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  1. Book ; Online: Mechanical Properties of Advanced Metallic Materials

    Zhang, Yang / Chen, Yuqiang

    2023  

    Keywords Technology: general issues ; History of engineering & technology ; Materials science ; low cycle fatigue ; microstructure ; titanium alloys ; thermal-mechanical alleviation ; current ; plasma arc cladding technology ; 2205 duplex stainless steel ; potentiodynamic polarization curve ; passive film composition ; aluminum micron powder ; microwave radiation ; energetic material ; aluminized high-energy material ; high-speed imaging ; laser monitor ; Fe-based alloy ; superelasticity ; martensitic transformation ; precipitate ; medium-entropy alloy ; twin boundary ; mechanical properties ; molecular dynamics ; Ti alloy ; microstructure evolution ; hot tensile deformation ; fracture mechanism ; 5083/6005A welding joint ; corrosion mechanism ; corrosion model ; fatigue life prediction model ; Cu-Al-Ag alloy ; martensite ; accumulative roll bonding (ARB) ; shape memory alloy (SMA) ; hybrid composites ; characterization ; zirconia ; graphite ; SEM ; selective laser melting ; Inconel 718 alloy ; laser energy density ; microhardness ; laser-based powder bed fusion ; titanium alloy ; Taguchi ; process optimization ; density ; A1. dendrite ; A1. particle pushing ; A1. diffusion ; A2. growth from melt ; B1. alloys ; Ti alloys ; β-phase ; laser cladding ; wear characterization ; biomedical applications ; physical vapor deposition ; pre-oxidation ; coating adhesion ; titanium ; ferritic stainless steel ; high-manganese steel ; structural steel ; phase interface ; reactive wetting ; contact angle ; refractory material
    Language English
    Size 1 electronic resource (242 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030377237
    ISBN 9783036569574 ; 303656957X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Evolution of phage display libraries for therapeutic antibody discovery.

    Zhang, Yang

    mAbs

    2023  Volume 15, Issue 1, Page(s) 2213793

    Abstract: Monoclonal antibodies (mAbs) and their derivatives have emerged as one of the most important classes of biotherapeutics in recent decades. The success of mAb is due to their high versatility, high target specificity, excellent clinical safety profile, ... ...

    Abstract Monoclonal antibodies (mAbs) and their derivatives have emerged as one of the most important classes of biotherapeutics in recent decades. The success of mAb is due to their high versatility, high target specificity, excellent clinical safety profile, and efficacy. Antibody discovery, the most upstream stage of the antibody development pipeline, plays a pivotal role in determination of the clinical outcome of an mAb product. Phage display technology, originally developed for peptide directed evolution, has been extensively applied to discovery of fully human antibodies due to its unprecedented advantages. The value of phage display technology has been proven by a number of approved mAbs, including several top-selling mAb drugs, derived from the technology. Since antibody phage display was first established over 30 years ago, phage display platforms have been developed to generate mAbs targeting difficult-to-target antigens and tackle the drawbacks present in in vivo antibody discovery approaches. More recently, the new generation of phage display libraries have been optimized for discovery of mAbs with "drug-like" properties. This review will summarize the principles of antibody phage display and design of three generations of antibody phage display libraries.
    MeSH term(s) Humans ; Antibodies, Monoclonal ; Cell Surface Display Techniques ; Bacteriophages
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2023-05-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2537838-7
    ISSN 1942-0870 ; 1942-0870
    ISSN (online) 1942-0870
    ISSN 1942-0870
    DOI 10.1080/19420862.2023.2213793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A scalable and extensible command training exam system architecture

    ZHANG Yang, ZHANG Junfeng

    Zhihui kongzhi yu fangzhen, Vol 45, Iss 5, Pp 137-

    2023  Volume 142

    Abstract: In view of the problems existing in the current exam system, such as separation from the command information system and difficulty in carrying out remote group training, a scalable and extensible command training exam system architecture is proposed to ... ...

