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Article ; Online: Liraglutide combined with metformin treatment for obese people with type 2 diabetes mellitus: a systematic review and meta-analysis.

Long, Yang / Zhang, Yuxi

2023 Volume 192, Issue 6, Page(s) 2809–2814

Abstract: Aim: To assess clinical efficacy and safety of liraglutide combined with metformin (LMT) in obese patients with type 2 diabetes (ODP) by conducting a meta-analysis of randomized controlled trials (RCTs).: Methods: PubMed, EMBASE, Cochrane Library, ... ...

Abstract	Aim: To assess clinical efficacy and safety of liraglutide combined with metformin (LMT) in obese patients with type 2 diabetes (ODP) by conducting a meta-analysis of randomized controlled trials (RCTs). Methods: PubMed, EMBASE, Cochrane Library, CNKI, CNKI, and VIP databases were systematically searched for randomized controlled trials (RCTs) through January 1, 2015 to investigate the effectiveness of liraglutide combined with metformin treatment (LMT) in obesity patients with type 2 diabetes (ODP). Meta-analysis (using generic inverse variance random effects model) was performed when there were two or more studies reporting on the same evaluation indicators. Review Manager V.5.3 was used to perform the meta-analysis. Results: A total of 1289 participants from 15 RCTs were selected for the final meta-analysis. A synthesis of current evidence of LMT for treating ODP was provided in this protocol. Conclusion: This review will offer insights for future research and provide reference for LMT treatment for ODP.
MeSH term(s)	Humans ; Metformin/therapeutic use ; Liraglutide/therapeutic use ; Hypoglycemic Agents/therapeutic use ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Obesity/complications ; Obesity/drug therapy
Chemical Substances	Metformin (9100L32L2N) ; Liraglutide (839I73S42A) ; Hypoglycemic Agents
Language	English
Publishing date	2023-04-10
Publishing country	Ireland
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	390895-1
ISSN	1863-4362 ; 0021-1265
ISSN (online)	1863-4362
ISSN	0021-1265
DOI	10.1007/s11845-023-03337-2
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Article: Research progress of circadian rhythm in cardiovascular disease: A bibliometric study from 2002 to 2022.

Tian, Hao / Zhao, Xiaoshuai / Zhang, Yuxi / Xia, Zhongyuan

Heliyon

2024 Volume 10, Issue 7, Page(s) e28738

Abstract: Background: Given that the circadian rhythm is intricately linked to cardiovascular physiological functions, the objective of this investigation was to employ bibliometric visualization analysis in order to scrutinize the trends, hotspots, and prospects ...

Abstract	Background: Given that the circadian rhythm is intricately linked to cardiovascular physiological functions, the objective of this investigation was to employ bibliometric visualization analysis in order to scrutinize the trends, hotspots, and prospects of the circadian rhythm and cardiovascular disease (CVD) over the past two decades. Methods: A thorough exploration of the literature related to the circadian rhythm and CVD was conducted via the Web of Science Core Collection database spanning the years 2002-2022. Advanced software tools, including citespace and VOSviewer, were employed to carry out a comprehensive analysis of the co-occurrence and collaborative relationships among countries, institutions, journals, references, and keywords found in this literature. Furthermore, correlation mapping was executed to provide a visual representation of the data. Results: The present study encompassed a total of 3399 published works, comprising of 2691 articles and 708 reviews. The publications under scrutiny were primarily derived from countries such as the United States, Japan, and China. The most prominent research institutions were found to be the University of Vigo, University of Minnesota, and Harvard University. Notably, the journal Chronobiology International, alongside its co-cited publications, had the most substantial contribution to the research in this field. Following an exhaustive analysis, the most frequently observed keywords were identified as circadian rhythm, blood pressure, hypertension, heart rate, heart rate variability, and melatonin. Furthermore, a nascent analysis indicated that future research might gravitate towards topics such as inflammation, metabolism, oxidative stress, and autophagy, thereby indicating new directions for investigation. Conclusion: This analysis represents the first instance of bibliometric scrutiny pertaining to circadian rhythm and its correlation with cardiovascular disease (CVD) through the use of visualization software. Notably, this study has succeeded in highlighting the recent research frontiers and prominent trajectories in this field, thereby providing a valuable contribution to the literature.
Language	English
Publishing date	2024-03-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e28738
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Article: Factors influencing family resilience in adult patients with acute leukemia undergoing chemotherapy: A qualitative study.

Sun, Xuhan / Wang, Yuqing / Lu, Xinyu / Zhang, Shuyu / Zhang, Yuxi

Asia-Pacific journal of oncology nursing

2024 Volume 11, Issue 4, Page(s) 100389

Abstract: Objective: To explore the factors influencing family resilience in adult patients with acute leukemia undergoing chemotherapy, with the aim of providing a theoretical basis for the development of strategies to strengthen their family resilience.: ... ...

