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Article ; Online: Recent Progress in Plasmonic based Electrochemiluminescence Biosensors: A Review.

Ma, Cheng / Zhang, Zhichen / Tan, Tingting / Zhu, Jun-Jie

2023 Volume 13, Issue 2

Abstract: Electrochemiluminescence (ECL) analysis has become a powerful tool in recent biomarker detection and clinic diagnosis due to its high sensitivity and broad linear range. To improve the analytical performance of ECL biosensors, various advanced ... ...

Abstract	Electrochemiluminescence (ECL) analysis has become a powerful tool in recent biomarker detection and clinic diagnosis due to its high sensitivity and broad linear range. To improve the analytical performance of ECL biosensors, various advanced nanomaterials have been introduced to regulate the ECL signal such as graphene, gold nanomaterials, and quantum dots. Among these nanomaterials, some plasmonic nanostructures play important roles in the fabrication of ECL biosensors. The plasmon effect for the ECL signal includes ECL quenching by resonant energy transfer, ECL enhancement by surface plasmon resonance enhancement, and a change in the polarized angle of ECL emission. The influence can be regulated by the distance between ECL emitters and plasmonic materials, and the characteristics of polarization angle-dependent surface plasmon coupling. This paper outlines the recent advances of plasmonic based ECL biosensors involving various plasmonic materials including noble metals and semiconductor nanomaterials. The detection targets in these biosensors range from small molecules, proteins, nucleic acids, and cells thanks to the plasmonic effect. In addition to ECL biosensors, ECL microscopy analysis with plasmonic materials is also highlighted because of the enhanced ECL image quality by the plasmonic effect. Finally, the future opportunities and challenges are discussed if more plasmonic effects are introduced into the ECL realm.
MeSH term(s)	Luminescent Measurements/methods ; Biosensing Techniques/methods ; Surface Plasmon Resonance/methods ; Photometry ; Gold/chemistry
Chemical Substances	Gold (7440-57-5)
Language	English
Publishing date	2023-01-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios13020200
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Recent progress in electrochemiluminescence microscopy analysis of single cells.

Zhang, Zhichen / Ma, Cheng / Xu, Qin / Zhu, Jun-Jie

The Analyst

2022 Volume 147, Issue 13, Page(s) 2884–2894

Abstract: Electrochemiluminescence (ECL) is produced by chemiluminescence reactions initiated by electrochemical methods. On this basis, ECL microscopy (ECLM) is an emerging visualization tool to directly study local electrochemical features with good spatial and ... ...

Abstract	Electrochemiluminescence (ECL) is produced by chemiluminescence reactions initiated by electrochemical methods. On this basis, ECL microscopy (ECLM) is an emerging visualization tool to directly study local electrochemical features with good spatial and temporal resolution. Recent progress in ECLM demonstrates that it is particularly important in single-cell studies on the morphological structures and functional characteristics of cells due to the unique heterogeneity of cells. Compared with other single-cell imaging methods, ECLM possesses advantages such as a low optical background, high sensitivity, simple instrumentation and surface-confined mode. In this mini-review, we discuss the recent development of single-cell ECLM and classify these works according to different ECL routes. Because ECL routes significantly influence the features of ECLM, such as the thickness of the emitting layer and the brightness of emitters, it is necessary to provide a new insight to revisit these works and discuss what ECL routes can be chosen to study single-cell processes from different perspectives. Considering the gradual growth in single-cell ECLM, we show the developmental trajectory and how these works connect with one another. In addition, the coexisting challenges as well as opportunities inspire us to design more ECLM methods to investigate local electrochemical phenomena.
MeSH term(s)	Biosensing Techniques/methods ; Electrochemical Techniques/methods ; Luminescence ; Luminescent Measurements/methods ; Microscopy
Language	English
Publishing date	2022-06-27
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d2an00709f
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Zs.A 2423: Show issues

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Article ; Online: Ratiometric electrochemiluminescence sensing and intracellular imaging of ClO

Ma, Cheng / Zhu, Yujing / Zhang, Zhichen / Chen, Xuan / Ji, Zhengping / Zhang, Lu-Nan / Xu, Qin

Analytical and bioanalytical chemistry

2024

Abstract: Electrochemiluminescence resonance energy transfer (ECL-RET) is a versatile signal transduction strategy widely used in the fabrication of chem/biosensors. However, this technique has not yet been applied in visualized imaging analysis of intracellular ... ...

