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Book ; Online ; E-Book: Transmission dynamics of tick-borne diseases with co-feeding, developmental and behavioural diapause

Wu, Jianhong / Zhang, Xue

(Lecture notes on mathematical modelling in the life sciences)

2020

Abstract: This monograph introduces some current developments in the modelling of the spread of tick-borne diseases. Effective modelling requires the integration of multiple frameworks. Here, particular attention is given to the previously neglected issues of tick ...

Author's details	Jianhong Wu, Xue Zhang
Series title	Lecture notes on mathematical modelling in the life sciences
Abstract	This monograph introduces some current developments in the modelling of the spread of tick-borne diseases. Effective modelling requires the integration of multiple frameworks. Here, particular attention is given to the previously neglected issues of tick developmental and behavioral diapause, tick-borne pathogen co-feeding transmission, and their interactions. An introduction to the required basics of structured population formulations and delay differential equations is given, and topics for future study are suggested. The described techniques will also be useful in the study of other vector-borne diseases. The ultimate aim of this project is to develop a general qualitative framework leading to tick-borne disease risk predictive tools and a decision support system. The target audience is mathematical biologists interested in modelling tick population dynamics and tick-borne disease transmission, and developing computational tools for disease prevention and control.
Keywords	Tick-borne diseases
Subject code	616.968
Language	English
Size	1 online resource (XIII, 160 p. 24 illus., 21 illus. in color.)
Edition	1st ed. 2020.
Publisher	Springer
Publishing place	Cham, Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	3-030-54024-3 ; 3-030-54023-5 ; 978-3-030-54024-1 ; 978-3-030-54023-4
DOI	10.1007/978-3-030-54024-1
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: T2T-YAO Reference Genome of Han Chinese - New Step in Advancing Precision Medicine in China.

Zhang, Xue

Genomics, proteomics & bioinformatics

2023 Volume 21, Issue 6, Page(s) 1083–1084

MeSH term(s)	Humans ; Precision Medicine/methods ; China ; Genome, Human/genetics ; Asian People/genetics ; East Asian People
Language	English
Publishing date	2023-09-22
Publishing country	England
Document type	Research Support, Non-U.S. Gov't ; Journal Article ; Editorial
ZDB-ID	2240213-5
ISSN	2210-3244 ; 1672-0229
ISSN (online)	2210-3244
ISSN	1672-0229
DOI	10.1016/j.gpb.2023.09.001
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Article ; Online: Graphic of intraoperative end-tidal carbon dioxide tension indicate pulmonary perfusion disorder during a lobectomy of lung: A case report.

Zhang, Xue / Wei, Wei

Asian journal of surgery

2024

Language	English
Publishing date	2024-02-20
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2024.02.032
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Article ; Online: Mechanism of chromosomal mosaicism in preimplantation embryos and its effect on embryo development.

Zhang, Xue / Zheng, Peng-Sheng

Journal of assisted reproduction and genetics

2024

Abstract: Aneuploidy is one of the main causes of miscarriage and in vitro fertilization failure. Mitotic abnormalities in preimplantation embryos are the main cause of mosaicism, which may be influenced by several endogenous factors such as relaxation of cell ... ...

Abstract	Aneuploidy is one of the main causes of miscarriage and in vitro fertilization failure. Mitotic abnormalities in preimplantation embryos are the main cause of mosaicism, which may be influenced by several endogenous factors such as relaxation of cell cycle control mechanisms, defects in chromosome cohesion, centrosome aberrations and abnormal spindle assembly, and DNA replication stress. In addition, incomplete trisomy rescue is a rare cause of mosaicism. However, there may be a self-correcting mechanism in mosaic embryos, which allows some mosaicisms to potentially develop into normal embryos. At present, it is difficult to accurately diagnose mosaicism using preimplantation genetic testing for aneuploidy. Therefore, in clinical practice, embryos diagnosed as mosaic should be considered comprehensively based on the specific situation of the patient.
Language	English
Publishing date	2024-02-22
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1112577-9
ISSN	1573-7330 ; 1058-0468
ISSN (online)	1573-7330
ISSN	1058-0468
DOI	10.1007/s10815-024-03048-2
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Article: Targeting SHMTs and MTHFDs in cancer: attractive opportunity for anti-tumor strategy.

