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  1. Article ; Online: Exploring the preparation of YbBa

    Wang, Yanan / Zhang, Zerong / Gao, Zhan / Wang, Lei / Wang, Qiuliang

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 8949

    Abstract: REBCO has been used extensively as coated conductors applied to superconducting magnets due to its exceptional superconducting properties. As a REBCO superconductor, ... ...

    Abstract REBCO has been used extensively as coated conductors applied to superconducting magnets due to its exceptional superconducting properties. As a REBCO superconductor, YbBa
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59829-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Interactive scalp acupuncture combined with suspension digital occupational therapy for upper limb motor dysfunction after stroke: a multi-center randomized controlled trial.

    Xu, Lei / Zhang, Zerong / Xu, Weiyong / Liu, Huan / Han, Xue / Wang, Min

    Zhongguo zhen jiu = Chinese acupuncture & moxibustion

    2024  Volume 44, Issue 2, Page(s) 129–133

    Abstract: Objectives: To observe the effects of interactive scalp acupuncture on upper limb motor function and activities of daily living in patients with upper limb motor dysfunction after stroke.: Methods: One hundred and twenty patients with upper limb ... ...

    Title translation 互动式头针结合悬吊下数字作业疗法治疗脑卒中后上肢运动功能障碍:多中心随机对照试验.
    Abstract Objectives: To observe the effects of interactive scalp acupuncture on upper limb motor function and activities of daily living in patients with upper limb motor dysfunction after stroke.
    Methods: One hundred and twenty patients with upper limb motor dysfunction after stroke were randomly divided into an observation group(60 cases, 2 cases dropped out)and a control group(60 cases, 1 case dropped out). Both groups were treated with routine medication and rehabilitation. The observation group was treated with interactive scalp acupuncture combined with suspension digital occupational therapy, interactive scalp acupuncture was applied at middle 2/5 of the parietal and temporal anterior oblique line, middle 2/5 of the parietal and temporal posterior oblique line and second lateral line of parietal of the hemiparalysis contralateral side, 30 min each time.The control group was treated with suspension digital occupational therapy alone. The treatment was given once a day, 5 times a week for 4 weeks in the two groups. The scores of Fugl-Meyer assessment scale of upper extremity(FMA-UE), action research arm test(ARAT), the modified Barthel index (MBI) and surface electromyography(sEMG)signal of the biceps and triceps on the affected side were observed before and after treatment in the two groups, and the clinical efficacy was evaluated.
    Results: After treatment, the FMA-UE, ARAT and MBI scores were increased compared with those before treatment in both groups(
    Conclusions: Interactive scalp acupuncture could improve upper limb motor function and activities of daily living in patients with upper limb motor dysfunction after stroke.
    MeSH term(s) Humans ; Stroke Rehabilitation ; Occupational Therapy ; Activities of Daily Living ; Scalp ; Stroke/complications ; Stroke/therapy ; Acupuncture Therapy ; Upper Extremity ; Treatment Outcome
    Language Chinese
    Publishing date 2024-02-12
    Publishing country China
    Document type Randomized Controlled Trial ; Multicenter Study ; Journal Article
    ISSN 0255-2930
    ISSN 0255-2930
    DOI 10.13703/j.0255-2930.20230507-k0001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Kai-Xin-San protects against mitochondrial dysfunction in Alzheimer's disease through SIRT3/NLRP3 pathway.

    Su, ShiJie / Chen, Gongcan / Gao, Minghuang / Zhong, Guangcheng / Zhang, Zerong / Wei, Dongyun / Luo, Xue / Wang, Qi

    Chinese medicine

    2023  Volume 18, Issue 1, Page(s) 26

    Abstract: Background: Kai-Xin-San (KXS) has been reported to have a good curative impact on dementia. The purpose of the study was to determine whether KXS might ameliorate cognitive deficits in APP/PS1 mice and to evaluate its neuroprotective mechanism.: ... ...

    Abstract Background: Kai-Xin-San (KXS) has been reported to have a good curative impact on dementia. The purpose of the study was to determine whether KXS might ameliorate cognitive deficits in APP/PS1 mice and to evaluate its neuroprotective mechanism.
    Methods: APP/PS1 mice were employed as an AD animal model; Aβ
    Results: The results indicated that KXS protected APP/PS1 mice against cognitive impairments. KXS suppressed neuronal apoptosis and oxidative stress among APP/PS1 mice. KXS and KXS-containing serum improved mitochondrial dysfunction and synaptic and neurotrophic factors regarding APP/PS1 mice. In addition, KXS and KXS-containing serum enhanced mitochondrial SIRT3 expression and reduced NLRP3 inflammasome expression in APP/PS1 mice.
    Conclusion: KXS improves cognitive dysfunction among APP/PS1 mice via regulating SIRT3-mediated neuronal cell apoptosis. These results suggested that KXS was proposed as a neuroprotective agent for AD progression.
    Language English
    Publishing date 2023-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2260322-0
    ISSN 1749-8546
    ISSN 1749-8546
    DOI 10.1186/s13020-023-00722-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Hesperetin attenuates cognitive dysfunction via SIRT6/NLRP3 pathway in scopolamine-induced mice.

    Jing, Shangwen / Wang, Xinyue / Zhang, Zerong / Cao, Dandan / Huang, Kongli / Wang, Yuting / Liu, Zhuangzhuang / Su, Shijie / Wang, Qi

    Metabolic brain disease

    2023  Volume 38, Issue 7, Page(s) 2443–2456

    Abstract: Neuroinflammation is a critical feature in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease (AD). Hesperetin can exert anti-inflammatory, antioxidant and other neuroprotective effects. In this study, the scopolamine (SCOP)- ... ...

    Abstract Neuroinflammation is a critical feature in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease (AD). Hesperetin can exert anti-inflammatory, antioxidant and other neuroprotective effects. In this study, the scopolamine (SCOP)-induced cognitive dysfunction in mice model was used to evaluate the neuroprotective effects of hesperetin. Behavioral tests (Morris water maze, open field, and novel object recognition tests) were conducted to evaluate the effect of hesperetin on cognitive dysfunction behaviors. Nissl staining and Immunofluorescence were used to evaluate hippocampal neuronal damage and microglial activation in mice. The levels of proinflammatory factors, oxidant stress, and the cholinergic neurotransmitter were detected by real-time quantitative fluorescence PCR (RT-qPCR) or biochemical reagent kits. Western blotting was used to detect the relative protein expression of the sirtuin 6 (SIRT6) / NOD-like receptor thermal protein domain associated protein 3 (NLRP3) pathway. Results showed that hesperetin could ameliorate SCOP-induced cognitive impairment and neuronal damage, and regulate the levels of cholinergic neurotransmitters in the hippocampal of AD mice. Hesperetin could also enhance antioxidant defense by regulating the levels of reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT). Hesperetin exerted anti-neuroinflammation effects through inhibiting of microglia activation and down-regulating the mRNA transcript levels of inflammatory cytokines, such as tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS). Meanwhile, hesperetin could attenuate the expression of NLRP3, apoptosis-associated speck-like protein containing a CARD (ASC), thioredoxin-interacting protein (TXNIP), and caspase-1 p20 and upregulate the expression of SIRT6 in SCOP-induced mice. Overall, our study suggested that hesperetin might ameliorate SCOP-induced cognitive dysfunction by improving cholinergic system dysfunction and suppressing oxidative stress and attenuating neuroinflammation via SIRT6/NLRP3 pathway in mice.
    MeSH term(s) Mice ; Animals ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Inflammasomes/metabolism ; Antioxidants ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Scopolamine ; Cognitive Dysfunction/chemically induced ; Cognitive Dysfunction/drug therapy ; Sirtuins
    Chemical Substances NLR Family, Pyrin Domain-Containing 3 Protein ; hesperetin (Q9Q3D557F1) ; Inflammasomes ; Antioxidants ; Neuroprotective Agents ; Scopolamine (DL48G20X8X) ; Sirtuins (EC 3.5.1.-)
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632824-6
    ISSN 1573-7365 ; 0885-7490
    ISSN (online) 1573-7365
    ISSN 0885-7490
    DOI 10.1007/s11011-023-01250-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Three-dimensional microporous and mesoporous covalent organic frameworks based on cubic building units.

    Liao, Li / Guan, Xinyu / Zheng, Haorui / Zhang, Zerong / Liu, Yaozu / Li, Hui / Zhu, Liangkui / Qiu, Shilun / Yao, Xiangdong / Fang, Qianrong

    Chemical science

    2022  Volume 13, Issue 32, Page(s) 9305–9309

    Abstract: Covalent organic frameworks (COFs) have attracted extensive interest due to their unique structures and various applications. However, structural diversities are still limited, which greatly restricts the development of COF materials. Herein, we report ... ...

    Abstract Covalent organic frameworks (COFs) have attracted extensive interest due to their unique structures and various applications. However, structural diversities are still limited, which greatly restricts the development of COF materials. Herein, we report two unusual cubic (8-connected) building units and their derived 3D imine-linked COFs with
    Language English
    Publishing date 2022-07-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d2sc02365b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Kaempferol suppression of acute colitis is regulated by the efflux transporters BCRP and MRP2.

    Liu, Yuanyuan / Lu, Yiyan / Li, Xiaoyan / Zhang, Zerong / Sun, Lizhu / Wang, Ying / He, Zhuoru / Liu, Zhongqiu / Zhu, Lijun / Fu, Ling

    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

    2022  Volume 179, Page(s) 106303

    Abstract: The bioavailability of most flavonoids is low but effective in vivo; however, the mechanism of the efficacy of flavonoids has not been elucidated. Kaempferol is typical flavonoids., preliminary research indicates that kaempferol has a significant anti- ... ...

