LIVIVO - Search results -

Search results

Result 1 - 10 of total 198

Search options

Book ; Online: Rethinking the Man-Land Relations in China

Ma, Li / Zhang, Yingnan / Gan, Muye / Shan, Zhengying

2023

Keywords	Research & information: general ; Geography ; border area ; ecological security ; spatiotemporal evolution ; sustainable development ; Yunnan Province ; carbon emission ; carbon neutrality ; land use change ; Beijing-Tianjin-Hebei ; LMDI ; high-speed rail ; cropland abandonment ; off-farm employment ; migration ; urbanization ; land use ; multi-functionality of cultivated land ; breadbasket ; spatiotemporal variation ; coupling-coordination degree ; influencing factors ; agricultural land ; soil erosion ; RUSLE ; hilly region ; oasis ; cultivated land function ; trade-off and synergy ; multi-function management ; Xinjiang ; land-use conflicts ; "production-living-ecological space" ; landscape ecological risk ; man-land relations ; cultivated land-use transition (CLUT) ; spatial morphology ; functional morphology ; drive mechanism ; main grain-producing areas ; coupling coordination degree model ; "production-living-ecological" functions ; human activity intensity ; the synchronous development model ; sustainable revitalization ; green development practices ; rural human-earth system science ; arid areas man-land relation ; Yanchi County ; China ; migrant workers ; immigrants ; land shortage ; labor shortage ; land transfer ; vulnerability as expected poverty ; farm households ; heterogeneity ; environmental decentralization ; urban construction land supply ; fiscal decentralization ; political centralization ; desertification ; Albedo-NDVI ; feature space ; climate change ; human activity ; Gonghe Basin ; PLEFs ; ecological niche theory ; coupling coordination ; Chongqing City ; human appropriation of net primary production (HANPP) ; urban and rural development ; human activities ; rural regional system ; rural transformation development ; poverty-stricken areas ; human-land relationship ; rural revitalization ; Yanshan-Taihang Mountains ; urbanization quality ; ecosystem services ; spatial-temporal variations ; Lanzhou-Xining urban agglomeration ; production-living-ecological function ; water use ; ecosystem service value ; rural-urban transition ; urban and rural integration ; urban and rural relations ; rural and urban disparities ; n/a
Language	English
Size	1 electronic resource (388 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Document type	Book ; Online
Note	English
HBZ-ID	HT030381067
ISBN	9783036586687 ; 3036586687
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Mouse Corneal Epithelial and Stromal Cell Isolation and Culture.

Zhang, Yingnan / Zhang, Lijun / Liu, Yongqing

Bio-protocol

2023 Volume 13, Issue 19, Page(s) e4829

Abstract: Corneal epithelium and stroma are the major cellular structures for ocular protection and vision accuracy; they play important roles in corneal wound healing and inflammation under pathological conditions. Unlike human, murine corneal and stromal ... ...

Abstract	Corneal epithelium and stroma are the major cellular structures for ocular protection and vision accuracy; they play important roles in corneal wound healing and inflammation under pathological conditions. Unlike human, murine corneal and stromal fibroblast cells are difficult to isolate for cell culture. In our laboratory, we successfully used an ex vivo culture procedure and an enzymatic procedure to isolate, purify, and culture mouse corneal epithelial and stromal fibroblast cells. Key features • Primary cell culture models of a disease are critical for cellular and molecular mechanism studies. • Corneal tissues with the limbus contain stem cells to generate both epithelial and stromal cells. • An ex vivo corneal culture provides a constant generation of primary corneal cells for multiple passages. • The isolated cells are validated by the corneal epithelial cell markers Krt12 and Cdh1 and the stromal fibroblast marker Vim.
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2833269-6
ISSN	2331-8325 ; 2331-8325
ISSN (online)	2331-8325
ISSN	2331-8325
DOI	10.21769/BioProtoc.4829
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: A phage-displayed disulfide constrained peptide discovery platform yields novel human plasma protein binders.

Gao, Xinxin / Kaluarachchi, Harini / Zhang, Yingnan / Hwang, Sunhee / Hannoush, Rami N

PloS one

2024 Volume 19, Issue 3, Page(s) e0299804

Abstract: Disulfide constrained peptides (DCPs) show great potential as templates for drug discovery. They are characterized by conserved cysteine residues that form intramolecular disulfide bonds. Taking advantage of phage display technology, we designed and ... ...

