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Article ; Online: Research and analysis of energy consumption and energy saving in buildings based on photovoltaic photothermal integration.

Cui, Yahan / Zhang, Xinyan

2024 Volume 14, Issue 1, Page(s) 923

Abstract: In order to reduce the energy consumption of buildings, an air source heat pump assisted rooftop photovoltaic-thermal integration system is designed. The installation area of photovoltaic modules and collectors will not only affect the power side, but ... ...

Abstract	In order to reduce the energy consumption of buildings, an air source heat pump assisted rooftop photovoltaic-thermal integration system is designed. The installation area of photovoltaic modules and collectors will not only affect the power side, but also affect the thermal side. Therefore, the basic architecture of the photovoltaic photothermal integration system is first established, and then the improved whale algorithm is used to optimize the photovoltaic photothermal integration system with the daily operating cost as the optimization goal. At the same time, the influence of the installation area of the photovoltaic photothermal module on the comprehensive performance of the system is analyzed, and the environmental and economic benefits of the photovoltaic photothermal system are analyzed. The results of the example show that the roof of the building has significant benefits in environmental protection and investment recovery period when the photovoltaic photothermal system with the optimal area ratio is installed on the roof of the building. The solar photovoltaic power generation system can reduce carbon dioxide emissions by 147.11 t within 25 years, and the solar collector system can save 170.5 thousand yuan in 1 year. It has achieved the purpose of saving energy, reducing carbon dioxide emissions and protecting the environment.
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-51209-1
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Article ; Online: HMGB1 Signaling-Mediated Tumor Immunity in Cancer Progress.

Wen, Jinlin / Zhang, Xinyan

Frontiers in bioscience (Landmark edition)

2023 Volume 28, Issue 10, Page(s) 260

Abstract: Tumor immunity is a cycle that begins with the release of antigens from tumor cells and ends with the destruction of tumor cells. High mobility group box 1 (HMGB1) is a nonhistone protein widely present in the nucleus of mammalian cells and can be ... ...

Abstract	Tumor immunity is a cycle that begins with the release of antigens from tumor cells and ends with the destruction of tumor cells. High mobility group box 1 (HMGB1) is a nonhistone protein widely present in the nucleus of mammalian cells and can be released by immune cells or tumor cells. As a proinflammatory mediator or alarm protein, the activity and function of HMGB1 are determined by the environment, binding receptors, redox status and posttranslational modifications (PTMs), and HMGB1 plays a key role in inflammation and tumor immune processes. In this review, we summarize in detail the current studies on the dual role of HMGB1 in tumor immunity, focusing mainly on immunosuppressive effects, such as regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs), as well as antitumor immunoenhancement effects, such as immunogenic cell death (ICD). Finally, we discuss the potential and challenges of HMGB1 in antitumor immunotherapy.
MeSH term(s)	Animals ; Humans ; HMGB1 Protein/metabolism ; Neoplasms/metabolism ; Signal Transduction ; Inflammation/metabolism ; T-Lymphocytes, Regulatory ; Tumor Microenvironment ; Mammals/metabolism
Chemical Substances	HMGB1 Protein
Language	English
Publishing date	2023-11-02
Publishing country	Singapore
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2704569-9
ISSN	2768-6698 ; 2768-6698
ISSN (online)	2768-6698
ISSN	2768-6698
DOI	10.31083/j.fbl2810260
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Article: Total Intravenous Anaesthesia for Laparoscopic Cholecystectomy in a Patient With Congenital Long QT Syndrome: A Case Report.

Zhang, Xinyan / Tan, Chun Lei

Cureus

2023 Volume 15, Issue 7, Page(s) e42707

Abstract: Long QT syndrome (LQTS) is characterised by QT interval prolongation and ventricular arrhythmia, leading to sudden cardiac death. Patients with acquired or congenital LQTS pose special challenges to anaesthetists perioperatively due to the risk of ... ...

Abstract	Long QT syndrome (LQTS) is characterised by QT interval prolongation and ventricular arrhythmia, leading to sudden cardiac death. Patients with acquired or congenital LQTS pose special challenges to anaesthetists perioperatively due to the risk of developing life-threatening arrhythmia. A variety of medications, including commonly used volatile anaesthetic agents are known to prolong QT interval and there has been growing evidence of using total intravenous anaesthesia (TIVA) instead of volatile agents for such patients. This is a case report of a 30-year-old patient with congenital LQTS and subcutaneous implantable cardioverter defibrillator (SICD) in situ who underwent laparoscopic cholecystectomy and endoscopic retrograde cholangiopancreatography (ERCP) under TIVA safely within two months. There were no arrhythmic events observed perioperatively. This case highlights the importance of comprehensive planning and meticulous preparation to avoid all possible QT-prolonging conditions during the perioperative period, especially in patients with acquired or congenital LQTS.
Language	English
Publishing date	2023-07-30
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.42707
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Article ; Online: Exposure to early-life adversity and long-term trajectories of multimorbidity among older adults in China: analysis of longitudinal data from the China Health and Retirement Longitudinal Study.

Liu, Huiying / Zhang, Mi / Zhang, Xinyan / Zhao, Xinyi

BMJ open

2024 Volume 14, Issue 3, Page(s) e075834

Abstract: Objectives: This study aimed to identify long-term distinct trajectories of multimorbidity with ageing from 50 to 85 years among Chinese older adults and examine the relationship between exposure to early-life adversity (ELA; including specific types of ...

Abstract	Objectives: This study aimed to identify long-term distinct trajectories of multimorbidity with ageing from 50 to 85 years among Chinese older adults and examine the relationship between exposure to early-life adversity (ELA; including specific types of adversity and accumulation of different adversities) and these long-term multimorbidity trajectories. Design: The group-based trajectory models identified long-term multimorbidity trajectories. Multinomial logistic regression models were used to examine the relationship between ELA and the identified multimorbidity trajectories. Setting: This study used data from the China Health and Retirement Longitudinal Study (CHARLS, 2011-2018) and the 2014 Life History Survey. Participants: We used data from 9112 respondents (aged 60 and above) of the 2018 wave of CHARLS. Outcome measures: Each respondent's history of chronic conditions and experiences of ELA were collected from the 2011-2018 waves of CHARLS and the 2014 Life History Survey. Results: Four heterogeneous long-term trajectories of multimorbidity development were identified: 'maintaining-low' (19.1%), 'low onset-rapidly increasing' (23.3%), 'middle onset-moderately increasing' (41.5%) and 'chronically-high' (16.2%). Our findings indicated that the heterogeneity can be explained by ELA experiences. Across various types of different ELA experiences, exposure to food insufficiency (relative risk ratios from 1.372 (95% CI 1.190 to 1.582) to 1.780 (95% CI 1.472 to 2.152)) and parental quarrel/divorce (relative risk ratios from 1.181 (95% CI 1.000 to 1.394) to 1.262 (95% CI 1.038 to 1.536)) had the most prominent associations with health deterioration. The accumulation of more different ELA experiences was associated with a higher relative risk of developing more severe multimorbidity trajectories (relative risk ratio for five to seven ELAs and chronically high trajectory: 7.555, 95% CI 4.993 to 11.431). Conclusions: There are heterogeneous long-term trajectories of multimorbidity in Chinese older adults, and the risk of multimorbidity associated with ELA accumulates over the lifespan. Our findings highlight the role of a supportive early-life family environment in promoting health development across the lifespan, advocating for the integration of life-course approaches to implementing health disparity interventions.
MeSH term(s)	Humans ; Aged ; Retirement ; Adverse Childhood Experiences ; Longitudinal Studies ; Multimorbidity ; China/epidemiology
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-075834
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Article ; Online: PSMOT: Online Occlusion-Aware Multi-Object Tracking Exploiting Position Sensitivity.

Zhao, Ranyang / Zhang, Xinyan / Zhang, Jianwei

Sensors (Basel, Switzerland)

2024 Volume 24, Issue 4

Abstract: Models based on joint detection and re-identification (ReID), which significantly increase the efficiency of online multi-object tracking (MOT) systems, are an evolution from separate detection and ReID models in the tracking-by-detection (TBD) paradigm. ...

Abstract	Models based on joint detection and re-identification (ReID), which significantly increase the efficiency of online multi-object tracking (MOT) systems, are an evolution from separate detection and ReID models in the tracking-by-detection (TBD) paradigm. It is observed that these joint models are typically one-stage, while the two-stage models become obsolete because of their slow speed and low efficiency. However, the two-stage models have naive advantages over the one-stage anchor-based and anchor-free models in handling feature misalignment and occlusion, which suggests that the two-stage models, via meticulous design, could be on par with the state-of-the-art one-stage models. Following this intuition, we propose a robust and efficient two-stage joint model based on R-FCN, whose backbone and neck are fully convolutional, and the RoI-wise process only involves simple calculations. In the first stage, an adaptive sparse anchoring scheme is utilized to produce adequate, high-quality proposals to improve efficiency. To boost both detection and ReID, two key elements-feature aggregation and feature disentanglement-are taken into account. To improve robustness against occlusion, the position-sensitivity is exploited, first to estimate occlusion and then to direct the post-process for anti-occlusion. Finally, we link the model to a hierarchical association algorithm to form a complete MOT system called PSMOT. Compared to other cutting-edge systems, PSMOT achieves competitive performance while maintaining time efficiency.
Language	English
Publishing date	2024-02-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24041199
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Article ; Online: Sleep and the Social Profiles of Individuals With Rett Syndrome.

Zhang, Xinyan / Smits, Marcel / Curfs, Leopold / Spruyt, Karen

Pediatric neurology

2024 Volume 152, Page(s) 153–161

Abstract: Background: This study investigates the distinctive social behaviors observed in individuals with Rett syndrome (RTT), characterized by the loss of spoken language, impaired eye gaze communication, gait abnormalities, and sleep issues. The research aims ...

Abstract	Background: This study investigates the distinctive social behaviors observed in individuals with Rett syndrome (RTT), characterized by the loss of spoken language, impaired eye gaze communication, gait abnormalities, and sleep issues. The research aims to identify social profiles in RTT and explore their correlation with sleep, sleep-disordered breathing (SDB), and daytime sleepiness. Methods: Standard overnight sleep macrostructure and respiratory parameters were assessed. Extracting 25 social-related items and one for daytime sleepiness from the Rett Syndrome Behavioral Questionnaire, factor analysis was applied to establish latent social profiles. These profiles were then correlated with sleep parameters. The nonparametric Mann-Whitney U test compared social profiles based on the presence of SDB (defined by an apnea-hypopnea index greater than one per hour) and daytime sleepiness. Results: The study involved 12 female subjects with confirmed RTT diagnoses and MECP2 mutations, aged 8.54 ± 5.30 years. The Rett Syndrome Behavioral Questionnaire revealed a total average score of 25.83 ± 12.34, indicating varying degrees of social impairments. Comprising 25 social-related items, factor analysis yielded four social profiles: "interactive motricity," "mood change," "anxiety/agitation," and "gazing." Longer sleep onset latency correlated with increased socio-behavioral impairments, particularly in interactive motricity reduction. Conversely, higher rapid eye movement sleep was associated with fewer interactive socio-motor behaviors. No significant differences in social profiles were found concerning the presence of SDB or daytime sleepiness. Conclusions: The findings suggest four distinct social profiles in RTT individuals, hinting at shared disrupted circuits between sensorimotor functioning and sleep-related neuronal pathways. Despite the absence of differences in SDB or daytime sleepiness, the study highlights the relationship between sleep parameters, such as sleep onset latency and rapid eye movement sleep, and socio-behavioral outcomes in RTT with MECP2 mutations.
MeSH term(s)	Humans ; Female ; Rett Syndrome/complications ; Rett Syndrome/genetics ; Polysomnography ; Sleep ; Sleep Apnea Syndromes/diagnosis ; Disorders of Excessive Somnolence/complications
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	639164-3
ISSN	1873-5150 ; 0887-8994
ISSN (online)	1873-5150
ISSN	0887-8994
DOI	10.1016/j.pediatrneurol.2024.01.004
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Article ; Online: Tri-frequency simultaneous ultrasound pickling for the acceleration of the NaCl content and quality improvement of pork (longissimus dorsi).

Zhang, Xinyan / Guo, Lina / Chen, Zhongyuan / Ma, Haile

Journal of the science of food and agriculture

2024

Abstract: Background: The pickling process with NaCl is an essential step for pork preservation. This study aimed to investigate the effect of different ultrasonic intensities of tri-frequency simultaneous ultrasound (TSIU) pickling on the NaCl content and ... ...

Abstract	Background: The pickling process with NaCl is an essential step for pork preservation. This study aimed to investigate the effect of different ultrasonic intensities of tri-frequency simultaneous ultrasound (TSIU) pickling on the NaCl content and quality of pork (longissimus dorsi). After 30 min pickling, the NaCl content, moisture content, pickling yield, cooking loss, textural properties, color, pH, moisture migration and distribution as well as microstructure of pork were assessed. Results: Results showed that among all the ultrasonic treatment intensities (85-150 W L Conclusion: Ultrasound marination of different intensities promoted the diffusion of NaCl and affected the quality of pork tenderloins. The TSIU at 101.3 W L
Language	English
Publishing date	2024-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.13448
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Article ; Online: Effects of landfill void fraction and moisture content on the formation of aerobic areas in a semi-aerobic bioreactor.

