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Article ; Online: Artist's Statement: The Road to Recovery.

Zhang, Xinyi Christine

Academic medicine : journal of the Association of American Medical Colleges

2022 Volume 97, Issue 8, Page(s) 1143

MeSH term(s)	Humans ; Medicine in the Arts ; Paintings
Language	English
Publishing date	2022-07-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	96192-9
ISSN	1938-808X ; 1040-2446
ISSN (online)	1938-808X
ISSN	1040-2446
DOI	10.1097/ACM.0000000000004742
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Article ; Online: Metabolic underpinnings of cancer-related fatigue.

Zhang, Xinyi / Perry, Rachel J

American journal of physiology. Endocrinology and metabolism

2024 Volume 326, Issue 3, Page(s) E290–E307

Abstract: Cancer-related fatigue (CRF) is one of the most prevalent and detrimental complications of cancer. Emerging evidence suggests that obesity and insulin resistance are associated with CRF occurrence and severity in cancer patients and survivors. In this ... ...

Abstract	Cancer-related fatigue (CRF) is one of the most prevalent and detrimental complications of cancer. Emerging evidence suggests that obesity and insulin resistance are associated with CRF occurrence and severity in cancer patients and survivors. In this narrative review, we analyzed recent studies including both preclinical and clinical research on the relationship between obesity and/or insulin resistance and CRF. We also describe potential mechanisms for these relationships, though with the caveat that because the mechanisms underlying CRF are incompletely understood, the mechanisms mediating the association between obesity/insulin resistance and CRF are similarly incompletely delineated. The data suggest that, in addition to their effects to worsen CRF by directly promoting tumor growth and metastasis, obesity and insulin resistance may also contribute to CRF by inducing chronic inflammation, neuroendocrinological disturbance, and metabolic alterations. Furthermore, studies suggest that patients with obesity and insulin resistance experience more cancer-induced pain and are at more risk of emotional and behavioral disruptions correlated with CRF. However, other studies implied a potentially paradoxical impact of obesity and insulin resistance to reduce CRF symptoms. Despite the need for further investigation utilizing interventions to directly elucidate the mechanisms of cancer-related fatigue, current evidence demonstrates a correlation between obesity and/or insulin resistance and CRF, and suggests potential therapeutics for CRF by targeting obesity and/or obesity-related mediators.
MeSH term(s)	Humans ; Insulin Resistance ; Neoplasms/complications ; Obesity/complications ; Fatigue/etiology
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	603841-4
ISSN	1522-1555 ; 0193-1849
ISSN (online)	1522-1555
ISSN	0193-1849
DOI	10.1152/ajpendo.00378.2023
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Article ; Online: Distant organ metastasis patterns and prognosis of lung adenosquamous carcinoma: a SEER database analysis.

Xing, Hongquan / Wu, Cong / Zhang, Dongdong / Zhang, Xinyi

Interdisciplinary cardiovascular and thoracic surgery

2024 Volume 38, Issue 2

Abstract: Objectives: Our purpose is to evaluate the patterns of organ metastasis and the prognosis in lung adenosquamous carcinoma patients with organ metastasis.: Methods: We collected the data from the surveillance epidemiology and end results database, ... ...

Abstract	Objectives: Our purpose is to evaluate the patterns of organ metastasis and the prognosis in lung adenosquamous carcinoma patients with organ metastasis. Methods: We collected the data from the surveillance epidemiology and end results database, covering the period of 2000-2018. Cox regression, Kaplan-Meier and log-rank analyses were performed. Results: Totally, 2698 patients were enrolled, comprising 851 (31.54%) patients diagnosed with organ metastasis and 2017 (68.46%) patients without organ metastasis. Patients with distant organ metastasis show a significant decrease in median overall survival. In addition to the aforementioned factors, age over 70 years, male, main bronchus, advanced T stage, larger tumour size, absence of primary tumour surgery and lack of radiotherapy have all been identified as prognostic indicators associated with a poorer outcome. In terms of treatment options, patients with organ metastasis can benefit from chemotherapy and primary tumour surgery. Moreover, in patients with organ metastasis, those who received a combination treatment of surgery, chemotherapy and radiotherapy displayed the most favourable prognosis, with a median overall survival of 17 months. Conclusions: We identified the prognostic indicators for organ metastasis in patients with lung adenosquamous carcinoma. Highly selected patients who undergo a combination treatment of surgery, chemotherapy and radiotherapy may experience the greatest survival benefit.
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Journal Article
ISSN	2753-670X
ISSN (online)	2753-670X
DOI	10.1093/icvts/ivae007
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Article ; Online: Complete genome sequence of a novel partitivirus with a dsRNA3 segment, isolated from Fusarium commune strain CP-SX-3 causing strawberry root rot.

