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Article ; Online: Image denoising and segmentation model construction based on IWOA-PCNN.

Zhang, Xiaojun

2023 Volume 13, Issue 1, Page(s) 19848

Abstract: The research suggests a method to improve the present pulse coupled neural network (PCNN), which has a complex structure and unsatisfactory performance in image denoising and image segmentation. Then, a multi strategy collaborative improvement whale ... ...

Abstract	The research suggests a method to improve the present pulse coupled neural network (PCNN), which has a complex structure and unsatisfactory performance in image denoising and image segmentation. Then, a multi strategy collaborative improvement whale optimization algorithm (WOA) is proposed, and an improved whale optimization algorithm (IWOA) is constructed. IWOA is used to find the optimal parameter values of PCNN to optimize PCNN. By combining the aforementioned components, the IWOA-PCNN model had the best image denoising performance, and the produced images were crisper and preserve more information. IWOA-PCNN processed pictures have an average PSNR of 35.87 and an average MSE of 0.24. The average processing time for photos with noise is typically 24.80 s, which is 7.30 s and 7.76 s faster than the WTGAN and IGA-NLM models, respectively. Additionally, the average NU value measures 0.947, and the average D value exceeds 1000. The aforementioned findings demonstrate that the suggested method can successfully enhance the PCNN, improving its capability for image denoising and image segmentation. This can, in part, encourage the use and advancement of the PCNN.
Language	English
Publishing date	2023-11-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-47089-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Significant Tumor Reduction With Traditional Chinese Medicine in a Patient With Advanced Prostate Cancer: A Case Report.

Zhang, Xiaojun

American journal of men's health

2022 Volume 16, Issue 5, Page(s) 15579883221130854

Abstract: Prostate cancer (PC) is the most common malignancy of the male genitourinary system. For patients with advanced progressive PC, the treatment strategies include second-line endocrine therapy, chemotherapy, and immunotherapy. Such therapeutic techniques ... ...

Abstract	Prostate cancer (PC) is the most common malignancy of the male genitourinary system. For patients with advanced progressive PC, the treatment strategies include second-line endocrine therapy, chemotherapy, and immunotherapy. Such therapeutic techniques are either too expensive or too toxic for some patients, and traditional Chinese medicine (TCM) has become an alternative for its low cost and low toxicity. The application of Shi-pi-san and Gui-zhi-Fu-ling-wan in PC has never been reported. We report their application on a 71-year-old male patient, who was diagnosed with PC and was undergoing endocrine therapy. He originally chose chemotherapy, and experienced acute renal failure, which required hemodialysis during hospitalization. He felt weak and opted for Chinese herbal medicine treatment. After treatment with Shi-pi-san and Gui-zhi-Fu-ling-wan, the patient's tumor and other symptoms were significantly reduced, and he reported feeling "refreshed." This case indicates that TCM treatment has unique advantages and is more tolerable than endocrine therapy and chemotherapy. Considering that the patient was undergoing hemodialysis treatment and using low-molecular-weight heparin (LMWH) to prevent blood coagulation while taking TCM, whether LMWH has a synergistic anticancer effect remains to be explored.
MeSH term(s)	Humans ; Male ; Aged ; Medicine, Chinese Traditional ; Heparin, Low-Molecular-Weight ; Prostatic Neoplasms/drug therapy
Chemical Substances	Heparin, Low-Molecular-Weight
Language	English
Publishing date	2022-10-31
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2275106-3
ISSN	1557-9891 ; 1557-9883
ISSN (online)	1557-9891
ISSN	1557-9883
DOI	10.1177/15579883221130854
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Article: Role of middle managers in dealing with hierarchy and network logics: exploration in the context of Sino-Foreign Cooperative University.

Li, Jiaxin / Zhang, Xiaojun

Frontiers in psychology

2024 Volume 15, Page(s) 1328675

Abstract: While organizations tend to introduce network mechanism to activate the potential of members in the hierarchical dominated context, it is not clear how individual members deal with the complexity caused by two logics of hierarchy and network. To address ... ...

