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  1. Article ; Online: A Genomic Perspective on the Origin and Emergence of SARS-CoV-2.

    Zhang, Yong-Zhen / Holmes, Edward C

    Cell

    2020  Volume 181, Issue 2, Page(s) 223–227

    Abstract: The ongoing pandemic of a new human coronavirus, SARS-CoV-2, has generated enormous global concern. We and others in China were involved in the initial genome sequencing of the virus. Herein, we describe what genomic data reveal about the emergence SARS- ... ...

    Abstract The ongoing pandemic of a new human coronavirus, SARS-CoV-2, has generated enormous global concern. We and others in China were involved in the initial genome sequencing of the virus. Herein, we describe what genomic data reveal about the emergence SARS-CoV-2 and discuss the gaps in our understanding of its origins.
    MeSH term(s) Animals ; Animals, Wild ; Betacoronavirus/genetics ; COVID-19 ; China ; Chiroptera/virology ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Disease Reservoirs/virology ; Environmental DNA ; Genome, Viral ; Pandemics ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Sequence Analysis, RNA ; Zoonoses/virology
    Chemical Substances Environmental DNA
    Keywords covid19
    Language English
    Publishing date 2020-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2020.03.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Resolving deep evolutionary relationships within the RNA virus phylum

    Sadiq, Sabrina / Chen, Yan-Mei / Zhang, Yong-Zhen / Holmes, Edward C

    Virus evolution

    2022  Volume 8, Issue 1, Page(s) veac055

    Abstract: The RNA virus ... ...

    Abstract The RNA virus phylum
    Language English
    Publishing date 2022-06-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2818949-8
    ISSN 2057-1577
    ISSN 2057-1577
    DOI 10.1093/ve/veac055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Discovery of hantaviruses in bats and insectivores and the evolution of the genus Hantavirus.

    Zhang, Yong-Zhen

    Virus research

    2014  Volume 187, Page(s) 15–21

    Abstract: Hantaviruses are among the most important zoonotic pathogens of humans, causing either hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS). From the period 1964-2006 almost all hantaviruses had been identified in rodents, ... ...

    Abstract Hantaviruses are among the most important zoonotic pathogens of humans, causing either hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS). From the period 1964-2006 almost all hantaviruses had been identified in rodents, with the exception of Thottapalayam virus (TPMV) isolated from shrews sampled in India. As a consequence, rodents were considered as the natural reservoir hosts. However, over the past seven years, most of the newly found hantavirus genotypes have been from either shrews or moles. Remarkably, in recent years divergent hantaviruses have also been identified in bats sampled from both Africa and Asia. All these data indicate that hantaviruses have a broad range of natural reservoir hosts. Phylogenetic analyses of the available sequences of hantaviruses suggest that hantaviruses might have first appeared in Chiroptera (bats) or Soricomorpha (moles and shrews), before emerging in rodent species. Although rodent hantaviruses cluster according to whether their hosts are members of the Murinae and Cricetidae, the phylogenetic histories of the viruses are not always congruent with those of their hosts, indicating that cross-species transmission events have occurred at all taxonomic levels. In sum, both cross-species transmission and co-divergence have produced the high genetic diversity of hantaviruses described to date.
    MeSH term(s) Africa ; Animals ; Asia ; Biological Evolution ; Chiroptera/classification ; Chiroptera/virology ; Genetic Variation ; Hantavirus/classification ; Hantavirus/genetics ; Hantavirus Infections/transmission ; Hantavirus Infections/veterinary ; Hantavirus Infections/virology ; Host Specificity ; Host-Pathogen Interactions ; Moles/classification ; Moles/virology ; Phylogeny ; Shrews/classification ; Shrews/virology
    Language English
    Publishing date 2014-07-17
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605780-9
    ISSN 1872-7492 ; 0168-1702
    ISSN (online) 1872-7492
    ISSN 0168-1702
    DOI 10.1016/j.virusres.2013.12.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A Genomic Perspective on the Origin and Emergence of SARS-CoV-2

    Zhang, Yong-Zhen / Holmes, Edward C

    Cell

    Abstract: The ongoing pandemic of a new human coronavirus, SARS-CoV-2, has generated enormous global concern. We and others in China were involved in the initial genome sequencing of the virus. Herein, we describe what genomic data reveal about the emergence SARS- ... ...

    Abstract The ongoing pandemic of a new human coronavirus, SARS-CoV-2, has generated enormous global concern. We and others in China were involved in the initial genome sequencing of the virus. Herein, we describe what genomic data reveal about the emergence SARS-CoV-2 and discuss the gaps in our understanding of its origins.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #17998
    Database COVID19

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  5. Article ; Online: A Genomic Perspective on the Origin and Emergence of SARS-CoV-2

    Zhang, Yong-Zhen / Holmes, Edward C.

