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  1. Book ; Online ; E-Book: Conserving and Managing Historical Urban Landscape

    Li, Xiaoxi / Zhang, Ye

    An Integrated Morphological Approach

    (The Urban Book Series,)

    2022  

    Abstract: This book focuses on urban morphology and its application to urban conservation and management. The rapid disappearance of historical urban landscapes, especially in developing countries, is largely attributed to the lack of historic awareness and broad- ... ...

    Author's details by Xiaoxi Li, Ye Zhang
    Series title The Urban Book Series,
    Abstract This book focuses on urban morphology and its application to urban conservation and management. The rapid disappearance of historical urban landscapes, especially in developing countries, is largely attributed to the lack of historic awareness and broad-brush demolition and redevelopment in urban development. The book provides a new, integrated morphological approach that enables fine-grained and cross-scale examination of urban form based on both its historicity and socio-economic potential, with the aims of informing more responsive and context-specific conservation and management of historical urban landscapes. The robustness of this new approach and the feasibility of its application to urban conservation practice are tested and demonstrated by three case studies in drastically different cultural contexts, namely Ludlow, a medieval town in the UK, Chinatown in Singapore and a historic quarter in Nanjing, China. Combining historico-geographical and configurational approaches, the book also makes a significant breakthrough in terms of coordinating and synthesizing different traditions of urban morphology, which has been a key challenge to this field over the past decades. In addition, by using multi-source data, ranging from conventional cartographic maps to computer-generated and open online data, the integrated approach innovatively relates qualitative and quantitative aspects of urban form and links the qualitative and quantitative analyses of formal structure. As an interdisciplinary study merging geography, urban history, urban planning and design, this book is to be primarily used as a reference book for graduate students and scholars in various fields who are interested in urban form and urban conservation and management. In addition, it offers practitioners in urban planning and design a useful tool for managing changes in historical urban landscapes. Lastly, it contributes to developing a common platform to facilitate dialogues among various stakeholders and participants in urban conservation practice.
    Keywords Geography ; Human geography ; Environmental sciences/Social aspects ; Human Geography ; Environmental Social Sciences
    Subject code 895.134
    Language English
    Size 1 online resource (216 pages)
    Edition 1st ed. 2022.
    Publisher Springer Nature Singapore ; Imprint: Springer
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-19-4222-6 ; 9789811942211 ; 978-981-19-4222-8 ; 9811942218
    DOI 10.1007/978-981-19-4222-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Folic acid-decorated astrocytes-derived exosomes enhanced the effect of temozolomide against glioma.

    Liu, Hong-Ming / Zhang, Ye

    The Kaohsiung journal of medical sciences

    2024  

    Abstract: A direct strategy to achieve specific treatments and reduce side effects is through cell type-specific drug delivery. Exosomes (Exos) can be modified with folic acid (FA) to prepare drug delivery systems targeting tumor cells that highly express FA ... ...

    Abstract A direct strategy to achieve specific treatments and reduce side effects is through cell type-specific drug delivery. Exosomes (Exos) can be modified with folic acid (FA) to prepare drug delivery systems targeting tumor cells that highly express FA receptors. This study aimed to produce an exo drug delivery system with FA decoration and temozolomide (TMZ) loading to improve the sustained TMZ release and targeting. We used DSPE-PEG
    Language English
    Publishing date 2024-03-14
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ZDB-ID 639302-0
    ISSN 2410-8650 ; 0257-5655
    ISSN (online) 2410-8650
    ISSN 0257-5655
    DOI 10.1002/kjm2.12819
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Alternative splicing in EMT and TGF-β signaling during cancer progression.

    Zhang, Ying E / Stuelten, Christina H

    Seminars in cancer biology

    2024  Volume 101, Page(s) 1–11

    Abstract: Epithelial to mesenchymal transition (EMT) is a physiological process during development where epithelial cells transform to acquire mesenchymal characteristics, which allows them to migrate and colonize secondary tissues. Many cellular signaling ... ...