Abstract	While organizations tend to introduce network mechanism to activate the potential of members in the hierarchical dominated context, it is not clear how individual members deal with the complexity caused by two logics of hierarchy and network. To address this gap, this study focuses on the role of middle managers in collaborating with others in the multiple-logic complexity. We identify three types of collaboration scenarios, top-down, bottom-up, and horizontal, through 27 semi-structured interviews within a Sino-Foreign Cooperative University from 2021 to 2023. Guided by the grounded theory approach, we conceptualize the composite role of middle managers as the translucent hand of explicit and implicit connections, which help us to interpret middle managers' tangibly and intangibly impact under a hybrid organization context. The empirical results also reveal that the boundary perception of authority and responsibility as an important factor determines middle managers' awareness of power involvement in cooperation. The findings extend the understanding of middle managers in network organizations in the higher education context and provide suggestions for the dynamic role of middle managers and hybrid university management in the information age.
Language	English
Publishing date	2024-02-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2024.1328675
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Article ; Online: Crbn-based molecular Glues: Breakthroughs and perspectives.

An, Juzeng / Zhang, Xiaojun

Bioorganic & medicinal chemistry

2024 Volume 104, Page(s) 117683

Abstract: CRBN is a substrate receptor for the Cullin Ring E3 ubiquitin ligase 4 (CRL4) complex. It has been observed that CRBN can be exploited by small molecules to facilitate the recruitment and ubiquitination of non-natural CRL4 substrates, resulting in the ... ...

Abstract	CRBN is a substrate receptor for the Cullin Ring E3 ubiquitin ligase 4 (CRL4) complex. It has been observed that CRBN can be exploited by small molecules to facilitate the recruitment and ubiquitination of non-natural CRL4 substrates, resulting in the degradation of neosubstrate through the ubiquitin-proteasome system. This phenomenon, known as molecular glue-induced protein degradation, has emerged as an innovative therapeutic approach in contrast to traditional small-molecule drugs. One key advantage of molecular glues, in comparison to conventional small-molecule drugs adhering to Lipinski's Rule of Five, is their ability to operate without the necessity for specific binding pockets on target proteins. This unique characteristic empowers molecular glues to interact with conventionally intractable protein targets, such as transcription factors and scaffold proteins. The ability to induce the degradation of these previously elusive targets by hijacking the ubiquitin-proteasome system presents a promising avenue for the treatment of recalcitrant diseases. Nevertheless, the rational design of molecular glues remains a formidable challenge due to the limited understanding of their mechanisms and actions. This review offers an overview of recent advances and breakthroughs in the field of CRBN-based molecular glues, while also exploring the prospects for a systematic approach to designing these compounds.
MeSH term(s)	Proteasome Endopeptidase Complex/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination ; Proteolysis ; Ubiquitin/metabolism
Chemical Substances	Proteasome Endopeptidase Complex (EC 3.4.25.1) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Ubiquitin
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2024.117683
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Article ; Online: Size specific dose estimation in pediatric CT: preliminary study and conversion factors.

Zhang, Jian / Zhang, Xiaojun

Radiation protection dosimetry

2024

Abstract: The objective of this paper is to compare the differences between volumetric CT dose index (CTDIVOL) and size-specific dose estimate (SSDEWED) based on water equivalent diameter (WED) in radiation dose measurement, and explore a new method for fast ... ...

Abstract	The objective of this paper is to compare the differences between volumetric CT dose index (CTDIVOL) and size-specific dose estimate (SSDEWED) based on water equivalent diameter (WED) in radiation dose measurement, and explore a new method for fast calculation of SSDEWED. The imaging data of 1238 cases of head, 1152 cases of chest and 976 cases of abdominopelvic were analyzed retrospectively, and they were divided into five age groups: ≤ 0.5, 0.5 ~ ≤ 1, 1 ~ ≤ 5, 5 ~ ≤ 10 and 10 ~ ≤ 15 years according to age. The area of interest (AR), CT value (CTR), lateral diameter (LAT) and anteroposterior diameter (AP) of the median cross-sectional image of the standard scanning range and the SSDEWED were manually calculated, and a t-test was used to compare the differences between CTDIVOL and SSDEWED in different age groups. Pearson analyzed the correlations between DE and age, DE and WED, f and age, and counted the means of conversion factors in each age group, and analyze the error ratios between SSDE calculated based on the mean age group conversion factors and actual measured SSDE. The CTDIVOL in head was (9.41 ± 1.42) mGy and the SSDEWED was (8.25 ± 0.70) mGy: the difference was statistically significant (t = 55.04, P < 0.001); the CTDIVOL of chest was (2.68 ± 0.91) mGy and the SSDEWED was (5.16 ± 1.16) mGy, with a statistically significant difference (t = -218.78, P < 0.001); the CTDIVOL of abdominopelvic was (3.09 ± 1.58) mGy and the SSDEWED was (5.89 ± 2.19) mGy: the difference was also statistically significant (t = -112.28, P < 0.001). The CTDIVOL was larger than the SSDEWED in the head except for the ≤ 0.5 year subgroup, and CTDIVOL was smaller than SSDEWED within each subgroup in chest and abdominopelvic. There were strong negative correlations between f and age (head: r = -0.81; chest: r = -0.89; abdominopelvic: r = -0.86; P < 0.001). The mean values of f at each examination region were 0.81 ~ 1.01 for head, 1.65 ~ 2.34 for chest and 1.71 ~ 2.35 for abdominopelvic region. The SSDEWED could be accurately estimated using the mean f of each age subgroup. SSDEWED can more accurately measure the radiation dose of children. For children of different ages and examination regions, the SSDEWED conversion factors based on age subgroup can be quickly adjusted and improve the accuracy of radiation dose estimation.
Language	English
Publishing date	2024-04-27
Publishing country	England
Document type	Journal Article
ZDB-ID	225912-6
ISSN	1742-3406 ; 0144-8420
ISSN (online)	1742-3406
ISSN	0144-8420
DOI	10.1093/rpd/ncae104
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Article: In the uncharted water: Meaning-making capacity and identity negotiation of Chinese lesbian and bisexual women.