Abstract	Objective: To explore the factors influencing family resilience in adult patients with acute leukemia undergoing chemotherapy, with the aim of providing a theoretical basis for the development of strategies to strengthen their family resilience. Methods: A descriptive phenomenological qualitative research method was used to select 11 adult acute leukemia chemotherapy patients for semi-structured interviews. Colaizzi 7-step analysis and NVivo 12.0 were used to summarize information and refine themes. Results: The main outcomes consisted of two themes and 11 sub-themes: protective factors for family resilience (positive traits, cognitive restructuring, positive family beliefs, organizational flexibility, clear communication, and social support) and risk factors for family resilience (symptom burden, self-concealment, role overload, economic distress, and social alienation). Conclusions: Health care professionals should pay attention to screening protective and risk factors for family resilience in adult acute leukemia chemotherapy patients, affirming the positive role of internal and external resources available in the family in stressful situations, alleviating patients' negative experiences, and promoting the recovery of family function.
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2984639-0
ISSN	2349-6673 ; 2347-5625
ISSN (online)	2349-6673
ISSN	2347-5625
DOI	10.1016/j.apjon.2024.100389
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Article ; Online: Retraction Note: Long noncoding RNA RBMS3-AS3 acts as a microRNA-4534 sponge to inhibit the progression of prostate cancer by upregulating VASH1.

Jiang, Zhenming / Zhang, Yuxi / Chen, Xi / Wu, Pingeng / Chen, Dong

Gene therapy

2024 Volume 31, Issue 3-4, Page(s) 197

Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Retraction of Publication
ZDB-ID	1191036-7
ISSN	1476-5462 ; 0969-7128
ISSN (online)	1476-5462
ISSN	0969-7128
DOI	10.1038/s41434-023-00439-5
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Article ; Online: Clinical application of neostigmine in antagonizing postoperative residual curarization after elective laparoscopic gastrointestinal surgery

CHEN Qiufen / MIN Su / YU Chang / LYU Feng / ZHANG Yuxi

陆军军医大学学报, Vol 45, Iss 8, Pp 825-

2023 Volume 834

Abstract: Objective To investigate the clinical effects of the timing and dosage of neostigmine on its antagonistic effects on postoperative residual curarization (PORC) induced by rocuronium in patients undergoing laparoscopic gastrointestinal surgery during ... ...

Abstract	Objective To investigate the clinical effects of the timing and dosage of neostigmine on its antagonistic effects on postoperative residual curarization (PORC) induced by rocuronium in patients undergoing laparoscopic gastrointestinal surgery during recovery of general anesthesia. Methods A total 220 patients undergoing elective laparoscopic gastrointestinal surgery in the First Affiliated Hospital of Chongqing Medical University from November 2021 to February 2022 were recruited in this study. They were randomly divided into 4 groups, with 55 patients in each group. After spontaneous muscle relaxation recovery to train-of-four count (TOFC)=1, the patients in groups A1 and A2 were intravenously given 0.04 mg/kg neostigmine +0.02 mg/kg atropine and 0.06 mg/kg neostigmine combined with 0.03 mg/kg atropine, respectively. In contrast, after spontaneous muscle relaxation recovery instead to train-of-four ratio (TOFr, T4/T1)=0.4, the patients in groups B1 and B2 were intravenously given 0.04 mg/kg neostigmine +0.02 mg/kg atropine and 0.06 mg/kg neostigmine +0.03 mg/kg atropine, respectively. The physical and physiological characteristics of the patients before operation, and the physiological parameters, medication, operation, anesthesia, bleeding volume, awakening and sedation of the patients during operation were recorded and analyzed comparatively. Hemodynamic changes before and after the administration of neostigmine were monitored and recorded. The durations from the last administration of muscle relaxant to different stages of muscle relaxation recovery, defined by the values of TOFC=1, TOFC=3, TOFr=0.4, TOFr=0.7 and TOFr=1.0, were analyzed comparatively. The changes in TOFr after extubation were also analyzed comparatively. Results Eighteen patients were excluded from the trial, and, consequently, 202 patients were finally enrolled. The A1, A2, B1 and B2 groups took 94.53 (95%CI: 92.84~96.23), 85.88 (95%CI: 84.91~86.86), 75.08 (95%CI: 72.95~77.20) and 68.30 min (95%CI: 66.53~70.07), respectively, to recover to ...
Keywords	neostigmine ; rocuronium ; postoperative residual curarization ; laparoscopic examination ; Medicine (General) ; R5-920
Subject code	610
Language	Chinese
Publishing date	2023-04-01T00:00:00Z
Publisher	Editorial Office of Journal of Army Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: AIM2 and Psoriasis.

Zhang, Yuxi / Xu, Xiaoqing / Cheng, Hui / Zhou, Fusheng

Frontiers in immunology

2023 Volume 14, Page(s) 1085448

Abstract: Psoriasis is a chronic inflammatory skin disease occurring worldwide, with multiple systemic complications, which seriously affect the quality of life and physical and mental health of patients. The pathogenesis of psoriasis is related to the environment, ...

Abstract	Psoriasis is a chronic inflammatory skin disease occurring worldwide, with multiple systemic complications, which seriously affect the quality of life and physical and mental health of patients. The pathogenesis of psoriasis is related to the environment, genetics, epigenetics, and dysregulation of immune cells such as T cells, dendritic cells (DCs), and nonimmune cells such as keratinocytes. Absent in melanoma 2 (
MeSH term(s)	Humans ; DNA-Binding Proteins/metabolism ; Inflammasomes/metabolism ; Keratinocytes ; Psoriasis/pathology ; Quality of Life
Chemical Substances	AIM2 protein, human ; DNA-Binding Proteins ; Inflammasomes
Language	English
Publishing date	2023-01-18
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1085448
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Article ; Online: Modular Divergent Synthesis of Functionalized Indoles via TFA-Promoted Amino-Claisen Rearrangement at Room Temperature.

Zhang, Yuxi / He, Yicheng / Liu, Teng / Guo, Wusheng

Organic letters

2023 Volume 25, Issue 15, Page(s) 2680–2684

Abstract: A conceptually novel approach for the modular and divergent synthesis of highly functionalized indoles via trifluoroacetic acid-promoted amino-Claisen rearrangement is reported. This metal-free protocol could be performed at room temperature with wide ... ...

Abstract	A conceptually novel approach for the modular and divergent synthesis of highly functionalized indoles via trifluoroacetic acid-promoted amino-Claisen rearrangement is reported. This metal-free protocol could be performed at room temperature with wide functional group tolerance. The substitution type of the resultant indoles could be easily adjusted by the variation of the starting propargyl amines. The resultant products could be easily transformed into different value-added indole derivatives with simple experimental operations.
Language	English
Publishing date	2023-04-06
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.3c00764
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Article ; Online: Abnormalities of glucose and lipid metabolism in myocardial ischemia-reperfusion injury.

Tian, Hao / Zhao, Xiaoshuai / Zhang, Yuxi / Xia, Zhongyuan

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 163, Page(s) 114827

Abstract: Myocardial ischemia-reperfusion injury is a common condition in cardiovascular diseases, and the mechanism of its occurrence involves multiple complex metabolic pathways and signaling pathways. Among these pathways, glucose metabolism and lipid ... ...

Abstract	Myocardial ischemia-reperfusion injury is a common condition in cardiovascular diseases, and the mechanism of its occurrence involves multiple complex metabolic pathways and signaling pathways. Among these pathways, glucose metabolism and lipid metabolism play important roles in regulating myocardial energy metabolism. Therefore, this article focuses on the roles of glucose metabolism and lipid metabolism in myocardial ischemia-reperfusion injury, including glycolysis, glucose uptake and transport, glycogen metabolism and the pentose phosphate pathway; and triglyceride metabolism, fatty acid uptake and transport, phospholipid metabolism, lipoprotein metabolism, and cholesterol metabolism. Finally, due to the different alterations and development of glucose metabolism and lipid metabolism in myocardial ischemia-reperfusion, there are also complex interregulatory relationships between them. In the future, modulating the equilibrium between glucose metabolism and lipid metabolism in cardiomyocytes and ameliorating aberrations in myocardial energy metabolism represent highly promising novel strategies for addressing myocardial ischemia-reperfusion injury. Therefore, a comprehensive exploration of glycolipid metabolism can offer novel theoretical and clinical insights into the prevention and treatment of myocardial ischemia-reperfusion injury.
MeSH term(s)	Humans ; Myocardial Reperfusion Injury/metabolism ; Glucose/metabolism ; Lipid Metabolism ; Myocardial Ischemia/metabolism ; Myocardium/metabolism
Chemical Substances	Glucose (IY9XDZ35W2)
Language	English
Publishing date	2023-05-02
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.114827
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Article: Changes of Plasma Blood Ammonia Levels of Chinese Healthy People and the Establishment of Reference Intervals.

Wang, Jinghong / Zhang, Yuxi / Xiang, Zhongyuan

Clinical laboratory

2023 Volume 69, Issue 1

Abstract: Background: Blood ammonia detection is used for the diagnosis or differential diagnosis of various hepatitis virus infections, severe liver cirrhosis, and hepatic encephalopathy. It is also one of the important indexes reflecting liver coma, Reyes ... ...

Abstract	Background: Blood ammonia detection is used for the diagnosis or differential diagnosis of various hepatitis virus infections, severe liver cirrhosis, and hepatic encephalopathy. It is also one of the important indexes reflecting liver coma, Reyes syndrome, and other diseases. However, blood ammonia changes rapidly with time. If samples are not sent and detected in time, the results will be wrong, resulting in clinical misdiagnosis and life danger to patients. The purpose of this paper is to explore the change of blood ammonia with time and establish its reference interval. Methods: For this study, 228 healthy patients (111 males and 117 females) were selected who underwent physical examination at the Health Management Center of the Second Xiangya Hospital of Central South University from April to May 2021. The blood ammonia detection kit (colorimetric method) produced by Roche Diagnostics GmbH of Germany was used for detection on the Roche cobas c702 automatic biochemical analyzer. After eliminating outliers from the obtained test results, they were grouped according to gender and age, and SPSS 26.0 software was employed to statistically analyze the blood ammonia test results. Results: The differences in blood ammonia levels at each detection time were statistically significant (p < 0.05). The differences in blood ammonia levels between male and female subjects at 1 hour, 2 hours, and 3 hours were statistically significant (p < 0.05), but all ages saw no statistically significant difference in blood ammonia levels between segments (p > 0.05). The blood ammonia levels of each detection time and different genders showed a normal distribution. Therefore, it is necessary to take the 95% (X ± 1.96S) results of both sides as the reference interval according to the detection time and gender, and establish the reference intervals. The 1-hour blood ammonia reference interval for healthy men in Changsha is 15.8 - 47.5 μmol/L, for healthy women it is 12.4 - 39.6 μmol/L; the 2-hour blood ammonia reference interval for healthy men is 22.3 - 56.5 μmol/L, and for healthy women it is 19.1 - 48.0 μmol/L; the reference interval of 3-hours blood ammonia for healthy men is 27.9 - 65.7 μmol/L, and for healthy women it is 24.6 - 56.7 μmol/L. Conclusions: There are differences in blood ammonia levels between men and women at different detection times in Changsha. A reference interval suitable for blood ammonia in healthy individuals in the region should be established according to the detection time and gender, so as to provide better relevant evidence for clinical diagnosis.
MeSH term(s)	Female ; Humans ; Male ; Ammonia ; East Asian People ; Health Status ; Hematologic Tests ; Hepatic Encephalopathy ; Reference Values ; China
Chemical Substances	Ammonia (7664-41-7)
Language	English
Publishing date	2023-01-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2022.220105
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Article ; Online: A Comparative Study of the Fatigue of the Lower Extremities According to the Type of Shoes Worn When Firing a 10 m Air Pistol.

Zhang, Yuxi / Zhang, Ze / Kim, Sukwon / Kim, Youngsuk

International journal of environmental research and public health

2023 Volume 20, Issue 2

Abstract: The purpose of this study was to compare the differences in shooting performance, physical stability, and lower extremity muscle fatigue in high-level shooters wearing shooting shoes and sports shoes, and to determine the causes. Eight high-level 10 m ... ...

Abstract	The purpose of this study was to compare the differences in shooting performance, physical stability, and lower extremity muscle fatigue in high-level shooters wearing shooting shoes and sports shoes, and to determine the causes. Eight high-level 10 m air pistol shooters wore shooting shoes and sports shoes in a simulated shooting qualification experiment (60 rounds in 75 min) and we recorded shooting scores, pressure centers (COP), and median frequency of muscle fatigue index (MDF). All the data are expressed as mean ± standard deviation and are compared using a paired t-test. Athletes in shooting shoes scored higher than those in sports shoes (p < 0.05); COP moved less in the front-to-back and left-to-right directions for athletes wearing shooting shoes rather than sports shoes; and fewer muscles experienced fatigue, with fatigue also occurring later, for athletes wearing shooting shoes rather than sports shoes. Shooting shoes may reduce the sway of athletes’ center of pressure in the anterior−posterior and left−right directions, enhance postural stability, and result in higher shooting scores. In addition, they may make shooters feel more comfortable and relaxed during long training sessions and competitions.
MeSH term(s)	Humans ; Athletic Performance/physiology ; Shoes ; Postural Balance/physiology ; Athletes ; Lower Extremity ; Firearms
Language	English
Publishing date	2023-01-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20021363
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