Zhang, Xue / Wang, Zhenhua

Frontiers in pharmacology

2024 Volume 15, Page(s) 1335785

Abstract: One-carbon metabolism is a universal metabolic process that mediates the transfer of one-carbon units for purine and thymidine synthesis. One-carbon metabolism has been found to be dysregulated in various cancer types due to its role in production of ... ...

Abstract	One-carbon metabolism is a universal metabolic process that mediates the transfer of one-carbon units for purine and thymidine synthesis. One-carbon metabolism has been found to be dysregulated in various cancer types due to its role in production of purine and pyrimidine nucleotides, epigenetic program, and redox homeostasis. One-carbon metabolism is composed a network of one-carbon metabolic enzymes. Disturbing the expression and enzymatic activity of these one-carbon metabolic enzymes could lead to fluctuations of metabolites in the tumor microenvironment. Serine hydroxymethyltransferases (SHMTs) and methylenetetrahydrofolate dehydrogenases (MTHFDs) are gradually recognized as important one-carbon metabolic enzymes for regulating tumor initiation and development, representing potential therapeutic targets for anti-tumor strategies. In the review, we primarily focused on the role of SHMTs and MTHFDs in cancer. Several inhibitors targeting MTHFDs and SHMTs have exert its potential to decrease tumor burden and inhibit tumor proliferation, highlighting the potential of targeting one-carbon metabolic enzymes for anti-cancer strategies.
Language	English
Publishing date	2024-02-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1335785
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Article: Geographically specific associations between county-level socioeconomic and household distress and mortality from drug poisoning, suicide, alcohol, and homicide among working-age adults in the United States.

Zhang, Xue / Monnat, Shannon M

SSM - population health

2024 Volume 25, Page(s) 101595

Abstract: Background: Mortality rates from drug poisoning, suicide, alcohol, and homicide vary significantly across the United States. This study explores localized relationships (i.e., geographically specific associations) between county-level economic and ... ...

Abstract	Background: Mortality rates from drug poisoning, suicide, alcohol, and homicide vary significantly across the United States. This study explores localized relationships (i.e., geographically specific associations) between county-level economic and household distress and mortality rates from these causes among working-age adults (25-64). Methods: Mortality data were from the National Vital Statistics System for 2014-2019. County-level socioeconomic distress (poverty, employment, income, education, disability, insurance) and household distress (single-parent, no vehicle, crowded housing, renter occupied) were from the 2009-2013 American Community Survey. We conducted Ordinary Least Squares (OLS) regression to estimate average associations and Geographically Weighted Regression (GWR) to estimate localized spatial associations between county-level distress and working-age mortality. Results: In terms of national average associations, OLS results indicate that a one standard deviation increase in socioeconomic distress was associated with an average of 6.1 additional drug poisoning deaths, 3.0 suicides, 2.1 alcohol-induced deaths, and 2.0 homicides per 100,000 population. A one standard deviation increase in household distress was associated with an average of 1.4 additional drug poisonings, 4.7 alcohol-induced deaths, and 1.1 homicides per 100,000 population. However, the GWR results showed that these associations vary substantially across the U.S., with socioeconomic and household distress associated with significantly higher mortality rates in some parts of the U.S than others, significantly lower rates in other parts of the U.S., and no significant associations in others. There were also some areas where distress overlapped to influence multiple causes of death, in a type of compounded disadvantage. Conclusions: Socioeconomic and household distress are significant and substantial predictors of higher rates of drug poisoning mortality, suicide, alcohol-induced deaths, and homicide in specific regions of the U.S. However, these associations are not universal. Understanding the place-level factors that contribute to them can inform geographically tailored strategies to reduce rates from these preventable causes of death in different places.
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article
ISSN	2352-8273
ISSN	2352-8273
DOI	10.1016/j.ssmph.2023.101595
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Article: Inhibition of GluN2B-containing NMDA receptors in early life combined with social stress in adulthood leads to alterations in prefrontal PNNs in mice.