Hang, Yang / Zhang, Xiaojun

Frontiers in psychology

2023 Volume 14, Page(s) 1147119

Abstract: Chinese lesbian and bisexual women (LBW) often face difficulties and challenges on campus due to their multiple, socially-oppressed identities. These students have to navigate through uncharted environments to make meaning of their identities. In this ... ...

Abstract	Chinese lesbian and bisexual women (LBW) often face difficulties and challenges on campus due to their multiple, socially-oppressed identities. These students have to navigate through uncharted environments to make meaning of their identities. In this qualitative study, by considering four environmental systems of student life, including the student club (microsystem), the university (mesosystem), families (exosystem), and society (macrosystem), we aim to explore what identity negotiation Chinese LBW students have in them and what their meaning-making capacity influence that identity negotiation. We find students experience identity security in the microsystem, identity differentiation-inclusion or inclusion in the mesosystem, and identity unpredictability-predictability or predictability in the exosystem and macrosystem. Moreover, they employ foundational, transitional (formulaic to foundational or symphonic), or symphonic meaning-making capacity to influence their identity negotiation. Suggestions are made for the university to create an inclusive climate accommodating students with different identities.
Language	English
Publishing date	2023-04-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1147119
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Article: Combining differentiating and integrating over time to sustain multiple institutional logics: a case study of a higher education institution.

Jiang, Ye / Zhang, Xiaojun

Frontiers in psychology

2023 Volume 14, Page(s) 1218569

Abstract: To understand how organizations adopt varying configurations of differentiating (i.e., compartmentalizing logics into different subunits or roles) and integrating (i.e., combining logics to highlight synergies) over time to navigate logic contestations ... ...

Abstract	To understand how organizations adopt varying configurations of differentiating (i.e., compartmentalizing logics into different subunits or roles) and integrating (i.e., combining logics to highlight synergies) over time to navigate logic contestations and extract logic complementarities for organizational innovation, we conduct a 15-year in-depth longitudinal case study of a higher education institution to examine how it devised innovative hybrid practices to manage and support college student development. By employing the grounded theory method, we develop a four-stage process model of the varying configurations of differentiating and integrating that expounds on how two contested logics are sustained and exploited over time. We assert that selective bridging
Language	English
Publishing date	2023-08-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1218569
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Article ; Online: A rare case of fetal retroperitoneal solid mature teratoma.

Zhang, Xiaojun / Ning, Junjie

Asian journal of surgery

2023 Volume 46, Issue 11, Page(s) 4776–4777

Abstract: article's main point: This article retrospectively analyzes clinical data from a rare case of fetal retroperitoneal solid, mature teratoma, aiming to provide insights into diagnosing and treating fetal teratomas. This case of fetal retroperitoneal ... ...