Zhao, Yumeng / Zhang, Xinyi / Mu, Tongyu / Wu, Xuehong

Archives of virology

2024 Volume 169, Issue 3, Page(s) 60

Abstract: A novel partitivirus, Fusarium commune partitivirus 1 (FcoPV1), was identified in Fusarium commune strain CP-SX-3 isolated from diseased roots of strawberry with symptoms of root rot. The complete genome of FcoPV1 comprises three double-stranded RNAs ( ... ...

Abstract	A novel partitivirus, Fusarium commune partitivirus 1 (FcoPV1), was identified in Fusarium commune strain CP-SX-3 isolated from diseased roots of strawberry with symptoms of root rot. The complete genome of FcoPV1 comprises three double-stranded RNAs (dsRNAs): dsRNA1 (1,825 nt), dsRNA2 (1,592 nt), and dsRNA3 (1,421 nt). dsRNA1 contains a single open reading frame (ORF1) encoding an RNA-dependent RNA polymerase (RdRp), and dsRNA2 contains a single ORF (ORF2) encoding a coat protein (CP). dsRNA3 is a possible satellite RNA that does not appear to encode a known protein. BLASTp analysis revealed that RdRp (86.59%) and CP (74.13%) encoded by the two ORFs (ORF1 and ORF2) had the highest sequence similarity to their counterparts in Fusarium equiseti partitivirus 1 (FePV1). Phylogenetic analysis based on the complete amino acid sequence of RdRp suggested that FcoPV1 should be considered a member of a new species in the proposed genus "Zetapartitivirus" within the family Partitiviridae. To the best of our knowledge, this is the first report of a zetapartitivirus infecting phytopathogenic F. commune.
MeSH term(s)	Fragaria ; Phylogeny ; Genome, Viral ; RNA-Dependent RNA Polymerase/genetics ; Fusarium
Chemical Substances	RNA-Dependent RNA Polymerase (EC 2.7.7.48)
Language	English
Publishing date	2024-03-02
Publishing country	Austria
Document type	Journal Article
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-024-06004-8
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Article ; Online: A Novel Strain of Fusarium oxysporum Virus 1 Isolated from

Hua, Huihui / Zhang, Xinyi / Xia, Jie / Wu, Xuehong

Journal of fungi (Basel, Switzerland)

2024 Volume 10, Issue 4

Abstract: A novel strain of Fusarium oxysporum virus 1 (FoV1) was identified from ... ...

Abstract	A novel strain of Fusarium oxysporum virus 1 (FoV1) was identified from the
Language	English
Publishing date	2024-03-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2784229-0
ISSN	2309-608X ; 2309-608X
ISSN (online)	2309-608X
ISSN	2309-608X
DOI	10.3390/jof10040252
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Article ; Online: Nonsense-mediated mRNA decay and metal ion homeostasis and detoxification in Saccharomyces cerevisiae.

Zhang, Xinyi / Kebaara, Bessie W

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine

2022 Volume 35, Issue 6, Page(s) 1145–1156

Abstract: The highly conserved Nonsense-mediated mRNA decay (NMD) pathway is a translation dependent mRNA degradation pathway. Although NMD is best known for its role in degrading mRNAs with premature termination codons (PTCs) generated during transcription, ... ...

Abstract	The highly conserved Nonsense-mediated mRNA decay (NMD) pathway is a translation dependent mRNA degradation pathway. Although NMD is best known for its role in degrading mRNAs with premature termination codons (PTCs) generated during transcription, splicing, or damage to the mRNAs, NMD is now also recognized as a pathway with additional important functions. Notably, NMD precisely regulates protein coding natural mRNAs, hence controlling gene expression within several physiologically significant pathways. Such pathways affected by NMD include nutritional bio-metal homeostasis and metal ion detoxification, as well as crosstalk between these pathways. Here, we focus on the relationships between NMD and various metal homeostasis and detoxification pathways. We review the described role that the NMD pathway plays in magnesium, zinc, iron, and copper homeostasis, as well as cadmium detoxification.
MeSH term(s)	Nonsense Mediated mRNA Decay ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Gene Expression Regulation, Fungal ; Saccharomyces cerevisiae Proteins/genetics ; RNA, Messenger/metabolism ; Homeostasis/genetics
Chemical Substances	Saccharomyces cerevisiae Proteins ; RNA, Messenger
Language	English
Publishing date	2022-10-18
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1112688-7
ISSN	1572-8773 ; 0966-0844
ISSN (online)	1572-8773
ISSN	0966-0844
DOI	10.1007/s10534-022-00450-0
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Article ; Online: MoleMCL: a multi-level contrastive learning framework for molecular pre-training.

Zhang, Xinyi / Xu, Yanni / Jiang, Changzhi / Shen, Lian / Liu, Xiangrong

Bioinformatics (Oxford, England)

2024 Volume 40, Issue 4

Abstract: Motivation: Molecular representation learning plays an indispensable role in crucial tasks such as property prediction and drug design. Despite the notable achievements of molecular pre-training models, current methods often fail to capture both the ... ...

Abstract	Motivation: Molecular representation learning plays an indispensable role in crucial tasks such as property prediction and drug design. Despite the notable achievements of molecular pre-training models, current methods often fail to capture both the structural and feature semantics of molecular graphs. Moreover, while graph contrastive learning has unveiled new prospects, existing augmentation techniques often struggle to retain their core semantics. To overcome these limitations, we propose a gradient-compensated encoder parameter perturbation approach, ensuring efficient and stable feature augmentation. By merging enhancement strategies grounded in attribute masking and parameter perturbation, we introduce MoleMCL, a new MOLEcular pre-training model based on multi-level contrastive learning. Results: Experimental results demonstrate that MoleMCL adeptly dissects the structure and feature semantics of molecular graphs, surpassing current state-of-the-art models in molecular prediction tasks, paving a novel avenue for molecular modeling. Availability and implementation: The code and data underlying this work are available in GitHub at https://github.com/BioSequenceAnalysis/MoleMCL.
MeSH term(s)	Drug Design ; Semantics
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1422668-6
ISSN	1367-4811 ; 1367-4803
ISSN (online)	1367-4811
ISSN	1367-4803
DOI	10.1093/bioinformatics/btae164
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Article ; Online: Increasing Burden of Osteoarthritis in China: Trends and Projections from the Global Burden of Disease Study 2019.

Hu, Shugang / Li, Yongwei / Zhang, Xinyi / Alkhatatbeh, Tariq / Wang, Wei

Medical science monitor : international medical journal of experimental and clinical research

2024 Volume 30, Page(s) e942626

Abstract: BACKGROUND This study aimed to evaluate the epidemiology of osteoarthritis in China in a comprehensive and reliable way, to project its future epidemiological patterns, and to mitigate its health hazards. MATERIAL AND METHODS Data were extracted and ... ...

Abstract	BACKGROUND This study aimed to evaluate the epidemiology of osteoarthritis in China in a comprehensive and reliable way, to project its future epidemiological patterns, and to mitigate its health hazards. MATERIAL AND METHODS Data were extracted and analyzed from the Global Burden of Diseases Study 2019. Trends in osteoarthritis epidemiology were explored using joinpoint regression analysis. Additionally, we analyzed dynamic trends using the sociodemographic index (SDI) of China. To assess and predict the epidemiology of osteoarthritis from 2020 to 2039, we used both the Bayesian age-period-cohort model and Nordpred model. RESULTS The number of prevalent cases, incident cases, and years lived with disability (YLDs) for osteoarthritis in China increased from 51.8, 4.6, and 1.8 million, respectively, in 1990, to 132.8, 10.7, and 4.7 million, respectively, in 2019, and the average annual percentage changes were 3.286, 2.938, and 3.324, respectively. The prevalence and YLDs peaked in the population aged over 90 years old, while the incidence peaked in the population aged around 50 years old. A significant positive correlation was found between osteoarthritis burden and SDI. Osteoarthritis burden is expected to continue to increase. In the population studied here, it was higher in women than in men, but this may invert by 2039. CONCLUSIONS The prevalence, incidence, and YLDs of osteoarthritis had significantly increased and may continue to increase during the next 2 decades. Prevention and treatment strategies should target women, middle-aged individuals, and the elderly.
MeSH term(s)	Aged ; Male ; Middle Aged ; Humans ; Female ; Aged, 80 and over ; Global Burden of Disease ; Bayes Theorem ; Prevalence ; Osteoarthritis/epidemiology ; Incidence ; China/epidemiology ; Global Health
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/MSM.942626
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Article ; Online: The development of global creative centers from a regional perspective: A case study of Milan's creative industries.

Shen, Cheng / Zhang, Xinyi / Li, Xiang

PloS one

2023 Volume 18, Issue 4, Page(s) e0281937

Abstract: With the advancement of globalization and the deepening interlock between cities globally, the research on urban culture and creative development should be expanded from a single city scale to regional and urban agglomeration scale. Creative clusters ... ...

Abstract	With the advancement of globalization and the deepening interlock between cities globally, the research on urban culture and creative development should be expanded from a single city scale to regional and urban agglomeration scale. Creative clusters will become an important spatial scale to break the bottleneck of urban development in the future. In Europe, cities such as London, Paris, and Milan have developed creative industries and built creative clusters relatively early, and hence they gradually become global creative centers. However, there are few studies on the development of their creative industries from a regional perspective. This research uses multi-source data within the scope selected and based on comprehensive standards, to analyze regional development characteristics of creative industries in Milan, creative clusters formed with Milan as its core, and influencing factors of its development. Through the study of a global creative center from a regional perspective, references for emerging creative cities and those that require industrial transformation can be achieved.
MeSH term(s)	Cities ; Industry ; London ; Paris ; Europe ; China ; Urbanization
Language	English
Publishing date	2023-04-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0281937
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Article ; Online: New taxa in the leafhopper tribe Deltocephalini (Hemiptera: Cicadellidae: Deltocephalinae) from China.

Zhang, Xinyi / Xu, Jing / Shah, Bismillah / Duan, Yani

Zootaxa

2023 Volume 5271, Issue 3, Page(s) 525–537

Abstract: Pseudomaiestas gen. nov. with Pseudomaiestas dietrichi sp. nov. (type species, China: Yunnan Prov.), and Maiestas anhuiensis sp. nov. (China: Anhui Prov.) are described and illustrated. A checklist to the known genera and species of Deltocephalini from ... ...

Abstract	Pseudomaiestas gen. nov. with Pseudomaiestas dietrichi sp. nov. (type species, China: Yunnan Prov.), and Maiestas anhuiensis sp. nov. (China: Anhui Prov.) are described and illustrated. A checklist to the known genera and species of Deltocephalini from China is given together with a generic key. The tribe now holds 14 genera and 59 species in total from China. The genera Alobaldia Emeljanov, Amblysellus Sleesman, Ctenurella Vilbaste, Graminella DeLong, Matsumuratettix Metcalf, Peitouellus Vilbaste, Polyamia DeLong, Recilia Edwards, Wyushinamia Zhang & Duan, and Pseudomaiestas Xu, Shah & Duan gen. nov. contain 1 species. Similarly, Yuanamia Zhang & Duan includes 2 species, Paramesodes Ishihara contains 6 species, Deltocephalus Burmeister has 7 species, and Maiestas Distant is recorded with 34 species respectively. A separate key for the Chinese Maiestas species is also given.
MeSH term(s)	Animals ; Hemiptera ; China
Language	English
Publishing date	2023-04-27
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5271.3.5
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