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Article ; Online: USP3 promotes cisplatin resistance in non-small cell lung cancer cells by suppressing ACOT7-regulated ferroptosis.

Tao, Rancen / Liu, Zuo / Zhang, Zhenning / Zhang, Zhenfa

2024

Abstract: This study aims to investigate the role and mechanism of ubiquitin-specific protease 3 (USP3) in cisplatin (DDP) in non-small cell lung cancer (NSCLC). USP3 expression in NSCLC cells was detected using reverse transcription quantitative PCR and Western ... ...

Abstract	This study aims to investigate the role and mechanism of ubiquitin-specific protease 3 (USP3) in cisplatin (DDP) in non-small cell lung cancer (NSCLC). USP3 expression in NSCLC cells was detected using reverse transcription quantitative PCR and Western blot. DDP-resistant cells were constructed and cell counting kit-8 assay determined the IC50 of cells to DDP. USP3 expression was silenced in DDP-resistant cells, followed by detection of cell proliferation by clone formation assay, iron ion contents, ROS, MDA, and GSH levels by kits, GPX4 and ACSL4 protein expressions by Western blot. The binding between USP3 and ACOT7 was analyzed using Co-IP, and the ubiquitination level of ACOT7 was measured. USP3 and ACOT7 were highly expressed in NSCLC cells and further increased in drug-resistant cells. USP3 silencing reduced the IC50 of cells to DDP and diminished the number of cell clones. Moreover, USP3 silencing suppressed GSH and GPX4 levels, upregulated iron ion contents, ROS, MDA, and ACSL4 levels, and facilitated ferroptosis. Mechanistically, USP3 upregulated ACOT7 protein expression through deubiquitination. ACOT7 overexpression alleviated the promoting effect of USP7 silencing on ferroptosis in NSCLC cells and enhanced DDP resistance. To conclude, USP3 upregulated ACOT7 protein expression through deubiquitination, thereby repressing ferroptosis in NSCLC cells and enhancing DDP resistance.
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1065301-6
ISSN	1473-5741 ; 0959-4973
ISSN (online)	1473-5741
ISSN	0959-4973
DOI	10.1097/CAD.0000000000001562
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Current situation analysis and development strategy of listed private enterprises in Dalian

Li Tingting / Zhang Zhenning / Lu Ping

SHS Web of Conferences, Vol 140, p

2022 Volume 01025

Abstract: The overall development of private enterprises in Dalian operates well. Especially, after the “opinions on creating a better development environment to support the reform and development of private enterprises” issued by the State Council, more and more ... ...

Abstract	The overall development of private enterprises in Dalian operates well. Especially, after the “opinions on creating a better development environment to support the reform and development of private enterprises” issued by the State Council, more and more private enterprises were encouraged to reform, financing and list according to the relevant policy. In this paper, we described the development status of private enterprises in Dalian, following with development and challenges of private enterprises, and eventually proposed the development strategies for them. The informative study provide the effective data and opinions on healthy developments of private enterprises in Dalian.
Keywords	Social Sciences ; H
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: MicroRNA-27b-3p inhibits the proliferation and invasion of cutaneous squamous cell carcinoma by targeting EGFR and MMP-13.

Liang, Daning / Zhang, Zhenning

Oncology letters

2021 Volume 22, Issue 4, Page(s) 729

Abstract: Cutaneous squamous cell carcinoma is a common malignant tumor. The aim of the present study was to examine the biological function of microRNA (miR)-27b-3p in cutaneous squamous cell carcinoma (CSCC) and its underlying mechanism. The relative expression ... ...

Abstract	Cutaneous squamous cell carcinoma is a common malignant tumor. The aim of the present study was to examine the biological function of microRNA (miR)-27b-3p in cutaneous squamous cell carcinoma (CSCC) and its underlying mechanism. The relative expression levels of miR-27b-3p were determined in A-431, Colo-16 and NHEK/SVTERT3-5 cell lines. The regulatory effects of miR-27b-3p on the proliferation of CSCC cells were evaluated using MTT and colony formation assays. Transwell assays were conducted to examine the role of miR-27b-5p in the migratory and invasive abilities of CSCC cells. The levels of EGFR, MMP-13, Akt, phosphorylated (p)-Akt, cyclin D1, N-cadherin (CAD) and E-CAD were detected in CSCC cells using reverse transcription-quantitative PCR and western blot analysis. Binding between miR-27b-3p and the 3'-untranslated region (UTR) of EGFR or MMP-13 was assessed using a dual-luciferase reporter assay. miR-27b-3p was significantly downregulated in CSCC cell lines, compared with the skin keratinocyte cell line. Transfection with a miR-27b-3p mimic significantly reduced the proliferative, migratory and invasive abilities of CSCC cells
Language	English
Publishing date	2021-08-10
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2021.12990
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: miR-216a-3p inhibits osteogenic differentiation of human adipose-derived stem cells via Wnt3a in the Wnt/β-catenin signaling pathway.

Liang, Daning / Song, Guodong / Zhang, Zhenning

Experimental and therapeutic medicine

2022 Volume 23, Issue 4, Page(s) 309

Abstract: The current study aimed to investigate the potential function and mechanism of microRNA (miR)-216a-3p in the osteogenic differentiation of human adipose-derived stem cells (hADSCs). Dynamic expression changes of miR-216a-3p in the osteogenic ... ...

Abstract	The current study aimed to investigate the potential function and mechanism of microRNA (miR)-216a-3p in the osteogenic differentiation of human adipose-derived stem cells (hADSCs). Dynamic expression changes of miR-216a-3p in the osteogenic differentiation of hADSCs were examined by reverse transcription-quantitative PCR (RT-qPCR). Regulatory effects of miR-216a-3p on the relative levels of osteogenesis-associated genes were also detected by RT-qPCR and western blotting. The relationship between miR-216a-3p and Wnt3a was verified through a dual-luciferase reporter assay. Furthermore, the influence of miR-216a-3p on the Wnt/β-catenin signaling pathway during the osteogenic differentiation of hADSCs was investigated by western blotting. The results revealed that during the osteogenic differentiation process of hADSCs, miR-216a-3p was downregulated and Wnt3a was upregulated. It was further verified that Wnt3a was the target of miR-216a-3p. Through inactivation of the Wnt/β-catenin signaling pathway, miR-216a-3p was able to mediate osteogenic differentiation of hADSCs. In conclusion, by targeting Wnt3a, miR-216a-3p mediated the osteogenic differentiation of hADSCs, which negatively regulated the Wnt/β-catenin signaling pathway.
Language	English
Publishing date	2022-02-24
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2022.11238
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Phase Mismatch Calibration for Dual-Channel Sliding Spotlight SAR-GMTI

Zhang, Zhenning / Yu, Weidong / Zheng, Mingjie / Zhao, Liangbo / Zhou, Zi-Xuan

Remote Sensing. 2022 Jan. 27, v. 14, no. 3

2022

Abstract: This article investigates channel phase mismatch calibration during the application of displaced-phase-center antenna (DPCA) in dual-channel sliding spotlight synthetic aperture radar (SAR) for ground moving target indication (GMTI). In sliding spotlight ...

Abstract	This article investigates channel phase mismatch calibration during the application of displaced-phase-center antenna (DPCA) in dual-channel sliding spotlight synthetic aperture radar (SAR) for ground moving target indication (GMTI). In sliding spotlight SAR, the utilization of beam progressive sweeping in azimuth causes antenna phase centers to be misaligned from the sensor path, resulting in the phase mismatch between channels. Then, spatial channel co-registration required in the DPCA cannot be achieved directly by an azimuth time shift. In this study, a calibration method based on scanning geometry of the dual-channel sliding spotlight SAR is developed to address this issue. Moreover, the effect of the phase mismatch calibration on the estimation of azimuth time difference between the two channels is derived and analyzed in depth. The clutter suppression results processed from experimental data acquired by a C-band dual-channel SAR system (Gaofen-3) operated in sliding spotlight mode are shown for the first time to demonstrate the effective phase mismatch calibration.
Keywords	antennae ; data collection ; geometry ; remote sensing ; synthetic aperture radar
Language	English
Dates of publication	2022-0127
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2513863-7
ISSN	2072-4292
ISSN	2072-4292
DOI	10.3390/rs14030617
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: SUGER

Zhang, Zhenning / Du, Boxin / Tong, Hanghang

A Subgraph-based Graph Convolutional Network Method for Bundle Recommendation

2022

Abstract: Bundle recommendation is an emerging research direction in the recommender system with the focus on recommending customized bundles of items for users. Although Graph Neural Networks (GNNs) have been applied in this problem and achieve superior ... ...

Abstract	Bundle recommendation is an emerging research direction in the recommender system with the focus on recommending customized bundles of items for users. Although Graph Neural Networks (GNNs) have been applied in this problem and achieve superior performance, existing methods underexplore the graph-level GNN methods, which exhibit great potential in traditional recommender system. Furthermore, they usually lack the transferability from one domain with sufficient supervision to another domain which might suffer from the label scarcity issue. In this work, we propose a subgraph-based Graph Neural Network model, SUGER, for bundle recommendation to handle these limitations. SUGER generates heterogeneous subgraphs around the user-bundle pairs, and then maps those subgraphs to the users' preference predictions via neural relational graph propagation. Experimental results show that SUGER significantly outperforms the state-of-the-art baselines in both the basic and the transfer bundle recommendation problems.
Keywords	Computer Science - Information Retrieval
Subject code	006
Publishing date	2022-05-05
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [Chiropractic plus plum-blossom needling combined with flexibility training on attention deficit in mentally-retarded adolescents].

