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Article ; Online: Comparative analysis of the effectiveness difference of SARS-COV-2 mRNA vaccine in different populations in the real world: A review.

Cai, Sihui / Chang, Chunyan / Zhang, Xiuhong / Qiao, Weizhen

2023 Volume 102, Issue 34, Page(s) e34805

Abstract: Coronavirus disease 2019 (COVID-19) has ravaged the world since December 2019. Up to now, it is still prevalent around the world. Vaccines are an important means to prevent the spread of COVID-19 and reduce severe disease and mortality. Currently, ... ...

Abstract	Coronavirus disease 2019 (COVID-19) has ravaged the world since December 2019. Up to now, it is still prevalent around the world. Vaccines are an important means to prevent the spread of COVID-19 and reduce severe disease and mortality. Currently, different types of novel coronavirus vaccines are still being developed and improved, and the relevant vaccines that have been approved for marketing have been widely vaccinated around the world. As vaccination coverage continues to grow, concerns about the efficacy and safety of vaccines after real-world use have grown. Some clinical studies have shown that vaccine effectiveness is closely related to antibody response after vaccination. Among them, the advantages of COVID-19 messenger ribonucleic acid (mRNA) vaccine, such as better adaptability to variant strains and better immune response ability, have attracted great attention. However, different populations with different genders, ages, previous COVID-19 infection history, underlying diseases and treatments will show different antibody responses after mRNA vaccination, which will affect the protection of the vaccine. Based on this, this paper reviews the reports related severe acute respiratory syndrome Coronavirus 2 mRNA vaccines, and summarizes the effectiveness of vaccines in different populations and different disease states and looked forward to the precise vaccination strategy of the vaccine in the future.
MeSH term(s)	Female ; Male ; Humans ; COVID-19 Vaccines ; SARS-CoV-2 ; COVID-19/prevention & control ; RNA, Messenger ; mRNA Vaccines
Chemical Substances	COVID-19 Vaccines ; RNA, Messenger ; mRNA Vaccines
Language	English
Publishing date	2023-01-26
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000034805
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Article ; Online: Abscisic acid-mediated cytosolic Ca

Cui, Meilin / Zhao, Yitao / Zhang, Xiuhong / Zhao, Wei

Journal of Zhejiang University. Science. B

2023 Volume 24, Issue 12, Page(s) 1174–1179

Abstract: Ganoderma lucidum is a mushroom widely used for its edible and medicinal properties. Primary bioactive constituents of G. lucidum are ganoderic triterpenoids (GTs), which exhibit important pharmacological activity. Abscisic acid (ABA), a plant hormone, ... ...

Title translation	脱落酸介导胞内Ca
Abstract	Ganoderma lucidum is a mushroom widely used for its edible and medicinal properties. Primary bioactive constituents of G. lucidum are ganoderic triterpenoids (GTs), which exhibit important pharmacological activity. Abscisic acid (ABA), a plant hormone, is associated with plant growth, development, and stress responses. ABA can also affect the growth, metabolism, and physiological activities of different fungi and participates in the regulation of the tetracyclic triterpenes of some plants. Our findings indicated that ABA treatment promoted GT accumulation by regulating the gene expression levels (squalene synthase (sqs), 3-hydroxy-3-methylglutaryl-CoA reductase (hmgr), and lanosterol synthase (ls)), and also activated cytosolic Ca
MeSH term(s)	Reishi/metabolism ; Triterpenes/pharmacology ; Triterpenes/metabolism ; Abscisic Acid/metabolism ; Antioxidants/metabolism
Chemical Substances	Triterpenes ; Abscisic Acid (72S9A8J5GW) ; Antioxidants
Language	Chinese
Publishing date	2023-07-03
Publishing country	China
Document type	Journal Article
ZDB-ID	2247290-3
ISSN	1862-1783 ; 1673-1581
ISSN (online)	1862-1783
ISSN	1673-1581
DOI	10.1631/jzus.B2300279
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Article ; Online: Role of Decidual Natural Killer Cells in Human Pregnancy and Related Pregnancy Complications.