Abstract	Electrochemiluminescence resonance energy transfer (ECL-RET) is a versatile signal transduction strategy widely used in the fabrication of chem/biosensors. However, this technique has not yet been applied in visualized imaging analysis of intracellular species due to the insulating nature of the cell membrane. Here, we construct a ratiometric ECL-RET analytical method for hypochlorite ions (ClO
Language	English
Publishing date	2024-03-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	201093-8
ISSN	1618-2650 ; 0016-1152 ; 0372-7920
ISSN (online)	1618-2650
ISSN	0016-1152 ; 0372-7920
DOI	10.1007/s00216-024-05236-6
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Article ; Online: Fe

Yin, Qiangqiang / Gao, Xiaolong / Zhang, Hao / Zhang, Zhichen / Yu, Xiaoyang / He, Jialong / Shi, Guangyue / Hao, Liguo

Biomedical materials (Bristol, England)

2024 Volume 19, Issue 3

Abstract: This study developed a probe ... ...

Abstract	This study developed a probe Fe
MeSH term(s)	Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/metabolism ; Breast Neoplasms/drug therapy ; Trastuzumab/chemistry ; Female ; Animals ; Humans ; Magnetic Resonance Imaging/methods ; Receptor, ErbB-2/metabolism ; Carbocyanines/chemistry ; Mice ; Cell Line, Tumor ; Magnetite Nanoparticles/chemistry ; Mice, Nude ; Mice, Inbred BALB C ; Particle Size ; Contrast Media/chemistry ; Spectroscopy, Fourier Transform Infrared
Chemical Substances	Trastuzumab (P188ANX8CK) ; Receptor, ErbB-2 (EC 2.7.10.1) ; Carbocyanines ; CY5.5 cyanine dye ; Magnetite Nanoparticles ; ERBB2 protein, human (EC 2.7.10.1) ; Contrast Media
Language	English
Publishing date	2024-04-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2265222-X
ISSN	1748-605X ; 1748-6041
ISSN (online)	1748-605X
ISSN	1748-6041
DOI	10.1088/1748-605X/ad3f61
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Article ; Online: Depleting SOX2 improves ischemic stroke via lncRNA PVT1/microRNA-24-3p/STAT3 axis.

Chen, Zhongjun / Fan, Tieping / Zhao, Xusheng / Zhang, Zhichen

Molecular medicine (Cambridge, Mass.)

2021 Volume 27, Issue 1, Page(s) 107

Abstract: Objectives: Studies have widely explored in the filed of ischemic stroke (IS) with their focus on transcription factors. However, few studies have pivoted on sex determining region Y-box 2 (SOX2) in IS. Thus, this study is launched to figure out the ... ...

Abstract	Objectives: Studies have widely explored in the filed of ischemic stroke (IS) with their focus on transcription factors. However, few studies have pivoted on sex determining region Y-box 2 (SOX2) in IS. Thus, this study is launched to figure out the mechanisms of SOX2 in IS. Methods: Rat middle cerebral artery occlusion (MCAO) was established as a stroke model. MCAO rats were injected with depleted SOX2 or long non-coding RNA plasmacytoma variant translocation 1 (PVT1) to explore their roles in neurological deficits, cerebral water content, neuron survival, apoptosis and oxidative stress. The relationship among SOX2, PVT1, microRNA (miR)-24-3p and signal transducer and activator of transcription 3 (STAT3) was verified by a series of experiments. Results: SOX2, PVT1 and STAT3 were highly expressed while miR-24-3p was poorly expressed in cerebral cortex tissues of MCAO rats. Depleted SOX2 or PVT1 alleviated brain injury in MCAO rats as reflected by neuronal apoptosis and oxidative stress restriction, brain water content reduction, and neurological deficit and neuron survival improvements. Overexpression of PVT1 functioned oppositely. Restored miR-24-3p abolished PVT1 overexpression-induced brain injury in MCAO rats. SOX2 directly promoted PVT1 expression and further increased STAT3 by sponging miR-24-3p. Conclusion: This study presents that depleting SOX2 improves IS via PVT1/miR-24-3p/STAT3 axis which may broaden our knowledge about the mechanisms of SOX2/PVT1/miR-24-3p/STAT3 axis and provide a reference of therapy for IS.
MeSH term(s)	Animals ; Biomarkers ; Cell Line ; Disease Susceptibility ; Gene Expression Regulation ; Genes, Reporter ; Humans ; Immunohistochemistry ; Ischemic Stroke/etiology ; Ischemic Stroke/metabolism ; Ischemic Stroke/pathology ; Male ; MicroRNAs/genetics ; Oxidative Stress ; RNA Interference ; RNA, Long Noncoding/genetics ; Rats ; SOXB1 Transcription Factors/genetics ; SOXB1 Transcription Factors/metabolism ; STAT3 Transcription Factor/metabolism ; Signal Transduction
Chemical Substances	Biomarkers ; MIRN24 microRNA, rat ; MicroRNAs ; RNA, Long Noncoding ; SOXB1 Transcription Factors ; STAT3 Transcription Factor ; Sox2 protein, rat
Language	English
Publishing date	2021-09-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1283676-x
ISSN	1528-3658 ; 1076-1551
ISSN (online)	1528-3658
ISSN	1076-1551
DOI	10.1186/s10020-021-00346-8
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Article ; Online: Magnetic resonance/fluorescence dual-modality contrast agents targeting α

