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Artikel ; Online: Retraction notice to "LncRNA GAS6-AS1 facilitates the progression of breast cancer by targeting the miR-324-3p/SETD1A axis to activate the PI3K/AKT pathway" [Eur. J. Cell Biol. 99 (2020) 151124].

Li, Sijie / Jia, Hongyao / Zhang, Zhiru / Wu, Di

2022 Band 102, Heft 1, Seite(n) 151269

Sprache	Englisch
Erscheinungsdatum	2022-09-17
Erscheinungsland	Germany
Dokumenttyp	Journal Article ; Retraction of Publication
ZDB-ID	391967-5
ISSN	1618-1298 ; 0070-2463 ; 0171-9335
ISSN (online)	1618-1298
ISSN	0070-2463 ; 0171-9335
DOI	10.1016/j.ejcb.2022.151269
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Circ_0000511 accelerates the proliferation, migration and invasion, and restrains the apoptosis of breast cancer cells through the miR‑326/TAZ axis.

Wu, Di / Jia, Hongyao / Zhang, Zhiru / Li, Sijie

International journal of oncology

2021 Band 58, Heft 4

Abstract: Circular RNA 0000511 (circ_0000511) has been observed to be dysregulated in breast cancer (BC). However, the functions of circ_0000511 in breast cancer remain unknown. The expression levels of circ_0000511, ribonuclease P RNA component H1, microRNA‑326 ( ... ...

Abstract	Circular RNA 0000511 (circ_0000511) has been observed to be dysregulated in breast cancer (BC). However, the functions of circ_0000511 in breast cancer remain unknown. The expression levels of circ_0000511, ribonuclease P RNA component H1, microRNA‑326 (miR‑326) and transcriptional co‑activator with PDZ‑binding motif (TAZ) were examined by reverse transcription‑quantitative PCR. Colony formation and MTT assays were conducted to analyze the cellular proliferative ability. The apoptotic rate was assessed by flow cytometry. Western blot analysis was used to evaluate the expression levels of B cell leukemia/lymphoma 2 (Bcl‑2), Bcl‑2 associated X apoptosis regulator, cleaved caspase‑3 and TAZ. Transwell assays were performed to evaluate the migration and invasion of BC cells. The target interaction between miR‑326 and circ_0000511 or TAZ was confirmed by dual‑luciferase reporter assay. Xenograft assay was used to identify the function of circ_0000511
Mesh-Begriff(e)	Adult ; Aged ; Aged, 80 and over ; Animals ; Apoptosis/physiology ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Movement/physiology ; Cell Proliferation/physiology ; Female ; Heterografts ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; MCF-7 Cells ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Middle Aged ; Prognosis ; RNA, Circular/genetics ; RNA, Circular/metabolism
Chemische Substanzen	Intracellular Signaling Peptides and Proteins ; MIRN326 microRNA, human ; MicroRNAs ; RNA, Circular ; WWTR1 protein, human
Sprache	Englisch
Erscheinungsdatum	2021-03-02
Erscheinungsland	Greece
Dokumenttyp	Journal Article
ZDB-ID	1154403-x
ISSN	1791-2423 ; 1019-6439
ISSN (online)	1791-2423
ISSN	1019-6439
DOI	10.3892/ijo.2021.5181
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Electronic health records in nursing from 2000 to 2020: A bibliometric analysis.

Luan, Ze / Zhang, Zhiru / Gao, Yanan / Du, Shiyuan / Wu, Nan / Chen, Yulu / Peng, Xin

Frontiers in public health

2023 Band 11, Seite(n) 1049411

Abstract: Background: Electronic health records (EHR) is the longitudinal data generated by patients in medical institutions and recorded by electronic medical information systems in the form of digital, which is also the most widespread application of big data ... ...

Abstract	Background: Electronic health records (EHR) is the longitudinal data generated by patients in medical institutions and recorded by electronic medical information systems in the form of digital, which is also the most widespread application of big data in medicine. The purpose of this study was to explore the application of electronic health records in the field of nursing and determine the current research status and hotspots. Methods: A bibliometric analysis of electronic health records in nursing was undertaken from 2000 to 2020. The literature comes from Web of Science Core Collection database. We used CiteSpace (version 5.7 R5; Drexel University), which is a Java-based software that especially visualized collaborative networks and research topics. Results: A total of 2616 publications were included in the study. We found that publications increased year by year. The Conclusion: With the popularization of information systems, the publications of EHR in the nursing field have increased year by year. This study provides the basic structure, potential cooperation, and research trends of EHR in the field of nursing from 2000 to 2020, and provides a reference for nurses to effectively use EHR to help clinical work or scientific researchers explore the potential significances of EHR.
Mesh-Begriff(e)	Humans ; Electronic Health Records ; Bibliometrics ; Accidental Falls ; Advance Care Planning ; Databases, Factual
Sprache	Englisch
Erscheinungsdatum	2023-02-09
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1049411
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: DRAIC promotes growth of breast cancer by sponging miR-432-5p to upregulate SLBP.