    Cell

    2020  Volume 181, Issue 2, Page(s) 223–227

    Keywords General Biochemistry, Genetics and Molecular Biology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2020.03.035
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Association of cigarette smoking with risk of colorectal cancer subtypes classified by gut microbiota.

    Cai, Jia-An / Zhang, Yong-Zhen / Yu, En-Da / Ding, Wei-Qun / Li, Zhao-Shen / Zhong, Liang / Cai, Quan-Cai

    Tobacco induced diseases

    2023  Volume 21, Page(s) 99

    Abstract: Introduction: Both cigarette smoking and gut microbiota play important roles in colorectal carcinogenesis. We explored whether the association between smoking and colorectal cancer (CRC) risk varies by gut microbial enterotypes and how smoking-related ... ...

    Abstract Introduction: Both cigarette smoking and gut microbiota play important roles in colorectal carcinogenesis. We explored whether the association between smoking and colorectal cancer (CRC) risk varies by gut microbial enterotypes and how smoking-related enterotypes promote colorectal carcinogenesis.
    Methods: A case-control study was conducted. Fecal microbiota was determined by 16S rDNA sequencing. The cases with CRC or adenoma were subclassified by gut microbiota enterotypes. Multivariate analyses were used to test associations between smoking and the odds of colorectal neoplasm subtypes. Mann-Whitney U tests were used to find differential genera, genes, and pathways between the subtypes.
    Results: Included in the study were 130 CRC patients (type I: n=77; type II: n=53), 120 adenoma patients (type I: n=66; type II: n=54), and 130 healthy participants. Smoking increased the odds for type II tumors significantly (all p for trend <0.05) but not for type I tumors. The associations of smoking with increased odds of colorectal neoplasm significantly differed by gut microbiota enterotypes (p<0.05 for heterogeneity). An increase in carcinogenic bacteria (genus
    Conclusions: Smoking was associated with a higher odds of type II colorectal neoplasms but not type I tumors, supporting a potential role for the gut microbiota in mediating the association between smoking and colorectal neoplasms.
    Language English
    Publishing date 2023-08-01
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2194616-4
    ISSN 1617-9625 ; 1617-9625
    ISSN (online) 1617-9625
    ISSN 1617-9625
    DOI 10.18332/tid/168515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Gut Microbiota Enterotypes Mediate the Effects of Dietary Patterns on Colorectal Neoplasm Risk in a Chinese Population.

    Cai, Jia-An / Zhang, Yong-Zhen / Yu, En-Da / Ding, Wei-Qun / Jiang, Qing-Wu / Cai, Quan-Cai / Zhong, Liang

    Nutrients

    2023  Volume 15, Issue 13

    Abstract: Colorectal cancer (CRC) risk is influenced by dietary patterns and gut microbiota enterotypes. However, the interaction between these factors remains unclear. This study examines this relationship, hypothesizing that different diets may affect colorectal ...

    Abstract Colorectal cancer (CRC) risk is influenced by dietary patterns and gut microbiota enterotypes. However, the interaction between these factors remains unclear. This study examines this relationship, hypothesizing that different diets may affect colorectal tumor risk in individuals with varied gut microbiota enterotypes. We conducted a case-control study involving 410 Han Chinese individuals, using exploratory structural equation modeling to identify two dietary patterns, and a Dirichlet multinomial mixture model to classify 250 colorectal neoplasm cases into three gut microbiota enterotypes. We assessed the association between dietary patterns and the risk of each tumor subtype using logistic regression analysis. We found that a healthy diet, rich in vegetables, fruits, milk, and yogurt, lowers CRC risk, particularly in individuals with type I (dominated by
    MeSH term(s) Humans ; Case-Control Studies ; Colorectal Neoplasms/pathology ; Diet, High-Fat ; East Asian People ; Gastrointestinal Microbiome ; Diet, Healthy
    Language English
    Publishing date 2023-06-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15132940
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Evolutionary trajectory of diverse SARS-CoV-2 variants at the beginning of COVID-19 outbreak.

    Lv, Jia-Xin / Liu, Xiang / Pei, Yuan-Yuan / Song, Zhi-Gang / Chen, Xiao / Hu, Shu-Jian / She, Jia-Lei / Liu, Yi / Chen, Yan-Mei / Zhang, Yong-Zhen

    Virus evolution

    2024  Volume 10, Issue 1, Page(s) veae020

    Abstract: Despite extensive scientific efforts directed toward the evolutionary trajectory of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in humans at the beginning of the COVID-19 epidemic, it remains unclear how the virus jumped into and evolved ...

