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Article: Effects of yoga on the intervention of levator ani hiatus in postpartum women: a prospective study.

Li, Qunfeng / Zhang, Xinling

2021 Volume 33, Issue 11, Page(s) 862–869

Abstract: Purpose] This study aimed to explore the application value of yoga intervention in early postpartum recovery of the levator ani muscle hiatus (LAH) area. [Participants and Methods] Females in natural labor from May 2020 to November 2020 in the Third ... ...

Abstract	[Purpose] This study aimed to explore the application value of yoga intervention in early postpartum recovery of the levator ani muscle hiatus (LAH) area. [Participants and Methods] Females in natural labor from May 2020 to November 2020 in the Third People's Hospital of Sun Yat-sen University Ultrasound Research Center were prospectively included for a pelvic ultrasound examination. The control group received no intervention. The experimental group received 60-min yoga once a week from week 1 to week 12 postpartum. A pelvic ultrasound examination was performed on the week 6 and week 12 postpartum. The LAH area was measured at rest, during contraction and Valsalva maneuver. [Results] A total of 128 participants who met the inclusion criteria were selected and randomly assigned to the control group (
Language	English
Publishing date	2021-11-09
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2038898-6
ISSN	0915-5287
ISSN	0915-5287
DOI	10.1589/jpts.33.862
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Article ; Online: An Improved YOLOv5 Algorithm for Vulnerable Road User Detection.

Yang, Wei / Tang, Xiaolin / Jiang, Kongming / Fu, Yang / Zhang, Xinling

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 18

Abstract: The vulnerable road users (VRUs), being small and exhibiting random movements, increase the difficulty of object detection of the autonomous emergency braking system for vulnerable road users AEBS-VRUs, with their behaviors highly random. To overcome ... ...

Abstract	The vulnerable road users (VRUs), being small and exhibiting random movements, increase the difficulty of object detection of the autonomous emergency braking system for vulnerable road users AEBS-VRUs, with their behaviors highly random. To overcome existing problems of AEBS-VRU object detection, an enhanced YOLOv5 algorithm is proposed. While the Complete Intersection over Union-Loss (CIoU-Loss) and Distance Intersection over Union-Non-Maximum Suppression (DIoU-NMS) are fused to improve the model's convergent speed, the algorithm also incorporates a minor object detection layer to increase the performance of VRU detection. A dataset for complex AEBS-VRUS scenarios is established based on existing datasets such as Caltech, nuScenes, and Penn-Fudan, and the model is trained using migration learning based on the PyTorch framework. A number of comparative experiments using models such as YOLOv6, YOLOv7, YOLOv8 and YOLOx are carried out. The results of the comparative evaluation show that the proposed improved YOLO5 algorithm has the best overall performance in terms of efficiency, accuracy and timeliness of target detection.
Language	English
Publishing date	2023-09-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23187761
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Article ; Online: Fabricating Materials of Institute Lavoisier-53(Fe)/zeolite imidazolate framework-8 hybrid materials as high-efficiency and reproducible adsorbents for removing organic pollutants.

Yuan, Ning / Zhang, Xinling / Chen, Tianxiang / Xu, Hao / Wang, Qibao

Journal of colloid and interface science

2023 Volume 646, Page(s) 438–451

Abstract: Environmental pollution by emerging contaminants has become an urgent problem. Herein, novel binary metal-organic framework hybrids were constructed from Materials of Institute Lavoisier-53(Fe) (MIL-53(Fe)) and zeolite imidazolate framework-8 (ZIF-8) for ...

Abstract	Environmental pollution by emerging contaminants has become an urgent problem. Herein, novel binary metal-organic framework hybrids were constructed from Materials of Institute Lavoisier-53(Fe) (MIL-53(Fe)) and zeolite imidazolate framework-8 (ZIF-8) for the first time. A battery of characterizations were employed to determine the MIL/ZIF hybrids' properties and morphology. Furthermore, the MIL/ZIF towards toxic antibiotics (tetracycline, ciprofloxacin and ofloxacin) were studied to explore their adsorption abilities. The present work disclosed that the obtained MIL-53(Fe)/ZIF-8 = 2:3 possessed an eminent specific surface area with an admirable removal efficiency of tetracycline (97.4%), ciprofloxacin (97.1%) and ofloxacin (92.4%), respectively. The tetracycline adsorption process conformed to the pseudo-second-order kinetic model and this process was more compatible with the Langmuir isotherm model with the highest adsorption capacity of 215.0 mg g
Language	English
Publishing date	2023-05-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.05.022
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Article ; Online: Analysis of Herdsmen's Credit Behavior under the Identification Scheme of Emotional and Psychological State.

Zhang, Xinling / Huang, Huijie / Zheng, Liyang

publication RETRACTED

Occupational therapy international

2022 Volume 2022, Page(s) 9288896

Abstract: Herdsmen's access to credit funds plays an important supporting role in promoting the modern economic development of pastoral areas and broadening the channels for herders to increase their income. This paper studies the credit behavior of herdsmen from ... ...

Abstract	Herdsmen's access to credit funds plays an important supporting role in promoting the modern economic development of pastoral areas and broadening the channels for herders to increase their income. This paper studies the credit behavior of herdsmen from the perspective of emotional and psychological state identification to analyze the current credit behavior of herdsmen. Firstly, the internal mechanism of herdsmen's credit and emotional and psychological identification research content are analyzed. Secondly, a scheme of emotional and psychological state identification is proposed, and a corresponding survey of herdsmen is carried out according to the scheme. Finally, the Probit and Heckman models are introduced to analyze the credit behavior of herdsmen. The results show that herdsmen with high emotional and psychological scores strongly demand credit. They are likely to have access to credit and have a high level of credit. Herdsmen with low scores of emotional and psychological characteristics have low or no apparent demand for credit, and their credit availability is also low. The herdsmen with high emotional and psychological characteristics have a 71% higher probability of generating credit demand than herdsmen with low openness. Their likelihood of obtaining credit is also 33.47% higher than herdsmen with low emotional and psychological characteristics. They also have easy access to higher loan amounts. The results provide a reference for related research and analysis of herdsman's credit behavior and economic development.
MeSH term(s)	Humans ; Occupational Therapy ; Income ; Surveys and Questionnaires
Language	English
Publishing date	2022-10-06
Publishing country	England
Document type	Journal Article ; Retracted Publication
ZDB-ID	2095334-3
ISSN	1557-0703 ; 0966-7903
ISSN (online)	1557-0703
ISSN	0966-7903
DOI	10.1155/2022/9288896
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Article ; Online: Five hub genes contributing to the oncogenesis and trastuzumab-resistance in gastric cancer.

Chen, Fahai / Wang, Yaping / Zhang, Xinling / Fang, Jianmin

Gene

2022 Volume 851, Page(s) 146942

Abstract: Background: Monoclonal antibodies, as the targeted therapeutic strategies, provide huge clinical benefits for tumor patients. However, after undergoing several times treatment, patients developed drug resistance which is a major bottleneck in clinical ... ...

Abstract	Background: Monoclonal antibodies, as the targeted therapeutic strategies, provide huge clinical benefits for tumor patients. However, after undergoing several times treatment, patients developed drug resistance which is a major bottleneck in clinical cancer therapy. In this study, we aimed to explore the potential molecular mechanism of trastuzumab-resistant and cancer progression, and identify valuable diagnosis biomarkers for gastric cancer. Materials and methods: Gene expression profiles and RNA-sequencing dataset of gastric cancer were acquired from Gene Expression Omnibus (GEO) dataset and The Cancer Genome Atlas (TCGA) dataset, respectively. The Differently expressed genes (DEGs) were screened by R programing language, and Gene Set Enrichment Analysis (GSEA), Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) were adopted separately to analyze the function and pathway of DEGs. Subsequently, Search Tool for the Retrieval of Interacting (STRING) and Cytoscape was performed to establish the protein-protein interaction (PPI) network and to screen hub genes. The Receiver Operating Characteristic (ROC) curves were used to evaluate the diagnostic values of the hub genes. Results: Integrated analysis of TCGA-STAD (Stomach adenocarcinoma) and GEO databases identified 310 common DEGs. GSEA, GO and KEGG enrichment analysis revealed several crucial enriched oncological signatures and trastuzumab-resistant signaling pathways, which may help to explain the potential modulating mechanisms of trastuzumab-resistant. Based on the PPI network, 10 hub genes were screened and five genes (GNGT1, KRT7, KRT16, SOX9, TIMP1) were identified with good performance in the diagnosis of gastric cancer by ROC analysis. Furthermore, Kaplan-Meier analysis and log-rank test suggested that upregulation of KRT16 was correlated with overall survival in gastric cancer. Conclusion: Overall, our study identified five hub genes that may play a critical role in promoting trastuzumab-resistant in gastric cancer, and would be a promising diagnostic and therapeutic biomarker for trastuzumab-resistant gastric cancer.
MeSH term(s)	Humans ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/genetics ; Trastuzumab/pharmacology ; Trastuzumab/therapeutic use ; Gene Expression Profiling ; Computational Biology ; Carcinogenesis/genetics ; Cell Transformation, Neoplastic/genetics ; Gene Expression Regulation, Neoplastic
Chemical Substances	Trastuzumab (P188ANX8CK)
Language	English
Publishing date	2022-10-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2022.146942
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Article ; Online: Negative pressure wound therapy for flap closed-incisions after 3D-printed prosthesis implantation in patients with chronic osteomyelitis with soft tissue defects.

Lin, Zhiyu / Zhang, Xinling / Chen, Yujie / Tian, Yun / Yang, Xin / Zhao, Zhenmin

BMC musculoskeletal disorders

2023 Volume 24, Issue 1, Page(s) 827

Abstract: Background: The flap closed-incisions healing after 3D-printed prosthesis implantation in Chronic Osteomyelitis with Soft Tissue Defects (COSTD) is critical. This study aimed to explore the safety and effectiveness of Negative Pressure Wound Therapy ( ... ...

Abstract	Background: The flap closed-incisions healing after 3D-printed prosthesis implantation in Chronic Osteomyelitis with Soft Tissue Defects (COSTD) is critical. This study aimed to explore the safety and effectiveness of Negative Pressure Wound Therapy (NPWT) in promoting flap closed-incisions healing. Methods: Retrospective analysis of clinical data was performed, including baseline, surgical and hospitalization information. The efficacy of NPWT was assessed by comparing the ASEPSIS scores, Visual Analogue Scale (VAS), Activity of Daily Living Scale (ADLS), and Lower Extremity Functional Scale (LEFS), as well as the major postoperative complications. Results: The study included 20 patients, 13 received conventional dressing (Control group) and 7 received NPWT treatment (NPWT group). These two groups exhibited a notable disparity in the distribution of ASEPSIS scores, and the median scores were 24 in Control group and 9 in NPWT group (p = 0.001). Eight patients in the Control group experienced major incisional complications, including 7 cases of exudation, 3 cases of infection, 2 cases of non-healing, and 1 case of dehiscence, while none were observed in the NPWT group (p = 0.015). The VAS, ADLS, and LEFS scores were significantly improved in the NPWT group compared to the Control group (p = 0.003, 0.017, and 0.043, respectively). Conclusions: The study findings suggest that NPWT applied to the healing process of flap closed-incisions after 3D prosthesis implantation in patients with COSTD can reduce the occurrence of postoperative major complications and promote the recovery of lower limb function and daily activities, which should be recommended for clinical practice.
MeSH term(s)	Humans ; Negative-Pressure Wound Therapy ; Surgical Wound Infection/etiology ; Retrospective Studies ; Postoperative Complications ; Prosthesis Implantation/adverse effects ; Osteomyelitis/surgery ; Osteomyelitis/complications ; Printing, Three-Dimensional
Language	English
Publishing date	2023-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2041355-5
ISSN	1471-2474 ; 1471-2474
ISSN (online)	1471-2474
ISSN	1471-2474
DOI	10.1186/s12891-023-06970-1
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Article ; Online: VEGFR2 targeted microbubble-based ultrasound molecular imaging improving the diagnostic sensitivity of microinvasive cervical cancer.

Zhong, Junlin / Su, Manting / Jiang, Ye / Huang, Licong / Chen, Ying / Huang, Zhuoshan / Zhang, Xinling

Journal of nanobiotechnology

2023 Volume 21, Issue 1, Page(s) 220

Abstract: Background: The current diagnostic methods of microinvasive cervical cancer lesions are imaging diagnosis and pathological evaluation. Pathological evaluation is invasive and imaging approaches are of extremely low diagnostic performance. There is a ... ...

Abstract	Background: The current diagnostic methods of microinvasive cervical cancer lesions are imaging diagnosis and pathological evaluation. Pathological evaluation is invasive and imaging approaches are of extremely low diagnostic performance. There is a paucity of effective and noninvasive imaging approaches for these extremely early cervical cancer during clinical practice. In recent years, ultrasound molecular imaging (USMI) with vascular endothelial growth factor receptor type 2 (VEGFR2) targeted microbubble (MB Results: We found MB Conclusions: Overall, MB
MeSH term(s)	Humans ; Female ; Pregnancy ; Animals ; Mice ; Uterine Cervical Neoplasms/diagnostic imaging ; Microbubbles ; Vascular Endothelial Growth Factor A ; Ultrasonography ; Molecular Imaging
Chemical Substances	Vascular Endothelial Growth Factor A
Language	English
Publishing date	2023-07-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2100022-0
ISSN	1477-3155 ; 1477-3155
ISSN (online)	1477-3155
ISSN	1477-3155
DOI	10.1186/s12951-023-01984-2
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Article ; Online: Human umbilical cord mesenchymal stem cell-derived exosomes combined with gelatin methacryloyl hydrogel to promote fractional laser injury wound healing.

Zhang, Xinling / Ding, Pengbing / Chen, Yujie / Lin, Zhiyu / Zhao, Xun / Xie, Hongbin

International wound journal

2023 Volume 20, Issue 10, Page(s) 4040–4049

Abstract: To investigate whether human umbilical cord mesenchymal stem cell-derived exosomes combined with gelatin methacryloyl (GelMA) hydrogel are beneficial in promoting healing of laser-injured skin wounds in mice. Supernatants of cultured human umbilical cord ...

Abstract	To investigate whether human umbilical cord mesenchymal stem cell-derived exosomes combined with gelatin methacryloyl (GelMA) hydrogel are beneficial in promoting healing of laser-injured skin wounds in mice. Supernatants of cultured human umbilical cord mesenchymal stem cells (HUC-MSCs) were collected to obtain human umbilical cord MSC-derived exosomes (HUC-MSCs-Exos), which were combined with GelMA hydrogel complex to treat a mouse fractional laser injury model. The study was divided into PBS group, EX (HUC-MSCs-Exos) group, GEL (GelMA hydrogel) group and EX+GEL (HUC-MSCs-Exos combined with GelMA hydrogel) group. The healing of laser-injured skin in each group was observed by gross view and dermatoscopy, and changes in skin structure, angiogenesis and proliferation-related indexes were observed during the healing process of laser-injured skin in each group. The results of the animal experiments showed that the EX and GEL groups alone and the EL+EX group exhibited less inflammatory response compared to the PBS group. The EX and GEL groups showed marked tissue proliferation and favourable angiogenesis, which promoted the wound healing well. The GEL+EX group had the most significant promotion of wound healing compared to the PBS group. qPCR results showed that the expression levels of proliferation-related factors, including KI67 and VEGF and angiogenesis-related factor CD31, were significantly higher in the GEL+EX group than in the other groups, with a time-dependent effect. The combination of HUC-MSCs-Exos and GelMA hydrogel is beneficial in reducing the early inflammatory response of laser-injured skin in mice and promoting its proliferation and angiogenesis, which in turn promotes wound healing.
MeSH term(s)	Humans ; Mice ; Animals ; Hydrogels/therapeutic use ; Exosomes/metabolism ; Wound Healing/physiology ; Disease Models, Animal ; Umbilical Cord ; Mesenchymal Stem Cells
Chemical Substances	Hydrogels ; gelatin methacryloyl
Language	English
Publishing date	2023-07-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2170920-8
ISSN	1742-481X ; 1742-4801
ISSN (online)	1742-481X
ISSN	1742-4801
DOI	10.1111/iwj.14295
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Article ; Online: Validation of a built-in software in automatically reconstructing the tomographic images of the levator ani muscle.

Qu, Enze / Wu, Shuangyu / Zhang, Man / Huang, Zeping / Zheng, Zhijuan / Zhang, Xinling

International urogynecology journal

2023 Volume 35, Issue 1, Page(s) 175–181

Abstract: Introduction and hypothesis: Transperineal ultrasound (TPUS) is an effective tool for evaluating the integrity of the levator ani muscle (LAM). Several operating steps are required to obtain the standard multi-slice image of the LAM, which is experience ...

Abstract	Introduction and hypothesis: Transperineal ultrasound (TPUS) is an effective tool for evaluating the integrity of the levator ani muscle (LAM). Several operating steps are required to obtain the standard multi-slice image of the LAM, which is experience dependent and time consuming. This study was aimed at evaluating the feasibility and reproducibility of the built-in software, Smart-pelvic™, in reconstructing standard tomographic images of LAM from 3D/4D TPUS volumes. Methods: This study was conducted at a tertiary teaching hospital, enrolling women who underwent TPUS. Tomographic images of the LAM were automatically reconstructed by Smart-pelvic Results: The ultrasound volume of a total of 104 patients were included in this study. Using Smart-pelvic Conclusions: Using Smart-pelvic
MeSH term(s)	Humans ; Female ; Reproducibility of Results ; Pelvic Floor/diagnostic imaging ; Ultrasonography/methods ; Software ; Imaging, Three-Dimensional
Language	English
Publishing date	2023-11-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1050631-7
ISSN	1433-3023 ; 0937-3462
ISSN (online)	1433-3023
ISSN	0937-3462
DOI	10.1007/s00192-023-05686-z
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Article ; Online: Value of Contrast-Enhanced Ultrasound Parameters in the Evaluation of Adnexal Masses with Ovarian-Adnexal Reporting and Data System Ultrasound.

Xu, Jing / Huang, Zeping / Zeng, Jie / Zheng, Zhijuan / Cao, Junyan / Su, Manting / Zhang, Xinling

Ultrasound in medicine & biology

2023 Volume 49, Issue 7, Page(s) 1527–1534

Abstract: Objective: The aim of this study was to determine whether incorporating qualitative parameters of contrast-enhanced ultrasound (CEUS) can increase the accuracy of adnexal lesion assessments with Ovarian-Adnexal Reporting and Data System (O-RADS) ... ...

Abstract	Objective: The aim of this study was to determine whether incorporating qualitative parameters of contrast-enhanced ultrasound (CEUS) can increase the accuracy of adnexal lesion assessments with Ovarian-Adnexal Reporting and Data System (O-RADS) ultrasound category 4 or 5. Methods: Retrospective analysis of patients with adnexal masses who underwent conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS) examinations between January and August of 2020. The study investigators reviewed and analyzed the morphological features of each mass before categorizing the US images independently according to the O-RADS system published by the American College of Radiology. In the CEUS analysis, the initial time and intensity of enhancement involving the wall and/or septation of the mass were compared with the uterine myometrium. Internal components of each mass were observed for signs of enhancement. The sensitivity, specificity, and Youden's index were calculated as the contrast variables and O-RADS. Results: Receiver operating characteristic curve analysis revealed that the best cutoff value was higher than O-RADS 4. When information on the extent of enhancement was applied to selectively upgrade O-RADS category 4 and selectively downgrade O-RADS category 5, the overall sensitivity increased to 90.2%, while the level of specificity (91.3%) remained the same. Conclusion: Incorporating additional information from CEUS with respect to the extent of enhancement helped to improve the sensitivity of O-RADS category 4 and 5 masses without loss of specificity.
MeSH term(s)	Female ; Humans ; Retrospective Studies ; Ultrasonography/methods ; ROC Curve ; Sensitivity and Specificity ; Adnexal Diseases/diagnostic imaging ; Adnexal Diseases/pathology
Language	English
Publishing date	2023-04-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186150-5
ISSN	1879-291X ; 0301-5629
ISSN (online)	1879-291X
ISSN	0301-5629
DOI	10.1016/j.ultrasmedbio.2023.02.015
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