Li, Sijie / Jia, Hongyao / Zhang, Zhiru / Wu, Di

Cancer gene therapy

2021 Band 29, Heft 7, Seite(n) 951–960

Abstract: Mounting evidence suggests that lncRNAs can exert functions in cancer progression in multiple manners. In recent years, competing endogenous RNA (ceRNA) has been widely reported in human cancers as a lncRNA-dominant molecular pathway. The current study ... ...

Abstract	Mounting evidence suggests that lncRNAs can exert functions in cancer progression in multiple manners. In recent years, competing endogenous RNA (ceRNA) has been widely reported in human cancers as a lncRNA-dominant molecular pathway. The current study aimed at proving the role of lncRNA downregulated RNA in cancer (DRAIC) in breast cancer (BRCA) progression. To be specific, qRT-PCR assay was conducted to measure the expression of DRAIC and other downstream target genes. It was uncovered that DRAIC was expressed at a high level in BRCA cells. Functional analyses, including CCK-8, colony formation, and EdU assays demonstrated that DRAIC depletion suppressed BRCA cell proliferation. In addition, cell apoptosis was promoted due to DRAIC knockdown. The inhibitory effect of DRAIC reduction on BRCA cell migration and invasion was proven by transwell assays. Mechanistically, DRAIC was confirmed to predominantly distribute in the cytoplasm and could interact with miR-432-5p. In addition, stem-loop binding protein (SLBP) was verified to be a downstream target of miR-432-5p and was positively regulated by DRAIC. Taken together, DRAIC sponged miR-432-5p to enhance SLBP expression, by which malignant behaviors of BRCA cells were promoted. Our findings may help to provide a promising therapeutic target for BRCA patients.
Mesh-Begriff(e)	Breast Neoplasms/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/genetics ; Nuclear Proteins/genetics ; RNA, Long Noncoding/genetics ; mRNA Cleavage and Polyadenylation Factors/genetics
Chemische Substanzen	MIRN432 microRNA, human ; MicroRNAs ; Nuclear Proteins ; RNA, Long Noncoding ; SLBP protein, human ; mRNA Cleavage and Polyadenylation Factors
Sprache	Englisch
Erscheinungsdatum	2021-10-13
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1212513-1
ISSN	1476-5500 ; 0929-1903
ISSN (online)	1476-5500
ISSN	0929-1903
DOI	10.1038/s41417-021-00388-4
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The 100 top-cited articles in uveitis from 1950 to 2022.

Huang, Li / Yang, Wei / Yao, Tianyu / Zhang, Zhiru / Gao, Xiaorong / Dan, Yujiao / He, Yue

International ophthalmology

2023 Band 43, Heft 12, Seite(n) 4631–4638

Abstract: Objectives: This bibliometric analysis aimed to clarify research characteristics and trends in research on uveitis by analyzing the top 100 most-cited articles.: Methods: We used the Web of Science database to search articles published in English ... ...

Abstract	Objectives: This bibliometric analysis aimed to clarify research characteristics and trends in research on uveitis by analyzing the top 100 most-cited articles. Methods: We used the Web of Science database to search articles published in English from January 1, 1950, to February 10, 2022, without other restrictions. The 100 most-cited articles related to uveitis were screened. The publication year, institution, author, journal, country, research topic, and research type of each article were analyzed. Results: The citations of the top 100 articles ranged from 144 to 2292 times. The years 2004 and 2005 included the largest number of articles published, with 17 in total. Most of the papers were published in Ophthalmology (n = 19), a specialized ophthalmology journal. The top 100 articles originated from 14 countries, with the most from the USA (n = 44). Twenty research institutions and 18 authors contributed two or more articles, with the National Eye Institute (USA) (n = 10) and Robert B. Nussenblatt (n = 10) contributing the most. The types of studies were mainly clinical studies (n = 64), focusing on the treatment of uveitis (n = 36). Conclusion: This study summarizes and analyzes the research characteristics and trends of uveitis. The contribution of the USA is explained, the past and current treatments of uveitis are emphasized, and the directions of future research are clarified.
Mesh-Begriff(e)	Humans ; Bibliometrics ; Uveitis
Sprache	Englisch
Erscheinungsdatum	2023-09-25
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	800087-6
ISSN	1573-2630 ; 0165-5701
ISSN (online)	1573-2630
ISSN	0165-5701
DOI	10.1007/s10792-023-02863-3
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: STAT3-induced HLA-F-AS1 promotes cell proliferation and stemness characteristics in triple negative breast cancer cells by upregulating TRABD.

Wu, Di / Jia, Hongyao / Zhang, Zhiru / Li, Sijie

Bioorganic chemistry

2021 Band 109, Seite(n) 104722

Abstract: Breast cancer (BC) is one of the most common malignances and is a leading cause of cancer-related deaths in women globally. Triple negative breast cancer (TNBC) is a common subtype of BC. Emerging evidence has indicated the crucial roles of long ... ...

Abstract	Breast cancer (BC) is one of the most common malignances and is a leading cause of cancer-related deaths in women globally. Triple negative breast cancer (TNBC) is a common subtype of BC. Emerging evidence has indicated the crucial roles of long noncoding RNAs (lncRNAs) in the tumorigenesis of TNBC. Our aim was to explore the role and regulatory mechanism of lncRNA HLA-F antisense RNA 1 (HLA-F-AS1) in TNBC cells. Cell counting kit-8 (CCK-8) assay, colony formation assay, flow cytometry analysis and western blot analysis were used to measure HLA-F-AS1-mediated cellular behaviors in TNBC. Xenograft tumor assay was applied to assess biological function of HLA-F-AS1 in vivo. Luciferase reporter assay and RNA pull down assay were used to verify the binding ability between molecules. Our findings demonstrated that HLA-F-AS1 expression was significantly upregulated in TNBC tissues and cells, and high level of HLA-F-AS1 indicated the poor prognosis of patients with TNBC. HLA-F-AS1 promoted TNBC progression by facilitating cell proliferation and stemness maintenance and inhibiting cell cycle arrest at G0/G1 stage and apoptosis in vitro as well as inducing tumor growth in vivo. HLA-F-AS1. In addition, signal transducer and activator of transcription 3 (STAT3) transcriptionally induced HLA-F-AS1 upregulation in TNBC cells via interacting with HLA-F-AS1 promoter. Moreover, HLA-F-AS1 acted as the molecular sponge of microRNA 541-3p (miR-541-3p) to elevate TRABD (TraB domain containing) expression in TNBC cells. Rescue experiments confirmed that the decrease of cell proliferation and stemness characteristics under silenced HLA-F-AS1 was rescued by TRABD overexpression in TNBC cells. In conclusion, STAT3-induced HLA-F-AS1 facilitates cell proliferation and stemness characteristics in TNBC by miR-541-3p-dependent upregulation of TRABD, which might provide a potential novel direction for the treatment of TNBC.
Mesh-Begriff(e)	Animals ; Cell Line, Tumor ; Cell Proliferation ; Down-Regulation ; Female ; Gene Expression Regulation, Neoplastic/physiology ; Gene Knockdown Techniques ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/metabolism ; Humans ; Metalloendopeptidases/genetics ; Metalloendopeptidases/metabolism ; Mice ; Mice, Nude ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Nanog Homeobox Protein/genetics ; Nanog Homeobox Protein/metabolism ; Neoplasms, Experimental ; Neoplastic Stem Cells ; Octamer Transcription Factor-3/genetics ; Octamer Transcription Factor-3/metabolism ; SOXB1 Transcription Factors/genetics ; SOXB1 Transcription Factors/metabolism ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; Triple Negative Breast Neoplasms/metabolism ; Up-Regulation
Chemische Substanzen	HLA-F antigens ; Histocompatibility Antigens Class I ; MIRN541 microRNA, human ; MicroRNAs ; NANOG protein, human ; Nanog Homeobox Protein ; Octamer Transcription Factor-3 ; POU5F1 protein, human ; SOX2 protein, human ; SOXB1 Transcription Factors ; STAT3 Transcription Factor ; STAT3 protein, human ; Metalloendopeptidases (EC 3.4.24.-)
Sprache	Englisch
Erscheinungsdatum	2021-02-10
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2021.104722
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Corrigendum to "TCF3-activated FAM201A enhances cell proliferation and invasion via miR-186-5p/TNKS1BP1 axis in triple-negative breast cancer" [Bioorg. Chem. 104 (2020) 104301].

Jia, Hongyao / Wu, Di / Zhang, Zhiru / Li, Sijie

Bioorganic chemistry

2021 Band 110, Seite(n) 104726

Sprache	Englisch
Erscheinungsdatum	2021-03-03
Erscheinungsland	United States
Dokumenttyp	Published Erratum
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2021.104726
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The Top 100 Most Cited Manuscripts in Retinopathy of Prematurity: A Bibliometric Analysis.

Zhang, Zhiru / Yang, Wei / Lv, Hongbin / Huang, Li / Yao, Tianyu / He, Yue

Seminars in ophthalmology

2023 Band 38, Heft 3, Seite(n) 306–311

Abstract: Purpose: To systematically summarize the research trends and emphases of ROP in the past decades by analyzing the characteristics of the top 100 cited ROP articles.: Methods: The 100 most cited articles on ROP published from January 1, 1950 to ... ...

Abstract	Purpose: To systematically summarize the research trends and emphases of ROP in the past decades by analyzing the characteristics of the top 100 cited ROP articles. Methods: The 100 most cited articles on ROP published from January 1, 1950 to December 31, 2021 were searched by Web of Science. Information such as year of publication, number of citations, journal and impact factor, type of research and topic, country of origin, institution and authorship of each article was extracted to analyze its characteristics. Results: A total of 15,928 articles were returned. These articles were published in 43 journals between 1952 and 2018, originating from 14 countries. The most widely published journal was Pediatrics (n = 19, IF = 8.109), followed by Archives of Ophthalmology (n = 15, IF = 4.399). The most cited paper (Gole et al. Archives of Ophthalmology 2005 Jul, 1614 citations) reported on the international classification of ROP. The most prevalent topic was the pathophysiology of ROP (n = 39), followed by the treatment of ROP (n = 32). Most were original research (n = 72), mainly based on research design of basic science. The most published articles were published in the United States (n = 61), and the institutions were Oregon Health & Science University, Dept Ophthalmol (n = 7). Conclusions: These 100 most frequently cited papers reflect the significant progress and several hot topics of ROP in recent decades, and this paper will help us further understand the knowledge and progress of ROP diagnosis and treatment.
Mesh-Begriff(e)	Infant, Newborn ; Humans ; Child ; Retinopathy of Prematurity ; Bibliometrics ; Ophthalmology
Sprache	Englisch
Erscheinungsdatum	2023-02-26
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	632820-9
ISSN	1744-5205 ; 0882-0538
ISSN (online)	1744-5205
ISSN	0882-0538
DOI	10.1080/08820538.2023.2177115
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Sirt3 Protects Retinal Pigment Epithelial Cells From High Glucose-Induced Injury by Promoting Mitophagy Through the AMPK/mTOR/ULK1 Pathway.

Yang, Wei / Qiu, Chen / Lv, Hongbin / Zhang, Zhiru / Yao, Tianyu / Huang, Li / Wu, Guihong / Zhang, Xueqin / Chen, Jie / He, Yue

Translational vision science & technology

2024 Band 13, Heft 3, Seite(n) 19

Abstract: Purpose: The regulation of mitophagy by Sirt3 has rarely been studied in ocular diseases. In the present study, we determined the effects of Sirt3 on AMPK/mTOR/ULK1 signaling pathway-mediated mitophagy in retinal pigment epithelial (RPE) cells in a high ...

Abstract	Purpose: The regulation of mitophagy by Sirt3 has rarely been studied in ocular diseases. In the present study, we determined the effects of Sirt3 on AMPK/mTOR/ULK1 signaling pathway-mediated mitophagy in retinal pigment epithelial (RPE) cells in a high glucose environment. Methods: The mRNA expression levels of Sirt3, AMPK, mTOR, ULK1, and LC3B in RPE cells under varying glucose conditions were measured by real-time polymerase chain reaction (RT-PCR). The expressions of Sirt3, mitophagy protein, and AMPK/mTOR/ULK1 signaling pathway-related proteins were detected by Western blotting. Lentivirus (LV) transfection mediated the stable overexpression of Sirt3 in cell lines. The experimental groups were NG (5.5 mM glucose), hypertonic, HG (30 mM glucose), HG + LV-GFP, and HG + LV-Sirt3. Western blotting was performed to detect the expressions of mitophagy proteins and AMPK/mTOR/ULK1-related proteins in a high glucose environment during the overexpression of Sirt3. Reactive oxygen species (ROS) production in a high glucose environment was measured by DCFH-DA staining. Mitophagy was detected by labeling mitochondria and lysosomes with MitoTracker and LysoTracker probes, respectively. Apoptosis was detected by flow cytometry. Results: Sirt3 expression was reduced in the high glucose group, inhibiting the AMPK/mTOR/ULK1 pathway, with diminished mitophagy and increased intracellular ROS production. The overexpression of Sirt3, increased expression of p-AMPK/AMPK and p-ULK1/ULK1, and decreased expression of p-mTOR/mTOR inhibited cell apoptosis and enhanced mitophagy. Conclusions: Sirt3 protected RPE cells from high glucose-induced injury by activating the AMPK/mTOR/ULK1 signaling pathway. Translational relevance: By identifying new targets of action, we aimed to establish effective therapeutic targets for diabetic retinopathy treatment.
Mesh-Begriff(e)	AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Autophagy-Related Protein-1 Homolog/genetics ; Autophagy-Related Protein-1 Homolog/metabolism ; Diabetic Retinopathy/metabolism ; Epithelial Cells/metabolism ; Glucose/toxicity ; Mitophagy/genetics ; Reactive Oxygen Species/metabolism ; Retina/metabolism ; Retina/pathology ; Sirtuin 3/genetics ; Sirtuin 3/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Humans
Chemische Substanzen	AMP-Activated Protein Kinases (EC 2.7.11.31) ; Autophagy-Related Protein-1 Homolog (EC 2.7.11.1) ; Glucose (IY9XDZ35W2) ; Reactive Oxygen Species ; Sirtuin 3 (EC 3.5.1.-) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; ULK1 protein, human (EC 2.7.11.1)
Sprache	Englisch
Erscheinungsdatum	2024-03-22
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2674602-5
ISSN	2164-2591 ; 2164-2591
ISSN (online)	2164-2591
ISSN	2164-2591
DOI	10.1167/tvst.13.3.19
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch ; Online: Trainable Fixed-Point Quantization for Deep Learning Acceleration on FPGAs

Dai, Dingyi / Zhang, Yichi / Zhang, Jiahao / Hu, Zhanqiu / Cai, Yaohui / Sun, Qi / Zhang, Zhiru

2024

Abstract: Quantization is a crucial technique for deploying deep learning models on resource-constrained devices, such as embedded FPGAs. Prior efforts mostly focus on quantizing matrix multiplications, leaving other layers like BatchNorm or shortcuts in floating- ... ...

Abstract	Quantization is a crucial technique for deploying deep learning models on resource-constrained devices, such as embedded FPGAs. Prior efforts mostly focus on quantizing matrix multiplications, leaving other layers like BatchNorm or shortcuts in floating-point form, even though fixed-point arithmetic is more efficient on FPGAs. A common practice is to fine-tune a pre-trained model to fixed-point for FPGA deployment, but potentially degrading accuracy. This work presents QFX, a novel trainable fixed-point quantization approach that automatically learns the binary-point position during model training. Additionally, we introduce a multiplier-free quantization strategy within QFX to minimize DSP usage. QFX is implemented as a PyTorch-based library that efficiently emulates fixed-point arithmetic, supported by FPGA HLS, in a differentiable manner during backpropagation. With minimal effort, models trained with QFX can readily be deployed through HLS, producing the same numerical results as their software counterparts. Our evaluation shows that compared to post-training quantization, QFX can quantize models trained with element-wise layers quantized to fewer bits and achieve higher accuracy on both CIFAR-10 and ImageNet datasets. We further demonstrate the efficacy of multiplier-free quantization using a state-of-the-art binarized neural network accelerator designed for an embedded FPGA (AMD Xilinx Ultra96 v2). We plan to release QFX in open-source format.
Schlagwörter	Computer Science - Machine Learning ; Computer Science - Computer Vision and Pattern Recognition
Thema/Rubrik (Code)	006
Erscheinungsdatum	2024-01-30
Erscheinungsland	us
Dokumenttyp	Buch ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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