Yin, Qiangqiang / Qi, Guiqiang / Wang, Shengchao / Tian, Hongda / Gao, Xiaolong / Zhang, Zhichen / Hao, Liguo

Biochemical and biophysical research communications

2023 Volume 664, Page(s) 86–93

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a malignant digestive system tumor with a poor late-stage prognosis. This study aimed to identify new methods for the early detection of PDAC. The nanoprobe A20FMDV2-Gd-5-FAM was developed using A20FMDV2 ( ... ...

Abstract	Pancreatic ductal adenocarcinoma (PDAC) is a malignant digestive system tumor with a poor late-stage prognosis. This study aimed to identify new methods for the early detection of PDAC. The nanoprobe A20FMDV2-Gd-5-FAM was developed using A20FMDV2 (N
MeSH term(s)	Mice ; Animals ; Humans ; Contrast Media ; Fluorescent Dyes ; Ligands ; Mice, Nude ; Cell Line, Tumor ; Peptides/chemistry ; Pancreatic Neoplasms/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Carcinoma, Pancreatic Ductal ; Magnetic Resonance Spectroscopy ; Pancreatic Neoplasms
Chemical Substances	Contrast Media ; Fluorescent Dyes ; Ligands ; Peptides
Language	English
Publishing date	2023-04-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2023.04.071
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Article ; Online: In Situ Ultrasound Irradiation for Regulating the Electrochemiluminescence Intensity and Layer

Zhang, Zhichen / Zhu, Yujing / Xing, Zejing / Li, Jing / Xu, Qin / Zhu, Jun-Jie / Ma, Cheng

Analytical Chemistry. 2023 June 09, v. 95, no. 25 p.9687-9696

2023

Abstract: Electrochemiluminescence (ECL) has manifested a surface-confined emitting character and a low light background occurring near the electrode surface. However, the luminescence intensity and emitting layer are limited by the slow mass diffusion rate and ... ...

Abstract	Electrochemiluminescence (ECL) has manifested a surface-confined emitting character and a low light background occurring near the electrode surface. However, the luminescence intensity and emitting layer are limited by the slow mass diffusion rate and electrode fouling in a stationary electrolyte. To address this problem, we developed an in situ strategy to flexibly regulate the ECL intensity and layer thickness by introducing an ultrasound (US) probe to the ECL detector and microscope. Herein, we explored the ECL responses and the thickness of ECL layer (TEL) under US irradiation in different ECL routes and systems. ECL microscopy with an ultrasonic probe discovered that ultrasonic radiation enhanced the ECL intensity under the catalytic route, while an opposite trend was observed under the oxidative-reduction route. Simulation results demonstrated that US promoted the direct electrochemical oxidation of TPrA radicals by the electrode rather than oxidant Ru(bpy)₃ ³⁺, which made the TEL thinner than that in the catalytic route under the same US condition. In situ US boosted the ECL signal from 1.2 times to 4.7 times by improving the mass transport and weakening electrode fouling due to the cavitation role. It significantly enhanced the ECL intensity beyond the diffusion-controlled ECL reaction rate. In addition, a synergistic sonochemical luminescence is validated in the luminol system to enhance the whole luminescence because cavitation bubbles of US promoted the generation of reactive oxygen species. This in situ US strategy provides a new opportunity to understand ECL mechanisms and a new tool in regulating TEL to meet the needs of ECL imaging.
Keywords	analytical chemistry ; electrochemiluminescence ; electrochemistry ; electrodes ; electrolytes ; irradiation ; light intensity ; mass transfer ; microscopy ; oxidants ; oxidation ; reactive oxygen species ; ultrasonic treatment ; ultrasonics
Language	English
Dates of publication	2023-0609
Size	p. 9687-9696.
Publishing place	American Chemical Society
Document type	Article ; Online
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c01718
Database	NAL-Catalogue (AGRICOLA)

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Article: Study on preparation of composite carbon rod for high-power electrode from coke with different structural characteristics

Zhang, Zhichen / Lou, Bin / Guo, Shuhai / Zhu, Wei / Gu, Meixia / Huang, Xiaoqiao / Liu, Dong

Journal of analytical and applied pyrolysis. 2022 Aug., v. 165

2022

Abstract: Different from lithium-ion batteries, composite carbon rod for high-power electrode was widely used in high-end manufacturing industry due to its good conductivity and low CTE. In this study, semi cokes with different structural characteristics was used ... ...