Abstract	article's main point: This article retrospectively analyzes clinical data from a rare case of fetal retroperitoneal solid, mature teratoma, aiming to provide insights into diagnosing and treating fetal teratomas. This case of fetal retroperitoneal teratoma provides the following insights into diagnosis and treatment: 1) Due to the special nature of the retroperitoneal space, retroperitoneal tumours grow hidden, especially in fetal retroperitoneal tumours that are even more difficult to detect. Prenatal ultrasound screening is of great value for the diagnosis of this disease. 2) Although ultrasound can determine the location and blood flow of the tumour and monitor changes in its size and composition, there is a certain degree of misdiagnosis due to fetal position, clinical experience, and imaging resolution. When necessary, fetal MRI can provide further evidence for prenatal diagnosis. 3) Although fetal retroperitoneal teratoma is rare, a few tumours grow rapidly and have the potential for malignant transformation. When a solid cystic mass lesion in the retroperitoneal space is found during the fetal period, this disease should be considered as one of the differential diagnoses and distinguished from fetal renal tumours, adrenal tumours, pancreatic cysts, meconium peritonitis, parasitic fetus, and lymphangioma, among others. 4) Based on the situation of the pregnant woman, fetus, and tumour, the time and method of termination of pregnancy should be decided. After birth, the timing and manner of surgery and postoperative follow-up should be determined by neonatology and pediatric surgery.
MeSH term(s)	Female ; Child ; Humans ; Infant, Newborn ; Pregnancy ; Retroperitoneal Space/pathology ; Retroperitoneal Neoplasms/pathology ; Retrospective Studies ; Teratoma/diagnosis ; Teratoma/pathology ; Teratoma/surgery ; Fetus/pathology ; Magnetic Resonance Imaging
Language	English
Publishing date	2023-05-17
Publishing country	Netherlands
Document type	Case Reports ; Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2023.05.016
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Article ; Online: Electroluminescent Clusters.

Zhang, Xiaojun / Xu, Hui

Angewandte Chemie (International ed. in English)

2023 Volume 63, Issue 10, Page(s) e202317597

Abstract: Optoelectronic cluster materials emerge rapidly in recent years especially for light-emitting devices, owing to their 100 % exciton harvesting and unique organic-inorganic hybrid structures with tunable excited-state characteristics for thermally ... ...

Abstract	Optoelectronic cluster materials emerge rapidly in recent years especially for light-emitting devices, owing to their 100 % exciton harvesting and unique organic-inorganic hybrid structures with tunable excited-state characteristics for thermally activated delayed fluorescence and/or phosphorescence and inheritable photo- and thermo-stability. However, for efficient electroluminescence, excited-state compositions of cluster emitters should be tuned through ligand engineering to enhance ligand-centered radiative components and reduce cluster-centered quenching states. Nonetheless, the balance of optoelectronic properties requires delicate and controllable ligand functionalization. On the other hand, in addition to balancing carrier fluxes, it showed that device engineering, especially host matrixes and interfacial optimization, can not only alleviate triplet quenching, but also modify processing and passivate defects. As consequence, the record external quantum efficiencies of cluster light-emitting diodes already reached ≈30 %. Herein, we overview recent progress of electroluminescent cluster materials and discuss their structure-property relationships, which would inspire the continuous efforts making cluster light-emitting diodes competent as the new generation of displays and lighting sources.
Language	English
Publishing date	2023-12-20
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202317597
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Article: Effect of Recombinant Human Epidermal Growth Factor Associated with Conventional Drug Therapy on the Dry Eye Symptom Score in Patients with Dry Eyes after Cataract Surgery: A Systematic Review and Meta-Analysis.

Sun, Changce / Zhang, Xiaojun

Journal of ophthalmology

2022 Volume 2022, Page(s) 5142851

Abstract: Objective: This study aimed to systematically assess the effect of recombinant human epidermal growth factor (rhEGF) associated with conventional drugs on the score of dry eye symptoms in patients with dry eyes after cataract surgery.: Methods: The ... ...

Abstract	Objective: This study aimed to systematically assess the effect of recombinant human epidermal growth factor (rhEGF) associated with conventional drugs on the score of dry eye symptoms in patients with dry eyes after cataract surgery. Methods: The online database was searched for the clinical controlled trials of rhEGF associated with conventional drugs in the therapy of dry eyes after cataract surgery. Until now, the retrieval timeframe is based on the establishment of the database. Separately, two researchers extracted the data. The bias risk of each included literature was assessed. Results: Eight clinical controlled studies were finally included, with 878 samples. The success rate of the study group was greatly higher, and the difference was statistically significant ( Conclusion: Sodium hyaluronate associated with rhEGF eye drops is successful to treat xerophthalmia after cataract operation. It successfully promotes corneal healing, promotes tear film stability, and increases basic tear secretion. This treatment scheme is worth popularizing and applying in clinics.
Language	English
Publishing date	2022-09-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2546525-9
ISSN	2090-0058 ; 2090-004X
ISSN (online)	2090-0058
ISSN	2090-004X
DOI	10.1155/2022/5142851
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