    Abstract Epithelial to mesenchymal transition (EMT) is a physiological process during development where epithelial cells transform to acquire mesenchymal characteristics, which allows them to migrate and colonize secondary tissues. Many cellular signaling pathways and master transcriptional factors exert a myriad of controls to fine tune this vital process to meet various developmental and physiological needs. Adding to the complexity of this network are post-transcriptional and post-translational regulations. Among them, alternative splicing has been shown to play important roles to drive EMT-associated phenotypic changes, including actin cytoskeleton remodeling, cell-cell junction changes, cell motility and invasiveness. In advanced cancers, transforming growth factor-β (TGF-β) is a major inducer of EMT and is associated with tumor cell metastasis, cancer stem cell self-renewal, and drug resistance. This review aims to provide an overview of recent discoveries regarding alternative splicing events and the involvement of splicing factors in the EMT and TGF-β signaling. It will emphasize the importance of various splicing factors involved in EMT and explore their regulatory mechanisms.
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1033980-2
    ISSN 1096-3650 ; 1044-579X
    ISSN (online) 1096-3650
    ISSN 1044-579X
    DOI 10.1016/j.semcancer.2024.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Application of Internet hospitals for first-visit patients with COVID-19 during the pandemic in China.

    Zhang, Ye / Zhang, Ye / Huang, Jie / Dong, Liang

    European journal of public health

    2023  Volume 33, Issue 5, Page(s) 789–795

    Abstract: Background: There has been controversy over whether to carry out online medical inquiries and electronic prescription for first-visit patients. While Internet hospitals have become crucial to ensure providing online diagnosis and prescription needs for ... ...

    Abstract Background: There has been controversy over whether to carry out online medical inquiries and electronic prescription for first-visit patients. While Internet hospitals have become crucial to ensure providing online diagnosis and prescription needs for first-visit COVID-positive patients.
    Objective: We describe the results and advantages of online medical treatment during the coronavirus disease 2019 (COVID-19) outbreak and analyse the results and advantages of online medical treatment.
    Methods: Data were collected from the patients who received online medical inquiry services through the COVID-19 Special Section of our Internet hospital. The user demographic characteristics, user behaviour, clinical symptoms and medical records were collected. Baseline data of offline outpatient patients were also collected.
    Results: A total of 16 173 online medical inquiries were included. The daily online outpatient service volume reached a peak of 2446 person-times. The median age was 29.92 years (SD 15.59), ranging from 20-39 years (n = 8870, 54.84%). A total of 89.20% (n = 14 426/16 173) patients had epidemic-related symptoms. Moreover, 23.35% of the people were diagnosed as COVID-19-positive through antigen or nucleic acid testing. Furthermore, 86.61% (14 008/16 173) of the patients visited our hospital for the first time or had no offline physical outpatient service record within the past 3 months. The demand for medical inquiries was mainly for drug dispensing, followed by medication guidance and disease diagnosis. And 2.07% (334/16 173) of the patients needed to go to the offline hospital for further treatment.
    Conclusion: The service model of the COVID-19 Special Section based on Internet hospitals provided the public with the necessary medical support during the COVID-19 outbreak. It provides a reference for future pandemics or public health emergencies.
    Language English
    Publishing date 2023-08-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1129243-x
    ISSN 1464-360X ; 1101-1262
    ISSN (online) 1464-360X
    ISSN 1101-1262
    DOI 10.1093/eurpub/ckad138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Metal-Organic Framework Gels for Adsorption and Catalytic Detoxification of Chemical Warfare Agents: A Review.

    Zhang, Ye / Tao, Cheng-An

    Gels (Basel, Switzerland)

    2023  Volume 9, Issue 10

    Abstract: Chemical warfare agents (CWAs) have brought great threats to human life and social stability, and it is critical to investigate protective materials. MOF (metal-organic framework) gels are a class with an extended MOF architecture that are mainly formed ... ...

