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  1. Article: [Research advances in preclinical models of oral mucosal melanoma].

    Huang, X Y / Shi, C J / Zhang, Z Y

    Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology

    2023  Volume 58, Issue 8, Page(s) 852–857

    Abstract: Oral mucosal melanoma (OMM), a subtype of melanoma which is commonly found in the eastern Asian populations, progresses with unclear pathogenesis, high malignancy and poor prognosis. Constructing different types of preclinical models for OMM, which ... ...

    Abstract Oral mucosal melanoma (OMM), a subtype of melanoma which is commonly found in the eastern Asian populations, progresses with unclear pathogenesis, high malignancy and poor prognosis. Constructing different types of preclinical models for OMM, which simulate clinical characteristics such as tumor invasion and metastasis, assists screening and efficacy-evaluation of drugs. This would promote personalized treatments for patients with OMM. However, lack of preclinical models makes one of the critical obstacles that hinder the recognition of mucosal melanoma and block the treatment breakthrough in mucosal melanoma. In recent years, certain progress has been made in the construction and application of OMM preclinical models. Various OMM preclinical models have been successfully constructed and carried out for further research, assisting in excavating personalized treatment strategies. In this review, we will summarize the latest progress in the researches on OMM preclinical models.
    MeSH term(s) Humans ; Mouth Neoplasms/pathology ; Melanoma/drug therapy ; Melanoma/pathology ; Mouth Mucosa/pathology
    Language Chinese
    Publishing date 2023-08-07
    Publishing country China
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 1027950-7
    ISSN 1002-0098
    ISSN 1002-0098
    DOI 10.3760/cma.j.cn112144-20221105-00571
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Research progress on neurotoxicity induced by metal pollutants through astrocytes].

    Zhang, Z Y / Zhao, X Y / Wu, Q Y

    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases

    2023  Volume 42, Issue 2, Page(s) 155–160

    Abstract: Metal pollutants in the natural environment and industrial environment can enter organisms through the respiratory tract and digestive tract causing adverse health effects. Many kinds of literatures confirm that metal pollutants have neurotoxicity. ... ...

    Abstract Metal pollutants in the natural environment and industrial environment can enter organisms through the respiratory tract and digestive tract causing adverse health effects. Many kinds of literatures confirm that metal pollutants have neurotoxicity. Recent studies have showed that astrocytes play an important role in neurotoxicity induced by metal pollutants. In this review, the latest progress of neurotoxicity induced by lead, mercury, cadmium, antimony and copper through astrocytes in recent years is summarized, which provides a new clue for the neurotoxicity research of metal pollutants.
    MeSH term(s) Humans ; Environmental Pollutants/toxicity ; Astrocytes ; Cadmium ; Mercury ; Copper ; Neurotoxicity Syndromes/etiology
    Chemical Substances Environmental Pollutants ; Cadmium (00BH33GNGH) ; Mercury (FXS1BY2PGL) ; Copper (789U1901C5)
    Language Chinese
    Publishing date 2023-12-16
    Publishing country China
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 1050900-8
    ISSN 1001-9391
    ISSN 1001-9391
    DOI 10.3760/cma.j.cn121094-20221203-00578
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Research prospect of preclinical model construction and precision therapy in ameloblastoma].

    Kang, X D / Sun, L L / Zhang, Z Y / Sun, S Y

    Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology

    2023  Volume 58, Issue 8, Page(s) 844–851

    Abstract: Ameloblastoma (AM) is a benign odontogenic tumor with unknown etiology. It is prone to recurrence and has a potential for malignant transformation. Patients often show high rates of relapse after curettage, or suffer from structural and functional damage ...

    Abstract Ameloblastoma (AM) is a benign odontogenic tumor with unknown etiology. It is prone to recurrence and has a potential for malignant transformation. Patients often show high rates of relapse after curettage, or suffer from structural and functional damage of jaw after partial resection. Whole-genome sequencing data revealed that BRAF mutations and SMO mutations were common and likely to be mutually exclusive in AM. It was also reported that BRAF inhibitors were effective in several patients carrying BRAF
    MeSH term(s) Humans ; Animals ; Mice ; Ameloblastoma/genetics ; Proto-Oncogene Proteins B-raf/genetics ; Mice, Nude ; Neoplasm Recurrence, Local ; Odontogenic Tumors ; Mutation
    Chemical Substances Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
    Language Chinese
    Publishing date 2023-08-27
    Publishing country China
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 1027950-7
    ISSN 1002-0098
    ISSN 1002-0098
    DOI 10.3760/cma.j.cn112144-20230703-00264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Application and significance of peripheral blood circulating plasma cells in the diagnosis of multiple myeloma].

    Chen, H / Zhao, Y / Zhang, Z Y / Jin, M L

    Zhonghua bing li xue za zhi = Chinese journal of pathology

    2023  Volume 52, Issue 10, Page(s) 1064–1068

    MeSH term(s) Humans ; Multiple Myeloma/diagnosis ; Plasma Cells ; Bone Marrow
    Language Chinese
    Publishing date 2023-10-05
    Publishing country China
    Document type Journal Article
    ZDB-ID 784533-9
    ISSN 0529-5807
    ISSN 0529-5807
    DOI 10.3760/cma.j.cn112151-20230306-00177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Application of single-cell transcriptome sequencing in mechanistic toxicology].

    Yu, Y J / Zhang, Z Y / Wei, Y H

    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine

    2022  Volume 56, Issue 1, Page(s) 29–32

    Abstract: Traditional bulk RNA sequencing assesses the average expression level of genes in tissues rather than the differences in cellular responses. Accordingly, it is hard to differentiate sensitive responding cells, leading to inaccurate identification of ... ...

    Abstract Traditional bulk RNA sequencing assesses the average expression level of genes in tissues rather than the differences in cellular responses. Accordingly, it is hard to differentiate sensitive responding cells, leading to inaccurate identification of toxicity pathways. Single-cell RNA sequencing (scRNA-seq) isolated single cells from tissue and subjected them to cell subtypes-specific transcriptome analysis. This technique in toxicological studies realizes the heterogeneous cellular responses in the tissue microenvironment upon chemical exposure. Thus it helps to identify sensitive responding cells and key molecular events, providing a powerful tool and a new perspective for exploring the mechanisms of toxicity and the modes of action. This review summarizes the development, principle, method, application and limitations of scRNA-seq in mechanistic toxicological researches, and discusses the prospect of multi-directional applications.
    MeSH term(s) Base Sequence ; Gene Expression Profiling ; Sequence Analysis, RNA ; Single-Cell Analysis ; Transcriptome
    Language Chinese
    Publishing date 2022-01-29
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 604575-3
    ISSN 0253-9624
    ISSN 0253-9624
    DOI 10.3760/cma.j.cn112150-20210513-00469
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2487: Show issues Location:
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  6. Article: [The applications of anti-CD20 monoclonal antibody in inborn error of immunity].

    Yang, X / Zhang, Z Y / Zhao, X D / Tang, X M

    Zhonghua er ke za zhi = Chinese journal of pediatrics

    2022  Volume 60, Issue 12, Page(s) 1342–1345

    MeSH term(s) Humans ; Antibodies, Monoclonal/therapeutic use ; Antineoplastic Agents
    Chemical Substances Antibodies, Monoclonal ; Antineoplastic Agents
    Language Chinese
    Publishing date 2022-11-22
    Publishing country China
    Document type Journal Article
    ZDB-ID 784523-6
    ISSN 0578-1310
    ISSN 0578-1310
    DOI 10.3760/cma.j.cn112140-20220927-00842
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 3292: Show issues Location:
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  7. Article ; Online: Successful treatment of generalized granuloma annulare with baricitinib.

    Yan, T M / Zhang, H / Wu, X Y / Zhang, Z Y

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2022  Volume 36, Issue 7, Page(s) e500–e502

    MeSH term(s) Azetidines/therapeutic use ; Granuloma Annulare/drug therapy ; Humans ; Purines/therapeutic use ; Pyrazoles ; Sulfonamides/therapeutic use
    Chemical Substances Azetidines ; Purines ; Pyrazoles ; Sulfonamides ; baricitinib (ISP4442I3Y)
    Language English
    Publishing date 2022-03-03
    Publishing country England
    Document type Letter
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.18031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3492: Show issues Location:
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    Zs.MO 413: Show issues

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  8. Article ; Online: Survival impact of postoperative radiotherapy in patients with olfactory neuroblastoma: 513 cases from the SEER database.

    Duo, G-S / Feng, J-L / Zhang, Z-Y / Wang, L-J

    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

    2022  Volume 26, Issue 5, Page(s) 663–669

    Abstract: Pupose: To evaluate the impact of postoperative radiotherapy (PORT) on survival in olfactory neuroblastoma (ONB) patients with different tumor staging.: Material and methods: Patients with ONB were selected in the Surveillance, Epidemiology and End ... ...

    Abstract Pupose: To evaluate the impact of postoperative radiotherapy (PORT) on survival in olfactory neuroblastoma (ONB) patients with different tumor staging.
    Material and methods: Patients with ONB were selected in the Surveillance, Epidemiology and End Results (SEER) database from 2004-2016. Survival analyses were performed using Kaplan-Meier (K-M) method, Cox regression analysis, and competing risk model.
    Results: A total of 513 patients were included in the study. Univariate and multivariate analysis results demonstrated that PORT was not an independent prognostic factor for overall survival (OS) of modified Kadish stage A and B patients (P=0.699 and P=0.248, respectively). Kadish stage C and D patients who underwent PORT had significantly better OS than those who did not undergo PORT (P=0.03 and P<0.0001). K-M curves revealed that the 5- and 10-year OS rates of patients who underwent PORT vs. non-PORT were 85.3% vs. 70.4% and 68.2% vs. 56.8% in stage C patients, respectively. For stage D patients, the 5-year OS rates were 70.7% and 42.6%, and 10-year OS rates were 53.4% and 29.5% in the PORT and non-PORT groups, respectively. The competitive risk model revealed that the 5-year cancer-specific cumulative mortality incidence decreased by 26.6% while the 10-year mortality incidence decreased by 41.4% in Kadish stage C patients who were treated using PORT; meanwhile, for Kadish stage D patients who were treated with PORT, the 5- and 10-year mortality incidences were reduced by 35.3% and 42.6%, respectively. Furthermore, we found that chemotherapy was not related to the prognosis of ONB patients (all P>0.05).
    Conclusion: Our results indicate that PORT improved survival outcomes of modified Kadish stage C and D ONB patients. However, PORT may not affect survival for modified Kadish stage A and B individuals. Chemotherapy was not recommended for ONB; therefore, further studies are warranted to determine its therapeutic significance.
    MeSH term(s) Esthesioneuroblastoma, Olfactory/radiotherapy ; Esthesioneuroblastoma, Olfactory/surgery ; Humans ; Nasal Cavity/pathology ; Neoplasm Staging ; Nose Neoplasms/radiotherapy ; Nose Neoplasms/surgery ; Prognosis ; Retrospective Studies
    Language English
    Publishing date 2022-03-04
    Publishing country France
    Document type Journal Article
    ZDB-ID 1397169-4
    ISSN 1769-6658 ; 1278-3218
    ISSN (online) 1769-6658
    ISSN 1278-3218
    DOI 10.1016/j.canrad.2021.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: High-throughput miRNA sequencing and identification of a novel ICE1-targeting miRNA in response to low temperature stress in Eucalyptus camaldulensis.

    Zhang, W-H / Zhang, Z-Y / Liu, Y / Tan, Z-Y / Zhou, Q / Lin, Y-Z

    Plant biology (Stuttgart, Germany)

    2023  Volume 25, Issue 4, Page(s) 541–550

    Abstract: MicroRNAs (miRNAs) play a crucial role in the growth, development, morphogenesis, signal transduction, and stress response in plants. The ICE (Inducer of CBF expression)-CBF (C-repeat binding factor)-COR (Cold-regulated gene) regulatory cascade is an ... ...

    Abstract MicroRNAs (miRNAs) play a crucial role in the growth, development, morphogenesis, signal transduction, and stress response in plants. The ICE (Inducer of CBF expression)-CBF (C-repeat binding factor)-COR (Cold-regulated gene) regulatory cascade is an important signalling pathway in plant response to low temperature stress, and it remains unknown whether this pathway is regulated by miRNAs. In this study, high-throughput sequencing was employed for predicting and identifying the miRNAs that were likely to target the ICE-CBF-COR pathway in Eucalyptus camaldulensis. A novel ICE1-targeting miRNA, eca-novel-miR-259-5p (nov-miR259), was further analysed. A total of 392 conserved miRNAs and 97 novel miRNAs were predicted, including 80 differentially expressed miRNAs. Of these, 30 miRNAs were predicted to be associated with the ICE-CBF-COR pathway. The full-length of mature nov-miR259 was 22 bp and its precursor gene was 60 bp in length, with a typical hairpin structure. The RNA ligase-mediated 5' amplification of cDNA ends (5'-RLM-RACE) and Agrobacterium-mediated tobacco transient expression assays demonstrated that nov-miR259 could cleave EcaICE1 in vivo. Moreover, qRT-PCR and Pearson's correlation analysis further revealed that the expression levels of nov-miR259 were almost significantly negatively correlated with those of its target gene, EcaICE1, and the other genes in the ICE-CBF-COR pathway. We first identified the nov-miR259 as a novel ICE1-targeting miRNA, and the nov-miR259-ICE1 module may be involved in regulating the cold stress response in E. camaldulensis.
    MeSH term(s) MicroRNAs/genetics ; MicroRNAs/metabolism ; Eucalyptus/genetics ; Eucalyptus/metabolism ; Temperature ; Cold Temperature ; Plants/metabolism ; High-Throughput Nucleotide Sequencing ; Gene Expression Regulation, Plant
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464075-2
    ISSN 1438-8677 ; 1435-8603
    ISSN (online) 1438-8677
    ISSN 1435-8603
    DOI 10.1111/plb.13520
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  10. Article: [Association of Polycyclic Aromatic Hydrocarbons exposure with sleep quality among coking plant workers].

    Zhang, Z Y / Li, X / Wang, X / Song, Z F / Sun, M / Zhang, H M

    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases

    2023  Volume 40, Issue 12, Page(s) 918–925

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Coke/analysis ; Occupational Exposure/adverse effects ; Occupational Exposure/analysis ; Polycyclic Aromatic Hydrocarbons/analysis ; Sleep Quality
    Chemical Substances Coke ; Polycyclic Aromatic Hydrocarbons
    Language Chinese
    Publishing date 2023-02-06
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1050900-8
    ISSN 1001-9391
    ISSN 1001-9391
    DOI 10.3760/cma.j.cn121094-20211227-00630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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