Abstract	Disulfide constrained peptides (DCPs) show great potential as templates for drug discovery. They are characterized by conserved cysteine residues that form intramolecular disulfide bonds. Taking advantage of phage display technology, we designed and generated twenty-six DCP phage libraries with enriched molecular diversity to enable the discovery of ligands against disease-causing proteins of interest. The libraries were designed based on five DCP scaffolds, namely Momordica charantia 1 (Mch1), gurmarin, Asteropsin-A, antimicrobial peptide-1 (AMP-1), and potato carboxypeptidase inhibitor (CPI). We also report optimized workflows for screening and producing synthetic and recombinant DCPs. Examples of novel DCP binders identified against various protein targets are presented, including human IgG Fc, serum albumin, vascular endothelial growth factor-A (VEGF-A) and platelet-derived growth factor (PDGF). We identified DCPs against human IgG Fc and serum albumin with sub-micromolar affinity from primary panning campaigns, providing alternative tools for potential half-life extension of peptides and small protein therapeutics. Overall, the molecular diversity of the DCP scaffolds included in the designed libraries, coupled with their distinct biochemical and biophysical properties, enables efficient and robust identification of de novo binders to drug targets of therapeutic relevance.
MeSH term(s)	Humans ; Peptide Library ; Vascular Endothelial Growth Factor A/metabolism ; Disulfides/metabolism ; Peptides/chemistry ; Bacteriophages/genetics ; Immunoglobulin G/metabolism
Chemical Substances	Peptide Library ; Vascular Endothelial Growth Factor A ; Disulfides ; Peptides ; Immunoglobulin G
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0299804
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Dissecting Drivers of Ozone Pollution during the 2022 Multicity Lockdowns in China Sheds Light on Future Control Direction.

Tan, Yue / Zhang, Yingnan / Wang, Tao / Chen, Tianshu / Mu, Jiangshan / Xue, Likun

Environmental science & technology

2024 Volume 58, Issue 16, Page(s) 6988–6997

Abstract: In 2022, many Chinese cities experienced lockdowns and heatwaves. We analyzed ground and satellite data using machine learning to elucidate chemical and meteorological drivers of changes in ... ...

Abstract	In 2022, many Chinese cities experienced lockdowns and heatwaves. We analyzed ground and satellite data using machine learning to elucidate chemical and meteorological drivers of changes in O
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.4c01197
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Light-degradable nanocomposite hydrogels for antibacterial wound dressing applications.

Fang, Changhao / Shen, Qiming / Zhang, Yingnan / Kanemaru, Karen / Serpe, Michael J

Journal of materials chemistry. B

2024 Volume 12, Issue 19, Page(s) 4686–4697

Abstract: Skin injuries infected by bacteria can cause life-threatening human diseases if not treated properly. In this work, we developed a light-degradable nanocomposite hydrogel to achieve both controlled antibiotic delivery and hydrogel degradation using light ...

Abstract	Skin injuries infected by bacteria can cause life-threatening human diseases if not treated properly. In this work, we developed a light-degradable nanocomposite hydrogel to achieve both controlled antibiotic delivery and hydrogel degradation using light as the sole stimulus. Specifically, we incorporated triclosan-loaded, poly(
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Staphylococcus aureus/drug effects ; Nanocomposites/chemistry ; Hydrogels/chemistry ; Hydrogels/pharmacology ; Hydrogels/chemical synthesis ; Animals ; Bandages ; Humans ; Light ; Swine ; Microbial Sensitivity Tests ; Nanogels/chemistry ; Wound Healing/drug effects ; Polyethylene Glycols/chemistry ; Cell Survival/drug effects ; Fibroblasts/drug effects ; Triclosan/chemistry ; Triclosan/pharmacology ; Biocompatible Materials/chemistry ; Biocompatible Materials/pharmacology
Language	English
Publishing date	2024-05-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d4tb00222a
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Towards Sustainable Management of Urban Ecological Space: A Zoning Approach Hybridized by Ecosystem Service Value and Ecological Risk Assessment

Wu, Yuzhe / Gu, Chenzhuo / Zhang, Yingnan

Land. 2022 Aug. 02, v. 11, no. 8

2022

Abstract: Massive growth is posing threat to the ecological security and sustainability of cities. Ecosystem service value (ESV) and ecological risk index (ERI) assessment can be conducted to enhance urban ecosystem management through the enhanced recognition of ... ...

