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  1. Article: Vitamin D levels and five cardiovascular diseases: A Mendelian randomization study.

    Zhang, Zhishuai / Qiu, Shizheng / Wang, Zhaoqing / Hu, Yang

    Heliyon

    2023  Volume 10, Issue 1, Page(s) e23674

    Abstract: Cardiovascular disease is the leading cause of death worldwide, whilst vitamin D levels have been found to be associated with cardiovascular disease. To investigate the causal relationship between vitamin D levels and five cardiovascular diseases, a ... ...

    Abstract Cardiovascular disease is the leading cause of death worldwide, whilst vitamin D levels have been found to be associated with cardiovascular disease. To investigate the causal relationship between vitamin D levels and five cardiovascular diseases, a genome-wide association study (GWAS) was carried out using data on vitamin D levels (sample size = 79366), angina pectoris (18168 cases and 187840 controls), coronary heart disease (21012 cases and 197780 controls), lacunar stroke (6030 cases and 248929 controls), heart attack (10693 cases and 451187 controls), and hypertension (55917 cases and 162837 controls), with a Mendelian randomization (MR) analysis being subsequently performed. Six single nucleotide polymorphisms were used as instrumental variables (IVs). In addition, sensitivity analysis was performed to verify the reliability of the MR results here. The results showed a causal relationship between vitamin D levels and angina pectoris (OR = 0.51, 95 % CI: 0.28-0.93, P = 0.03), coronary heart disease (OR = 0.53, 95 % CI: 0.34-0.81, P = 0.004), and lacunar stroke (OR = 0.41, 95 % CI: 0.20-0.86, P = 0.02), but no causal relationship with heart attacks (OR = 1.00, 95 % CI: 0.99-1.01, P = 0.76) or hypertension (OR = 0.99, 95 % CI: 0.73-1.34, P = 0.94). Additionally, our IVs data showed no heterogeneity or pleiotropy, whilst the results of the MR analysis were reliable. This study contributes to the prevention and treatment of these five cardiovascular diseases.
    Language English
    Publishing date 2023-12-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e23674
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  2. Article ; Online: Cloning, tissue expression and imprinting status analysis of the NDN gene in Dolang sheep.

    Zhang, Yongjie / Sui, Zhiyuan / Zhang, Zhishuai / Wang, Chenguang / Li, Xiaojun / Xing, Feng

    Molecular biology reports

    2024  Volume 51, Issue 1, Page(s) 166

    Abstract: Background: Genomic imprinting refers to expressing parent-specific genes in mammalian diploid cells. The NDN gene is maternally imprinted in humans and mice and correlates with the timing of puberty. This study aimed to investigate its imprinting ... ...

    Abstract Background: Genomic imprinting refers to expressing parent-specific genes in mammalian diploid cells. The NDN gene is maternally imprinted in humans and mice and correlates with the timing of puberty. This study aimed to investigate its imprinting status and its relationship with the onset of puberty in Dolang sheep.
    Methods and results: In this study, cloning and sequencing obtained the NDN gene cDNA sequence of 1082 bp of Dolang sheep, coding for 325 amino acids. Similarity analysis and phylogenetic tree showed that the NDN gene conformed to the law of speciation and was highly conserved among mammals. RT-qPCR results showed the highest expression of NDN mRNA was found in the hypothalamus at puberty, and the expression was significantly increased and then significantly decreased from prepuberty to postpuberty in the hypothalamus, pituitary, and ovary and oviduct. Based on expressed single nucleotide polymorphism (SNP), the NDN gene was expressed monoallelically in the tissues of adult and neonatal umbilical cords, and the expressed allele was paternally inherited. The NDN promoter region of 3400 bp was obtained by cloning and identified in monoallelic-expressing tissues (hypothalamus, ovary, spleen) as a differentially methylated region (DMR).
    Conclusion: These findings will enrich the number of imprinted genes in sheep and suggest that the NDN gene could be a candidate gene for studying puberty initiation in Dolang sheep.
    MeSH term(s) Animals ; Female ; Alleles ; Amino Acids ; Cloning, Molecular ; Genes, cdc ; Phylogeny ; Sheep/genetics
    Chemical Substances Amino Acids
    Language English
    Publishing date 2024-01-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-023-08990-5
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  3. Article ; Online: Analysis of Lin28B Promoter Activity and Screening of Related Transcription Factors in Dolang Sheep

    Sui, Zhiyuan / Zhang, Yongjie / Zhang, Zhishuai / Wang, Chenguang / Li, Xiaojun / Xing, Feng / Chu, Mingxing

    Genes (Basel). 2023 May 07, v. 14, no. 5

    2023  

    Abstract: The Lin28B gene is involved in the initiation of puberty, but its regulatory mechanisms remain unclear. Therefore, in this study, we aimed to study the regulatory mechanism of the Lin28B promoter by cloning the Lin28B proximal promoter for bioinformatic ... ...

    Abstract The Lin28B gene is involved in the initiation of puberty, but its regulatory mechanisms remain unclear. Therefore, in this study, we aimed to study the regulatory mechanism of the Lin28B promoter by cloning the Lin28B proximal promoter for bioinformatic analysis. Next, a series of deletion vectors were constructed based on the bioinformatic analysis results for dual-fluorescein activity detection. The transcriptional regulation mechanism of the Lin28B promoter region was analyzed by detecting mutations in transcription factor-binding sites and overexpression of transcription factors. The dual-luciferase assay showed that the Lin28B promoter region −837 to −338 bp had the highest transcriptional activity, and the transcriptional activity of the Lin28B transcriptional regulatory region decreased significantly after Egr1 and SP1 mutations. Overexpression of the Egr1 transcription factor significantly enhanced the transcription of Lin28B, and the results indicated that Egr1 and SP1 play important roles in regulating Lin28B. These results provide a theoretical basis for further research on the transcriptional regulation of sheep Lin28B during puberty initiation.
    Keywords bioinformatics ; genes ; promoter regions ; puberty ; sheep ; transcription (genetics) ; transcription factors
    Language English
    Dates of publication 2023-0507
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14051049
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  4. Article ; Online: Lin28B

    Sui, Zhiyuan / Zhang, Yongjie / Zhang, Zhishuai / Wang, Chenguang / Li, Xiaojun / Xing, Feng

    Archives animal breeding

    2023  Volume 66, Issue 3, Page(s) 217–224

    Abstract: Although ovine puberty initiation has been previously studied, the mechanism by which the RNA-binding protein Lin28B affects this process has not been investigated. The present study aimed to investigate the effects ... ...

    Abstract Although ovine puberty initiation has been previously studied, the mechanism by which the RNA-binding protein Lin28B affects this process has not been investigated. The present study aimed to investigate the effects of
    Language English
    Publishing date 2023-07-28
    Publishing country Germany
    Document type Journal Article
    ISSN 2363-9822
    ISSN (online) 2363-9822
    DOI 10.5194/aab-66-217-2023
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  5. Article ; Online: Analysis of

    Sui, Zhiyuan / Zhang, Yongjie / Zhang, Zhishuai / Wang, Chenguang / Li, Xiaojun / Xing, Feng / Chu, Mingxing

    Genes

    2023  Volume 14, Issue 5

    Abstract: ... ...

    Abstract The
    MeSH term(s) Animals ; Sheep/genetics ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Binding Sites ; Promoter Regions, Genetic ; Gene Expression Regulation/genetics ; Protein Binding
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2023-05-07
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14051049
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  6. Article ; Online: Prophage Induction Causes

    Liu, Xing / Ye, Yin / Zhang, Zhishuai / Rensing, Christopher / Zhou, Shungui / Nealson, Kenneth H

    Environmental science & technology

    2023  Volume 57, Issue 15, Page(s) 6196–6204

    Abstract: Sustaining a metabolically active electroactive biofilm (EAB) is essential for the high efficiency and durable operation of microbial fuel cells (MFCs). However, EABs usually decay during long-term operation, and, until now, the causes remain unknown. ... ...

    Abstract Sustaining a metabolically active electroactive biofilm (EAB) is essential for the high efficiency and durable operation of microbial fuel cells (MFCs). However, EABs usually decay during long-term operation, and, until now, the causes remain unknown. Here, we report that lysogenic phages can cause EAB decay in
    MeSH term(s) Bioelectric Energy Sources/microbiology ; Biofilms ; Electrodes ; Geobacter ; Virus Activation
    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.2c08443
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  7. Article ; Online: Analysis of Methylation and mRNA Expression of

    Sui, Zhiyuan / Zhang, Zhishuai / Zhang, Yongjie / Zhang, Jihu / Li, Qingjin / Xing, Feng

    DNA and cell biology

    2023  Volume 42, Issue 3, Page(s) 130–139

    Abstract: ... ...

    Abstract Lin28B
    MeSH term(s) Animals ; Sheep/genetics ; DNA Methylation ; CpG Islands/genetics ; Promoter Regions, Genetic ; Hypothalamus/metabolism ; RNA, Messenger/metabolism
    Chemical Substances RNA, Messenger
    Language English
    Publishing date 2023-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1024454-2
    ISSN 1557-7430 ; 0198-0238 ; 1044-5498
    ISSN (online) 1557-7430
    ISSN 0198-0238 ; 1044-5498
    DOI 10.1089/dna.2022.0281
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2061: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Analysis of the Imprinting Status and Expression of the

    Zhang, Yongjie / Sui, Zhiyuan / Zhang, Zhishuai / Wang, Chenguang / Li, Xiaojun / Xing, Feng

    DNA and cell biology

    2023  Volume 42, Issue 11, Page(s) 689–696

    Abstract: Genomic imprinting refers to the expression of parent-specific genes in diploid mammalian cells. ...

    Abstract Genomic imprinting refers to the expression of parent-specific genes in diploid mammalian cells.
    MeSH term(s) Mice ; Humans ; Animals ; Sheep/genetics ; Genomic Imprinting/genetics ; Puberty/genetics ; Mammals/metabolism ; Proteins/metabolism
    Chemical Substances MAGEL2 protein, human ; Proteins
    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1024454-2
    ISSN 1557-7430 ; 0198-0238 ; 1044-5498
    ISSN (online) 1557-7430
    ISSN 0198-0238 ; 1044-5498
    DOI 10.1089/dna.2023.0166
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  9. Article: Anode respiration-dependent biological nitrogen fixation by Geobacter sulfurreducens

    Jing, Xianyue / Liu, Xing / Zhang, Zhishuai / Wang, Xin / Rensing, Christopher / Zhou, Shungui

    Water research. 2022 Jan. 01, v. 208

    2022  

    Abstract: The present nitrogen fixation industry is usually energy-intensive and environmentally detrimental. Therefore, it is appealing to find alternatives. Here, we achieved both a synchronized biological nitrogen fixation and electric energy production by ... ...

    Abstract The present nitrogen fixation industry is usually energy-intensive and environmentally detrimental. Therefore, it is appealing to find alternatives. Here, we achieved both a synchronized biological nitrogen fixation and electric energy production by using Geobacter sulfurreducens in a microbial electrochemical system. The results showed that G. sulfurreducens was able to fix nitrogen depending on anode respiration, producing a maximum current density of 0.17 ± 0.015 mA cm⁻² and a nitrogen-fixing activity of ca. 0.78 μmol C₂H₄ mg protein⁻¹ h⁻¹, thereby achieving a net total nitrogen-fixing rate of ca. 5.6 mg L⁻¹ day⁻¹. Specifically, nitrogen fixation did not impair coulombic efficiency. Transcriptomic and metabolic analyses demonstrated that anode respiration provided sufficient energy to drive nitrogen fixation, and in turn nitrogen fixation promoted anode respiration of the cell by increasing acetate catabolism but reducing acetate anabolism. Furthermore, we showed that G. sulfurreducens could be supplied in a bioelectrochemical system for N-deficient wastewater treatment to relieve N-deficiency stress contributing to the formation of an electroactive biofilm, thereby simultaneously achieving nitrogen fixation, current generation and dissoluble organic carbon removal. Our study revealed a synergistic effect between biological nitrogen fixation and current generation by G. sulfurreducens, providing a green nitrogen fixation alternative through shifting the nitrogen fixation field from energy consumption to energy production and having implications for N-deficient wastewater treatment.
    Keywords Geobacter sulfurreducens ; acetates ; anabolism ; anodes ; bioelectrochemistry ; biofilm ; catabolism ; electric power ; energy ; industry ; nitrogen ; nitrogen fixation ; organic carbon ; research ; synergism ; transcriptomics ; wastewater treatment ; water
    Language English
    Dates of publication 2022-0101
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 202613-2
    ISSN 1879-2448 ; 0043-1354
    ISSN (online) 1879-2448
    ISSN 0043-1354
    DOI 10.1016/j.watres.2021.117860
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  10. Article: Transcriptome Sequencing-Based Mining of Genes Associated With Pubertal Initiation in Dolang Sheep.

    Zhang, Zhishuai / Sui, Zhiyuan / Zhang, Jihu / Li, Qingjin / Zhang, Yongjie / Xing, Feng

    Frontiers in genetics

    2022  Volume 13, Page(s) 818810

    Abstract: Improving the fertility of sheep is an important goal in sheep breeding as it greatly increases the productivity. Dolang sheep is a typical representative breed of lamb in Xinjiang and is the main local sheep breed and meat source in the region. To ... ...

    Abstract Improving the fertility of sheep is an important goal in sheep breeding as it greatly increases the productivity. Dolang sheep is a typical representative breed of lamb in Xinjiang and is the main local sheep breed and meat source in the region. To explore the genes associated with the initiation of puberty in Dolang sheep, the hypothalamic tissues of Dolang sheep prepubertal, pubertal, and postpubertal periods were collected for RNA-seq analysis on the Illumina platform, generating 64.08 Gb clean reads. A total of 575, 166, and 648 differentially expressed genes (DEGs) were detected in prepuberty_vs._puberty, postpuberty_vs._prepuberty, and postpuberty_vs._puberty analyses, respectively. Based on Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses, the related genes involved in the initiation of puberty in Dolang sheep were mined. Ten genes that have direct or indirect functions in the initiation of puberty in Dolang sheep were screened using the GO and KEGG results. Additionally, quantitative real-time PCR was used to verify the reliability of the RNA-Seq data. This study provided a new approach for revealing the mechanism of puberty initiation in sheep and provided a theoretical basis and candidate genes for the breeding of early-pubertal sheep by molecular techniques, and at the same time, it is also beneficial for the protection, development, and utilization of the fine genetic resources of Xinjiang local sheep.
    Language English
    Publishing date 2022-03-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.818810
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