    Abstract Despite extensive scientific efforts directed toward the evolutionary trajectory of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in humans at the beginning of the COVID-19 epidemic, it remains unclear how the virus jumped into and evolved in humans so far. Herein, we recruited almost all adult coronavirus disease 2019 (COVID-19) cases appeared locally or imported from abroad during the first 8 months of the outbreak in Shanghai. From these patients, SARS-CoV-2 genomes occupying the important phylogenetic positions in the virus phylogeny were recovered. Phylogenetic and mutational landscape analyses of viral genomes recovered here and those collected in and outside of China revealed that all known SARS-CoV-2 variants exhibited the evolutionary continuity despite the co-circulation of multiple lineages during the early period of the epidemic. Various mutations have driven the rapid SARS-CoV-2 diversification, and some of them favor its better adaptation and circulation in humans, which may have determined the waxing and waning of various lineages.
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2818949-8
    ISSN 2057-1577
    ISSN 2057-1577
    DOI 10.1093/ve/veae020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The emergence and cross species transmission of newly discovered tick-borne Bunyavirus in China.

    Zhang, Yong-Zhen / Xu, Jianguo

    Current opinion in virology

    2016  Volume 16, Page(s) 126–131

    Abstract: A novel tick-borne Bunyavirus, discovered in China and later in South Korea and Japan, is now known as Huaiyangshan virus or severe fever with thrombocytopenia syndrome virus and has been identified as the causative agent of a hemorrhagic fever-like ... ...

    Abstract A novel tick-borne Bunyavirus, discovered in China and later in South Korea and Japan, is now known as Huaiyangshan virus or severe fever with thrombocytopenia syndrome virus and has been identified as the causative agent of a hemorrhagic fever-like disease. Of five species of ticks carrying Huaiyangshan viruses, Haemaphysalis longicornis was the most abundant in regions where the virus was endemic. Its usual hosts (cattle, goats, dogs, rats and chickens) tested positive for Huaiyangshan virus RNA and had a high seroprevalence. The distribution of H. longicornis and the migratory routes of four wild fowl across China, South Korea and Japan are coincident. Thus a tick and migratory bird model for the transmission of the Huaiyangshan virus was proposed.
    MeSH term(s) Animal Migration ; Animals ; Animals, Domestic/virology ; Arachnid Vectors/virology ; Birds/virology ; Bunyaviridae Infections/epidemiology ; Bunyaviridae Infections/transmission ; Bunyaviridae Infections/virology ; China/epidemiology ; Communicable Diseases, Emerging ; Humans ; Orthobunyavirus/classification ; Orthobunyavirus/genetics ; Tick-Borne Diseases ; Ticks/virology
    Language English
    Publishing date 2016-02
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2611378-8
    ISSN 1879-6265 ; 1879-6257
    ISSN (online) 1879-6265
    ISSN 1879-6257
    DOI 10.1016/j.coviro.2016.02.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Discovery of hantaviruses in bats and insectivores and the evolution of the genus Hantavirus

    Zhang, Yong-Zhen

    Virus research. 2014 July 17, v. 187

    2014  

    Abstract: Hantaviruses are among the most important zoonotic pathogens of humans, causing either hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS). From the period 1964–2006 almost all hantaviruses had been identified in rodents, ... ...

    Abstract Hantaviruses are among the most important zoonotic pathogens of humans, causing either hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS). From the period 1964–2006 almost all hantaviruses had been identified in rodents, with the exception of Thottapalayam virus (TPMV) isolated from shrews sampled in India. As a consequence, rodents were considered as the natural reservoir hosts. However, over the past seven years, most of the newly found hantavirus genotypes have been from either shrews or moles. Remarkably, in recent years divergent hantaviruses have also been identified in bats sampled from both Africa and Asia. All these data indicate that hantaviruses have a broad range of natural reservoir hosts. Phylogenetic analyses of the available sequences of hantaviruses suggest that hantaviruses might have first appeared in Chiroptera (bats) or Soricomorpha (moles and shrews), before emerging in rodent species. Although rodent hantaviruses cluster according to whether their hosts are members of the Murinae and Cricetidae, the phylogenetic histories of the viruses are not always congruent with those of their hosts, indicating that cross-species transmission events have occurred at all taxonomic levels. In sum, both cross-species transmission and co-divergence have produced the high genetic diversity of hantaviruses described to date.
    Keywords Chiroptera ; Cricetidae ; disease reservoirs ; fever ; genetic variation ; genotype ; Hantavirus ; hosts ; humans ; insectivores ; moles ; Murinae ; pathogens ; phylogeny ; rodents ; shrews ; Soricomorpha ; Africa ; India
    Language English
    Dates of publication 2014-0717
    Size p. 15-21.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 605780-9
    ISSN 1872-7492 ; 0168-1702
    ISSN (online) 1872-7492
    ISSN 0168-1702
    DOI 10.1016/j.virusres.2013.12.035
    Database NAL-Catalogue (AGRICOLA)

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