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Article: Advances in the two-dimensional layer materials for cancer diagnosis and treatment: unique advantages beyond the microsphere.

Zhang, Zheng-Wei / Yang, Yang / Wu, Han / Zhang, Tong

Frontiers in bioengineering and biotechnology

2023 Volume 11, Page(s) 1278871

Abstract: In recent years, two-dimensional (2D) layer materials have shown great potential in the field of cancer diagnosis and treatment due to their unique structural, electronic, and chemical properties. These non-spherical materials have attracted increasing ... ...

Abstract	In recent years, two-dimensional (2D) layer materials have shown great potential in the field of cancer diagnosis and treatment due to their unique structural, electronic, and chemical properties. These non-spherical materials have attracted increasing attention around the world because of its widely used biological characteristics. The application of 2D layer materials like lamellar graphene, transition metal dichalcogenides (TMDs), and black phosphorus (BPs) and so on have been developed for CT/MRI imaging, serum biosensing, drug targeting delivery, photothermal therapy, and photodynamic therapy. These unique applications for tumor are due to the multi-variable synthesis of 2D materials and the structural characteristics of good ductility different from microsphere. Based on the above considerations, the application of 2D materials in cancer is mainly carried out in the following three aspects: 1) In terms of accurate and rapid screening of tumor patients, we will focus on the enrichment of serum markers and sensitive signal transformation of 2D materials; 2) The progress of 2D nanomaterials in tumor MRI and CT imaging was described by comparing the performance of traditional contrast agents; 3) In the most important aspect, we will focus on the progress of 2D materials in the field of precision drug delivery and collaborative therapy, such as photothermal ablation, sonodynamic therapy, chemokinetic therapy, etc. In summary, this review provides a comprehensive overview of the advances in the application of 2D layer materials for tumor diagnosis and treatment, and emphasizes the performance difference between 2D materials and other types of nanoparticles (mainly spherical). With further research and development, these multifunctional layer materials hold great promise in the prospects, and challenges of 2D materials development are discussed.
Language	English
Publishing date	2023-09-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2023.1278871
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Article: A new method for measuring airborne elemental carbon using PUF disk passive samplers

Zhang, Zheng Wei / Shahpoury, Pourya / Zhang, Wendy / Harner, Tom / Huang, Lin

Chemosphere. 2022 Mar. 13,

2022

Abstract: Carbonaceous aerosol species, such as elemental carbon (EC), are important Short-Lived Climate Forcers (SLCFs), contributing to climate and health effects of air pollution. The quantification of carbonaceous aerosols has been conventionally carried out ... ...

Abstract	Carbonaceous aerosol species, such as elemental carbon (EC), are important Short-Lived Climate Forcers (SLCFs), contributing to climate and health effects of air pollution. The quantification of carbonaceous aerosols has been conventionally carried out using active air sampling followed by various analytical techniques, such as thermal/thermal-optical analysis. Active sampling requires specific equipment and infrastructure with electricity and therefore may not be the best choice for studying carbonaceous aerosols at remote locations. Passive sampling on the other hand provides a simple and cost-effective alternative to study time-weighted temporal and spatial trends. For the first time in this study, we have developed a method to examine the viability of measuring EC using polyurethane foam passive air samplers (PUF-PAS) coupled with a thermal analysis, i.e., EnCan-Total-900 (ECT9). The method was found reproducible with coefficients of variation as low as 3% for EC measured in ambient passive samples. The method had relatively low background with EC levels in blanks being as low as 0.1% of those in deployed samples, allowing quantification within a wide range of concentrations. The results indicate a homogenous distribution of particles within the PUF-PAS substrate. EC concentrations measured with the passive method were not significantly different from those obtained from active samples at the study sites (p > 0.01). This proof of concept of the PUF-PAS method provides an opportunity to cost-effectively expand measurements of elemental carbon at the global scale, and could be further extended to include other carbonaceous aerosol species in the future. This helps address regional data gaps for improving uncertainties of SLCF impacts on global climate forcing and to inform policy decisions.
Keywords	aerosols ; air ; air pollution ; carbon ; climate ; cost effectiveness ; electricity ; foams ; infrastructure ; issues and policy ; polyurethanes ; thermal analysis ; viability
Language	English
Dates of publication	2022-0313
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2022.134323
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Article ; Online: A new method for measuring airborne elemental carbon using PUF disk passive samplers.