    Abstract In view of the problems existing in the current exam system, such as separation from the command information system and difficulty in carrying out remote group training, a scalable and extensible command training exam system architecture is proposed to provide technical support for integrating and invoking the relevant components of the command information system and carrying out large-scale group training. Firstly, the component integration framework of multi-system integration and the integrated exam course evaluation mode are proposed to realize the assessment of each course including command skills. Then, a multi-level server exam structure is designed. On this basis, through the application of virtualization cluster and other technologies, the rapid deployment of the system under diverse conditions and the large-scale remote group training application is realized.
    Keywords knowledge reasoning|rule base|mapping evaluation|interest region ; Military Science ; U
    Language Chinese
    Publishing date 2023-10-01T00:00:00Z
    Publisher Editorial Office of Command Control and Simulation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book ; Online: A New Fine-grained Alignment Method for Image-text Matching

    Zhang, Yang

    2023  

    Abstract: Image-text retrieval is a widely studied topic in the field of computer vision due to the exponential growth of multimedia data, whose core concept is to measure the similarity between images and text. However, most existing retrieval methods heavily ... ...

    Abstract Image-text retrieval is a widely studied topic in the field of computer vision due to the exponential growth of multimedia data, whose core concept is to measure the similarity between images and text. However, most existing retrieval methods heavily rely on cross-attention mechanisms for cross-modal fine-grained alignment, which takes into account excessive irrelevant regions and treats prominent and non-significant words equally, thereby limiting retrieval accuracy. This paper aims to investigate an alignment approach that reduces the involvement of non-significant fragments in images and text while enhancing the alignment of prominent segments. For this purpose, we introduce the Cross-Modal Prominent Fragments Enhancement Aligning Network(CPFEAN), which achieves improved retrieval accuracy by diminishing the participation of irrelevant regions during alignment and relatively increasing the alignment similarity of prominent words. Additionally, we incorporate prior textual information into image regions to reduce misalignment occurrences. In practice, we first design a novel intra-modal fragments relationship reasoning method, and subsequently employ our proposed alignment mechanism to compute the similarity between images and text. Extensive quantitative comparative experiments on MS-COCO and Flickr30K datasets demonstrate that our approach outperforms state-of-the-art methods by about 5% to 10% in the rSum metric.
    Keywords Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Artificial Intelligence ; Computer Science - Multimedia
    Subject code 004
    Publishing date 2023-11-03
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Integrating the results of at-home diagnostic testing with public health surveillance to better track COVID-19 and future public health threats.

    Zhang, Yang / Basta, Nicole E

    Lancet regional health. Americas

    2024  Volume 30, Page(s) 100680

    Language English
    Publishing date 2024-02-03
    Publishing country England
    Document type Journal Article
    ISSN 2667-193X
    ISSN (online) 2667-193X
    DOI 10.1016/j.lana.2024.100680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Spectral precision improvement with demagnifying spectral images in spectroscopic nanoscopy.

    Song, Ki-Hee / Zhang, Yang

    Journal of the Optical Society of America. A, Optics, image science, and vision

    2024  Volume 41, Issue 1, Page(s) 39–44

    Abstract: Spectroscopic nanoscopy (SN) has been recognized as a key functional imaging tool in cell biology and chemistry because it offers the unique capability to simultaneously obtain the spatial and spectral information for single molecules. However, it has an ...

    Abstract Spectroscopic nanoscopy (SN) has been recognized as a key functional imaging tool in cell biology and chemistry because it offers the unique capability to simultaneously obtain the spatial and spectral information for single molecules. However, it has an intrinsic issue in using the limited photon budget from single emitters divided into two imaging channels to concurrently acquire spatial and spectral images. Accordingly, this issue lowers the spatial localization and spectral precision. Although several techniques have been introduced to improve the spatial precision in SN, improving the spectral precision has been overlooked so far. Here we propose a method to improve the spectral precision by optically manipulating the width of the spectroscopic signatures using a demagnifier. We evaluate its performance using numerical simulations with systematic investigations of several underlying optimal parameters such as the demagnification factor and the integration width in the proposed configuration. We also present achievable spectral precision values with different signal and background levels. Compared to the existing SN system, the 3× demagnifier-based configuration shows an approximate 35% improvement, from 2.9 nm to 1.9 nm, in the spectral precision at the 1000 photons signal level.
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 283633-6
    ISSN 1520-8532 ; 1084-7529 ; 0740-3232
    ISSN (online) 1520-8532
    ISSN 1084-7529 ; 0740-3232
    DOI 10.1364/JOSAA.497634
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2689: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: [Enhance the understanding lumbar spinal stenosis and optimize the treatment plan].