Gao, Li-Li / Zhang, Zhen-Ning / Zhai, Jia-Li / Yu, Wen-Bing / Li, Shi-Ming

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

2022 Volume 42, Issue 7, Page(s) 749–752

Abstract: Objective: To observe the clinical efficacy of chiropractic plus plum-blossom needling combined with flexibility training for attention deficit in mentally-retarded adolescents.: Methods: Thirty adolescents with mild mental retardation were randomly ... ...

Abstract	Objective: To observe the clinical efficacy of chiropractic plus plum-blossom needling combined with flexibility training for attention deficit in mentally-retarded adolescents. Methods: Thirty adolescents with mild mental retardation were randomly divided into a medical rehabilitation plus flexibility training group (10 cases, 2 cases dropped off), a flexibility training group (10 cases, 1 case dropped off) and a control group (10 cases). The patients in the flexibility training group received flexibility training, once every other day, 3 times a week for 12 weeks. The patients in the medical rehabilitation plus flexibility training group received chiropractic and plum-blossom needling at Baihui (GV 20) and Sishencong (EX-HN 1) on the basis of the treatment in the flexibility training group, once every other day, 3 times a week for 12 weeks. The patients in the control group did not receive any targeted physical training and medical rehabilitation. Tobii Pro Spectrum eye movement instrument was used to test the attention concentration (T), attention span (M), attention transfer (γ%) and attention distribution (η). Results: Compared before treatment, T and M in the medical rehabilitation plus flexibility training group and the flexibility training group were increased after treatment ( Conclusion: The chiropractic plus plum blossom needling combined with flexibility training can improve the attention deficit in mentally-retarded adolescents.
MeSH term(s)	Acupuncture Therapy ; Adolescent ; Chiropractic ; Flowers ; Humans ; Prunus domestica ; Vascular Surgical Procedures
Language	Chinese
Publishing date	2022-07-06
Publishing country	China
Document type	Journal Article ; Randomized Controlled Trial
ISSN	0255-2930
ISSN	0255-2930
DOI	10.13703/j.0255-2930.20210704-k0001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Hepatic ER stress suppresses adipose browning through ATF4-CIRP-ANGPTL3 cascade.

Lv, Sihan / Zhou, Yingqun / Chen, Jiaojiao / Yuan, Huiwen / Zhang, Zhen-Ning / Luan, Bing

Cell reports

2022 Volume 40, Issue 13, Page(s) 111422

Abstract: Hepatic endoplasmic reticulum (ER) stress is a hallmark of obesity-induced liver steatosis and contributes to the progress of steatosis and insulin resistance in liver. However, its influence on adipose function is still unclear. Here, we identify a ... ...

Abstract	Hepatic endoplasmic reticulum (ER) stress is a hallmark of obesity-induced liver steatosis and contributes to the progress of steatosis and insulin resistance in liver. However, its influence on adipose function is still unclear. Here, we identify a hepatic ER stress-induced activating transcription factor 4 (ATF4)-cold-inducible RNA-binding protein (CIRP)-angiopoietin-related protein3 (ANGPTL3) cascade critical for the regulation of adipose browning. We find that obesity increases CIRP expression in liver through ER stress-induced ATF4. CIRP in turn binds to the 3' UTR and increases mRNA stability of ANGPTL3. ANGPTL3 secreted from liver suppresses uncoupling protein 1 expression through integrin α
MeSH term(s)	3' Untranslated Regions ; Activating Transcription Factor 4/metabolism ; Adipose Tissue/metabolism ; Angiopoietin-Like Protein 3 ; Angiopoietin-like Proteins/genetics ; Angiopoietin-like Proteins/metabolism ; Angiopoietins/genetics ; Angiopoietins/metabolism ; Endoplasmic Reticulum Stress/genetics ; Fatty Liver/metabolism ; Humans ; Integrins/metabolism ; JNK Mitogen-Activated Protein Kinases/metabolism ; Liver/metabolism ; Obesity/metabolism ; RNA-Binding Proteins/metabolism ; Uncoupling Protein 1/metabolism
Chemical Substances	3' Untranslated Regions ; ANGPTL3 protein, human ; ATF4 protein, human ; Angiopoietin-Like Protein 3 ; Angiopoietin-like Proteins ; Angiopoietins ; Integrins ; RNA-Binding Proteins ; Uncoupling Protein 1 ; Activating Transcription Factor 4 (145891-90-3) ; JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2022-09-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2022.111422
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Quality of life after lung cancer surgery: sublobar resection versus lobectomy.

