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  1. Article: An overview of extrahepatic cholangiocarcinoma: from here to where?

    Yang, Yongheng / Zhang, Xiaolu

    Frontiers in oncology

    2023  Volume 13, Page(s) 1171098

    Abstract: Extrahepatic cholangiocarcinoma (eCCA) contains perihilar cholangiocarcinoma and distal cholangiocarcinoma both of which can arise at any point of the biliary tree and originate from disparate anatomical sites. Generally, the incidence of eCCA is ... ...

    Abstract Extrahepatic cholangiocarcinoma (eCCA) contains perihilar cholangiocarcinoma and distal cholangiocarcinoma both of which can arise at any point of the biliary tree and originate from disparate anatomical sites. Generally, the incidence of eCCA is increasing globally. Though surgical resection is the principal treatment of choice for the early stages of eCCA, optimal survival remains restricted by the high risk of recurrence when most patients are present with unresectable disease or distant metastasis. Furthermore, both intra- and intertumoral heterogeneity make it laborious to determine molecularly targeted therapies. In this review, we mainly focused on current findings in the field of eCCA, mostly including epidemiology, genomic abnormalities, molecular pathogenesis, tumor microenvironment, and other details while a summary of the biological mechanisms driving eCCA may shed light on intricate tumorigenesis and feasible treatment strategies.
    Language English
    Publishing date 2023-05-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1171098
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Why do people (not) share guilt with others?

    Zhang, Xiaolu / Zeelenberg, Marcel / Breugelmans, Seger M

    Cognition & emotion

    2023  Volume 37, Issue 5, Page(s) 927–941

    Abstract: ... ...

    Abstract ABSTRACT
    MeSH term(s) Humans ; Guilt ; Emotions
    Language English
    Publishing date 2023-06-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639123-0
    ISSN 1464-0600 ; 0269-9931
    ISSN (online) 1464-0600
    ISSN 0269-9931
    DOI 10.1080/02699931.2023.2221425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3087: Show issues Location:
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  3. Article ; Online: Memo1 reduces copper-mediated reactive oxygen species in breast cancer cells.

    Zhang, Xiaolu / Walke, Gulshan / Wittung-Stafshede, Pernilla

    Journal of inorganic biochemistry

    2023  Volume 247, Page(s) 112335

    Abstract: The mediator of ERBB2-driven cell motility protein 1, Memo1, plays important roles in cancer signaling pathways. We recently reported Memo1 to coordinate reduced copper ions and protect them from reactive oxygen species (ROS) generation in vitro. We here ...

    Abstract The mediator of ERBB2-driven cell motility protein 1, Memo1, plays important roles in cancer signaling pathways. We recently reported Memo1 to coordinate reduced copper ions and protect them from reactive oxygen species (ROS) generation in vitro. We here assess if this Memo1 activity is at play in breast cancer cells. Copper additions to MDA-MB-231 cells promoted cell death, and this toxicity was exaggerated when Memo1 expression was reduced by silencing RNA. Using three different commercial ROS probes, we revealed that copper additions increased intracellular ROS levels, and these were further elevated when Memo1 expression was silenced. We propose that, in addition to other functions, Memo1 protects cancer cells from unwanted copper-mediated redox reactions. This may be a required safety mechanism in cancer cells as they have a high demand for copper.
    MeSH term(s) Humans ; Female ; Reactive Oxygen Species/metabolism ; Copper/pharmacology ; Copper/metabolism ; Breast Neoplasms/drug therapy ; Oxidation-Reduction ; Signal Transduction ; Cell Line, Tumor
    Chemical Substances Reactive Oxygen Species ; Copper (789U1901C5)
    Language English
    Publishing date 2023-07-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 162843-4
    ISSN 1873-3344 ; 0162-0134
    ISSN (online) 1873-3344
    ISSN 0162-0134
    DOI 10.1016/j.jinorgbio.2023.112335
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1730: Show issues Location:
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  4. Article: Ethanol-induced transcriptional and translational changes in Aldh1l1-Egfp/Rpl10a cortical astrocyte cultures.

    Hashimoto, Joel G / Zhang, Xiaolu / Guizzetti, Marina

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 1193304

    Abstract: The role astrocytes play in brain development and function has garnered greater attention as the diversity of roles they are involved in has become apparent. We have previously shown that ethanol-exposed astrocytes alter neuronal neurite outgrowth in ... ...

    Abstract The role astrocytes play in brain development and function has garnered greater attention as the diversity of roles they are involved in has become apparent. We have previously shown that ethanol-exposed astrocytes alter neuronal neurite outgrowth in an
    Language English
    Publishing date 2023-06-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1193304
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  5. Article ; Online: Characteristics and functions of memory regulatory T cells in normal pregnancy cycle and pregnancy complications.

    Chen, Zeyang / Zhou, Xiaojiao / Qu, Hongmei / Zhang, Xiaolu / Kwak-Kim, Joanne / Wang, Wenjuan

    Journal of reproductive immunology

    2024  Volume 163, Page(s) 104235

    Abstract: Regulatory T cells (Tregs) are activated and expanded after exposure to fetal-specific (paternal) antigens. A proportion of Tregs differentiate into memory Tregs (mTregs), exhibiting immune memory function and exerting more potent immunosuppression than ... ...