    Abstract Chemical warfare agents (CWAs) have brought great threats to human life and social stability, and it is critical to investigate protective materials. MOF (metal-organic framework) gels are a class with an extended MOF architecture that are mainly formed using metal-ligand coordination as an effective force to drive gelation, and these gels combine the unique characteristics of MOFs and organic gel materials. They have the advantages of a hierarchically porous structure, a large specific surface area, machinable block structures and rich metal active sites, which inherently meet the requirements for adsorption and catalytic detoxification of CWAs. A series of advances have been made in the adsorption and catalytic detoxification of MOF gels as chemical warfare agents; however, overall, they are still in their infancy. This review briefly introduces the latest advances in MOF gels, including pure MOF gels and MOF composite gels, and discusses the application of MOF gels in the adsorption and catalytic detoxification of CWAs. Meanwhile, the influence of microstructures (pore structures, metal active site, etc.) on the detoxification performance of protective materials is also discussed, which is of great significance in the exploration of high-efficiency protective materials. Finally, the review looks ahead to next priorities. Hopefully, this review can inspire more and more researchers to enrich the performance of MOF gels for applications in chemical protection and other purification and detoxification processes.
    Language English
    Publishing date 2023-10-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels9100815
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Basal level of ppGpp coordinates

    Grucela, Paulina Katarzyna / Zhang, Yong Everett

    Microbial cell (Graz, Austria)

    2023  Volume 10, Issue 11, Page(s) 248–260

    Abstract: The universal stringent response alarmone ppGpp (guanosine penta and tetra phosphates) plays a crucial role in various aspects of fundamental cell physiology (e.g., cell growth rate, cell size) and thus bacterial tolerance to and survival of external ... ...

    Abstract The universal stringent response alarmone ppGpp (guanosine penta and tetra phosphates) plays a crucial role in various aspects of fundamental cell physiology (e.g., cell growth rate, cell size) and thus bacterial tolerance to and survival of external stresses, including antibiotics. Besides transient antibiotic tolerance (persistence), ppGpp was recently found to contribute to
    Language English
    Publishing date 2023-10-25
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 2814756-X
    ISSN 2311-2638
    ISSN 2311-2638
    DOI 10.15698/mic2023.11.808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: cAMP competitively inhibits periplasmic phosphatases to coordinate nutritional growth with competence of Haemophilus influenzae.

    Kronborg, Kristina / Zhang, Yong Everett

    The Journal of biological chemistry

    2023  Volume 299, Issue 12, Page(s) 105404

    Abstract: Most naturally competent bacteria tightly regulate the window of the competent state to maximize their ecological fitness under specific conditions. Development of competence by Haemophilus influenzae strain Rd KW20 is stimulated by cAMP and inhibited by ...

    Abstract Most naturally competent bacteria tightly regulate the window of the competent state to maximize their ecological fitness under specific conditions. Development of competence by Haemophilus influenzae strain Rd KW20 is stimulated by cAMP and inhibited by purine nucleotides, respectively. In contrast, cAMP inhibits cell growth, but nucleotides are important for KW20 growth. However, the mechanisms underlying the abovementioned reciprocal effects are unclear. Here, we first identified a periplasmic acid phosphatase AphA
    MeSH term(s) Adenosine/metabolism ; Haemophilus influenzae/genetics ; Haemophilus influenzae/metabolism ; NAD/metabolism ; Phosphoric Monoester Hydrolases/genetics ; Phosphoric Monoester Hydrolases/metabolism ; Purine Nucleotides/metabolism ; Cyclic AMP/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism
    Chemical Substances Adenosine (K72T3FS567) ; NAD (0U46U6E8UK) ; Phosphoric Monoester Hydrolases (EC 3.1.3.2) ; Purine Nucleotides ; Cyclic AMP (E0399OZS9N) ; Bacterial Proteins
    Language English
    Publishing date 2023-10-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2023.105404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Radiotherapy Alone vs Radiotherapy With Concurrent Chemoradiotherapy and Survival of Patients With Low-Risk Nasopharyngeal Carcinoma.

