LIVIVO - Search results -

Search results

Result 1 - 10 of total 431

Search options

Book ; Online: Dynamic interactive group decision making method on two-dimensional language

Zhang, Yukun

2023

Abstract: The language evaluation information of the interactive group decision method at present is based on the one-dimension language variable. At the same time, multi-attribute group decision making method based on two-dimension linguistic information only use ...

Abstract	The language evaluation information of the interactive group decision method at present is based on the one-dimension language variable. At the same time, multi-attribute group decision making method based on two-dimension linguistic information only use single-stage and static evaluation method. In this paper, we propose a dynamic group decision making method based on two-dimension linguistic information, combining dynamic interactive group decision making methods with two-dimensional language evaluation information The method first use Two-Dimensional Uncertain Linguistic Generalized Weighted Aggregation (DULGWA) Operators to aggregate the preference information of each decision maker, then adopting dynamic information entropy method to obtain weights of attributes at each stage. Finally we propose the group consistency index to quantify the termination conditions of group interaction. One example is given to verify the developed approach and to demonstrate its effectiveness Comment: arXiv admin note: substantial text overlap with arXiv:2311.18116
Keywords	Computer Science - Computation and Language ; Computer Science - Social and Information Networks
Subject code	410
Publishing date	2023-11-29
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book ; Online: Multi-round Dynamic Group Decision Making Method On 2-Dimension Uncertain Linguistic Variables

Zhang, Yukun

2023

Abstract	The language evaluation information of the interactive group decision method at present is based on the one-dimension language variable. At the same time, multi-attribute group decision making method based on two-dimension linguistic information only use single-stage and static evaluation method. In this paper, we propose a dynamic group decision making method based on two-dimension linguistic information, combining dynamic interactive group decision making methods with two-dimensional language evaluation information The method first use Two-Dimensional Uncertain Linguistic Generalized Weighted Aggregation (DULGWA) Operators to aggregate the preference information of each decision maker, then adopting dynamic information entropy method to obtain weights of attributes at each stage. Finally we propose the group consistency index to quantify the termination conditions of group interaction. One example is given to verify the developed approach and to demonstrate its effectiveness.
Keywords	Computer Science - Social and Information Networks
Subject code	410
Publishing date	2023-11-29
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: 5-Hydroxytryptophan acts as a gap junction inhibitor to limit the spread of chemotherapy-induced cardiomyocyte injury and mitochondrial dysfunction.

Sun, Wenshe / Lu, Qi / Zhang, Yukun / Xing, Dongming

Aging

2024 Volume 16, Issue 5, Page(s) 4889–4903

Abstract: Anthracycline chemotherapeutics like doxorubicin (DOX) are widely used against various cancers but are accompanied by severe cardiotoxic effects that can lead to heart failure. Through whole transcriptome sequencing and pathological tissue analysis in a ... ...

Abstract	Anthracycline chemotherapeutics like doxorubicin (DOX) are widely used against various cancers but are accompanied by severe cardiotoxic effects that can lead to heart failure. Through whole transcriptome sequencing and pathological tissue analysis in a murine model, our study has revealed that DOX impairs collagen expression in the early phase, causing extracellular matrix anomalies that weaken the mechanical integrity of the heart. This results in ventricular wall thinning and dilation, exacerbating cardiac dysfunction. In this work, we have identified 5-hydroxytryptophan (5-HTP) as a potent inhibitor of gap junction communication. This inhibition is key to limiting the spread of DOX-induced cardiotoxicity. Treatment with 5-HTP effectively countered the adverse effects of DOX on the heart, preserving ventricular structure and ejection fraction. Moreover, 5-HTP enhanced mitochondrial respiratory function, as shown by the O2k mitochondrial function assay, by improving mitochondrial complex activity and ATP production. Importantly, the cardioprotective benefits of 5-HTP did not interfere with DOX's ability to combat cancer. These findings shed light on the cardiotoxic mechanisms of DOX and suggest that 5-HTP could be a viable strategy to prevent heart damage during chemotherapy, offering a foundation for future clinical development. This research opens the door for 5-HTP to be considered a dual-purpose agent that can protect the heart without compromising the oncological efficacy of anthracycline chemotherapy.
MeSH term(s)	Mice ; Animals ; Myocytes, Cardiac/metabolism ; 5-Hydroxytryptophan/metabolism ; 5-Hydroxytryptophan/pharmacology ; Doxorubicin/toxicity ; Antibiotics, Antineoplastic/pharmacology ; Cardiotoxicity/pathology ; Mitochondrial Diseases/metabolism ; Apoptosis
Chemical Substances	5-Hydroxytryptophan (C1LJO185Q9) ; Doxorubicin (80168379AG) ; Antibiotics, Antineoplastic
Language	English
Publishing date	2024-03-10
Publishing country	United States
Document type	Journal Article
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.205641
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Automatic detection of beacon towers in historical aerial images using improved FCOS