    Abstract Regulatory T cells (Tregs) are activated and expanded after exposure to fetal-specific (paternal) antigens. A proportion of Tregs differentiate into memory Tregs (mTregs), exhibiting immune memory function and exerting more potent immunosuppression than naive Tregs (nTregs). However, it is unclear how mTregs are regulated during normal and pathological pregnancies (e.g., gestational diabetes mellitus (GDM) and preeclampsia (PE)). In this study, PD-1, HLA-G, and HLA-DR expressions on memory CD4
    Language English
    Publishing date 2024-03-19
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 424421-7
    ISSN 1872-7603 ; 0165-0378
    ISSN (online) 1872-7603
    ISSN 0165-0378
    DOI 10.1016/j.jri.2024.104235
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1483: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Post translational modifications of connexin 43 in ventricular arrhythmias after myocardial infarction.

    Yang, Fan / Zhang, Xiao-Lu / Liu, Huan-Huan / Qian, Ling-Ling / Wang, Ru-Xing

    Molecular biology reports

    2024  Volume 51, Issue 1, Page(s) 329

    Abstract: Ventricular arrhythmias are the leading cause of sudden cardiac death in patients after myocardial infarction (MI). Connexin43 (Cx43) is the most important gap junction channel-forming protein in cardiomyocytes. Dysfunction of Cx43 contributes to ... ...

    Abstract Ventricular arrhythmias are the leading cause of sudden cardiac death in patients after myocardial infarction (MI). Connexin43 (Cx43) is the most important gap junction channel-forming protein in cardiomyocytes. Dysfunction of Cx43 contributes to impaired myocardial conduction and the development of ventricular arrhythmias. Following an MI, Cx43 undergoes structural remodeling, including expression abnormalities, and redistribution. These alterations detrimentally affect intercellular communication and electrical conduction within the myocardium, thereby increasing the susceptibility to post-infarction ventricular arrhythmias. Emerging evidence suggests that post-translational modifications play essential roles in Cx43 regulation after MI. Therefore, Cx43-targeted management has the potential to be a promising protective strategy for the prevention and treatment of post infarction ventricular arrhythmias. In this article, we primarily reviewed the regulatory mechanisms of Cx43 mediated post-translational modifications on post-infarction ventricular arrhythmias. Furthermore, Cx43-targeted therapy have also been discussed, providing insights into an innovative treatment strategy for ventricular arrhythmias after MI.
    MeSH term(s) Humans ; Arrhythmias, Cardiac/metabolism ; Connexin 43/genetics ; Connexin 43/metabolism ; Myocardial Infarction/complications ; Myocardial Infarction/metabolism ; Myocardium/metabolism ; Protein Processing, Post-Translational
    Chemical Substances Connexin 43 ; GJA1 protein, human
    Language English
    Publishing date 2024-02-23
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-024-09290-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Synovia tissue-specific exosomes participate in the dual variation of the osteoarthritis microenvironment via miR-182.

    Wu, Shiqiang / Luo, Jun / Zhang, Xiaolu / Wang, Liangmin / Cai, Liquan / Xu, Jie

    Experimental cell research

    2024  Volume 436, Issue 2, Page(s) 113981

    Abstract: Osteoarthritis (OA) is the most common type of joint disease and the leading cause of chronic disability among older adults. As an important component of the joint, synovium influences the inflammatory and degenerative process of OA. This study found ... ...

    Abstract Osteoarthritis (OA) is the most common type of joint disease and the leading cause of chronic disability among older adults. As an important component of the joint, synovium influences the inflammatory and degenerative process of OA. This study found that miRNA 182 (miR-182) in synovium-specific exosomes can modulate inflammation and apoptotic signaling. It also regulated different biological functions to promote the progression of OA. Experiments based on rat OA model and synovium samples from OA patients, we found that synovium-derived miR-182 regulates inflammatory response in the early stage of OA by regulating the expression level of forkhead box O-3 (FOXO3). However, the expression of miR-182 was significantly increased in synovial tissue of advanced OA, which was involved in the apoptotic signal of severe OA. These findings suggest that miR-182 may directly regulate OA progression by modulating FOXO3 production inflammation, and apoptosis.
    MeSH term(s) Humans ; Rats ; Animals ; Aged ; Synovial Fluid/metabolism ; Exosomes/genetics ; Exosomes/metabolism ; Osteoarthritis/genetics ; Osteoarthritis/metabolism ; Inflammation/genetics ; Inflammation/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Chondrocytes/metabolism
    Chemical Substances MicroRNAs ; Mirn182 microRNA, human ; MIRN182 microRNA, rat
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1493-x
    ISSN 1090-2422 ; 0014-4827
    ISSN (online) 1090-2422
    ISSN 0014-4827
    DOI 10.1016/j.yexcr.2024.113981
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Analysis of heavy metal and polycyclic aromatic hydrocarbon pollution characteristics of a typical metal rolling industrial site based on data mining.