Zhang, Zheng Wei / Shahpoury, Pourya / Zhang, Wendy / Harner, Tom / Huang, Lin

Chemosphere

2022 Volume 299, Page(s) 134323

Abstract	Carbonaceous aerosol species, such as elemental carbon (EC), are important Short-Lived Climate Forcers (SLCFs), contributing to climate and health effects of air pollution. The quantification of carbonaceous aerosols has been conventionally carried out using active air sampling followed by various analytical techniques, such as thermal/thermal-optical analysis. Active sampling requires specific equipment and infrastructure with electricity and therefore may not be the best choice for studying carbonaceous aerosols at remote locations. Passive sampling on the other hand provides a simple and cost-effective alternative to study time-weighted temporal and spatial trends. For the first time in this study, we have developed a method to examine the viability of measuring EC using polyurethane foam passive air samplers (PUF-PAS) coupled with a thermal analysis, i.e., EnCan-Total-900 (ECT9). The method was found reproducible with coefficients of variation as low as 3% for EC measured in ambient passive samples. The method had relatively low background with EC levels in blanks being as low as 0.1% of those in deployed samples, allowing quantification within a wide range of concentrations. The results indicate a homogenous distribution of particles within the PUF-PAS substrate. EC concentrations measured with the passive method were not significantly different from those obtained from active samples at the study sites (p > 0.01). This proof of concept of the PUF-PAS method provides an opportunity to cost-effectively expand measurements of elemental carbon at the global scale, and could be further extended to include other carbonaceous aerosol species in the future. This helps address regional data gaps for improving uncertainties of SLCF impacts on global climate forcing and to inform policy decisions.
MeSH term(s)	Air Pollutants/analysis ; Carbon/analysis ; Environmental Monitoring/methods ; Polyurethanes/chemistry
Chemical Substances	Air Pollutants ; Polyurethanes ; Carbon (7440-44-0)
Language	English
Publishing date	2022-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2022.134323
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Article: Salt Tolerance in Soybeans: Focus on Screening Methods and Genetics.

Guan, Rong-Xia / Guo, Xiao-Yang / Qu, Yue / Zhang, Zheng-Wei / Bao, Li-Gao / Ye, Rui-Yun / Chang, Ru-Zhen / Qiu, Li-Juan

Plants (Basel, Switzerland)

2023 Volume 13, Issue 1

Abstract: Salinity greatly affects the production of soybeans in arid and semi-arid lands around the world. The responses of soybeans to salt stress at germination, emergence, and other seedling stages have been evaluated in multitudes of studies over the past ... ...

Abstract	Salinity greatly affects the production of soybeans in arid and semi-arid lands around the world. The responses of soybeans to salt stress at germination, emergence, and other seedling stages have been evaluated in multitudes of studies over the past decades. Considerable salt-tolerant accessions have been identified. The association between salt tolerance responses during early and later growth stages may not be as significant as expected. Genetic analysis has confirmed that salt tolerance is distinctly tied to specific soybean developmental stages. Our understanding of salt tolerance mechanisms in soybeans is increasing due to the identification of key salt tolerance genes. In this review, we focus on the methods of soybean salt tolerance screening, progress in forward genetics, potential mechanisms involved in salt tolerance, and the importance of translating laboratory findings into field experiments via marker-assisted pyramiding or genetic engineering approaches, and ultimately developing salt-tolerant soybean varieties that produce high and stable yields. Progress has been made in the past decades, and new technologies will help mine novel salt tolerance genes and translate the mechanism of salt tolerance into new varieties via effective routes.
Language	English
Publishing date	2023-12-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants13010097
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Article: Discovering adventitious roots in Glycine tomentella Hayata: lack of adventitious roots as a morphological and taxonomic species indicator is worth considering

Zhang, Zheng-Wei / Li, Xiang-Hua / Wang, Xu-Dong / Wang, Ke-Jing

Genetic resources and crop evolution. 2020 Aug., v. 67, no. 6

2020

Abstract: Glycine tomentella Hayata is characterized by a lack of adventitious roots. In China, G. tomentella is distributed only on the southeastern coast. Here, 59 G. tomentella natural populations on the islands and coasts in Fujian and Guangdong Provinces were ...

Abstract	Glycine tomentella Hayata is characterized by a lack of adventitious roots. In China, G. tomentella is distributed only on the southeastern coast. Here, 59 G. tomentella natural populations on the islands and coasts in Fujian and Guangdong Provinces were morphologically investigated. We discovered G. tomentella (2n = 80 tetraploid) having adventitious roots existed ubiquitously along the southeastern coast of China. Fasciated stem variation was also discovered in populations at three sites.
Keywords	Glycine tomentella ; coasts ; evolution ; tetraploidy ; China
Language	English
Dates of publication	2020-08
Size	p. 1345-1350.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	1134125-7
ISSN	0925-9864
ISSN	0925-9864
DOI	10.1007/s10722-020-00929-0
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Article: The influence of chemical composition, aerosol acidity, and metal dissolution on the oxidative potential of fine particulate matter and redox potential of the lung lining fluid

Shahpoury, Pourya / Zhang, Zheng Wei / Arangio, Andrea / Celo, Valbona / Dabek-Zlotorzynska, Ewa / Harner, Tom / Nenes, Athanasios

Environment international. 2021 Mar., v. 148

2021

Abstract: Air pollution is a major environmental health risk and it contributes to respiratory and cardiovascular diseases and excess mortality worldwide. The adverse health effects have been associated with the inhalation of fine particulate matter (PM₂.₅) and ... ...

Abstract	Air pollution is a major environmental health risk and it contributes to respiratory and cardiovascular diseases and excess mortality worldwide. The adverse health effects have been associated with the inhalation of fine particulate matter (PM₂.₅) and induction of respiratory oxidative stress. In this work, we quantified the oxidative potential (OP) of PM₂.₅ from several Canadian cities (Toronto, Hamilton, Montreal, Vancouver) using a recently developed bioanalytical method which measures the oxidation of lung antioxidants, glutathione, cysteine, and ascorbic acid, the formation of glutathione disulfide and cystine, and the related redox potential (RP) in a simulated epithelial lining fluid (SELF). We evaluated the application of empirical SELF RP as a new metric for aerosol OP. We further investigated how PM₂.₅ chemical composition and OP are related across various emission source sectors and whether these features are linked to specific properties of aerosol aqueous phase, such as pH and metal-ligand complexation. The OP indicators including SELF RP were strongly correlated among each other, indicating that the empirical RP could be used as a reliable metric in future studies. OP based on ascorbic acid showed dependency on the emission source sectors, most likely due to variation in the solubility of Fe. Traffic emissions resulted in the highest OP, followed by industrial emissions and resuspended crustal matter. OP presented low correlation with PM₂.₅ concentrations, low-moderate correlation with the aerosol organic matter, and moderate-strong association with black carbon and transition metals across the sites. We did not find strong association between the concentration of biomass burning tracers and OP. Copper was the only metal that showed high association with OP across all sites, whereas the correlation with other metals, such as iron, manganese, and titanium, showed clear dependency on the source sectors. The aerosol pH correlated negatively with ambient temperature and positively with biomass burning tracers and the levels of nitrate, ammonium, and aerosol liquid water content. The solubility of Fe was associated with sulfate and aerosol pH at most sites, suggesting the involvement of proton-mediated dissolution pathway, while this was not visible at the site influenced by industrial emission, most likely due to the abundance of pyrogenic Fe. The effect of metal-ligand complexation on the solubility of transition metals, in particular Fe, was clearly observed at all sites, whereas a combined effect with aerosol pH, and a subsequent impact on OP, was only seen at the traffic site in Toronto. The enhanced solubility of Fe due to proton- and ligand-mediated dissolution pathways and subsequent formation of reactive oxygen species may in part explain the health effects of PM₂.₅ seen in previous epidemiological studies.
Keywords	acidity ; aerosols ; air pollution ; ambient temperature ; ammonium ; analytical methods ; ascorbic acid ; biomass ; breathing ; carbon ; cysteine ; cystine ; environmental health ; epithelium ; glutathione ; iron ; liquids ; lungs ; manganese ; mortality ; nitrates ; organic matter ; oxidation ; oxidative stress ; pH ; particulates ; reactive oxygen species ; redox potential ; risk ; solubility ; sulfates ; titanium ; traffic ; water content
Language	English
Dates of publication	2021-03
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2020.106343
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Article ; Online: Gut microbiota-based metabolites of Xiaoyao Pills (a typical Traditional Chinese medicine) ameliorate depression by inhibiting fatty acid amide hydrolase levels in brain.

Zhang, Zheng-Wei / Han, Pei / Fu, Jie / Yu, Hang / Xu, Hui / Hu, Jia-Chun / Lu, Jin-Yue / Yang, Xin-Yu / Zhang, Hao-Jian / Bu, Meng-Meng / Jiang, Jian-Dong / Wang, Yan

Journal of ethnopharmacology

2023 Volume 313, Page(s) 116555

Abstract: Ethnopharmacological relevance: Traditional Chinese medicines (TCMs) are often prepared in oral dosage forms, making TCMs interact with gut microbiota after oral administration, which could affect the therapeutic effect of TCM. Xiaoyao Pills (XYPs) are ... ...

Abstract	Ethnopharmacological relevance: Traditional Chinese medicines (TCMs) are often prepared in oral dosage forms, making TCMs interact with gut microbiota after oral administration, which could affect the therapeutic effect of TCM. Xiaoyao Pills (XYPs) are a commonly used TCM in China to treat depression. The biological underpinnings, however, are still in its infancy due to its complex chemical composition. Aim of the study: The study aims to explore XYPs' underlying antidepressant mechanism from both in vivo and in vitro. Materials and methods: XYPs were composed of 8 herbs, including the root of Bupleurum chinense DC., the root of Angelica sinensis (Oliv.) Diels, the root of Paeonia lactiflora Pall., the sclerotia of Poria cocos (Schw.) Wolf, the rhizome of Glycyrrhiza uralensis Fisch., the leaves of Mentha haplocalyx Briq., the rhizome of Atractylis lancea var. chinensis (Bunge) Kitam., and the rhizome of Zingiber officinale Roscoe, in a ratio of 5:5:5:5:4:1:5:5. The chronic unpredictable mild stress (CUMS) rat models were established. After that, the sucrose preference test (SPT) was carried out to evaluate if the rats were depressed. After 28 days of treatment, the forced swimming test and SPT were carried out to evaluate the antidepressant efficacy of XYPs. The feces, brain and plasma were taken out for 16SrRNA gene sequencing analysis, untargeted metabolomics and gut microbiota transformation analysis. Results: The results revealed multiple pathways affected by XYPs. Among them, the hydrolysis of fatty acids amide in brain decreased most significant via XYPs treatment. Moreover, the XYPs' metabolites which mainly derived from gut microbiota (benzoic acid, liquiritigenin, glycyrrhetinic acid and saikogenin D) were found in plasma and brain of CUMS rats and could inhibit the levels of FAAH in brain, which contributed to XYPs' antidepressant effect. Conclusions: The potential antidepressant mechanism of XYPs by untargeted metabolomics combined with gut microbiota-transformation analysis was revealed, which further support the theory of gut-brain axis and provide valuable evidence of the drug discovery.
MeSH term(s)	Rats ; Animals ; Medicine, Chinese Traditional ; Depression/drug therapy ; Gastrointestinal Microbiome ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Brain
Chemical Substances	xiaoyao ; fatty-acid amide hydrolase (EC 3.5.1.-) ; Drugs, Chinese Herbal ; Antidepressive Agents
Language	English
Publishing date	2023-04-25
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116555
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Article ; Online: Biotransformation of antioxidant eriocitrin into characteristic metabolites by the gut microbiota.

Zhang, Hao-Jian / Yu, Hang / Fu, Jie / Keranmu, Adili / Zhang, Zheng-Wei / Xu, Hui / Hu, Jia-Chun / Lu, Jin-Yue / Yang, Xin-Yu / Bu, Meng-Meng / Zhai, Zhao / Wang, Jing-Yue / Jiang, Jian-Dong / Wang, Yan

Journal of Asian natural products research

2023 Volume 26, Issue 4, Page(s) 510–518

Abstract: Eriocitrin is a flavonoid glycoside with strong antioxidant capacity that has a variety of pharmacological activities, such as hypolipidemic, anticancer and anti-inflammatory effects. We found that the gut microbiota could rapidly metabolize eriocitrin. ... ...

Abstract	Eriocitrin is a flavonoid glycoside with strong antioxidant capacity that has a variety of pharmacological activities, such as hypolipidemic, anticancer and anti-inflammatory effects. We found that the gut microbiota could rapidly metabolize eriocitrin. By using LC/MS
MeSH term(s)	Gastrointestinal Microbiome ; Antioxidants/pharmacology ; Flavonoids/pharmacology ; Biotransformation ; Flavanones
Chemical Substances	eriocitrin (AS293HR5XQ) ; Antioxidants ; Flavonoids ; Flavanones
Language	English
Publishing date	2023-09-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2077926-4
ISSN	1477-2213 ; 1028-6020
ISSN (online)	1477-2213
ISSN	1028-6020
DOI	10.1080/10286020.2023.2251123
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Article ; Online: Super-enhancers: A new frontier for glioma treatment.

Cheng, Meng / Zhang, Zheng Wei / Ji, Xing Hu / Xu, Yadi / Bian, Erbao / Zhao, Bing

Biochimica et biophysica acta. Reviews on cancer

2020 Volume 1873, Issue 2, Page(s) 188353

Abstract: Glioma is the most common primary malignant tumor in the human brain. Although there are a variety of treatments, such as surgery, radiation and chemotherapy, glioma is still an incurable disease. Super-enhancers (SEs) are implicated in the control of ... ...

Abstract	Glioma is the most common primary malignant tumor in the human brain. Although there are a variety of treatments, such as surgery, radiation and chemotherapy, glioma is still an incurable disease. Super-enhancers (SEs) are implicated in the control of tumor cell identity, and they promote oncogenic transcription, which supports tumor cells. Inhibition of the SE complex, which is required for the assembly and maintenance of SEs, may repress oncogenic transcription and impede tumor growth. In this review, we discuss the unique characteristics of SEs compared to typical enhancers, and we summarize the recent advances in the understanding of their properties and biological role in gene regulation. Additionally, we highlight that SE-driven lncRNAs, miRNAs and genes are involved in the malignant phenotype of glioma. Most importantly, the application of SE inhibitors in different cancer subtypes has introduced new directions in glioma treatment.
MeSH term(s)	Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Brain Neoplasms/drug therapy ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Carcinogenesis/drug effects ; Carcinogenesis/genetics ; Enhancer Elements, Genetic/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Glioma/drug therapy ; Glioma/genetics ; Glioma/pathology ; Humans ; MicroRNAs/genetics ; Oncogenes/genetics ; RNA, Long Noncoding/genetics ; Transcription, Genetic/drug effects
Chemical Substances	Antineoplastic Agents ; MicroRNAs ; RNA, Long Noncoding
Language	English
Publishing date	2020-02-26
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2918802-7
ISSN	1879-2561 ; 0304-419X
ISSN (online)	1879-2561
ISSN	0304-419X
DOI	10.1016/j.bbcan.2020.188353
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Article ; Online: Metabolites analysis of plantamajoside based on gut microbiota-drug interaction.

Xu, Hui / Yu, Hang / Fu, Jie / Zhang, Zheng-Wei / Hu, Jia-Chun / Lu, Jin-Yue / Yang, Xin-Yu / Bu, Meng-Meng / Jiang, Jian-Dong / Wang, Yan

Phytomedicine : international journal of phytotherapy and phytopharmacology

2023 Volume 116, Page(s) 154841

Abstract: Background: Plantaginis Herba (Plantago asiatica L.) has the effects of clearing heat and diuresis, oozing wet and drenching. As the main active components of Plantaginis Herba (Plantago asiatica L.), plantamajoside have a wide range of antitumor ... ...

Abstract	Background: Plantaginis Herba (Plantago asiatica L.) has the effects of clearing heat and diuresis, oozing wet and drenching. As the main active components of Plantaginis Herba (Plantago asiatica L.), plantamajoside have a wide range of antitumor activities but very low bioavailability. The process of interacting between plantamajoside and gut microbiota remains unclear. Purpose: To illustrate the process of interacting between plantamajoside and gut microbiota based on high-resolution mass spectrometry and targeted metabolomics methods. Study design and methods: This experiment was divided into two parts. First, metabolites produced from plantamajoside by gut microbiota were identified and quantified based on high-resolution mass spectrometry and LC-MS/MS. Additionally, stimulation of plantamajoside on gut microbiota-derived metabolites was determined by targeted metabolomics and gas chromatography. Results: We first found that plantamajoside was rapidly metabolized by gut microbiota. Then, we identified metabolites of plantamajoside by high-resolution mass spectrometry and speculated that plantamajoside was metabolized into five metabolites including calceolarioside A, dopaol glucoside, hydroxytyrosol, 3-(3-hydroxyphenyl) propionic acid (3-HPP) and caffeic acid. Among them, we quantitatively analyzed four possible metabolites based on LC‒MS/MS and found that hydroxytyrosol and 3-HPP were final products by the gut microbiota. In addition, we studied whether plantamajoside could affect the short-chain fatty acid (SCFA) and amino acid metabolites. We found that plantamajoside could inhibit the acetic acid, kynurenic acid (KYNA) and kynurenine (KN) produced by intestinal bacteria and promote the indole propionic acid (IPA) and indole formaldehyde (IALD) produced by intestinal bacteria. Conclusion: An interaction between plantamajoside and gut microbiota was revealed in this study. Unlike the traditional metabolic system, the special metabolic characteristics of plantamajoside in gut microbiota was found. Plantamajoside was metabolized into the following active metabolites: calceolarioside A, dopaol glucoside, hydroxytyrosol, caffeic acid and 3-HPP. Besides, plantamajoside could affect SCFA and tryptophan metabolism by gut microbiota. Especially, the exogenous metabolites hydroxytyrosol, caffeic acid and endogenous metabolites IPA may have potential association with the antitumor activity of plantamajoside.
MeSH term(s)	Gastrointestinal Microbiome ; Chromatography, Liquid/methods ; Tandem Mass Spectrometry/methods ; Glucosides/pharmacology ; Drug Interactions
Chemical Substances	calceolarioside A (84744-28-5) ; plantamajoside (104777-68-6) ; propionic acid (JHU490RVYR) ; caffeic acid (U2S3A33KVM) ; 3,4-dihydroxyphenylethanol (10597-60-1) ; 3-hydroxyphenylpropionic acid ; Glucosides
Language	English
Publishing date	2023-04-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.154841
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