    Zhang, Yang / Sun, Tian-Sheng

    Zhongguo gu shang = China journal of orthopaedics and traumatology

    2024  Volume 37, Issue 4, Page(s) 327–330

    MeSH term(s) Humans ; Spinal Stenosis/therapy ; Spinal Stenosis/surgery ; Lumbar Vertebrae/surgery
    Language Chinese
    Publishing date 2024-04-25
    Publishing country China
    Document type Journal Article
    ISSN 1003-0034
    ISSN 1003-0034
    DOI 10.12200/j.issn.1003-0034.20240325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: LINC02605 involved in paediatric Mycoplasma pneumoniae pneumonia complicated with diarrhoea via miR-539-5p/CXCL1 axis.

    Zhang, Yang / Wu, Zeming

    European journal of clinical investigation

    2024  , Page(s) e14234

    Abstract: Background: To investigate the involvement of LINC02605 in the progression of paediatric Mycoplasma pneumoniae pneumonia (MPP).: Methods: One hundred and thirty-two children with MPP (90 simple MPP and 42 MPP + diarrhoea) were enrolled, and their ... ...

    Abstract Background: To investigate the involvement of LINC02605 in the progression of paediatric Mycoplasma pneumoniae pneumonia (MPP).
    Methods: One hundred and thirty-two children with MPP (90 simple MPP and 42 MPP + diarrhoea) were enrolled, and their plasma was collected for detection of LINC026505 expression. CCK-8 kit and commercial apoptosis kit were introduced to determine cell growth and apoptosis. In silico prediction analyses were conducted to predict the downstream miRNA for LINC02605, following verification by dual luciferase reporter assay. The lipid-associated membrane proteins (LAMPs) were used to treat A549 and Coca-2 cells.
    Results: LIN02605 was highly expressed in the MPP, especially in MPP complicated with diarrhoea. LINC02605 downregulation in A549 cells correlated with significant suppression of cell apoptosis rate and growth inhibition rate in vitro. Introduction of miR-539-5p inhibited luciferase activity in a reporter system containing the wild-type LINC02605 and CXCL1. After stimulation with LAMPs, overexpression of LINC02605 and CXCL1 and inhibition of miR-539-5p were found. miR-539-5p and CXCL1 knockdown resulted in a rescue effect on the LINC02605-inhibited cell apoptosis. LAMPs induced IL-1β in intestinal epithelial cells and IL-1β induced LINC02605 expression in A549 cells.
    Conclusions: LINC02605 was upregulated in MPP and miR-539-5p was a target for LINC02605. LINC02605 may be involved in the crosstalk between the gastrointestinal tract and the respiratory tract.
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.14234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 677: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Attentional Bias Toward Cigarette-Related Cues in Male Smokers is Modulated by Cognitive Control Mechanisms.

    Zhang, Yang / Chen, ZhiChen

    Substance use & misuse

    2024  Volume 59, Issue 8, Page(s) 1256–1260

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Male ; Cues ; Attentional Bias/physiology ; Adult ; Young Adult ; Smokers/psychology ; Stroop Test ; Cognition ; Cigarette Smoking/psychology ; Reaction Time ; Attention/physiology ; Smoking/psychology
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1310358-1
    ISSN 1532-2491 ; 1082-6084
    ISSN (online) 1532-2491
    ISSN 1082-6084
    DOI 10.1080/10826084.2024.2340968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 935: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Book ; Online: Algorithms of Real-Time Navigation and Control of Autonomous Unmanned Vehicles

    Zhang, Yang

    2022  

    Abstract: The rapid development of robotics has benefited by more and more people putting their attention to it. With the demand for robots is growing for the purpose of fulfilling tasks instead of humans, how to control the robot better is becoming a hot topic. ... ...

    Abstract The rapid development of robotics has benefited by more and more people putting their attention to it. With the demand for robots is growing for the purpose of fulfilling tasks instead of humans, how to control the robot better is becoming a hot topic. For obstacle avoidance, we proposed algorithms for both 2D planar environments and 3D space environments. The example cases we raise are those that need to be addressed but have always been ignored. In addition, we put efforts into trajectory planning for robots. The two scenarios we set are self-driving cars on the road and reconnaissance and surveillance of drones. For future expectations, there are some possible directions. How to combine traditional navigation algorithms and high-tech algorithms together so as to fulfill the tasks perfectly while the computational efficiency is not too high is a worthy topic. In addition, extending the obstacle avoidance algorithms to more competitive situations. Moreover, cooperation among multi robots are worth attention by researchers. All in all, there is still a long way to go for the development of navigation and control of mobile robots. Despite this, we believe we do not need to wait for too long time to see the revolution of robots.
    Keywords Electrical Engineering and Systems Science - Systems and Control
    Subject code 629
    Publishing date 2022-08-22
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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