Liang, Yi-Rui / Zhang, Xue-Han

Sheng li xue bao : [Acta physiologica Sinica

2024 Volume 76, Issue 1, Page(s) 1–11

Abstract: Perineuronal nets (PNNs) are specialized extracellular matrix (ECM) structures present in the central nervous system (CNS) and have been identified as significant regulators of developmental plasticity in the developing cortex. PNNs are particularly ... ...

Abstract	Perineuronal nets (PNNs) are specialized extracellular matrix (ECM) structures present in the central nervous system (CNS) and have been identified as significant regulators of developmental plasticity in the developing cortex. PNNs are particularly enriched in the cortex surrounding parvalbumin-expressing (PV
MeSH term(s)	Animals ; Humans ; Mice ; Cell Adhesion Molecules ; Central Nervous System ; Cerebral Cortex ; Extracellular Matrix ; Nuclear Proteins ; Receptors, N-Methyl-D-Aspartate ; Stress, Psychological
Chemical Substances	Cell Adhesion Molecules ; Nuclear Proteins ; PNN protein, human ; Receptors, N-Methyl-D-Aspartate ; NR2B NMDA receptor
Language	English
Publishing date	2024-02-28
Publishing country	China
Document type	Journal Article
ZDB-ID	604308-2
ISSN	0371-0874
ISSN	0371-0874
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Article: [Genistein loaded by PRF improved bone healing in obese mice].

Zhang, Xue-Bing / Li, Qi

Shanghai kou qiang yi xue = Shanghai journal of stomatology

2024 Volume 33, Issue 1, Page(s) 13–21

Abstract: Purpose: To clarify the effect of genistein(GEN) on osteogenic differentiation and explore the effect of GEN loaded by platelet-rich fibrin (PRF) on the repair process of bone defects in obese mice.: Methods: In in vitro experiments, the effect of ... ...

Abstract	Purpose: To clarify the effect of genistein(GEN) on osteogenic differentiation and explore the effect of GEN loaded by platelet-rich fibrin (PRF) on the repair process of bone defects in obese mice. Methods: In in vitro experiments, the effect of GEN(0, 0.1, 1, 10, 50 μmol/L) on the proliferation of mouse embryonic osteoblast precursor cells (MC3T3-E1) was determined by CCK 8. Alkaline phosphatase(ALP) staining and quantitative detection of ALP activity were performed to determine the changes of ALP activity in cells; RNA and protein expression levels of ALP, osteopontin (OPN) and osteocalcin (OCN) were detected by quantitative real-time PCR(qRT-PCR) and Western blot. Alizarin red staining was used to define the effect of GEN on mineralization of MC3T3-E1. To verify the feasibility of the PRF drug loading, the ultrastructure of PRF was subsequently observed under SEM. In in vivo experiments, obese C57 mouse models were established by high-fat diet feeding. On this basis, skull defect models with a diameter of 2.8 mm were established, and the prepared GEN/PRF complexes were placed into the bone defect area. The effects of GEN on skull defect repair in obese mice were evaluated by Micro-CT scanning and hematoxylin-eosin(H-E) staining. Statistical analysis was performed with GraphPad Prism 5.0 software package. Results: CCK 8 results showed that 0.1, 1 μmol/L GEN promoted cell proliferation within 7 days(P＜0.05); 10 μmol/L GEN had no significant effect on the process of cell proliferation. From the second day, 50 μmol/L GEN significantly inhibited cell growth and showed cytotoxicity(P＜0.05). These two concentrations had similar effects in promoting cellular osteogenic differentiation. SEM results showed that PRF presented a 3-dimensional network structure, providing space for loading drug molecules. In in vivo experiments, the body weight of mice in the high-fat diet (HFD) group was 27.7% greater than that in the normal diet group(P＜0.05) and had abnormal glucose tolerance (P＜0.05). Micro-CT showed that compared with the normal diet group, the number of bone trabeculae in the femur of obese mice was decreased(P＜0.05), the distance between bone trabeculae was widened(P＜0.05), and the bone density was decreased (P＜0.05). In addition, GEN (0.1, 1.0 μmol/L) loaded by PRF increased bone volume fraction in the skull of obese mice (P＜0.05). H-E results showed that GEN/PRF promoted the healing of the bone defects. Conclusions: GEN promotes osteogenic differentiation of MC3T3-E1, and it can effectively accelerate the healing of cranial bone defects after loading with PRF in obese mice.
MeSH term(s)	Animals ; Mice ; Osteogenesis/genetics ; Genistein/pharmacology ; Mice, Obese ; Platelet-Rich Fibrin ; Sincalide/pharmacology ; Cell Differentiation/genetics ; Osteoblasts
Chemical Substances	Genistein (DH2M523P0H) ; Sincalide (M03GIQ7Z6P)
Language	Chinese
Publishing date	2024-04-07
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2269714-7
ISSN	1006-7248
ISSN	1006-7248
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Article: Crystal structure and Hirshfeld analysis of diethyl (2

Zhang, Xue-Jun

Acta crystallographica. Section E, Crystallographic communications

2021 Volume 77, Issue Pt 9, Page(s) 895–898

Abstract: The mol-ecule of title compound, ... ...

Abstract	The mol-ecule of title compound, C
Language	English
Publishing date	2021-08-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2041947-8
ISSN	2056-9890 ; 1600-5368
ISSN	2056-9890 ; 1600-5368
DOI	10.1107/S2056989021007829
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Article ; Online: Building a City with Low Noise Pollution: Exploring the Mental Health Effect Thresholds of Spatiotemporal Environmental Noise Exposure and Urban Planning Solution.

Zhang, Xue / Zhou, Suhong

International journal of environmental research and public health

2023 Volume 20, Issue 5

Abstract: Urban noise pollution and health hazards have become serious social problems and challenges. Noise prevention and control is the most cost-effective health strategy. However, in urban planning and noise control, reliable evidence is still lacking on ... ...

Abstract	Urban noise pollution and health hazards have become serious social problems and challenges. Noise prevention and control is the most cost-effective health strategy. However, in urban planning and noise control, reliable evidence is still lacking on individual spatiotemporal environmental noise exposure and its mental health effects. This study used real-time noise exposure data and GPS trackers from 142 volunteers aged 18 to 60 years in Guangzhou, and further analyzed the differences in environmental noise exposure and its mental health impact thresholds under individual spatiotemporal behavior. The results showed that the noise exposure of residents under daily activities has obvious differences in time, space and place. Regarding the threshold relationship between noise exposure and mental health, noise exposure at night, work, personal affairs, travel and sleep activities, as well as at home and work had a threshold effect on residents' mental health. Noise thresholds were 60 dB, 60 dB, and about 34 dB at night, during work or at a workplace, and while sleeping, respectively. The optimal sound environment for personal affairs, traveling, and at home was around 50 dB, 55-70 dB, and 45 dB, respectively. The environmental noise exposure assessment and mental health impact threshold analysis based on the spatial and temporal activities of individuals will provide important reference for government management departments in planning and policy formulation.
MeSH term(s)	Humans ; Noise ; Mental Health ; City Planning ; Environmental Exposure ; Social Problems
Language	English
Publishing date	2023-02-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20054222
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