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Book ; Thesis: Effektivität und Verträglichkeit von Biologics und konventionellen systemischen Therapien bei mittelschwerer bis schwerer Psoriasis vulgaris

Zhang, Zhengguang

eine Metaanalyse randomisierter kontrollierter Studien

2008

Author's details	vorgelegt von Zhengguang Zhang
Language	German
Size	II, 97 Bl., 30 cm
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dresden, Techn. Univ., Diss., 2008
HBZ-ID	HT016095885
Database	Catalogue ZB MED Medicine, Health

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Article: A double‐edged sword: reactive oxygen species (ROS) during the rice blast fungus and host interaction

Liu, Xinyu / Zhang, Zhengguang

FEBS journal. 2022 Sept., v. 289, no. 18

2022

Abstract: Magnaporthe oryzae is a hemibiotrophic fungus that also needs host nutrients for propagation during infection. During its interaction with rice, reactive oxygen species (ROS) mediate important signaling reactions impacting both the pathogen and the host. ...

Abstract	Magnaporthe oryzae is a hemibiotrophic fungus that also needs host nutrients for propagation during infection. During its interaction with rice, reactive oxygen species (ROS) mediate important signaling reactions impacting both the pathogen and the host. In M. oryzae, the accumulation of ROS is important for the formation and maturation of the infectious structure appressorium. On the other hand, upon M. oryzae infection, rice generates further ROS to restrict invasive hyphae (IH) spreading. Despite ROS receptors remaining to be identified, M. oryzae recruits several strategies to respond and suppress ROS accumulation through the secretion of various effector molecules. These findings suggest that the balance between the generation and scavenging of ROS is sophisticatedly controlled during M. oryzae‐rice interaction. In this review, we discuss advances to understand the regulation mechanisms for the generation, accumulation, and transduction of ROS.
Keywords	Magnaporthe oryzae ; appressoria ; blast disease ; fungi ; hyphae ; pathogens ; reactive oxygen species ; rice ; secretion
Language	English
Dates of publication	2022-09
Size	p. 5505-5515.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	REVIEW
ZDB-ID	2173655-8
ISSN	1742-4658 ; 1742-464X
ISSN (online)	1742-4658
ISSN	1742-464X
DOI	10.1111/febs.16171
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Correction to: The natural medicinal fungus Huaier promotes the anti‑hepatoma efficacy of sorafenib through the mammalian target of rapamycin‑mediated autophagic cell death.

Zhang, Zhengguang / Shen, Cunsi / Zhou, Fuqiong

Medical oncology (Northwood, London, England)

2023 Volume 40, Issue 2, Page(s) 83

Language	English
Publishing date	2023-01-21
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1201189-7
ISSN	1559-131X ; 0736-0118 ; 1357-0560
ISSN (online)	1559-131X
ISSN	0736-0118 ; 1357-0560
DOI	10.1007/s12032-022-01920-8
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Article ; Online: Shikonin potentiates therapeutic efficacy of oxaliplatin through reactive oxygen species-mediated intrinsic apoptosis and endoplasmic reticulum stress in oxaliplatin-resistant colorectal cancer cells.

Zhang, Zhengguang / Shen, Cunsi / Zhou, Fuqiong / Zhang, Yajie

Drug development research

2023 Volume 84, Issue 3, Page(s) 542–555

Abstract: Oxaliplatin (OXA) has been recognized as a third-generation platinum-based chemotherapeutic agent with stellar therapeutic efficacy in managing colorectal cancer (CRC). Nevertheless, resistance to OXA in CRC patients hinders its effectiveness. Shikonin ( ... ...

Abstract	Oxaliplatin (OXA) has been recognized as a third-generation platinum-based chemotherapeutic agent with stellar therapeutic efficacy in managing colorectal cancer (CRC). Nevertheless, resistance to OXA in CRC patients hinders its effectiveness. Shikonin (SHI), a natural naphthoquinone derived from Arnebia euchroma (Royle) Johnst., features a broad pharmacological profile and minimal toxicities. To assess the synergism of SHI and OXA towards OXA-resistant CRC cells (HCT116
MeSH term(s)	Animals ; Mice ; Humans ; Oxaliplatin/pharmacology ; Oxaliplatin/therapeutic use ; Reactive Oxygen Species/metabolism ; Apoptosis ; Naphthoquinones/pharmacology ; Naphthoquinones/therapeutic use ; Cell Line, Tumor ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/metabolism ; Endoplasmic Reticulum Stress
Chemical Substances	Oxaliplatin (04ZR38536J) ; Reactive Oxygen Species ; shikonin (3IK6592UBW) ; Naphthoquinones
Language	English
Publishing date	2023-02-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604587-x
ISSN	1098-2299 ; 0272-4391
ISSN (online)	1098-2299
ISSN	0272-4391
DOI	10.1002/ddr.22044
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Article ; Online: Doubling of surface oceanic meridional heat transport by non-symmetry of mesoscale eddies.

Wang, Hailin / Qiu, Bo / Liu, Hanrui / Zhang, Zhengguang

Nature communications

2023 Volume 14, Issue 1, Page(s) 5460

Abstract: Oceanic transport of heat by ubiquitous mesoscale eddies plays a critical role in regulating climate variability and redistributing excess heat absorbed by ocean under global warming. Eddies have long been simplified as axisymmetric vortices and their ... ...

Abstract	Oceanic transport of heat by ubiquitous mesoscale eddies plays a critical role in regulating climate variability and redistributing excess heat absorbed by ocean under global warming. Eddies have long been simplified as axisymmetric vortices and their influence on heat transport remains unclear. Here, we combine satellite and drifter data and show that oceanic mesoscale eddies are asymmetric and directionally-dependent, and are controlled by their self-sustaining nature and their dynamical environment. Both the direction and amplitude of eddy-induced heat fluxes are significantly influenced by eddy's asymmetry and directional dependence. When the eddy velocity field is decomposed into asymmetric and symmetric components, the eddy kinetic energy exhibits a nearly equal partition between these two components. The total eddy-induced meridional heat flux similarly doubles the heat flux induced by the symmetric components, highlighting the crucial contribution of eddy asymmetry on the magnitude of eddy-induced oceanic heat transport.
Language	English
Publishing date	2023-09-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-41294-7
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Article ; Online: Comprehensive Characterization of Immune Cell Infiltration Characteristics and Drug Sensitivity Analysis in Inflammatory Breast Cancer Based on Bioinformatic Strategy.

Zhang, Zhengguang / Wu, Haitao / Shen, Cunsi / Zhou, Fuqiong

Biochemical genetics

2023 Volume 62, Issue 2, Page(s) 1021–1039

Abstract: Inflammatory breast cancer (IBC) is a rare and highly invasive form of breast cancer, renowned for its aggressive behavior, malignant capacity, and unfavorable prognosis. Despite considerable advancements in comprehending the underlying biology of IBC, ... ...

Abstract	Inflammatory breast cancer (IBC) is a rare and highly invasive form of breast cancer, renowned for its aggressive behavior, malignant capacity, and unfavorable prognosis. Despite considerable advancements in comprehending the underlying biology of IBC, the immune cell infiltration (ICI) profile in IBC remains inadequately elucidated. The current work endeavors to investigate the ICI characteristics of IBC and ascertain the pivotal immune cell subtypes and genes that impact its prognosis. The present study employed microarray data from the GEO database to demonstrate that IBC exhibited a lower abundance of activated mast cells (AMC) in comparison to non-inflammatory breast cancer (nIBC) or normal breast tissue (NBT). Additionally, the mRNA expression level of the gene polo-like kinase 5 (PLK5), which was correlated with AMC, was found to be lower in IBC relative to nIBC or NBT. Furthermore, this investigation provided compelling evidence indicating a potential association between a decreased mRNA expression level of PLK5 and a shorter progression-free survival in patients with breast cancer. The gene set enrichment analysis performed on PLK5 revealed that the gene expression in IBC was closely associated with diverse immune functions and pathways. Besides, a negative correlation has been established between PLK5 mRNA expression level and a majority of immune checkpoint-related genes, thereby suggesting the potential suitability of immunotherapy treatment for IBC. In summary, this study offers valuable insights into the ICI profile of IBC and identifies potential target PLK5 for improving its clinical management.
MeSH term(s)	Humans ; Inflammatory Breast Neoplasms/genetics ; Inflammatory Breast Neoplasms/metabolism ; Inflammatory Breast Neoplasms/pathology ; Gene Expression Profiling ; Computational Biology ; RNA, Messenger
Chemical Substances	RNA, Messenger
Language	English
Publishing date	2023-07-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2168-4
ISSN	1573-4927 ; 0006-2928
ISSN (online)	1573-4927
ISSN	0006-2928
DOI	10.1007/s10528-023-10460-3
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Article ; Online: A double-edged sword: reactive oxygen species (ROS) during the rice blast fungus and host interaction.

Liu, Xinyu / Zhang, Zhengguang

The FEBS journal

2021 Volume 289, Issue 18, Page(s) 5505–5515

Abstract	Magnaporthe oryzae is a hemibiotrophic fungus that also needs host nutrients for propagation during infection. During its interaction with rice, reactive oxygen species (ROS) mediate important signaling reactions impacting both the pathogen and the host. In M. oryzae, the accumulation of ROS is important for the formation and maturation of the infectious structure appressorium. On the other hand, upon M. oryzae infection, rice generates further ROS to restrict invasive hyphae (IH) spreading. Despite ROS receptors remaining to be identified, M. oryzae recruits several strategies to respond and suppress ROS accumulation through the secretion of various effector molecules. These findings suggest that the balance between the generation and scavenging of ROS is sophisticatedly controlled during M. oryzae-rice interaction. In this review, we discuss advances to understand the regulation mechanisms for the generation, accumulation, and transduction of ROS.
MeSH term(s)	Ascomycota ; Magnaporthe ; Oryza/microbiology ; Plant Diseases/microbiology ; Reactive Oxygen Species
Chemical Substances	Reactive Oxygen Species
Language	English
Publishing date	2021-09-06
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2173655-8
ISSN	1742-4658 ; 1742-464X
ISSN (online)	1742-4658
ISSN	1742-464X
DOI	10.1111/febs.16171
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Article ; Online: Exploiting Nanotechnology for Drug Delivery: Advancing the Anti-Cancer Effects of Autophagy-Modulating Compounds in Traditional Chinese Medicine.

Liu, Zixian / Lu, Tianming / Qian, Ruoning / Wang, Zian / Qi, Ruogu / Zhang, Zhengguang

International journal of nanomedicine

2024 Volume 19, Page(s) 2507–2528

Abstract: Background: Cancer continues to be a prominent issue in the field of medicine, as demonstrated by recent studies emphasizing the significant role of autophagy in the development of cancer. Traditional Chinese Medicine (TCM) provides a variety of anti- ... ...

Abstract	Background: Cancer continues to be a prominent issue in the field of medicine, as demonstrated by recent studies emphasizing the significant role of autophagy in the development of cancer. Traditional Chinese Medicine (TCM) provides a variety of anti-tumor agents capable of regulating autophagy. However, the clinical application of autophagy-modulating compounds derived from TCM is impeded by their restricted water solubility and bioavailability. To overcome this challenge, the utilization of nanotechnology has been suggested as a potential solution. Nonetheless, the current body of literature on nanoparticles delivering TCM-derived autophagy-modulating anti-tumor compounds for cancer treatment is limited, lacking comprehensive summaries and detailed descriptions. Methods: Up to November 2023, a comprehensive research study was conducted to gather relevant data using a variety of databases, including PubMed, ScienceDirect, Springer Link, Web of Science, and CNKI. The keywords utilized in this investigation included "autophagy", "nanoparticles", "traditional Chinese medicine" and "anticancer". Results: This review provides a comprehensive analysis of the potential of nanotechnology in overcoming delivery challenges and enhancing the anti-cancer properties of autophagy-modulating compounds in TCM. The evaluation is based on a synthesis of different classes of autophagy-modulating compounds in TCM, their mechanisms of action in cancer treatment, and their potential benefits as reported in various scholarly sources. The findings indicate that nanotechnology shows potential in enhancing the availability of autophagy-modulating agents in TCM, thereby opening up a plethora of potential therapeutic avenues. Conclusion: Nanotechnology has the potential to enhance the anti-tumor efficacy of autophagy-modulating compounds in traditional TCM, through regulation of autophagy.
MeSH term(s)	Humans ; Medicine, Chinese Traditional ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Drug Delivery Systems ; Neoplasms/drug therapy ; Nanotechnology ; Autophagy
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2024-03-12
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S455407
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Article ; Online: Dietary antioxidant quercetin overcomes the acquired resistance of Sorafenib in Sorafenib-resistant hepatocellular carcinoma cells through epidermal growth factor receptor signaling inactivation.

Zhang, Zhengguang / Wu, Haitao / Zhang, Yajie / Shen, Cunsi / Zhou, Fuqiong

Naunyn-Schmiedeberg's archives of pharmacology

2023 Volume 397, Issue 1, Page(s) 559–574

Abstract: Sorafenib (SOR) is a molecular targeting agent commonly utilized as a primary treatment for advanced and inoperable hepatocellular carcinoma (HCC). Regrettably, the effectiveness of SOR is frequently hindered by the resistance of multiple HCC cases. The ... ...

Abstract	Sorafenib (SOR) is a molecular targeting agent commonly utilized as a primary treatment for advanced and inoperable hepatocellular carcinoma (HCC). Regrettably, the effectiveness of SOR is frequently hindered by the resistance of multiple HCC cases. The current investigation endeavors to examine the potential of the natural product quercetin (QUE) in reversing the acquired resistance of SOR-resistant cells, known as Huh7
MeSH term(s)	Humans ; Sorafenib/pharmacology ; Carcinoma, Hepatocellular/pathology ; Antioxidants/pharmacology ; Quercetin/pharmacology ; Quercetin/therapeutic use ; Liver Neoplasms/pathology ; Phosphatidylinositol 3-Kinases/metabolism ; Molecular Docking Simulation ; Drug Resistance, Neoplasm ; Proto-Oncogene Proteins c-akt/metabolism ; Cell Line, Tumor ; Signal Transduction ; ErbB Receptors/metabolism ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cell Proliferation
Chemical Substances	Sorafenib (9ZOQ3TZI87) ; Antioxidants ; Quercetin (9IKM0I5T1E) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; ErbB Receptors (EC 2.7.10.1) ; Antineoplastic Agents
Language	English
Publishing date	2023-07-25
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-023-02605-3
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Article ; Online: The natural medicinal fungus Huaier promotes the anti-hepatoma efficacy of sorafenib through the mammalian target of rapamycin-mediated autophagic cell death.

Zhang, Zhengguang / Shen, Cunsi / Zhou, Fuqiong

Medical oncology (Northwood, London, England)

2022 Volume 39, Issue 12, Page(s) 221

Abstract: Sorafenib (SOR) is currently the first line molecular targeting agent for advanced liver cancer therapy. Unfortunately, the insensitivity of liver cancer patients to SOR relatively limits its effectiveness. Huaier (HUA), a natural medicinal parasitic ... ...

Abstract	Sorafenib (SOR) is currently the first line molecular targeting agent for advanced liver cancer therapy. Unfortunately, the insensitivity of liver cancer patients to SOR relatively limits its effectiveness. Huaier (HUA), a natural medicinal parasitic fungus found on the Sophora japonica Linn., has been widely employed as an adjuvant medication for numerous malignancies due to its potent anti-tumoral properties. This study aims to elucidate the enhancing therapeutic efficacy of HUA on SOR treatment in hepatocellular carcinoma (HCC) cells and mouse models. The CCK-8, clone formation, flow cytometry, immunofluorescence, transmission electron microscopy, western blot, bioinformatic analysis, and xenograft tumor assays were performed to evaluate the synergistic anti-hepatoma efficacy and mechanisms of HUA-SOR combination treatment on HCC cells. The results revealed combination treatment further inhibited proliferation, promoted apoptosis, enhanced autophagy of HCC cells, and suppressed the growth of transplanted tumors in mice, compared with either HUA or SOR treatment alone. For Hep3B and Huh7 cells, the optimal synergistic doses of HUA in combination with SOR were 8 mg/mL + 4 μM and 4 mg/mL + 2 μM, with combination index values of 0.646 and 0.588, respectively. Additionally, the underlying mechanisms might be related to biological processes that are mediated by mammalian target of rapamycin (mTOR). The combination treatment downregulated the protein expression levels of p-mTOR, p-p70S6K, p62, and upregulated the protein expression levels of Beclin-1 and LC3B-II. The mTOR activator MHY1485 attenuated the effect of HUA-SOR combination by inhibiting autophagy, suggesting HUA may potentiate the sensitivity of HCC cells to SOR by partially inducing mTOR-mediated autophagic cell death. These findings might provide a rationale experimental foundation for clinical applications of HUA with SOR.
MeSH term(s)	Animals ; Autophagic Cell Death ; Beclin-1 ; Carcinoma, Hepatocellular/drug therapy ; Complex Mixtures ; Fungi ; Humans ; Liver Neoplasms/drug therapy ; Mammals ; Mice ; Ribosomal Protein S6 Kinases, 70-kDa ; Sincalide ; Sirolimus ; Sorafenib/pharmacology ; TOR Serine-Threonine Kinases ; Trametes
Chemical Substances	Beclin-1 ; Complex Mixtures ; huaier ; Sorafenib (9ZOQ3TZI87) ; Ribosomal Protein S6 Kinases, 70-kDa (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Sincalide (M03GIQ7Z6P) ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2022-09-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1201189-7
ISSN	1559-131X ; 0736-0118 ; 1357-0560
ISSN (online)	1559-131X
ISSN	0736-0118 ; 1357-0560
DOI	10.1007/s12032-022-01797-7
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