Zhao, Xinyu / Zhang, Xin / Zhang, Xinyan

Waste management (New York, N.Y.)

2024 Volume 181, Page(s) 34–43

Abstract: The main disposal method for municipal solid waste (MSW), including the growing worldwide volumes of kitchen waste, involves transport to landfills. Because kitchen waste is mainly composed of organic matter and has a high moisture content, large amounts ...

Abstract	The main disposal method for municipal solid waste (MSW), including the growing worldwide volumes of kitchen waste, involves transport to landfills. Because kitchen waste is mainly composed of organic matter and has a high moisture content, large amounts of leachate and landfill gas are generated when it is sent to landfills. Therefore, rapid waste stabilization is essential. In this study, four semi-aerobic bioreactors (named NS, SS, MS, and LS) were established with void fractions of 33.76%, 39.84%, 44.62%, and 41.31%, respectively. The results showed that the void fractions of landfill directly affected the gas flow path. When the landfill void fraction was small (e.g., NS), most airflow traveled directly through the pipeline and minimal airflow entered the waste layer. When the landfill void fraction was large (e.g., MS), air easily entered the waste layer and some air flowed into the gas vent with the landfill gas. As the reaction proceeded, the void fraction gradually decreased due to gravity-induced sedimentation. During the water addition experiment, the voids were occupied by water, leading to formation of an anaerobic area. Among the four bioreactors, only MS had negligible formation of an anaerobic zone in the center. Methane (CH
MeSH term(s)	Bioreactors ; Waste Disposal Facilities ; Refuse Disposal/methods ; Aerobiosis ; Solid Waste/analysis
Chemical Substances	Solid Waste
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2001471-5
ISSN	1879-2456 ; 0956-053X
ISSN (online)	1879-2456
ISSN	0956-053X
DOI	10.1016/j.wasman.2024.03.027
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Article: A meta-review of standard polysomnography parameters in Rett Syndrome.

Zhang, Xin-Yan / Spruyt, Karen

Frontiers in neurology

2022 Volume 13, Page(s) 963626

Abstract: Rett Syndrome (RTT, OMIM 312750), a unique rare neurodevelopmental disorder, mostly affects females and causes severe multi-disabilities including poor sleep. This meta-analysis systematically reviewed the polysomnographic (PSG) data of individuals with ... ...

Abstract	Rett Syndrome (RTT, OMIM 312750), a unique rare neurodevelopmental disorder, mostly affects females and causes severe multi-disabilities including poor sleep. This meta-analysis systematically reviewed the polysomnographic (PSG) data of individuals with RTT on both sleep macrostructure and sleep respiratory indexes and compared them to literature normative values. Studies were collected from PubMed, Web of Science, PsycINFO, Ebsco, Scopus, and Cochrane Library till 26 April 2022. Across 13 included studies, the 134 selected RTT cases were mostly females being Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=198099, identifier: CRD 42020198099.
Language	English
Publishing date	2022-09-20
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2022.963626
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Article ; Online: Analyzing the overall effects of the microbiome abundance data with a Bayesian predictive value approach.

Zhang, Xinyan / Yi, Nengjun

Statistical methods in medical research

2022 Volume 31, Issue 10, Page(s) 1992–2003

Abstract: The microbiome abundance data is known to be over-dispersed and sparse count data. Among various zero-inflated models, zero-inflated negative binomial (ZINB) model and zero-inflated beta binomial (ZIBB) model are the methods to analyze the microbiome ... ...

Abstract	The microbiome abundance data is known to be over-dispersed and sparse count data. Among various zero-inflated models, zero-inflated negative binomial (ZINB) model and zero-inflated beta binomial (ZIBB) model are the methods to analyze the microbiome abundance data. ZINB and ZIBB have two sets of parameters, which are for modeling the zero-inflation part and the count part separately. Most previous methods have focused on making inferences in terms of separate case-control effect for the zero-inflation part and the count part. However, in a case-control study, the primary interest is normally focused on the inference and a single interpretation of the overall unconditional mean (also known as the overall effect) of the microbiome abundance in microbiome studies. Here, we propose a Bayesian predictive value (BPV) approach to estimate the overall effect of the microbiome abundance. This approach is implemented based on R package
MeSH term(s)	Bayes Theorem ; Case-Control Studies ; Markov Chains ; Microbiota ; Models, Statistical
Language	English
Publishing date	2022-06-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1136948-6
ISSN	1477-0334 ; 0962-2802
ISSN (online)	1477-0334
ISSN	0962-2802
DOI	10.1177/09622802221107106
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