    Abstract The bioavailability of most flavonoids is low but effective in vivo; however, the mechanism of the efficacy of flavonoids has not been elucidated. Kaempferol is typical flavonoids., preliminary research indicates that kaempferol has a significant anti-colon cancer and anti-inflammatory effect. We reported previously that the triple recycling pathways significantly increase the local bioavailability of flavonoids and prolong the residence time of flavonoids in the liver and intestines, which is likely the mode by which flavonoids exert local efficacy. Notably, Efflux transporters (ETs), such as Breast cancer resistance protein (BCRP) and Multi drug resistance-associated protein 2 (MRP2), are the main regulatory molecules of the enterohepatic triple recycling pathways. Thus, our current study explored the regulation of kaempferol by BCRP and MRP2 and the role of BCRP and MRP2 in the suppression of Dextran sulfate sodium (DSS)-induced colitis by kaempferol. Herein, four mouse model was constructed, and the Ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was established to simultaneously quantify kaempferol and its 3 metabolites and investigate the oral pharmacokinetic characteristics and tissue distribution of these compounds. In Bcrp
    MeSH term(s) Mice ; Animals ; ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Kaempferols/pharmacology ; Neoplasm Proteins/metabolism ; Multidrug Resistance-Associated Proteins ; Tandem Mass Spectrometry ; ATP-Binding Cassette Transporters/metabolism ; Membrane Transport Proteins ; Colitis/chemically induced ; Colitis/drug therapy ; Neoplasms
    Chemical Substances ATP Binding Cassette Transporter, Subfamily G, Member 2 ; Kaempferols ; Neoplasm Proteins ; Multidrug Resistance-Associated Proteins ; ATP-Binding Cassette Transporters ; Membrane Transport Proteins
    Language English
    Publishing date 2022-10-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1154366-8
    ISSN 1879-0720 ; 0928-0987
    ISSN (online) 1879-0720
    ISSN 0928-0987
    DOI 10.1016/j.ejps.2022.106303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Unique chemical activity in porous YbB

    Li, Zhihui / Chen, Jixin / Zhang, Hao / Yang, Jinxing / Hu, Minmin / Sun, Luchao / Zhang, Zerong / Zhang, Yongheng / Li, Meishuan

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 20227

    Abstract: High purity layered ... ...

    Abstract High purity layered YbB
    Language English
    Publishing date 2020-11-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-77267-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Acupuncture for balance dysfunction in patients with stroke: A systematic review protocol.

    Xu, Lei / Dong, YouKang / Wang, Min / Chen, LiQiu / Zhang, ZeRong / Su, DongSheng / Zhang, Feng / Lei, Zhen / Xu, WeiYong / Didier, Kuete Kamtsop Christian / Du, YuanHao

    Medicine

    2018  Volume 97, Issue 31, Page(s) e11681

    Abstract: Background: Balance dysfunctions in stroke survivors are common and have significant impact on functional independence and rehabilitation. As a crucial technique of Traditional Chinese Medicine, acupuncture has been used widely for balance dysfunctions ... ...

    Abstract Background: Balance dysfunctions in stroke survivors are common and have significant impact on functional independence and rehabilitation. As a crucial technique of Traditional Chinese Medicine, acupuncture has been used widely for balance dysfunctions after stroke, although its effective evidence is not clear. Hence, we plan this systematic review protocol to evaluate the value of its efficacy and safety for balance dysfunctions after stroke.
    Methods: We will search the databases from the publishment to April 2018: Web of Science, PubMed, Medline, Cochrane Library, EBASE, WHO International Clinical Trials Registry Platform, Wanfang, Chinese Biomedical Literature Database, Chinese Scientific Journal Database (VIP), and China National Knowledge Infrastructure. The clinical efficacy will be accepted as the primary outcomes. RevMan V.5.3 software will be used to compute the data synthesis when a meta-analysis is allowed.
    Results: This systematic review and meta-analysis will provide a high-quality synthesis of current evidence of acupuncture for balance dysfunctions after stroke including clinical efficacy, balance ability, walking ability, and activity of daily life etcetera.
    Conclusion: This protocol will determine whether acupuncture is an effective and safety intervention for balance dysfunctions after stroke.
    MeSH term(s) Acupuncture Therapy/methods ; Aged ; Clinical Protocols ; Female ; Humans ; Male ; Middle Aged ; Postural Balance/physiology ; Sensation Disorders/etiology ; Sensation Disorders/therapy ; Stroke/complications ; Stroke/physiopathology ; Stroke Rehabilitation/methods ; Systematic Reviews as Topic ; Treatment Outcome
    Language English
    Publishing date 2018-08-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000011681
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Die Reform des Arbeits- und Lohnsystems in der Stadtwirtschaft Chinas

    Zhang, Zerong / Yue, Bing

    Chinas Weg zur Marktwirtschaft S. 399-449

    Beurteilung und Rückblick

    1993  

    Author's details von Zhang Zerong und Yue Bing
    Keywords Arbeitskräftelenkung ; Lohnpolitik ; Wirtschaftsreform ; Städtischer Arbeitsmarkt ; China
    Language German
    Publisher Lit-Verl.
    Publishing place Münster [u.a.]
    Document type Article
    Database ECONomics Information System

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