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Article ; Online: The development of p53 tumor diagnosis and drug design strategy in its disordered region

Zhang Yiyun

E3S Web of Conferences, Vol 78, p

2019 Volume 01001

Abstract: As a tumor suppressor protein, p53 is directly involved in the control of cell cycle arrest, which plays a crucial role in cell metabolism, growth, apoptosis and responses to different types of damage or stress processes. And since the tumor and cancer ... ...

Abstract	As a tumor suppressor protein, p53 is directly involved in the control of cell cycle arrest, which plays a crucial role in cell metabolism, growth, apoptosis and responses to different types of damage or stress processes. And since the tumor and cancer are usually related to the mutation or functional inactivation of the p53, it’s necessary to investigate the mechanism of p53 functioning the tumor and other disease, trying to figure out its drug design strategy. In this paper, a brief introduction of p53 is given, including the structure, function and properties. Subsequently, the relationship of p53 gene and cancer is also discussed. In the end, a new rational drug-design for disordered region of p53 was summarized
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hypoxia-derived molecular subtype and gene signature characterize prognoses and therapeutic responses in head and neck squamous cell carcinoma.

Zou, Jianjun / Chu, Shidong / Zhou, Huaien / Zhang, Yiyun

Medicine

2024 Volume 103, Issue 6, Page(s) e37233

Abstract: Intratumoral hypoxia is widely associated with the development of malignancy, treatment resistance, and worse prognoses. This study aims to investigate the role of hypoxia-related genes (HRG) in the immune landscape, treatment response, and prognosis of ... ...

Abstract	Intratumoral hypoxia is widely associated with the development of malignancy, treatment resistance, and worse prognoses. This study aims to investigate the role of hypoxia-related genes (HRG) in the immune landscape, treatment response, and prognosis of head and neck squamous cell carcinoma (HNSCC). The transcriptome and clinical data of HNSCC were downloaded from TCGA and GEO databases, and HNSCC molecular subtypes were identified using non-negative matrix factorization (NMF) clustering. Prognostic models were constructed using univariate, Lasso, and multivariate Cox regression analyses. The relationship between HRGs and immune cell infiltration, immune therapy response, and drug sensitivity was evaluated, and a nomogram was constructed. 47 HRGs were differentially expressed in HNSCC, among which 10 genes were significantly associated with HNSCC prognosis. Based on these 10 genes, 2 HNSCC molecular subtypes were identified, which showed significant heterogeneity in terms of prognosis, immune infiltration, and treatment response. A total of 3280 differentially expressed genes were identified between the subtypes. After univariate, Lasso, and multivariate Cox regression analysis, 18 genes were selected to construct a novel prognostic model, which showed a significant correlation with B cells, T cells, and macrophages. Using this model, HNSCC was classified into high-risk and low-risk groups, which exhibited significant differences in terms of prognosis, immune cell infiltration, immune therapy response, and drug sensitivity. Finally, a nomogram based on this model and radiotherapy was constructed, which showed good performance in predicting HNSCC prognosis and guiding personalized treatment strategies. The decision curve analysis demonstrated its better clinical applicability compared to other strategies. HRGs can identify 2 HNSCC molecular subtypes with significant heterogeneity, and the HRG-derived risk model has the potential for prognostic prediction and guiding personalized treatment strategies.
MeSH term(s)	Humans ; Squamous Cell Carcinoma of Head and Neck/genetics ; Squamous Cell Carcinoma of Head and Neck/therapy ; Prognosis ; Nomograms ; Hypoxia ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/therapy
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037233
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Article ; Online: Telomere maintenance genes-derived prognosis signature characterizes immune landscape and predicts prognosis of head and neck squamous cell carcinoma.

Zou, Jianjun / Chu, Shidong / Bao, Qingfu / Zhang, Yiyun

Medicine

2023 Volume 102, Issue 31, Page(s) e34586

Abstract: Telomere dysfunction has been identified as a biological marker of cancer progression in several types of cancer, including Head and Neck Squamous Cell Carcinoma (HNSCC). This study aimed to characterize the telomere maintenance genes (TMG)-related ... ...

Abstract	Telomere dysfunction has been identified as a biological marker of cancer progression in several types of cancer, including Head and Neck Squamous Cell Carcinoma (HNSCC). This study aimed to characterize the telomere maintenance genes (TMG)-related signature in prognosis and treatment response in HNSCC. The transcriptome and clinical data of HNSCC were obtained from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus databases, respectively. Non-negative matrix factorization (NMF) was used to identify molecular subtypes derived from TMG. Gene set enrichment analysis (GSEA) was performed to analyze the differentially expressed pathways between subtypes, and a risk score model derived from TMG was established. Kaplan-Meier survival analysis was used to evaluate inter-group prognostic features, and the correlation between TMG-derived molecular subtypes and risk score model with immune infiltration, immunotherapy, and chemosensitivity was assessed. Two HNSCC subtypes were identified based on 59 TMG-related genes, which exhibit significant heterogeneity in prognosis, immune cell infiltration, and treatment response. Additionally, a TMG-derived risk signature containing 9 genes was developed to assess the prognosis of HNSCC patients. The signature had significant predictive ability for HNSCC prognosis and was significantly correlated with immune cell infiltration and immunotherapy response. A nomogram integrating the risk signature, N stage and radiotherapy was constructed to predict 1-, 3-, and 5-year overall survival (OS) of HNSCC patients, which had better performance than other prognostic models and included TMG-derived risk score, radiotherapy, and N stage. This study identified TMG-derived molecular subtypes in HNSCC and developed a novel prognostic score model, highlighting the potential value of TMG in HNSCC prognosis and immunotherapy.
MeSH term(s)	Humans ; Squamous Cell Carcinoma of Head and Neck/genetics ; Prognosis ; Nomograms ; Immunotherapy ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/therapy
Language	English
Publishing date	2023-08-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000034586
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Article ; Online: A Chinese-Specific Reference Amounts Study With TNO Food Allergen Risk Assessment Models - China, 2022.

Sun, Jinfang / Wu, Di / Zhang, Yiyun / Wu, Yongning

China CDC weekly

2022 Volume 4, Issue 34, Page(s) 756–760

Abstract: What is already known about this topic?: There are no consistent regulations on possible unintended allergen presence in food. The Netherlands Organization for Applied Scientific Research (TNO) has been committed to developing a quantitative risk ... ...

Abstract	What is already known about this topic?: There are no consistent regulations on possible unintended allergen presence in food. The Netherlands Organization for Applied Scientific Research (TNO) has been committed to developing a quantitative risk assessment methodology for the unintentional intake of allergens. What is added by this report?: This study aims to derive the optimal food consumption point for a deterministic food allergy risk assessment under the TNO framework based on Chinese national consumption data. A case study has been presented as an illustration. What are the implications for public health practice?: A robust evidence-based food consumption input in quantitative risk assessment of unintended allergens is necessary for future public policy on Precautionary Allergen Labeling for specific products to meet the safety objectives and to be adequately conservative.
Language	English
Publishing date	2022-10-22
Publishing country	China
Document type	Journal Article
ISSN	2096-7071
ISSN (online)	2096-7071
DOI	10.46234/ccdcw2022.160
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Article ; Online: The association between non-symbolic number comparison and mathematical abilities depends on fluency.

Zhang, Yiyun / Ma, Yuanyuan / Zhou, Xinlin

Cognitive processing

2022 Volume 23, Issue 3, Page(s) 423–439

Abstract: Numerous studies have explored the correlation between non-symbolic number comparison and mathematical abilities in children, but the results have been inconsistent. The underlying mental processing featuring fluency may affect the correlation. The ... ...

Abstract	Numerous studies have explored the correlation between non-symbolic number comparison and mathematical abilities in children, but the results have been inconsistent. The underlying mental processing featuring fluency may affect the correlation. The current study tested the fluency hypothesis that non-symbolic number comparison is associated with mathematical fluency in the development of mathematical ability. Non-symbolic number comparison, arithmetic computation, mathematical reasoning, non-symbolic number estimation, symbolic number comparison, and a series of basic cognitive processing tasks, including mental rotation, non-verbal matrix reasoning, and choice reaction time, were administered to 1072 first- to fourth-grade children. The results show that non-symbolic number comparison (measured via numerosity comparison) was the only independent predictor of arithmetic computation in higher grades, even after controlled for age, gender, basic cognitive processing, non-symbolic number estimation (measured via numerosity estimation), and symbolic number comparison (measured via digit comparison). However, it did not correlate with mathematical reasoning in any grade. These findings support the fluency hypothesis for developmental correlation between non-symbolic number comparison and mathematical abilities. That is, non-symbolic number comparison correlates with mathematical ability featuring fluency.
MeSH term(s)	Aptitude ; Child ; Cognition ; Humans ; Mathematics ; Problem Solving ; Reaction Time
Language	English
Publishing date	2022-06-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2075054-7
ISSN	1612-4790 ; 1612-4782
ISSN (online)	1612-4790
ISSN	1612-4782
DOI	10.1007/s10339-022-01098-x
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Article: Visual Perception Supports Adults in Numerosity Processing and Arithmetical Performance.

He, Xinyao / Zhou, Xinlin / Zhao, Jin / Zhang, Yiyun

Frontiers in psychology

2021 Volume 12, Page(s) 722261

Abstract: Previous studies have found a correlation between numerosity processing and arithmetical performance. Visual perception has already been indicated as the shared cognitive mechanism between these two; however, these studies mostly focused on children. It ... ...

Abstract	Previous studies have found a correlation between numerosity processing and arithmetical performance. Visual perception has already been indicated as the shared cognitive mechanism between these two; however, these studies mostly focused on children. It is not clear whether the association between numerosity processing and arithmetical performance still existed following the development of individual arithmetical performance. Consequently, the underlying role of visual perception in numerosity processing and arithmetical performance has not been sufficiently studied in adults. For this study, researchers selected a total of 205 adult participants with an average age of 22years. The adults were administered arithmetic tests, numerosity comparison, and visual figure matching. Mental rotation, choice reaction time, and nonverbal intelligence were used as cognitive covariates. Results showed that numerosity comparison of adults correlated with their arithmetical performance, even after controlling for age and gender differences as well as general cognitive processing. However, after controlled for visual figure matching, the well-established association between numerosity comparison and arithmetic performance disappeared. These results supported the visual perception hypothesis, that visual perception measured by visual figure matching can account for the correlation between numerosity comparison and arithmetic performance. This indicated that even for adult populations, visual perceptual ability was the underlying component of numerosity processing and arithmetic performance.
Language	English
Publishing date	2021-10-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2021.722261
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Article ; Online: Large second-order susceptibility from a quantized indium tin oxide monolayer.

Zhang, Yiyun / Gao, Bingtao / Lepage, Dominic / Tong, Yuanbiao / Wang, Pan / Xia, Wendi / Niu, Junru / Feng, Yiming / Chen, Hongsheng / Qian, Haoliang

Nature nanotechnology

2024 Volume 19, Issue 4, Page(s) 463–470

Abstract: Due to their high optical transparency and electrical conductivity, indium tin oxide thin films are a promising material for photonic circuit design and applications. However, their weak optical nonlinearity has been a substantial barrier to nonlinear ... ...

Abstract	Due to their high optical transparency and electrical conductivity, indium tin oxide thin films are a promising material for photonic circuit design and applications. However, their weak optical nonlinearity has been a substantial barrier to nonlinear signal processing applications. In this study, we show that an atomically thin (~1.5 nm) indium tin oxide film in the form of an air/indium tin oxide/SiO
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2254964-X
ISSN	1748-3395 ; 1748-3387
ISSN (online)	1748-3395
ISSN	1748-3387
DOI	10.1038/s41565-023-01574-1
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Article ; Online: Spiky Artificial Peroxidases with V-O-Fe Pair Sites for Combating Antibiotic-Resistant Pathogens.

Huang, Haoju / Geng, Wei / Wu, Xizheng / Zhang, Yiyun / Xie, Lan / Ma, Tian / Cheng, Chong

Angewandte Chemie (International ed. in English)

2023 Volume 63, Issue 1, Page(s) e202310811

Abstract: With the sharp rise of antibiotic-resistant pathogens worldwide, it is of enormous importance to create new strategies for combating pathogenic bacteria. Here, we create an iron oxide-based spiky artificial peroxidase (POD) with V-O-Fe pair sites (V- ... ...

Abstract	With the sharp rise of antibiotic-resistant pathogens worldwide, it is of enormous importance to create new strategies for combating pathogenic bacteria. Here, we create an iron oxide-based spiky artificial peroxidase (POD) with V-O-Fe pair sites (V-Fe
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Methicillin-Resistant Staphylococcus aureus ; Peroxidases ; Biofilms
Chemical Substances	Anti-Bacterial Agents ; Peroxidases (EC 1.11.1.-)
Language	English
Publishing date	2023-11-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202310811
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Article ; Online: Influencing factors of two-way social support for the old adults in China: A cross-sectional study.

Dai, Shimeng / Shi, Yingying / Zhang, Yiyun / Ye, Can / Deng, Zhaoyao / Jiang, Sisi / Dong, Chaoqun

Geriatric nursing (New York, N.Y.)

2023 Volume 54, Page(s) 192–198

Abstract: This study aims to investigate the status and influencing factors of two-way social support among old adults. A cross-sectional study of 408 convenient samples of old adults was conducted using socio-demographic questionnaire, Brief 2-Way Social Support ... ...

Abstract	This study aims to investigate the status and influencing factors of two-way social support among old adults. A cross-sectional study of 408 convenient samples of old adults was conducted using socio-demographic questionnaire, Brief 2-Way Social Support Scale, Modified Barthel index, General Well-being Schedule, Family APGAR Index, and Lubben Social Network Scale 6. The two-way social support score for old adults in China was (43.74±7.86), with the receiving and giving social support scoring (22.80±4.06) and (20.94±4.52), respectively. The multiple linear regression analysis revealed that family care, residence place, socioeconomic status, and social network were associated with both receiving and giving social support. Chronic diseases and religious beliefs were related to receiving social support, while gender, general well-being, and residence form were related to giving social support. Tailored interventions based on the distinct influencing factors are needed to enhance old adults' social support both as recipients and providers.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Socioeconomic Factors ; China ; Social Support ; Surveys and Questionnaires
Language	English
Publishing date	2023-10-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	632559-2
ISSN	1528-3984 ; 0197-4572
ISSN (online)	1528-3984
ISSN	0197-4572
DOI	10.1016/j.gerinurse.2023.09.007
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Article ; Online: Numerosity sense correlates with fluent mathematical abilities.

Zhang, Yiyun / An, Ning / Chen, Jiani / Zhou, Xinlin / Cui, Zhanling

Acta psychologica

2022 Volume 228, Page(s) 103655

Abstract: Although a great deal of research has shown a relationship between numerosity sense and mathematical ability, some studies have failed to do so. The main source of this inconsistency could be the varied ways of measuring mathematical abilities. The ... ...

Abstract	Although a great deal of research has shown a relationship between numerosity sense and mathematical ability, some studies have failed to do so. The main source of this inconsistency could be the varied ways of measuring mathematical abilities. The current investigation explored several types of mathematical ability, from basic number processing and arithmetic computation to numerical reasoning and arithmetic learning. We hypothesized that the correlation between numerosity sense and mathematical ability depends on mathematical fluency. A total of 415 college students (178 males and 237 females, mean age = 20.42 years, range = 18.58-22.92 years) were recruited to complete seven mathematical tasks and two numerosity tasks, as well as other tasks that measured cognitive covariates. The results showed that after controlling for age, gender, and related general cognitive factors, numerosity sense still predicted substantial variation in parity judgment, visual digit comparison, and computation, but it did not predict variation in numerosity estimation, auditory digit comparison, number series completion, or digit associate learning. The results suggest that numerosity sense correlates with mathematical abilities that accompany fluency.
MeSH term(s)	Adolescent ; Adult ; Aptitude ; Cognition ; Female ; Humans ; Judgment ; Male ; Mathematical Concepts ; Mathematics ; Problem Solving ; Young Adult
Language	English
Publishing date	2022-06-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1480049-4
ISSN	1873-6297 ; 0001-6918
ISSN (online)	1873-6297
ISSN	0001-6918
DOI	10.1016/j.actpsy.2022.103655
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