Article ; Online: Motor symptoms of Parkinson's disease are affected by temperature: A controlled pilot study.
2024 Volume 14, Issue 1, Page(s) e3369
Abstract: Purpose: The motor symptoms (MS) of Parkinson's disease (PD) have been affecting the quality of life in patients. In clinical practice, most patients with PD report that MS are more severe in winter than in summer, and hyperthermic baths (HTB) could ... ...
| Abstract | Purpose: The motor symptoms (MS) of Parkinson's disease (PD) have been affecting the quality of life in patients. In clinical practice, most patients with PD report that MS are more severe in winter than in summer, and hyperthermic baths (HTB) could temporarily improve MS. The study aimed to evaluate the effects of seasonal variation and aquatic thermal environment of HTB on the MS of PD. Patients and methods: A cross-sectional study of 203 Chinese Han patients was performed. Univariate and multivariate analyses were performed to analyze seasonal variation in MS relative to baseline data (sex, age at onset, duration, season of birth, Hoehn and Yahr stage, family history, levodopa equivalent dose, and the effect of HTB on MS). Ten subjects participated in the HTB study, and one patient dropped out. The paired Wilcoxon rank test was used to assess the differences in the Movement Disorder Society-United Parkinson's disease Rating Scale (MDS-UPDRS) part III motor examination total scores and the modified Webster Symptoms Score between non-HTB and before HTB and between non-HTB and after HTB. Results: The improvement of MS after HTB was an independent risk factor for seasonal variation in MS (OR, 25.203; 95% CI, 10.951-58.006; p = .000). Patients with PD had significant improvements in the MDS-UPDRS part III motor examination total scores, especially in bradykinesia (p = .043), rigidity (p = .008), posture (p = .038), and rest tremor amplitude (p = .047). Conclusion: Seasonal variation in temperature and water temperature of HTB may affect MS in some patients with PD. Simple HTB could be recommended as physiotherapy for patients with PD who report temperature-sensitive MS. |
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| MeSH term(s) | Humans ; Cross-Sectional Studies ; Parkinson Disease/drug therapy ; Pilot Projects ; Quality of Life ; Salicylates ; Temperature |
| Chemical Substances | 4-trifluoromethylsalicylic acid (328-90-5) ; Salicylates |
| Language | English |
| Publishing date | 2024-02-20 |
| Publishing country | United States |
| Document type | Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2623587-0 |
| ISSN | 2162-3279 ; 2162-3279 |
| ISSN (online) | 2162-3279 |
| ISSN | 2162-3279 |
| DOI | 10.1002/brb3.3369 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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