Li, Zhe / Zhang, Mengdi / Zhang, Yukun / Li, Yan

International Journal of Remote Sensing. 2023 Feb. 01, v. 44, no. 3 p.1089-1113

2023

Abstract: Beacon towers are an important infrastructure responsible for transmitting military information in ancient times. However, many of the beacons have disappeared due to natural erosion and man-made vandalism. Historical U2 aerial images provide heritage ... ...

Abstract	Beacon towers are an important infrastructure responsible for transmitting military information in ancient times. However, many of the beacons have disappeared due to natural erosion and man-made vandalism. Historical U2 aerial images provide heritage and geographical information over the last century to research the beacon tower system. However, the fragmented distribution of beacons and the greyscale colouring of the aerial images make it difficult to manually identify small-sized beacons in a wide range of aerials. This study introduced deep learning to automatically detect beacons in U2 images. Three improvements were added to the standard Fully Convolutional One-Stage Object Detection (FCOS) network: 1) The structure of the Feature Pyramid Network (FPN) was adjusted to enhance the small objects feature at lower layers; 2) The standard convolutional kernel in backbone network was replaced with DCNv2 to account for irregular towers; 3) NMS was replaced with Soft-NMS to improve the accuracy of the detection box prediction. Our results demonstrate that more than 60% average precision (AP) can be obtained using our improved FCOS. After testing, the results showed that the three-part methodology can automatically detect most beacons in historical U2 aerial images, reduce the manual miss rate, and improve efficiency. The results of the test were the first to successfully identify destroyed beacons, recreate the beacon route, and retrace the beacon siting strategy. Our method helps to speed up the efficiency of heritage excavation in historical aerial images, and it may provide a convenient means of processing in other architectural heritage restoration studies.
Keywords	automatic detection ; infrastructure ; prediction ; spatial data ; vandalism ; the Great Wall ; historical aerial images ; object detection ; beacon tower ; remote sensing archaeology
Language	English
Dates of publication	2023-0201
Size	p. 1089-1113.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1497529-4
ISSN	1366-5901 ; 0143-1161
ISSN (online)	1366-5901
ISSN	0143-1161
DOI	10.1080/01431161.2023.2174388
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article: Effect of Duty Cycle on Cutting Force for Ultrasonic Vibration-Assisted Milling Carbon Fiber-Reinforced Polymer Laminates.

Zhang, Yukun / Ren, Junxue / Zhou, Jinhua

Materials (Basel, Switzerland)

2023 Volume 16, Issue 23

Abstract: Cutting force is an important factor that affects the surface quality of machining carbon fiber-reinforced polymer (CFRP). High cutting force can lead to surface damage such as the burrs and the delamination in the machining process of CFRP. Ultrasonic ... ...

Abstract	Cutting force is an important factor that affects the surface quality of machining carbon fiber-reinforced polymer (CFRP). High cutting force can lead to surface damage such as the burrs and the delamination in the machining process of CFRP. Ultrasonic vibration-assisted machining (UVAM) can reduce the cutting force in the machining process. This work is focused on the relationship between the duty cycle and the cutting force in UVAM of CFRP. Based on the kinematics of UVAM, the movement of the cutting tool edge and the tool-workpiece separation in UVAM were analyzed, and a calculation formula for the duty cycle was obtained. The milling experiment of CFRP was conducted to compare the cutting force between UVAM and conventional machining (CM), and the relationship between the reduction in the cutting force in UVAM and the duty cycle was determined. The experimental results showed that when the duty cycle was 0.2916, the cutting force of UVAM was reduced by 7.4% to 27% compared with that of CM. When the duty cycle was 1, the cutting force of UVAM was reduced by -4.5% to 7.5% compared with that of CM. Therefore, the effect of reducing the cutting force of UVAM can be enhanced by adjusting the process parameters to reduce the duty cycle of UVAM, and a lower cutting force can be obtained.
Language	English
Publishing date	2023-11-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16237457
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Multimodal motor imagery decoding method based on temporal spatial feature alignment and fusion.

Zhang, Yukun / Qiu, Shuang / He, Huiguang

Journal of neural engineering

2023 Volume 20, Issue 2

Abstract: ... ...