Zhang, Xiuhong / Wei, Haiming

Frontiers in immunology

2021 Volume 12, Page(s) 728291

Abstract: Pregnancy is a unique type of immunological process. Healthy pregnancy is associated with a series of inflammatory events: implantation (inflammation), gestation (anti-inflammation), and parturition (inflammation). As the most abundant leukocytes during ... ...

Abstract	Pregnancy is a unique type of immunological process. Healthy pregnancy is associated with a series of inflammatory events: implantation (inflammation), gestation (anti-inflammation), and parturition (inflammation). As the most abundant leukocytes during pregnancy, natural killer (NK) cells are recruited and activated by ovarian hormones and have pivotal roles throughout pregnancy. During the first trimester, NK cells represent up to 50-70% of decidua lymphocytes. Differently from peripheral-blood NK cells, decidual natural killer (dNK) cells are poorly cytolytic, and they release cytokines/chemokines that induce trophoblast invasion, tissue remodeling, embryonic development, and placentation. NK cells can also shift to a cytotoxic identity and carry out immune defense if infected
MeSH term(s)	Animals ; Cytokines/metabolism ; Cytotoxicity, Immunologic ; Decidua/immunology ; Decidua/metabolism ; Decidua/pathology ; Embryo Implantation ; Female ; Fetal Development ; Histocompatibility, Maternal-Fetal ; Humans ; Immune Tolerance ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Parturition ; Phenotype ; Placentation ; Pregnancy ; Pregnancy Complications/immunology ; Pregnancy Complications/metabolism ; Pregnancy Complications/pathology ; Signal Transduction
Chemical Substances	Cytokines
Language	English
Publishing date	2021-08-26
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.728291
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Article ; Online: Unraveling neoantigen-associated genes in bladder cancer: An in-depth analysis employing 101 machine learning algorithms.

Lv, Fang / Xiong, Qi / Qi, Meiying / Dai, Caixia / Zhang, Xiuhong / Cheng, Shunhua

Environmental toxicology

2024 Volume 39, Issue 5, Page(s) 2528–2544

Abstract: The therapeutic outcomes for bladder cancer (BLCA) remain suboptimal. Concurrently, there is a growing appreciation for the role of neoantigens in tumors. In this study, we explored the mechanisms underlying the involvement of neoantigen-associated genes ...

Abstract	The therapeutic outcomes for bladder cancer (BLCA) remain suboptimal. Concurrently, there is a growing appreciation for the role of neoantigens in tumors. In this study, we explored the mechanisms underlying the involvement of neoantigen-associated genes in BLCA and their impact on prognosis. Our analysis incorporated both single-cell sequencing and bulk sequencing data sourced from publicly available databases. By employing a comprehensive set of 10 machine learning algorithms, we generated 101 algorithm combinations. The optimal combination, determined based on consistency indices, was utilized to construct a prognostic model comprising nine genes (CAPG, ACTA2, PDIA6, AKNA, PTMS, SNAP23, ID2, CD3G, SP140). Subsequently, we validated this model in an independent cohort, demonstrating its robust testing efficacy. Moreover, we explored the correlations between various clinical traits, model scores, and genes. Leveraging extensive public data resources, we conducted a drug sensitivity analysis to provide insights for targeted drug screening. Additionally, consensus clustering analysis and immune infiltration analysis were performed on bulk sequencing datasets and immunotherapy cohorts. These analyses yield valuable insights into the role of neoantigens in BLCA, guiding future research endeavors.
MeSH term(s)	Humans ; Urinary Bladder Neoplasms/genetics ; Algorithms ; Drug Evaluation, Preclinical ; DNA-Binding Proteins ; Nuclear Proteins ; Transcription Factors
Chemical Substances	AKNA protein, human ; DNA-Binding Proteins ; Nuclear Proteins ; Transcription Factors
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.24123
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Zs.A 2676: Show issues

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Article ; Online: Spatial responses of water quality to river density and connectivity alterations on the Taihu Plain.