    Li, De'an / Deng, Yirong / Liu, LiLi / Wang, Jun / Huang, Zaoquan / Zhang, Xiaolu

    Environmental geochemistry and health

    2024  Volume 46, Issue 5, Page(s) 146

    Abstract: With the transformation and upgrading of industries, the environmental problems caused by industrial residual contaminated sites are becoming increasingly prominent. Based on actual investigation cases, this study analyzed the soil pollution status of a ... ...

    Abstract With the transformation and upgrading of industries, the environmental problems caused by industrial residual contaminated sites are becoming increasingly prominent. Based on actual investigation cases, this study analyzed the soil pollution status of a remaining sites of the copper and zinc rolling industry, and found that the pollutants exceeding the screening values included Cu, Ni, Zn, Pb, total petroleum hydrocarbons and 6 polycyclic aromatic hydrocarbon monomers. Based on traditional analysis methods such as the correlation coefficient and spatial distribution, combined with machine learning methods such as SOM + K-means, it is inferred that the heavy metal Zn/Pb may be mainly related to the production history of zinc rolling. Cu/Ni may be mainly originated from the production history of copper rolling. PAHs are mainly due to the incomplete combustion of fossil fuels in the melting equipment. TPH pollution is speculated to be related to oil leakage during the industrial use period and later period of vehicle parking. The results showed that traditional analysis methods can quickly identify the correlation between site pollutants, while SOM + K-means machine learning methods can further effectively extract complex hidden relationships in data and achieve in-depth mining of site monitoring data.
    MeSH term(s) Copper/analysis ; Polycyclic Aromatic Hydrocarbons/analysis ; Lead/analysis ; Soil Pollutants/analysis ; Metals, Heavy/analysis ; Zinc/analysis ; Environmental Pollution/analysis ; Soil ; Environmental Pollutants/analysis ; Data Mining ; Environmental Monitoring/methods ; China ; Risk Assessment
    Chemical Substances Copper (789U1901C5) ; Polycyclic Aromatic Hydrocarbons ; Lead (2P299V784P) ; Soil Pollutants ; Metals, Heavy ; Zinc (J41CSQ7QDS) ; Soil ; Environmental Pollutants
    Language English
    Publishing date 2024-04-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 52039-1
    ISSN 1573-2983 ; 0142-7245 ; 0269-4042
    ISSN (online) 1573-2983
    ISSN 0142-7245 ; 0269-4042
    DOI 10.1007/s10653-024-01928-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4723: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article: Cardiac involved and autopsy in two patients with systemic sclerosis: Two cases report.

    Yu, Hang / Wen, Qinwen / Zhang, Xiaolu / Zhang, Hanqing / Wu, Xiudi

    Heliyon

    2023  Volume 9, Issue 5, Page(s) e15555

    Abstract: Systemic sclerosis (SSc) is a connective tissue disease with high mortality. One of the most common causes of death in potential SSc patients is cardiac arrest. However, the pathogenesis of cardiac death is not very clear. As far as we know, there are ... ...

    Abstract Systemic sclerosis (SSc) is a connective tissue disease with high mortality. One of the most common causes of death in potential SSc patients is cardiac arrest. However, the pathogenesis of cardiac death is not very clear. As far as we know, there are few autopsy reports on this subject. Our autopsy report on two fatal cases of heart injury in SSc patients revealed evidence of myocarditis, focal myocardial necrosis, and myocardial fibrosis. Our findings suggest that chronic inflammation of the heart may lead to extensive fibrosis, which could contribute to the high mortality rate observed in SSc patients. Early detection of heart injury in SSc patients using existing technology is necessary to improve patient outcomes. Future research should focus on developing more effective methods for early detection and management of heart involvement in SSc.
    Language English
    Publishing date 2023-04-18
    Publishing country England
    Document type Case Reports
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e15555
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  10. Article ; Online: Enhanced Photovoltaic Properties of Y6 Derivatives with Asymmetric Terminal Groups: A Theoretical Insight.

    Xiang, Yunjie / Cao, Zhijun / Zhang, Xiaolu / Zou, Zhuo / Zheng, Shaohui

    International journal of molecular sciences

    2023  Volume 24, Issue 19

    Abstract: Y6 derivatives with asymmetric terminal groups have attracted considerable attention in recent years. However, the effects of the asymmetric modification of terminal groups on the photovoltaic performance of Y6 derivatives are not well understood yet. ... ...

    Abstract Y6 derivatives with asymmetric terminal groups have attracted considerable attention in recent years. However, the effects of the asymmetric modification of terminal groups on the photovoltaic performance of Y6 derivatives are not well understood yet. Therefore, we designed a series of Y6-based acceptors with asymmetric terminal groups by endowing them with various electron-withdrawing abilities and different conjugated rings to conduct systematic research. The electron-withdrawing ability of the Y6-D1 terminal group (substituted by IC-2F and IC-2NO
    MeSH term(s) Bandages ; Electron Transport ; Electrons ; Thiazoles ; Thiophenes
    Chemical Substances Thiazoles ; Thiophenes
    Language English
    Publishing date 2023-09-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241914753
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