Abstract	Objective
MeSH term(s)	Imagination ; Electroencephalography/methods ; Brain ; Movement ; Neural Networks, Computer ; Brain-Computer Interfaces ; Algorithms
Language	English
Publishing date	2023-03-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2170901-4
ISSN	1741-2552 ; 1741-2560
ISSN (online)	1741-2552
ISSN	1741-2560
DOI	10.1088/1741-2552/acbfdf
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6071: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Tumor immune dysfunction and exclusion subtypes in bladder cancer and pan-cancer: a novel molecular subtyping strategy and immunotherapeutic prediction model.

Zheng, Kun / Hai, Youlong / Chen, Hongqi / Zhang, Yukun / Hu, Xiaoyong / Ni, Kai

Journal of translational medicine

2024 Volume 22, Issue 1, Page(s) 365

Abstract: Background: Molecular subtyping is expected to enable precise treatment. However, reliable subtyping strategies for clinical application remains defective and controversial. Given the significance of tumor immune dysfunction and exclusion (TIDE), we ... ...

Abstract	Background: Molecular subtyping is expected to enable precise treatment. However, reliable subtyping strategies for clinical application remains defective and controversial. Given the significance of tumor immune dysfunction and exclusion (TIDE), we aimed to develop a novel TIDE-based subtyping strategy to guide personalized immunotherapy in the bladder cancer (BC). Methods: Transcriptome data of BC was used to evaluate the heterogeneity and the status of TIDE patterns. Subsequently, consensus clustering was applied to classify BC patients based on TIDE marker-genes. Patients' clinicopathological, molecular features and signaling pathways of the different TIDE subtypes were well characterized. We also utilize the deconvolution algorithms to analyze the tumor microenvironment, and further explore the sensitivity and mechanisms of each subtype to immunotherapy. Furthermore, BC patient clinical information, real-world BC samples and urine samples were collected for the validation of our findings, which were used for RNA-seq analysis, H&E staining, immunohistochemistry and immunofluorescence staining, and enzyme-linked immunosorbent assay. Finally, we also explored the conservation of our novel TIDE subtypes in pan-cancers. Results: We identified 69 TIDE biomarker genes and classified BC samples into three subtypes using consensus clustering. Subtype I showed the lowest TIDE status and malignancy with the best prognosis and highest sensitivity to immune checkpoint blockade (ICB) treatment, which was enriched of metabolic related signaling pathways. Subtype III represented the highest TIDE status and malignancy with the poorest prognosis and resistance to ICB treatment, resulting from its inhibitory immune microenvironment and T cell terminal exhaustion. Subtype II was in a transitional state with intermediate TIDE level, malignancy, and prognosis. We further confirmed the existence and characteristics of our novel TIDE subtypes using real-world BC samples and collected patient clinical data. This subtyping method was proved to be more efficient than previous known methods in identifying non-responders to immunotherapy. We also propose that combining our TIDE subtypes with known biomarkers can potentially improve the sensitivity and specificity of these biomarkers. Moreover, besides guiding ICB treatment, this classification approach can assist in selecting the frontline or recommended drugs. Finally, we confirmed that the TIDE subtypes are conserved across the pan-tumors. Conclusions: Our novel TIDE-based subtyping method can serve as a powerful clinical tool for BC and pan-cancer patients, and potentially guiding personalized therapy decisions for selecting potential beneficiaries and excluding resistant patients of ICB therapy.
MeSH term(s)	Humans ; Urinary Bladder Neoplasms ; Immunotherapy ; Biomarkers, Tumor ; Algorithms ; Cluster Analysis ; Tumor Microenvironment ; Prognosis
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2024-04-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-024-05186-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Near-infrared dual-response fluorescent probe for detection of N

Xu, Chen / Zhang, Yukun / Ren, Mingguang / Liu, Keyin / Wu, Qin / Zhang, Chunling / Kong, Fangong

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2024 Volume 314, Page(s) 124180

Abstract: ... ...

Abstract	N
MeSH term(s)	Animals ; Humans ; Fluorescent Dyes ; Viscosity ; Zebrafish ; Xanthenes ; Water ; Hydrazines ; HeLa Cells ; Spectrometry, Fluorescence
Chemical Substances	Fluorescent Dyes ; Xanthenes ; Water (059QF0KO0R) ; Hydrazines
Language	English
Publishing date	2024-03-22
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2024.124180
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 51/98: Show issues
Z 1611 a: Show issues
924/340: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: A new and improved aquaponics system model for food production patterns for urban architecture

Zhang, Yong / Zhang, Yu-kun / Li, Zhe

Journal of cleaner production. 2022 Mar. 15, v. 342

2022

Abstract: Productive cities are one of the most important ways to achieve urban sustainable development. In the comprehensive production function, food production is the most basic function and should be defined as a priority. Considering the characteristics of ... ...