Lu, Miao / Hua, Jian / Zhang, Xiuhong / Wei, Huaidong / Yu, Zhihui

Environmental science and pollution research international

2023 Volume 30, Issue 43, Page(s) 97808–97823

Abstract: With the advancement of urbanization, the structure and connectivity of river networks have been changed by the interference of human activities, resulting in a series of water environment problems. Numerous studies have indicated that river networks are ...

Abstract	With the advancement of urbanization, the structure and connectivity of river networks have been changed by the interference of human activities, resulting in a series of water environment problems. Numerous studies have indicated that river networks are associated with water quality; unfortunately, few studies have revealed the contributions of the structure and connectivity of river networks to variations in water quality. Taking one water conservancy region with dense and braided rivers on the Taihu Plain as an example, we depicted the spatial aggregations of water quality using the Getis-Ord Gi* index, quantified the variations in polluted regions using the standard deviational ellipse method, and quantified the influence of river density and connectivity on water quality during the different seasons. The results showed that (1) the water quality during the flood season was better than that during the non-flood season, especially in the western region; (2) the spatial aggregations of most water quality indicators were higher and the polluted regions increased in size during the flood period compared to the non-flood period; and (3) the relative contribution rates of the river density and connectivity exhibited mean values of 62.5% (61.2%) and 37.5% (38.8%) in the flood (non-flood) period. Our results provide theoretical support for enhancing water environment management.
MeSH term(s)	Humans ; Rivers ; Water Quality ; Floods ; Seasons ; Urbanization
Language	English
Publishing date	2023-08-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-29140-1
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Article ; Online: Marine toxin domoic acid alters protistan community structure and assembly process in sediments.

Li, Zelong / Wang, Jing / Fan, Jingfeng / Yue, Hao / Zhang, Xiuhong

Marine environmental research

2023 Volume 191, Page(s) 106131

Abstract: Domoic acid (DA)-producing algal blooms have been the issue of worldwide concerns in recent decades, but there has never been any attempt to investigate the effects of DA on microbial ecology in marine environments. Protists are considered to be key ... ...

Abstract	Domoic acid (DA)-producing algal blooms have been the issue of worldwide concerns in recent decades, but there has never been any attempt to investigate the effects of DA on microbial ecology in marine environments. Protists are considered to be key regulators of microbial activity, community structure and evolution, we therefore explore the effect of DA on the ecology of protists via metagenome in this work. The results indicate that trace amounts of DA can act as a stressor to alter alpha and beta diversity of protistan community. Among trophic functional groups, consumers and phototrophs are negative responders of DA, implying DA is potentially capable of functional-level effects in the ocean. Moreover, microecological theory reveals that induction of DA increases the role of deterministic processes in microbial community assembly, thus altering the biotic relationships and successional processes in symbiotic patterns. Finally, we demonstrate that the mechanism by which DA shapes protistan ecological network is by acting on phototrophs, which triggers cascading effects in networks and eventually leading to shifts in ecological succession of protists. Overall, our results present the first perspective regarding the effects of DA on marine microbial ecology, which will supplement timely information on the ecological impacts of DA in the ocean.
MeSH term(s)	Marine Toxins ; Kainic Acid/toxicity ; Eukaryota ; Microbiota
Chemical Substances	domoic acid (M02525818H) ; Marine Toxins ; Kainic Acid (SIV03811UC)
Language	English
Publishing date	2023-08-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1502505-6
ISSN	1879-0291 ; 0141-1136
ISSN (online)	1879-0291
ISSN	0141-1136
DOI	10.1016/j.marenvres.2023.106131
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Article ; Online: Marine toxin domoic acid alters protistan community structure and assembly process in sediments

Li, Zelong / Wang, Jing / Fan, Jingfeng / Yue, Hao / Zhang, Xiuhong

Marine Environmental Research. 2023 Aug. 09, p.106131-

2023 , Page(s) 106131–

Abstract	Domoic acid (DA)-producing algal blooms have been the issue of worldwide concerns in recent decades, but there has never been any attempt to investigate the effects of DA on microbial ecology in marine environments. Protists are considered to be key regulators of microbial activity, community structure and evolution, we therefore explore the effect of DA on the ecology of protists via metagenome in this work. The results indicate that trace amounts of DA can act as a stressor to alter alpha and beta diversity of protistan community. Among trophic functional groups, consumers and phototrophs are negative responders of DA, implying DA is potentially capable of functional-level effects in the ocean. Moreover, microecological theory reveals that induction of DA increases the role of deterministic processes in microbial community assembly, thus altering the biotic relationships and successional processes in symbiotic patterns. Finally, we demonstrate that the mechanism by which DA shapes protistan ecological network is by acting on phototrophs, which triggers cascading effects in networks and eventually leading to shifts in ecological succession of protists. Overall, our results present the first perspective regarding the effects of DA on marine microbial ecology, which will supplement timely information on the ecological impacts of DA in the ocean.
Keywords	algae ; autotrophs ; community structure ; domoic acid ; ecological succession ; evolution ; metagenomics ; microbial activity ; microbial communities ; protists ; research ; species diversity ; toxins ; Metagenome ; Trophic structure ; Ecological impact
Language	English
Dates of publication	2023-0809
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	1502505-6
ISSN	1879-0291 ; 0141-1136
ISSN (online)	1879-0291
ISSN	0141-1136
DOI	10.1016/j.marenvres.2023.106131
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Adverse events of epidiolex: A real-world drug safety surveillance study based on the FDA adverse event reporting system (FAERS) database.

Zhou, Qin / Du, Zhiqiang / Qu, Kankan / Shen, Yuan / Jiang, Ying / Zhu, Haohao / Zhang, Xiuhong

Asian journal of psychiatry

2023 Volume 90, Page(s) 103828

Abstract: Epidiolex, the first FDA-approved drug with cannabis extract, treats Dravet and Lennox-Gastaut syndromes. Using data from the FAERS database between 2018 and 2023, this study analyzed 13,275 Epidiolex-related adverse events. Through computational methods ...

Abstract	Epidiolex, the first FDA-approved drug with cannabis extract, treats Dravet and Lennox-Gastaut syndromes. Using data from the FAERS database between 2018 and 2023, this study analyzed 13,275 Epidiolex-related adverse events. Through computational methods (ROR, PRR, BCPNN, EBGM), we found that real-world adverse reactions largely align with those in Epidiolex's drug leaflet. However, Seizure cluster, Blood ketone body decrease, Cortical visual impairment, Hyperactive pharyngeal reflex, and Poverty of speech emerged as potential new side effects not previously listed, warranting further attention for drug safety.
MeSH term(s)	United States/epidemiology ; Humans ; Cannabidiol ; Adverse Drug Reaction Reporting Systems ; Drug-Related Side Effects and Adverse Reactions ; United States Food and Drug Administration ; Software
Chemical Substances	Cannabidiol (19GBJ60SN5)
Language	English
Publishing date	2023-11-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2456678-0
ISSN	1876-2026 ; 1876-2018
ISSN (online)	1876-2026
ISSN	1876-2018
DOI	10.1016/j.ajp.2023.103828
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Article ; Online: Metabolomic responses based on transcriptome of the hepatopancreas in Exopalaemon carinicauda under carbonate alkalinity stress.

