA levels of Col1a1, Eln, Fn1, Ctgf, and Fgf2 were reduced. Mechanistically, tandem mass tags (TMT)- based quantitative proteomics analysis revealed a significant increase in GBP5 in the lungs of BLM mice but a decrease in that of BLM + Sel mice; this phenomenon was confirmed by western blotting and RT-qPCR. NLRP3 inflammasome signaling was significantly enriched in both the BLM group and BLM + Sel group based on GO and KEGG analyses of differentially expressed proteins between the groups. Furthermore, Sel reduced the expression of NLRP3, cleaved caspase 1, and ASC in vivo and in vitro, and decreased the levels of IL-1β, IL-18, and IFN-r in lung tissue and BALF. SiRNA-GBP5 inhibited NLRP3 signaling in vitro, and overexpression of GBP5 inhibited the protective effect of Sel against BLM-induced cellular injury. Taken together, our findings indicate that Sel ameliorates BLM-induced pulmonary fibrosis by targeting GBP5 via NLRP3 inflammasome signaling. Thus, the XPO1 inhibitor - Sel might be a potential therapeutic agent for pulmonary fibrosis.
MeSH term(s)	Mice ; Animals ; Pulmonary Fibrosis/chemically induced ; Pulmonary Fibrosis/drug therapy ; Pulmonary Fibrosis/metabolism ; Inflammasomes/metabolism ; Bleomycin/adverse effects ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Mice, Inbred C57BL ; Lung/pathology ; Hydrazines ; Triazoles
Chemical Substances	Inflammasomes ; Bleomycin (11056-06-7) ; selinexor (31TZ62FO8F) ; NLR Family, Pyrin Domain-Containing 3 Protein ; Hydrazines ; Triazoles
Language	English
Publishing date	2024-02-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2024.111734
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Article: HMMR potential as a diagnostic and prognostic biomarker of cancer-speculation based on a pan-cancer analysis.

Shang, Junyi / Zhang, Xiaoju / Hou, Guangjie / Qi, Yong

Frontiers in surgery

2023 Volume 9, Page(s) 998598

Abstract: Background: Although the status of universal upregulation for the Hyaluronan-Mediated Motility Receptor (HMMR) in pan-cancer is still unknown, HMMR is upregulated and associated with poor prognosis for some tumors.: Methods: Exploring HMMR expression ...

Abstract	Background: Although the status of universal upregulation for the Hyaluronan-Mediated Motility Receptor (HMMR) in pan-cancer is still unknown, HMMR is upregulated and associated with poor prognosis for some tumors. Methods: Exploring HMMR expression in different tumor types using The Cancer Genome Atlas (TCGA) or other public databases for a pan-cancer analysis, exploring the relationship between HMMR and tumor prognosis, and exploring the role of HMMR in tumor immunity. Results: No matter the pairing or unpairing of data, HMMR expression generally increased compared to corresponding normal tissue. Based on a CCLE study, our results indicated that HMMR is widely expressed in various tumor cells. For most tumor types, high HMMR expression was associated with reduced Overall Survival (OS), Return to Functional Status (RFS), and Platinum Free Interval (PFI). ROC curves indicated that HMMR displays high prediction potential for most tumor types. In pan-cancer, HMMR is correlated with some clinical staging, immune cells, and immune checkpoints for some tumors. The GO/KEGG enrichment analysis results for proteins most closely related to HMMR indicate that the most highly enriched pathways are all related to tumor development. Conclusions: Our pan-cancer analysis of HMMR suggests that HMMR can be used as a potential diagnostic and prognostic indicator of pan-cancer and that HMMR may be involved in tumor development.
Language	English
Publishing date	2023-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2022.998598
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Article ; Online: Prognostic and onco-immunological value of immune-related eRNAs-driven genes in lung adenocarcinoma.

Wu, Xuan / Zhao, Xingru / Zhou, Chao / Wei, Nan / Xu, Zhiwei / Zhang, Xiaoju

Journal of cancer research and clinical oncology

2024 Volume 150, Issue 4, Page(s) 188

Abstract: Background: We aimed to comprehensively analyze the clinical value of immune-related eRNAs-driven genes in lung adenocarcinoma (LUAD) and find the potential biomarkers for prognosis and therapeutic response to improve the survival of this malignant ... ...

Abstract	Background: We aimed to comprehensively analyze the clinical value of immune-related eRNAs-driven genes in lung adenocarcinoma (LUAD) and find the potential biomarkers for prognosis and therapeutic response to improve the survival of this malignant disease. Materials and methods: Pearson's correlation analysis was performed to identify the immune-related eRNAs-driven genes. Cox regression and least absolute shrinkage and selection operator (LASSO) analyses were used to construct this prognostic risk signature. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were used to investigate the underlying molecular mechanism. The single sample gene set enrichment analysis (ssGSEA) algorithm was conducted to evaluate the immune status based on the signature. The quantitative real-time PCR (qRT-PCR) analysis was performed to evaluate the expression value of the signature genes between LUAD tissues and adjacent lung tissues. Results: Five immune-related eRNAs-driven genes (SHC1, GDF10, CCL14, FYN, and NOD1) were identified to construct a prognostic risk signature with favorable predictive capacity. The patients with high-risk scores based on the signature were significantly associated with the malignant clinical features compared with those with low-risk scores. Kaplan-Meier analysis demonstrated that the sample in the low-risk group had a prolonged survival compared with those in the high-risk group. This risk signature was validated to have a promising predictive capacity and reliability in diverse clinical situations and independent cohorts. The functional enrichment analysis demonstrated that humoral immune response and intestinal immune network for IgA production pathway might be the underlying molecular mechanism related to the signature. The proportion of the vast majority of immune infiltrating cells in the high-risk group was significantly lower than that in the low-risk group, and the immunotherapy response rate in the low-risk group was significantly higher than that in the high-risk group. Moreover, BI-2536, sepantronium bromide, and ULK1 were the potential drugs for the treatment of patients with higher risk scores. Finally, the experiment in vivo and database analysis indicated that CCL14, FYN, NOD1, and GDF10 are the potential LUAD suppressor and SHC1 is a potential treatment target for LUAD. Conclusion: Above all, we constructed a prognostic risk signature with favorable predictive capacity in LUAD, which was significantly associated with malignant features, immunosuppressive tumor microenvironment, and immunotherapy response and may provide clinical benefit in clinical decisions.
MeSH term(s)	Humans ; Prognosis ; Enhancer RNAs ; Reproducibility of Results ; Adenocarcinoma of Lung/genetics ; Lung Neoplasms/genetics ; Tumor Microenvironment
Chemical Substances	Enhancer RNAs
Language	English
Publishing date	2024-04-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-024-05687-5
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Article ; Online: CD146 Promotes EMT-Mediated Migration and Invasion of NSCLC via PI3K/Akt Signaling Pathway.

Wei, Nan / Wu, Xuan / Yu, Yi / Zhou, Huanhuan / Cui, Kai / Zhao, Xingru / Zhang, Xiaoju

Frontiers in bioscience (Landmark edition)

2024 Volume 29, Issue 4, Page(s) 140

Abstract: Background: Recurrence and metastasis are the main causes of non-small cell lung cancer (NSCLC)-related death. CD146 has been identified as a potential risk factor for poor prognosis, closely related to the distant metastasis and drug resistance in ... ...

Abstract	Background: Recurrence and metastasis are the main causes of non-small cell lung cancer (NSCLC)-related death. CD146 has been identified as a potential risk factor for poor prognosis, closely related to the distant metastasis and drug resistance in various cancers. However, the clinical significance of CD146 in NSCLC requires further investigation. Materials and methods: This study explored the correlation between CD146 expression and clinical variables using tumor tissue samples collected from our hospital. CD146 expression levels in NSCLC cell lines and tissues were assessed and compared using immunohistochemistry, real-time polymerase chain reaction (RT-qPCR), flow cytometry, and western blot analysis. The invasion and migration capabilities of tumor cells were determined using transwell and wound healing assays. The levels of proteins related to epithelial-mesenchymal transition (EMT) as well as the underlying PI3K/Akt signaling pathway was measured by western blotting. Results: We discovered that CD146 expression is significantly associated with the EMT signaling pathway. High CD146 expression predicted lymph node metastasis, metastasis to distant organs, advanced Tumor, Node, Metastasis (TNM) staging, and poor survival in NSCLC patients. Wound healing and transwell assays showed that knocking down CD146 significantly suppressed cell migration along with cell invasion in NSCLC, whereas overexpressing CD146 notably enhanced these processes. Western blot analysis revealed significantly reduced levels of N-cadherin, vimentin, snail, twist, PI3K, and AKT phosphorylation in shCD146 H460 cells compared to vector control cells. Treatment with PI3K inhibitor PI3K-IN-1 increased E-cadherin expression levels but reduced N-cadherin, Twist, Vimentin, PI3K, and AKT phosphorylation levels in pcDNA3.1-CD146 A549 cells compared with the vector control cells. Conclusions: CD146 expression acts as a prognostic risk factor for adverse outcomes in NSCLC, promoting invasion and metastasis by activating the EMT through the PI3K/Akt signaling pathway. These findings underscore the potential therapeutic strategies targeting CD146, offering new treatment options for NSCLC patients, especially those at risk of metastasis.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Epithelial-Mesenchymal Transition/genetics ; CD146 Antigen/metabolism ; CD146 Antigen/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Cell Movement/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Signal Transduction ; Male ; Female ; Middle Aged ; Neoplasm Invasiveness ; Cell Line, Tumor ; A549 Cells
Chemical Substances	CD146 Antigen ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; MCAM protein, human
Language	English
Publishing date	2024-04-29
Publishing country	Singapore
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2704569-9
ISSN	2768-6698 ; 2768-6698
ISSN (online)	2768-6698
ISSN	2768-6698
DOI	10.31083/j.fbl2904140
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Article: Metagenomic next-generation sequencing in the diagnose of pulmonary infection with airway complications in a lung transplant recipient.

Liu, Hongmei / Xu, Huan / Liu, Hui / Zhao, Zhigang / Zhang, Xiaoju

Heliyon

2023 Volume 9, Issue 9, Page(s) e19611

Abstract: We reported a case of a 60-year-old male with fever, cough, expectoration, and chest distress after right lung transplanted. Blood examination showed elevated C-reaction protein (CRP), white blood cell (WBC), and ammonia. Computed tomography (CT) ... ...

Abstract	We reported a case of a 60-year-old male with fever, cough, expectoration, and chest distress after right lung transplanted. Blood examination showed elevated C-reaction protein (CRP), white blood cell (WBC), and ammonia. Computed tomography (CT) revealed patchy high-density shadows and few pleural effusions in the transplanted lung. Bronchoscopy illustrated anastomotic fistula, and pseudomembrane and mucus plugs around the right main bronchial anastomosis. Carbapenem-resistant
Language	English
Publishing date	2023-08-29
Publishing country	England
Document type	Case Reports
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e19611
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Article: Preventing lower limb lymphedema after pelvic lymphadenectomy with progressive resistance exercise training: A randomized controlled trial.

Zhang, Jiajia / Zhou, Changming / Ma, Qin / Zhang, Yi / Zhang, Xiaoju

Asia-Pacific journal of oncology nursing

2023 Volume 11, Issue 1, Page(s) 100333

Abstract: Objective: This study aimed to assess the efficacy of a self-designed progressive resistance exercise training program for preventing the development of lower limb lymphedema.: Methods: An open-label randomized controlled trial was conducted in ... ...

Abstract	Objective: This study aimed to assess the efficacy of a self-designed progressive resistance exercise training program for preventing the development of lower limb lymphedema. Methods: An open-label randomized controlled trial was conducted in patients who underwent radical surgery for cervical cancer treatment in our department between October 7, 2019, and October 7, 2021. The participants were randomly assigned to one of three groups: progressive resistance exercise training, graduated compression stocking, and control group. Results: A total of 267 patients were enrolled (89 in each group). The incidence of lower limb lymphedema was 9.0% ( Conclusions: Progressive resistance exercise training is an effective strategy for preventing lower limb lymphedema after pelvic lymphadenectomy for cervical cancer. It imposes no additional economic burden and can be performed conveniently without the need for dedicated exercise facilities. This makes it particularly accessible to patients in developing countries, allowing them to exercise at their convenience. Trial registration: ChiCTR1800014905.
Language	English
Publishing date	2023-11-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2984639-0
ISSN	2349-6673 ; 2347-5625
ISSN (online)	2349-6673
ISSN	2347-5625
DOI	10.1016/j.apjon.2023.100333
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Article ; Online: Criteria for lung cancer screening and standardized management in China.

Wang, Qi / Zhang, Xiaoju / Yang, Dawei / Bai, Li / Bai, Chunxue

Chinese medical journal

2023 Volume 136, Issue 14, Page(s) 1639–1641

MeSH term(s)	Humans ; Lung Neoplasms/diagnosis ; Early Detection of Cancer ; China ; Mass Screening
Language	English
Publishing date	2023-06-02
Publishing country	China
Document type	Journal Article
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000002733
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