Abstract	Different from lithium-ion batteries, composite carbon rod for high-power electrode was widely used in high-end manufacturing industry due to its good conductivity and low CTE. In this study, semi cokes with different structural characteristics was used as aggregate and coal tar pitch was adopted as binder and impregnant to prepare composite carbon rod for high-power electrode, and the bonding and impregnation behavior was also investigated. It was found that calcination promoted ordered stacking of planar aromatic lamellae of acicular domain texture and aggravated the structural defects of mosaic texture. Coal tar pitch with low aromaticity and high toluene insoluble (TI) as bonded and impregnated pitch possessed higher adhesion but low weight gain ratio after calcination. While higher TI content of coal tar pitch enhanced the weight gain ratio, but the adhesion of composite carbon rod declined. In addition, the carbonaceous sheets derived from coal tar pitch gradually extended and covered the surface of orderly graphited sheets generated from acicular domain texture and contributed to the lowest CTE of 1.43 * 10⁻⁶·℃⁻¹ as well as the lowest specific resistance of 6.03μΩ·m. While the structural defects and voids generated from disordered mosaic texture could not be completely filled, thereby resulting in highest CTE of 2.20 * 10⁻⁶·℃⁻¹ and highest specific resistance of 9.55μΩ·m.
Keywords	adhesion ; carbon ; coal tar ; electrodes ; pyrolysis ; texture ; toluene ; weight gain
Language	English
Dates of publication	2022-08
Publishing place	Elsevier B.V.
Document type	Article
ISSN	0165-2370
DOI	10.1016/j.jaap.2022.105551
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: cRGD-Conjugated GdIO Nanoclusters for the Theranostics of Pancreatic Cancer through the Combination of T

Wang, Shengchao / Qi, Guiqiang / Zhang, Zhichen / Yin, Qiangqiang / Li, Na / Li, Zhongtao / Shi, Guangyue / Hu, Haifeng / Hao, Liguo

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 16

Abstract: Clinically, magnetic resonance imaging (MRI) often uses contrast agents (CAs) to improve image contrast, but single-signal MRI CAs are often susceptible to calcification, hemorrhage, and magnetic sensitivity. Herein, iron acetylacetone and gadolinium ... ...

Abstract	Clinically, magnetic resonance imaging (MRI) often uses contrast agents (CAs) to improve image contrast, but single-signal MRI CAs are often susceptible to calcification, hemorrhage, and magnetic sensitivity. Herein, iron acetylacetone and gadolinium acetylacetone were used as raw materials to synthesize a T
MeSH term(s)	Humans ; Docetaxel ; Precision Medicine ; Gadolinium ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/drug therapy ; Magnetic Resonance Imaging ; Iron ; Tumor Microenvironment ; Pancreatic Neoplasms
Chemical Substances	Docetaxel (15H5577CQD) ; acetylacetone (46R950BP4J) ; gadolinium oxide (5480D0NHLJ) ; Gadolinium (AU0V1LM3JT) ; perferryl iron (14127-54-9) ; Iron (E1UOL152H7)
Language	English
Publishing date	2023-08-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28166134
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Article ; Online: In Situ Ultrasound Irradiation for Regulating the Electrochemiluminescence Intensity and Layer.

Zhang, Zhichen / Zhu, Yujing / Xing, Zejing / Li, Jing / Xu, Qin / Zhu, Jun-Jie / Ma, Cheng

Analytical chemistry

2023 Volume 95, Issue 25, Page(s) 9687–9696

Abstract	Electrochemiluminescence (ECL) has manifested a surface-confined emitting character and a low light background occurring near the electrode surface. However, the luminescence intensity and emitting layer are limited by the slow mass diffusion rate and electrode fouling in a stationary electrolyte. To address this problem, we developed an in situ strategy to flexibly regulate the ECL intensity and layer thickness by introducing an ultrasound (US) probe to the ECL detector and microscope. Herein, we explored the ECL responses and the thickness of ECL layer (TEL) under US irradiation in different ECL routes and systems. ECL microscopy with an ultrasonic probe discovered that ultrasonic radiation enhanced the ECL intensity under the catalytic route, while an opposite trend was observed under the oxidative-reduction route. Simulation results demonstrated that US promoted the direct electrochemical oxidation of TPrA radicals by the electrode rather than oxidant Ru(bpy)
Language	English
Publishing date	2023-06-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c01718
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Zs.A 4033: Show issues

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