    Liu, Yang / Zhang, Ye

    JAMA

    2023  Volume 329, Issue 3, Page(s) 260–261

    MeSH term(s) Humans ; Antineoplastic Combined Chemotherapy Protocols ; Chemoradiotherapy ; Disease-Free Survival ; Nasopharyngeal Carcinoma/drug therapy ; Nasopharyngeal Carcinoma/pathology ; Nasopharyngeal Neoplasms/drug therapy ; Nasopharyngeal Neoplasms/radiotherapy ; Neoplasm Staging ; Radiotherapy, Intensity-Modulated ; Retrospective Studies
    Language English
    Publishing date 2023-01-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2022.21027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Unmanned Aerial Vehicle Cooperative Data Dissemination Based on Graph Neural Networks.

    Xing, Na / Zhang, Ye / Wang, Yuehai / Zhou, Yang

    Sensors (Basel, Switzerland)

    2024  Volume 24, Issue 3

    Abstract: Unmanned Aerial Vehicles (UAVs) have critical applications in various real-world scenarios, including mapping unknown environments, military reconnaissance, and post-disaster search and rescue. In these scenarios where communication infrastructure is ... ...

    Abstract Unmanned Aerial Vehicles (UAVs) have critical applications in various real-world scenarios, including mapping unknown environments, military reconnaissance, and post-disaster search and rescue. In these scenarios where communication infrastructure is missing, UAVs will form an ad hoc network and perform tasks in a distributed manner. To efficiently carry out tasks, each UAV must acquire and share global status information and data from neighbors. Meanwhile, UAVs frequently operate in extreme conditions, including storms, lightning, and mountainous areas, which significantly degrade the quality of wireless communication. Additionally, the mobility of UAVs leads to dynamic changes in network topology. Therefore, we propose a method that utilizes graph neural networks (GNN) to learn cooperative data dissemination. This method leverages the network topology relationship and enables UAVs to learn a decision policy based on local data structure, ensuring that all UAVs can recover global information. We train the policy using reinforcement learning that enhances the effectiveness of each transmission. After repeated simulations, the results validate the effectiveness and generalization of the proposed method.
    Language English
    Publishing date 2024-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s24030887
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Case Report: Persistent left superior vena cava: an incidental finding during peripherally inserted central catheter placement.

    Pan, Shi-Xiang / Zhang, Ye-Ling / Fang, Fang

    Frontiers in surgery

    2024  Volume 10, Page(s) 1254937

    Abstract: Background: A peripherally inserted central catheter (PICC) is a specialized type of long-term intravenous catheter commonly employed for administering chemotherapy. The operation and management of PICC should exclusively be carried out by trained ... ...

    Abstract Background: A peripherally inserted central catheter (PICC) is a specialized type of long-term intravenous catheter commonly employed for administering chemotherapy. The operation and management of PICC should exclusively be carried out by trained healthcare professionals equipped with the requisite knowledge of anatomy, procedural technique and patient care. Persistent left superior vena cava (PLSVC) is a vascular malformation which is typically asymptomatic in clinical presentation, almost always identified during invasive surgery or imaging examinations.
    Case presentation: Herein, we detailed a case involving a breast cancer patient whose PLSVC was identified during the placement of PICC because of the negative P-wave in electrocardiogram (ECG). Subsequent examination, including chest x-ray imaging, postoperative enhanced CT of the chest, ECG, and consultation with an experienced imaging physician confirmed that the patient's variant type was PLSVC type I. 2160. Removal of the catheter was deemed unnecessary, as the catheter tip was appropriately positioned and no other concomitant cardiovascular malformations were detected.
    Conclusion: The PLSVC is a vascular anomaly and is relatively uncommon within the general population. The operator should possess a thorough familiarity with the potential anatomical variations of left superior vena cava, and specialized case profile should be established for patients diagnosed with PLSVC.
    Language English
    Publishing date 2024-01-03
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2023.1254937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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