Abstract	Massive growth is posing threat to the ecological security and sustainability of cities. Ecosystem service value (ESV) and ecological risk index (ERI) assessment can be conducted to enhance urban ecosystem management through the enhanced recognition of these values and risks in decision-making. This paper aimed to measure spatiotemporal ESV and ERI for Shizuishan City located in central China, and, based on this, how to zone urban ecological space using land cover data (for the years 2010, 2015, and 2020). The management options of different zones were suggested to mitigate and manage any potential negative impacts on urban ecological security. Results show that: (1) The spatial distribution characteristic of ESV is “high in the south and low in the north”. The total ESV exhibited an upward tendency from 2010 to 2020. (2) The high-ERI areas were distributed in the peripheral region, while the low-ERI areas were concentrated in the central region. The ERI of water was in decline continuously, whereas the ERI of wetland maintained a high level. (3) The zoning approach integrating ESV and ERI assessment can truly reflect the status of the environment and better clarify the direction of ecological development for different areas. Among four different ecological zones, the high-ESV and low-ERI areas (I) have abundant ecological resources, and they are set as “Priority Development Areas”. The low-ESV and low-ERI areas (II) are set as “Ecological Improvement Areas” because the area of ecological lands are confined. The low-ESV and high-ERI areas (III) have a fragile ecological environment, and they are set as “Exploitation-Prohibited Areas”. The high-ESV and high-ERI areas (IV) are mainly distributed near water and wetland, and they are set as “Research-focused Areas”.
Keywords	decision making ; ecosystem management ; ecosystem services ; environmental assessment ; land cover ; risk ; urban areas ; wetlands ; China
Language	English
Dates of publication	2022-0802
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2682955-1
ISSN	2073-445X
ISSN	2073-445X
DOI	10.3390/land11081220
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Meshless Search SR-STAP for Airborne Radar Based on Meta-Heuristic Algorithms.

Hou, Yunfei / Zhang, Yingnan / Gui, Wenzhu / Wang, Di / Dong, Wei

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 23

Abstract: The sparse recovery (SR) space-time adaptive processing (STAP) method has excellent clutter suppression performance under the condition of limited observation samples. However, when the cluttering is nonlinear in a spatial-Doppler profile, it will cause ... ...

Abstract	The sparse recovery (SR) space-time adaptive processing (STAP) method has excellent clutter suppression performance under the condition of limited observation samples. However, when the cluttering is nonlinear in a spatial-Doppler profile, it will cause an off-grid effect and reduce the sparse recovery performance. A meshless search using a meta-heuristic algorithm (MH) can completely eliminate the off-grid effect in theory. Therefore, genetic algorithm (GA), differential evolution (DE), particle swarm optimization (PSO), and grey wolf optimization (GWO) methods are applied to SR-STAP for selecting exact clutter atoms in this paper. The simulation results show that MH-STAP can estimate the clutter subspace more accurately than the traditional algorithm; PSO-STAP and GWO-STAP showed better clutter suppression performance in four MH-STAP methods. To search for more accurate clutter atoms, PSO and GWO are combined to improve the method's capacity for global optimization. Meanwhile, the fitness function is improved by using prior knowledge of the clutter distribution. The simulation results show that the improved PSO-GWO-STAP algorithm provides excellent clutter suppression performance, which solves the off-grid problem better than does single MH-STAP.
Language	English
Publishing date	2023-11-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23239444
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Charge-Sensitive Optical Detection of Binding Kinetics between Phage-Displayed Peptide Ligands and Protein Targets.

Liang, Runli / Zhang, Yingnan / Ma, Guangzhong / Wang, Shaopeng

Biosensors

2022 Volume 12, Issue 6

Abstract: Phage display technology has been a powerful tool in peptide drug development. However, the supremacy of phage display-based peptide drug discovery is plagued by the follow-up process of peptides synthesis, which is costly and time consuming, but is ... ...