Qin, Zhen / Ge, Qianqian / Wang, Jiajia / Li, Mingdong / Zhang, Xiuhong / Li, Jian / Li, Jitao

Ecotoxicology and environmental safety

2023 Volume 268, Page(s) 115723

Abstract: High carbonate alkalinity is one of the major stress factors for survival of aquatic animals in saline-alkaline water. Exopalaemon carinicauda is a good model for studying the saline-alkaline adaption mechanism in crustacean because of its great adaptive ...

Abstract	High carbonate alkalinity is one of the major stress factors for survival of aquatic animals in saline-alkaline water. Exopalaemon carinicauda is a good model for studying the saline-alkaline adaption mechanism in crustacean because of its great adaptive capacity to alkalinity stress. In this study, non-targeted liquid chromatography-mass spectrometry (LC-MS) metabolomics analyses based on high-throughput RNA sequencing (RNA-Seq) were used to study the metabolomic responses of hepatopancreas in E. carinicauda at 12 h and 36 h after acute carbonate alkalinity stress. The results revealed that most of the significantly differential metabolites were related to the lipid metabolism. In particular, the sphingolipid metabolism was observed at 12 h, the glycerophospholipid metabolism was detected at 36 h, and the linoleic acid metabolic pathway was significantly enriched at both 12 h and 36 h. The combined transcriptome and metabolome analysis showed that energy consumption increased at 12 h, resulting in significant enrichment of AMPK signaling pathways, which contributed to maintain energy homeostasis. Subsequently, the hepatopancreas provided sufficient energy supply through cAMP signaling pathway and glycerophosphate metabolism to maintain normal metabolic function at 36 h. These findings might help to understand the molecular mechanisms of the E. carinicauda under carbonate alkalinity stress, thereby promote the research and development of saline-alkaline resistant shrimp.
MeSH term(s)	Animals ; Transcriptome ; Hepatopancreas ; Palaemonidae/genetics ; Palaemonidae/metabolism ; Carbonates/metabolism
Chemical Substances	Carbonates
Language	English
Publishing date	2023-11-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2023.115723
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Zs.A 1418: Show issues

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Article: Tigecycline-associated acute pancreatitis in a child with pulmonary cystic fibrosis: A case report and literature review.

Chang, Chunyan / Qiao, Weizhen / Wang, Hongmei / Zhang, Xiuhong

International journal of clinical pharmacology and therapeutics

2021 Volume 60, Issue 1, Page(s) 41–45

Abstract: Tigecycline is a tetracycline-class antibacterial indicated for the treatment of complicated skin and skin-structure infections, complicated intra-abdominal infections, and community-acquired bacterial pneumonia. It has a broad-spectrum antibacterial ... ...

Abstract	Tigecycline is a tetracycline-class antibacterial indicated for the treatment of complicated skin and skin-structure infections, complicated intra-abdominal infections, and community-acquired bacterial pneumonia. It has a broad-spectrum antibacterial activity. It has identified gastrointestinal side-effects, particularly nausea and vomiting. With the increasing clinical use of tigecycline, its associated acute pancreatitis has been frequently reported in adults. However, cases of tigecycline-induced acute pancreatitis have rarely been described in children. In this study, we report a case of acute pancreatitis caused by the use of tigecycline in a child with pulmonary cystic fibrosis. In this case, abdominal pain, nausea, and vomiting occurred on the 5
MeSH term(s)	Acute Disease ; Adult ; Anti-Bacterial Agents/adverse effects ; Child ; Cystic Fibrosis/drug therapy ; Humans ; Minocycline/adverse effects ; Pancreatitis/chemically induced ; Pancreatitis/diagnosis ; Pancreatitis/drug therapy ; Tigecycline
Chemical Substances	Anti-Bacterial Agents ; Tigecycline (70JE2N95KR) ; Minocycline (FYY3R43WGO)
Language	English
Publishing date	2021-10-03
Publishing country	Germany
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	124384-6
ISSN	0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
ISSN	0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
DOI	10.5414/CP204073
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