Abstract	Productive cities are one of the most important ways to achieve urban sustainable development. In the comprehensive production function, food production is the most basic function and should be defined as a priority. Considering the characteristics of buildings and the limitations of the urban environment, aquaponics is a safe and healthy green technology that protects the ecological environment and that has high potential to combine urban buildings and plant cultivation technology. Research on aquaponic systems has become increasingly mature, but some new problems that cannot be ignored, such as low nitrogen utilization efficiency, high aeration cost and noise problems, and unreliable water quality. In this study, a new aquaponics system model (photosynthesis reoxygenation aquaponics, PRO-AP) was proposed, and it was expected that the structure of the system can be adjusted by adding macroalgae to improve the existing problems in aquaponics. An experiment was conducted to preliminarily explore the feasibility of the proposed mode of operation. Spirogyra was added to the aquaponics system, and the DO, pH, TDS, EC, ammonia nitrogen and removal of the key nutrients from the systems were monitored during the operation. The results showed that the dissolved oxygen content in the system increased markedly and that the pH drop caused by nitrifying bacteria could be balanced when Spirogyra was irradiated with effective light. In addition, Spirogyra played a certain role in biofiltration in the aquaponic system, which reduced the values of TDS and EC, the contents of NH₄⁺, NO₃⁻ and PO₄³⁻ also decreased, and the nitrite content first increased and then decreased after a period of time. Finally, under the ratio of fish and vegetables in this experiment, the existence of Spirogyra did not create a negative image of the yield and root system of vegetables in aquaponics systems. The results showed that the aquaponic system with macroalgae has a stronger self-regulation ability. PRO-AP is an effective method in urban food production and is a very promising mode of production in the sustainable development of productive cities.
Keywords	Spirogyra ; aeration ; ammonium nitrogen ; aquaponics ; biofiltration ; dissolved oxygen ; fish ; food production ; macroalgae ; models ; nitrites ; nutrient use efficiency ; pH ; photosynthesis ; production functions ; root systems ; sustainable development ; sustainable technology ; urban areas ; water quality
Language	English
Dates of publication	2022-0315
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0959-6526
DOI	10.1016/j.jclepro.2022.130867
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article ; Online: The clinicopathological significance and potential function of ULK1 in colon cancer.

Lv, Peng / Wu, Zixi / Lai, Lin / Zhang, Yukun / Pei, Bo

Biotechnology & genetic engineering reviews

2023 , Page(s) 1–14

Abstract: Uncoordinated 51-like kinase 1 (ULK1) is an essential part involved in autophagy to maintain cell viability and homeostasis. Herein, the expression levels of ULK1 in colon cancer (CC) were investigated, and its clinicopathological features and potential ... ...

Abstract	Uncoordinated 51-like kinase 1 (ULK1) is an essential part involved in autophagy to maintain cell viability and homeostasis. Herein, the expression levels of ULK1 in colon cancer (CC) were investigated, and its clinicopathological features and potential function were analyzed. Data of ULK1 were obtained from a public database. UCSC XENA RNAseq data were uniformly processed by using the Toil process. STRING was employed for identification of co-expression genes and development of PPI networks whose interaction scores exceeded 0.4. The level of immune cells for tumor infiltration was calculated by means of single-sample GSEA (ssGSEA) on the basis of mRNA data of CC. The ULK1 expression was upregulated compared with both paired and unpaired normal tissues. The mRNA expression of ULK1 was upregulated in CC patients with lymph node metastasis, lymphatic invasion, and pathological stages of 3 and 4. The disease-specific survival (DSS), progression-free interval (PFI), and the overall survival (OS) of patients with upregulated mRNA expression of ULK1 were drastically reduced. Functionally, any changes related to the biological process of ULK1 may be related to macroautophagy, autophagosome organization and autophagosome assembly. As a co-expressed gene (CEG), ATG101 was up-regulated in CC tissues and indicated poor survival. ULK1 is closely related to immune cells. ULK1 expression is upregulated in CC cells and upregulation of ULK1 may serve as an accurate prognostic factor, thereby providing novel intervention targets for therapy.
Language	English
Publishing date	2023-05-16
Publishing country	England
Document type	Journal Article
ZDB-ID	49457-4
ISSN	2046-5556 ; 0264-8725
ISSN (online)	2046-5556
ISSN	0264-8725
DOI	10.1080/02648725.2023.2210952
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Se 1012: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito