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Artikel ; Online: Carotid Artery Stenting for the Treatment of Fatal Acute Cerebral Infarction Associated with Aortic Dissection.

Dang, Yuan-Yuan / Zhang, Zhen-Hai / Shen, Chun-Sen

2020 Band 68, Heft 1, Seite(n) 185–188

Abstract: Acute aortic dissection (AAD) complicated with acute cerebral infarction lacks a unified treatment plan. We report probably the most effective treatment of a type A AAD with acute cerebral infarction leading to coma. A 43-year-old man presented with ... ...

Abstract	Acute aortic dissection (AAD) complicated with acute cerebral infarction lacks a unified treatment plan. We report probably the most effective treatment of a type A AAD with acute cerebral infarction leading to coma. A 43-year-old man presented with acute hemiplegia and unconsciousness. He was diagnosed as acute cerebral infarction. After an ineffective emergency intravenous thrombolysis, a Digital Subtraction Angiography (DSA) examination revealed the severe cerebral artery occlusion, and the TICI 3 level was achieved by stent implantation in the left common carotid artery with significant neurological recovery. A type A AAD was found at the 1 month follow-up ultrasound examination and a further thoracic surgery was performed successfully. Carotid ultrasound is helpful for the diagnosis of AAD from acute cerebral infarction. Carotid artery stenting followed by thoracic surgery is effective in this kind of emergency situations. Further studies are needed to determine the exact indications.
Mesh-Begriff(e)	Adult ; Aneurysm, Dissecting/complications ; Aneurysm, Dissecting/diagnosis ; Aneurysm, Dissecting/surgery ; Brain Ischemia/diagnosis ; Brain Ischemia/etiology ; Brain Ischemia/surgery ; Carotid Arteries/surgery ; Carotid Artery, Common/surgery ; Fatal Outcome ; Humans ; Infarction, Middle Cerebral Artery/surgery ; Male ; Stents ; Stroke/diagnosis ; Stroke/etiology ; Stroke/surgery
Sprache	Englisch
Erscheinungsdatum	2020-03-04
Erscheinungsland	India
Dokumenttyp	Case Reports
ZDB-ID	415522-1
ISSN	1998-4022 ; 0028-3886
ISSN (online)	1998-4022
ISSN	0028-3886
DOI	10.4103/0028-3886.279679
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: [Effect of ginseng rare ginsenoside components combined with paclitaxel on A549 lung cancer].

Yang, Lei / Zhang, Zhen-Hai / Jia, Xiao-Bin

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2018 Band 43, Heft 7, Seite(n) 1446–1452

Abstract: Traditional Chinese medicine combined with anticancer drugs is a new direction of clinical cancer therapy in recent years. In this study, the optimal ratio of ginseng rare ginsenoside components and paclitaxel was optimized by MTT method, and the ... ...

Abstract	Traditional Chinese medicine combined with anticancer drugs is a new direction of clinical cancer therapy in recent years. In this study, the optimal ratio of ginseng rare ginsenoside components and paclitaxel was optimized by MTT method, and the proliferative, apoptotic and anti-tumor effects of lung cancer A549 cells were investigated. It was found that the inhibitory effect on the proliferation of lung cancer A549 cells was the same as that on paclitaxel when the ratio of rare ginseng rare ginsenoside components to paclitaxel was 4∶6. Further studies showed that the combined therapy significantly increased the inductive effect of apoptosis in A549 cells, and up-regulated the expression of caspase-3 protein and down-regulated the ratio of Bcl-2/Bax. The tumor-bearing mice model showed that the combination therapy of ginseng rare ginsenoside components and paclitaxel could significantly inhibit the growth of tumor and alleviate the toxic and side effects of paclitaxel on liver. A multi-component system of ginseng rare ginsenoside components-paclitaxel was established in this paper. The proliferation and growth of lung cancer A549 cells were inhibited by paclitaxel-induced apoptosis, the dosage of paclitaxel and the toxicity of paclitaxel were reduced, and the effect of anti-lung cancer was enhanced, which provided a theoretical basis for later studies and clinical application.
Mesh-Begriff(e)	A549 Cells ; Animals ; Apoptosis ; Cell Proliferation ; Ginsenosides/pharmacology ; Humans ; Lung Neoplasms/drug therapy ; Mice ; Paclitaxel/pharmacology ; Panax/chemistry ; Xenograft Model Antitumor Assays
Chemische Substanzen	Ginsenosides ; Paclitaxel (P88XT4IS4D)
Sprache	Chinesisch
Erscheinungsdatum	2018-07-05
Erscheinungsland	China
Dokumenttyp	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20180117.002
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: [Big data: the progress and applications of antibody repertoire sequencing].

Zhang, Zai-Bao / Guan, Qian / Zhang, Zhen-Hai

Nan fang yi ke da xue xue bao = Journal of Southern Medical University

2015 Band 35, Heft 4, Seite(n) 463–467

Abstract: Antibody, the major effector in adaptive immunity, plays key roles in protective and pathogenic immune responses. Integrative analyses of antibody development, differentiation, and maturation promote the research in immune mechanism, vaccine design, and ... ...

Abstract	Antibody, the major effector in adaptive immunity, plays key roles in protective and pathogenic immune responses. Integrative analyses of antibody development, differentiation, and maturation promote the research in immune mechanism, vaccine design, and therapies for autoimmune disorders. The development of next generation sequencing technologies has enabled large-scale characterization of functional antibody repertoires. With the advantages of next generation sequencing, antibody and antibody repertoire analysis have been successfully used in identification of HIV-1-broadly neutralizing antibodies, design of rationale structure-based vaccine, and development of immunology. With increasing sequence length and precision, improvement of experimental protocols and bioinformatics analyses, and development of single cell sequencing technology, antibody repertoire sequencing will expedite the research in antibody-related immune response, and thus facilitates vaccine design for infectious diseases, clinical diagnosis and interference of autoimmune diseases. This review introduces the technologies, progresses, applications, and caveats of antibody repertoire sequencing.
Mesh-Begriff(e)	Antibodies/chemistry ; Antibodies, Neutralizing ; Antibody Formation ; HIV-1 ; High-Throughput Nucleotide Sequencing ; Humans ; Vaccines
Chemische Substanzen	Antibodies ; Antibodies, Neutralizing ; Vaccines
Sprache	Chinesisch
Erscheinungsdatum	2015-04
Erscheinungsland	China
Dokumenttyp	English Abstract ; Journal Article ; Review
ZDB-ID	2250951-3
ISSN	1673-4254
ISSN	1673-4254
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: [Thermosensitive gel of polysaccharide from Ganoderma applanatum combined with paclitaxel for mice with 4T1 breast cancer].

Tang, Lan / Zhu, Zhuan-Feng / Cao, Li-Peng / Shen, Miao / Gao, Yan / Tu, Chao-Jie / Zhang, Zhen-Hai / Shan, Wei-Guang

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2020 Band 45, Heft 11, Seite(n) 2533–2539

Abstract: Polysaccharide from Ganoderma applanatum has the activities of anti-tumor and enhancing immune function. There were no reports on antitumor effect of its intratumoral injection. In this study, the polysaccharide was extracted from G. applanatum by water ... ...

Abstract	Polysaccharide from Ganoderma applanatum has the activities of anti-tumor and enhancing immune function. There were no reports on antitumor effect of its intratumoral injection. In this study, the polysaccharide was extracted from G. applanatum by water extraction and alcohol precipitation, and purified by ceramic membrane after removing protein by Sevage method. The total polysaccharide content from G. applanatum(PGA)was about 63%. The combination of PGA and paclitaxel showed synergistic effect on cytotoxicity of 4 T1 cells at lower concentrations in vitro. In addition, the growth curve of 4 T1 cells showed that PGA could retard the growth of 4 T1 cells gradually. The PGA thermosensitive gel(PGA-TG)was prepared by using poloxamer 188 and 407. The gel temperature was 36 ℃, and the PGA-TG could effectively slow down the release rate of PGA in vitro. 4 T1 breast cancer-bearing mice were used as a model to evaluate the therapeutic effect of intratumoral injection of PGA combined with tail vein injection of nanoparticle albumin-bound paclitaxel(nab-PTX). In high and low dose PGA groups, each mice was given with 2.25, 1.125 mg PGA respectively, twice in total, and the dosage of paclitaxel was 15 mg·kg~(-1), once every 3 days, for a total of five times. The tumor inhibition rate was 29.65% in the high dose PGA-TG group, 58.58% in the nab-PTX group, 63.37% in low dose PGA-TG combined with nab-PTX group, and 68.10% in high dose PGA-TG combined with nab-PTX group respectively. The inhibitory effect in high dose PGA-TG group combined with nab-PTX on tumors was significantly higher than that in nab-PTX group(P<0.05). The results showed that paclitaxel therapy combined with intratumoral injection of PGA-TG could improve the therapeutic effect for 4 T1 mice and reduce the side effects of chemotherapy.
Mesh-Begriff(e)	Animals ; Breast Neoplasms ; Cell Line, Tumor ; Ganoderma ; Mice ; Neoplasms ; Paclitaxel ; Poloxamer ; Polysaccharides
Chemische Substanzen	Polysaccharides ; Poloxamer (106392-12-5) ; Paclitaxel (P88XT4IS4D)
Sprache	Chinesisch
Erscheinungsdatum	2020-07-05
Erscheinungsland	China
Dokumenttyp	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20200328.304
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Optimization and anticancer activity in vitro and in vivo of baohuoside I incorporated into mixed micelles based on lecithin and Solutol HS 15.

Yan, Hong-Mei / Song, Jie / Zhang, Zhen-Hai / Jia, Xiao-Bin

Drug delivery

2016 Band 23, Heft 8, Seite(n) 2911–2918

Abstract: Baohuoside I, extracted from the Herba epimedii, is an effective but a poorly soluble antitumor drug. To improve its solubility, formulation of baohuoside I-loaded mixed micelles with lecithin and Solutol HS 15 (BLSM) has been performed in this study. We ...

Abstract	Baohuoside I, extracted from the Herba epimedii, is an effective but a poorly soluble antitumor drug. To improve its solubility, formulation of baohuoside I-loaded mixed micelles with lecithin and Solutol HS 15 (BLSM) has been performed in this study. We performed a systematic comparative evaluation of the antiproliferative effect, cellular uptake, antitumor efficacy, and in vivo tumor targeting of these micelles using non-small cell lung cancer (NSCLC) A549 cells. Results showed that the obtained micelles have a mean particle size of around 62.54 nm, and the size of micelles was narrowly distributed. With the improved cellular uptake, BLSM displayed a more potent antiproliferative action on A549 cell lines than baohuoside I; half-maximal inhibitory concentration (IC
Mesh-Begriff(e)	A549 Cells ; Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Cell Line, Tumor ; Chemistry, Pharmaceutical/methods ; Drug Carriers/chemistry ; Drug Delivery Systems/methods ; Flavonoids/chemistry ; Flavonoids/physiology ; Humans ; Lecithins/chemistry ; Lung Neoplasms/drug therapy ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Micelles ; Particle Size ; Polyethylene Glycols/chemistry ; Solubility ; Stearic Acids/chemistry ; Xenograft Model Antitumor Assays/methods
Chemische Substanzen	Antineoplastic Agents ; Drug Carriers ; Flavonoids ; Lecithins ; Micelles ; Stearic Acids ; baohuoside I (113558-15-9) ; Polyethylene Glycols (30IQX730WE) ; Solutol HS 15 (61909-81-7)
Sprache	Englisch
Erscheinungsdatum	2016-10
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	1213261-5
ISSN	1521-0464 ; 1071-7544
ISSN (online)	1521-0464
ISSN	1071-7544
DOI	10.3109/10717544.2015.1120365
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: [Solidification of magnolol phospholipid complex with polyvingypyrrolidone].

Dai, Yun-Hao / Wang, Man / Ju, Jian-Ming / Zhang, Zhen-Hai

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2016 Band 41, Heft 12, Seite(n) 2250–2254

Abstract: In this study, magnolol phospholipid complex (MPC) was prepared and solidified with polyvingypyrrolidone (PVPP). The influence of PVPP on MPC's flowability, dissolution and oral bioavailability was investigated. The results of phase characterization ... ...

Abstract	In this study, magnolol phospholipid complex (MPC) was prepared and solidified with polyvingypyrrolidone (PVPP). The influence of PVPP on MPC's flowability, dissolution and oral bioavailability was investigated. The results of phase characterization using differential scanning calorimetry (DSC), infrared spectroscopy (IR), and scanning electron microscopy (SEM) showed that magnolol existed in solidified powder and MPC in an amorphous state. In flowability and dissolution experiments, solidified powder showed significant superiority. At the same time, it showed a higher oral bioavailability compared with MPC, with AUC0-∞ of 73.47 μg•h•mL⁻¹ vs. 63.48 μg•h•mL⁻¹. This process for solidifying powder with PVPP is simple and convenient.
Sprache	Chinesisch
Erscheinungsdatum	2016-06
Erscheinungsland	China
Dokumenttyp	English Abstract ; Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.4268/cjcmm20161213
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: [Research progress of lactoferrin as drug carriers].

Tang, Hui-xian / Zhang, Zhen-hai / Zhao, Zhi-ying / Lü, Hui-xia

Yao xue xue bao = Acta pharmaceutica Sinica

2015 Band 50, Heft 6, Seite(n) 675–681

Abstract: Lactoferrin (Lf) is one of the food protein belonged to the innate immune system. Apart from its main biological function of binding and transport of iron ions, lactoferrin also has many other functions and properties such as antibacterial, antiviral, ... ...

Abstract	Lactoferrin (Lf) is one of the food protein belonged to the innate immune system. Apart from its main biological function of binding and transport of iron ions, lactoferrin also has many other functions and properties such as antibacterial, antiviral, antiparasitic, catalytic, anti-cancer, anti-allergic and radioprotecting. Lf is usually used as additives of food and cosmetics. The research of lactoferrin has been increasingly reported, and the application of lactoferrin as a drug carrier has drawn extensive attention over the recent year. In this paper, researches of lactoferrin as drug carriers are classified and summarized in brain targeting, liver tumor targeting, lung tumor targeting and oral delivery systems according to their different characteristics.
Mesh-Begriff(e)	Administration, Oral ; Brain ; Drug Carriers ; Humans ; Lactoferrin/chemistry ; Neoplasms
Chemische Substanzen	Drug Carriers ; Lactoferrin (EC 3.4.21.-)
Sprache	Chinesisch
Erscheinungsdatum	2015-06
Erscheinungsland	China
Dokumenttyp	English Abstract ; Journal Article ; Review
ZDB-ID	788758-9
ISSN	0513-4870
ISSN	0513-4870
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: [Study on andrographolide solid dispersion vectored by hydroxyapatite].

Hu, Shao-Ying / Zhang, Zhen-Hai / Jia, Xiao-Bin

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2013 Band 38, Heft 3, Seite(n) 341–345

Abstract: Objective: To prepare andrographolide solid dispersion, with hydroxyapatite as vector, in order to increase drug dissolution.: Method: Andrographolide and hydroxyapatite were dispersed in 95% ethanol. The solvent evaporation method was adopted to ... ...

Abstract	Objective: To prepare andrographolide solid dispersion, with hydroxyapatite as vector, in order to increase drug dissolution. Method: Andrographolide and hydroxyapatite were dispersed in 95% ethanol. The solvent evaporation method was adopted to prepare andrographolide solid dispersion, in order to study its dissolution behavior, stability and physical characteristics. Result: The solid dispersion prepared with andrographolide and hydroxyapatite with the proportion of 1:8 existed in the vector in an amorphous form, according to differential scanning calorimetry, scanning electron microscopy and X-ray powder diffraction. The in vitro dissolution of andrographolide solid dispersions was up to 93% at 45 min. After the accelerated stability test for three months, the drug dissolution and content in andrographolide solid dispersion showed no significant change. Conclusion: The prepared solid dispersions with hydroxyapatite as the vector can effectively improve the stability and dissolution of water-insoluble drug andrographolide.
Mesh-Begriff(e)	Calorimetry, Differential Scanning ; Diterpenes/chemistry ; Drug Compounding/methods ; Drug Stability ; Drugs, Chinese Herbal/chemistry ; Durapatite/chemistry ; Ethanol/chemistry ; Microscopy, Electron, Scanning ; Reproducibility of Results ; Solubility ; Solvents/chemistry ; Time Factors ; Water/chemistry ; X-Ray Diffraction
Chemische Substanzen	Diterpenes ; Drugs, Chinese Herbal ; Solvents ; Water (059QF0KO0R) ; Ethanol (3K9958V90M) ; andrographolide (410105JHGR) ; Durapatite (91D9GV0Z28)
Sprache	Chinesisch
Erscheinungsdatum	2013-02
Erscheinungsland	China
Dokumenttyp	English Abstract ; Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: [Preparation and application on compound excipient of sodium stearyl fumarate and plasdone S-630].

Jiang, Yan-Rong / Zhang, Zhen-Hai / Jia, Xiao-Bin

Yao xue xue bao = Acta pharmaceutica Sinica

2013 Band 48, Heft 1, Seite(n) 125–130

Abstract: The compound excipient containing sodium stearyl fumarate and plasdone S-630 was prepared by applying spray drying method. The basic physical properties of compound excipient were studied by solubility test, scanning electron microscope, differential ... ...

Abstract	The compound excipient containing sodium stearyl fumarate and plasdone S-630 was prepared by applying spray drying method. The basic physical properties of compound excipient were studied by solubility test, scanning electron microscope, differential scanning calorimeter, X-ray diffraction and Fourier transform infra-red spectroscopy. The effect of compound excipient on moisture absorption and ferulic acid in vitro dissolution of spray drying power of angelica were investigated. The results showed that the chemical constituents of compound excipient did not change before and after spray drying. The water soluble compound excipient can improve significantly moisture absorption and has application prospect.
Mesh-Begriff(e)	Acetates/chemistry ; Calorimetry, Differential Scanning ; Coumaric Acids/administration & dosage ; Coumaric Acids/chemistry ; Drug Compounding ; Excipients/chemistry ; Fumarates/chemistry ; Microscopy, Electron, Scanning ; Particle Size ; Povidone/analogs & derivatives ; Povidone/chemistry ; Solubility ; Spectroscopy, Fourier Transform Infrared ; Surface Properties ; Wettability ; X-Ray Diffraction
Chemische Substanzen	Acetates ; Coumaric Acids ; Excipients ; Fumarates ; copolyvidonum Plasdone S-630 ; sodium stearyl fumarate (7CV7WJK4UI) ; ferulic acid (AVM951ZWST) ; Povidone (FZ989GH94E)
Sprache	Chinesisch
Erscheinungsdatum	2013-01
Erscheinungsland	China
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	788758-9
ISSN	0513-4870
ISSN	0513-4870
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: [Evaluation of drug release behavior in vitro of ginkgolides component drug release unit].

Liu, Dan / Zhang, Zhen-Hai / Chen, Xiao-Yun / Jia, Xiao-Bin

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2014 Band 39, Heft 8, Seite(n) 1426–1429

Abstract: Traditional Chinese medicine (TCM) composition is a multi-component multiple drug release system and more components preparation system. How to evaluate the drug release behavior of diversification has been a block for the modernization of TCM. This ... ...

Abstract	Traditional Chinese medicine (TCM) composition is a multi-component multiple drug release system and more components preparation system. How to evaluate the drug release behavior of diversification has been a block for the modernization of TCM. This article through to study of more representative components of ginkgolides drug release and similarity analysis of more representative components of ginkgolides drug release behavior and use Weight coefficient method to integrate the multicomponent drug release curve. So it can provide the idea and method for drug evaluation of TCM component preparation.
Mesh-Begriff(e)	Drugs, Chinese Herbal/chemistry ; Ginkgolides/chemistry ; Kinetics ; Solubility
Chemische Substanzen	Drugs, Chinese Herbal ; Ginkgolides
Sprache	Chinesisch
Erscheinungsdatum	2014-04
Erscheinungsland	China
Dokumenttyp	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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