Jiang, Shuai / Wang, Bao / Zhang, Mengzhe / Liu, Zuo / Xiao, Zengtuan / Gong, Jialin / Wang, Xiaofei / Zhang, Zhenning / Zhang, Zhenfa

BMC surgery

2023 Volume 23, Issue 1, Page(s) 353

Abstract: Background: This study aimed to compare the postoperative quality of life (PQOL) between non-small-cell lung cancer (NSCLC) patients who underwent video-assisted thoracoscopic sublobar resection (subsegment, segment, or wedge) and lobectomy. Meanwhile, ... ...

Abstract	Background: This study aimed to compare the postoperative quality of life (PQOL) between non-small-cell lung cancer (NSCLC) patients who underwent video-assisted thoracoscopic sublobar resection (subsegment, segment, or wedge) and lobectomy. Meanwhile, we developed a PQOL scale for patients with NSCLC after optimization. Methods: Developing and evaluating the postoperative quality-of-life scale of non-small-cell lung cancer (NSCLC-PQOL) followed by the international principles for developing quality-of-life scale. Therefore, we used the NSCLC-PQOL scale to evaluate the PQOL of patients who underwent different surgeries. Results: The overall PQOL of patients who underwent video-assisted thoracoscopic lobectomy and sublobar resection gradually worsened from discharge to 3 months postoperatively and progressively improved from three to 6 months postoperatively. And the sublobar resection group showed better PQOL in chest tightness, breath shortness, breathlessness, cough and expectoration than the lobectomy group, and the differences were statistically significant (P < 0.05). The final version of the NSCLC-PQOL contained three dimensions: "signs-symptoms", "psychological and psychiatric", and "social-life" dimensions. Conclusions: The sublobar resection group showed better PQOL in "chest tightness", "breath shortness", "breathlessness", "cough", and "expectoration" than the lobectomy group. Twenty-two items formed a well-behaved PQOL scale after being validated satisfactorily. The scale was a suitable rating tool for evaluating the NSCLC-PQOL of patients. Trial registration: As this study was a retrospective study and not a clinical trial, we did not register this study in the Chinese Clinical Trial Registry.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/surgery ; Carcinoma, Non-Small-Cell Lung/pathology ; Lung Neoplasms/surgery ; Lung Neoplasms/pathology ; Retrospective Studies ; Quality of Life ; Pneumonectomy/methods ; Neoplasm Staging
Language	English
Publishing date	2023-11-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2050442-1
ISSN	1471-2482 ; 1471-2482
ISSN (online)	1471-2482
ISSN	1471-2482
DOI	10.1186/s12893-023-02259-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Narrow linewidth optical frequency comb based on a directly modulated microcavity laser with optical feedback.

Wang, Ting / Yang, Yue-De / Hao, You-Zeng / Zhang, Zhen-Ning / Shi, Yang / Chen, You-Ling / Xiao, Jin-Long / Huang, Yong-Zhen

Optics express

2023 Volume 31, Issue 8, Page(s) 12200–12211

Abstract: A narrow linewidth optical frequency comb (OFC) based on a directly modulated microcavity laser with external optical feedback is investigated numerically and demonstrated experimentally. Based on the numerical simulations with rate equations, the ... ...

Abstract	A narrow linewidth optical frequency comb (OFC) based on a directly modulated microcavity laser with external optical feedback is investigated numerically and demonstrated experimentally. Based on the numerical simulations with rate equations, the evolution of the optical and electrical spectra is presented for the direct-modulated microcavity laser with increased feedback strength, and the linewidth property is improved at suitable feedback conditions. The simulation results also show good robustness for the generated OFC in terms of feedback strength and phase. Moreover, the OFC generation experiment is performed by combining with the dual-loop feedback structure to suppress the side mode, and an OFC with a side-mode suppression ratio of 31 dB is realized. Thanks to the high electro-optical response of the microcavity laser, a 15-tone OFC with a frequency interval of 10 GHz is obtained. Finally, the linewidth of each comb tooth is measured to be around 7 kHz under the feedback power of 47 µW, which indicates an enormous compression of approximately 2000 times compared with the free-running continuous-wave microcavity laser.
Language	English
Publishing date	2023-05-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.487449
Database	MEDical Literature Analysis and Retrieval System OnLINE

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