Abstract	Phage display technology has been a powerful tool in peptide drug development. However, the supremacy of phage display-based peptide drug discovery is plagued by the follow-up process of peptides synthesis, which is costly and time consuming, but is necessary for the accurate measurement of binding kinetics in order to properly triage the best peptide leads during the affinity maturation stages. A sensitive technology is needed for directly measuring the binding kinetics of peptides on phages to reduce the time and cost of the entire process. Here, we show the capability of a charge-sensitive optical detection (CSOD) method for the direct quantification of binding kinetics of phage-displayed peptides to their target protein, using whole phages. We anticipate CSOD will contribute to streamline the process of phage display-based drug discovery.
MeSH term(s)	Bacteriophages/genetics ; Bacteriophages/metabolism ; Kinetics ; Ligands ; Peptide Library ; Peptides/metabolism ; Protein Binding
Chemical Substances	Ligands ; Peptide Library ; Peptides
Language	English
Publishing date	2022-06-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios12060394
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Novel Simulation and Analysis of Mie-Scattering Lidar for Detecting Atmospheric Turbulence Based on Non-Kolmogorov Turbulence Power Spectrum Model.

Zhang, Yingnan / Mao, Jiandong / Li, Juan / Gong, Xin

Entropy (Basel, Switzerland)

2022 Volume 24, Issue 12

Abstract: The Mie-scattering lidar can detect atmospheric turbulence intensity by using the return signals of Gaussian beams at different heights. The power spectrum method and Zernike polynomial method are used to simulate the non-Kolmogorov turbulent phase plate, ...

Abstract	The Mie-scattering lidar can detect atmospheric turbulence intensity by using the return signals of Gaussian beams at different heights. The power spectrum method and Zernike polynomial method are used to simulate the non-Kolmogorov turbulent phase plate, respectively, and the power spectrum method with faster running speed is selected for the subsequent simulation. In order to verify the possibility of detecting atmospheric turbulence by the Mie-scattering lidar, some numerical simulations are carried out. The power spectrum method is used to simulate the propagation of the Gaussian beam from the Mie-scattering lidar in a vertical path. The propagation characteristics of the Gaussian beam using a non-Kolmogorov turbulence model are obtained by analyzing the intensity distribution and spot drift effect. The simulation results show that the scintillation index of simulation is consistent with the theoretical value trend, and the accuracy is very high, indicating that the method of atmospheric turbulence detection using Mie-scattering lidar is effective. The simulation plays a guiding role for the subsequent experimental platform construction and equipment design.
Language	English
Publishing date	2022-12-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e24121764
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Expression of miRNA-1-3p and its target gene in hair follicle cycle development of Liaoning Cashmere goat

Zhang, Guishan / Xu, Jing / Zhang, Yingnan / Yang, Shubao / Jiang, Huaizhi

Animal Biotechnology. 2023 Oct. 2, v. 34, no. 6 p.1937-1942

2023

Abstract: MicroRNA exerts an important regulatory role in almost all the biological process, including hair follicle development in Liaoning Cashmere goat. In order to improve the Cashmere performance of goat, the regulatory role of microRNA in hair follicle cycle ...

Abstract	MicroRNA exerts an important regulatory role in almost all the biological process, including hair follicle development in Liaoning Cashmere goat. In order to improve the Cashmere performance of goat, the regulatory role of microRNA in hair follicle cycle has drawn hotspot attention. However, the molecular mechanisms of miRNA-1-3p involved in hair follicle development are poorly understood. In this study, we found that miRNA-1-3p was less expressed in anagen stage of hair follicle cycle of Cashmere goat than that in telogen stage by using RT-qPCR and immunoblotting analysis, in contrast to the expression pattern of FGF14. The Dual-Luciferase reporter assay was employed to verify the relationship between miRNA-1-3p and FGF14. The results showed that miRNA-1-3p specifically binds to the 3′UTR of FGF14 mRNA, and FGF14 is the target gene of miR-1-3p. In conclusion, this study shows that miRNA-1-3p may regulate hair follicle development in Liaoning Cashmere goats by targeting FGF14.
Keywords	Cashmere (goat breed) ; bioluminescence assay ; biotechnology ; genes ; goats ; hair follicles ; immunoblotting ; microRNA ; China ; miRNA-1-3p ; FGF14 ; Liaoning Cashmere goat ; hair follicle cycle
Language	English
Dates of publication	2023-1002
Size	p. 1937-1942.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2043243-4
ISSN	1532-2378 ; 1049-5398
ISSN (online)	1532-2378
ISSN	1049-5398
DOI	10.1080/10495398.2022.2058519
Database	NAL-Catalogue (AGRICOLA)

Order via subito

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito