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  1. Article ; Online: Saponin extract from Achyranthes bidentata Blume alleviates disuse-induced muscle atrophy through PI3K/Akt signaling pathway

    Shi, Yi / Zhang, Zhuang-Wei / Du, Ming-Ming / Wu, Jing / Li, Jian-Xin

    Journal of Ethnopharmacology. 2023 Aug., v. 312 p.116458-

    2023  

    Abstract: The roots of Achyranthes bidentata Blume are one of the regularly used herbal drugs in Chinese medicine, and has been applied for strengthening the muscle and bone for a long time. However, its effect on muscle remains unclear. This paper aims to explore ...

    Abstract The roots of Achyranthes bidentata Blume are one of the regularly used herbal drugs in Chinese medicine, and has been applied for strengthening the muscle and bone for a long time. However, its effect on muscle remains unclear. This paper aims to explore the anti-muscle atrophy effect of A. bidentata, and to clarify the possible signaling pathways involved. The saponin extract of the roots of A. bidentata (ABSE) was prepared and analyzed, and its activity on myoblast differentiation was assayed with C2C12 cell culture. ABSE was then orally administered at dosage of 35, 70 and 140 mg/kg/day to disuse-induced muscle atrophy mice. The studies on mice body weight and muscle quality were conducted, and Western blot was used for exploring the possible signaling pathways involved in the muscle protective action aided with transcriptome analysis. The total saponin content of ABSE was 59.1%. ABSE promoted the C2C12 cells differentiation to myotube in C2C12 differentiation assay. Further study with disuse-induced muscle atrophy mice model demonstrated that ABSE significantly increased muscle fiber diameter as well as the proportion of slow muscle fibers. Possible mechanism study aided with transcriptome analysis revealed that ABSE alleviated muscle atrophy at least through activation of PI3K/Akt pathway in vivo & vitro. The saponin extract of the root of A. bidentata (ABSE) has a protective effect on muscle atrophy, and showed a considerable potential in prevention and treatment of muscle atrophy.
    Keywords Achyranthes japonica ; Oriental traditional medicine ; Western blotting ; body weight ; cell culture ; models ; muscle fibers ; muscles ; muscular atrophy ; myoblasts ; myotubes ; protective effect ; saponins ; transcriptomics ; Saponin extract ; Achyranthes bidentata ; Muscle atrophy ; Transcriptome analysis ; PI3K/Akt
    Language English
    Dates of publication 2023-08
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116458
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  2. Article ; Online: Saponin extract from Achyranthes bidentata Blume alleviates disuse-induced muscle atrophy through PI3K/Akt signaling pathway.

    Shi, Yi / Zhang, Zhuang-Wei / Du, Ming-Ming / Wu, Jing / Li, Jian-Xin

    Journal of ethnopharmacology

    2023  Volume 312, Page(s) 116458

    Abstract: Ethnopharmacological relevance: The roots of Achyranthes bidentata Blume are one of the regularly used herbal drugs in Chinese medicine, and has been applied for strengthening the muscle and bone for a long time. However, its effect on muscle remains ... ...

    Abstract Ethnopharmacological relevance: The roots of Achyranthes bidentata Blume are one of the regularly used herbal drugs in Chinese medicine, and has been applied for strengthening the muscle and bone for a long time. However, its effect on muscle remains unclear.
    Aim of the study: This paper aims to explore the anti-muscle atrophy effect of A. bidentata, and to clarify the possible signaling pathways involved.
    Materials and methods: The saponin extract of the roots of A. bidentata (ABSE) was prepared and analyzed, and its activity on myoblast differentiation was assayed with C2C12 cell culture. ABSE was then orally administered at dosage of 35, 70 and 140 mg/kg/day to disuse-induced muscle atrophy mice. The studies on mice body weight and muscle quality were conducted, and Western blot was used for exploring the possible signaling pathways involved in the muscle protective action aided with transcriptome analysis.
    Results: The total saponin content of ABSE was 59.1%. ABSE promoted the C2C12 cells differentiation to myotube in C2C12 differentiation assay. Further study with disuse-induced muscle atrophy mice model demonstrated that ABSE significantly increased muscle fiber diameter as well as the proportion of slow muscle fibers. Possible mechanism study aided with transcriptome analysis revealed that ABSE alleviated muscle atrophy at least through activation of PI3K/Akt pathway in vivo & vitro.
    Conclusions: The saponin extract of the root of A. bidentata (ABSE) has a protective effect on muscle atrophy, and showed a considerable potential in prevention and treatment of muscle atrophy.
    MeSH term(s) Mice ; Animals ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Proto-Oncogene Proteins c-akt ; Achyranthes ; Phosphatidylinositol 3-Kinases ; Saponins/pharmacology ; Saponins/therapeutic use ; Signal Transduction ; Muscular Atrophy/drug therapy ; Muscular Atrophy/prevention & control
    Chemical Substances Plant Extracts ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Saponins
    Language English
    Publishing date 2023-04-06
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116458
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  3. Article: EPA and DHA differentially coordinate the crosstalk between host and gut microbiota and block DSS-induced colitis in mice by a reinforced colonic mucus barrier

    Fang, Jian / Zhang, ZhuangWei / Cheng, Yinyin / Yang, Haitao / Zhang, Hui / Xue, Zhe / Lu, Songtao / Dong, Yichen / Song, Chunyan / Zhang, Xiaohong / Zhou, Yuping

    Food & function. 2022 Apr. 20, v. 13, no. 8

    2022  

    Abstract: Background: Ulcerative colitis (UC) is a chronic inflammatory disorder of the colon with a continuously remitting and relapsing course. Its etiology is closely related to abnormal interactions between host and gut microbiota. The mucus barrier lining the ...

    Abstract Background: Ulcerative colitis (UC) is a chronic inflammatory disorder of the colon with a continuously remitting and relapsing course. Its etiology is closely related to abnormal interactions between host and gut microbiota. The mucus barrier lining the gastrointestinal tract is necessary to coordinate host and gut microbiota interaction by nourishing and modulating the microbiota. Differential effects of the anti-inflammatory fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on UC progression in mice were firstly addressed by our previous work; here, the mechanism for their respective effects were further uncovered from host–microbiome crosstalk based on mucus barrier modulation to pave the way for UC therapy. Methods: Assessment of the disease activity index and histopathology score was conducted in mice with dextran sodium sulfate (DSS)-induced colitis pre-treated with different doses of EPA and DHA. Mucin generation, glycosylation and secretion were evaluated by a combination of electron microscopy, specific mucous staining, and qPCR. Western blotting was used to analyze the underlying molecular events. Fecal short chain fatty acids were detected using gas chromatography, and the gut microbial composition was analyzed using 16S rRNA sequencing. Results: Compared with DHA, the more potent inhibitory effect of high dose EPA on DSS-induced colitis was reconfirmed, which was underlain by a reinforced mucus layer as indicated by increased mucin granule release, mucus layer stratification and markedly upregulated expression of the key modulators involved in goblet cell differentiation. In turn a remarkably enhanced mucus barrier in the EPA group functioned to modulate the gut microbiome, as demonstrated by the enriched abundance of the phylum Bacteroidetes and mucin-degrading bacterium Akkermansia muciniphila producing acetic and propionic acids. Conclusions: EPA and DHA differentially coordinate the interaction between the host and the gut microbiota and relieve mucus barrier disruption in DSS-induced colitis. EPA may develop into a promising adjunctive therapy for UC.
    Keywords Bacteroidetes ; bacteria ; cell differentiation ; colon ; dextran ; digestive tract ; docosahexaenoic acid ; eicosapentaenoic acid ; electron microscopy ; etiology ; gas chromatography ; glycosylation ; histopathology ; intestinal microorganisms ; mucins ; mucus ; secretion ; sodium sulfate ; therapeutics ; ulcerative colitis
    Language English
    Dates of publication 2022-0420
    Size p. 4399-4420.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d1fo03815j
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  4. Article ; Online: EPA and DHA differentially coordinate the crosstalk between host and gut microbiota and block DSS-induced colitis in mice by a reinforced colonic mucus barrier.

    Fang, Jian / Zhang, ZhuangWei / Cheng, Yinyin / Yang, Haitao / Zhang, Hui / Xue, Zhe / Lu, Songtao / Dong, Yichen / Song, Chunyan / Zhang, Xiaohong / Zhou, Yuping

    Food & function

    2022  Volume 13, Issue 8, Page(s) 4399–4420

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Animals ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis/microbiology ; Colitis, Ulcerative/drug therapy ; Colon/metabolism ; Dextran Sulfate/adverse effects ; Disease Models, Animal ; Docosahexaenoic Acids/pharmacology ; Eicosapentaenoic Acid/pharmacology ; Gastrointestinal Microbiome ; Mice ; Mice, Inbred C57BL ; Mucins/metabolism ; Mucus/metabolism ; RNA, Ribosomal, 16S/genetics ; RNA, Ribosomal, 16S/metabolism ; Verrucomicrobia
    Chemical Substances Mucins ; RNA, Ribosomal, 16S ; Docosahexaenoic Acids (25167-62-8) ; Dextran Sulfate (9042-14-2) ; Eicosapentaenoic Acid (AAN7QOV9EA)
    Language English
    Publishing date 2022-04-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d1fo03815j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Sulforaphane ameliorates glucose intolerance in obese mice via the upregulation of the insulin signaling pathway

    Xu, Yan / Fu, Jian-Fei / Chen, Jia-Hui / Zhang, Zhuang-Wei / Zou, Zu-Quan / Han, Li-Yuan / Hua, Qi-Hang / Zhao, Jin-Shun / Zhang, Xiao-Hong / Shan, Yu-Juan

    Food & function. 2018 Sept. 19, v. 9, no. 9 p.4695-4701

    2018  

    Abstract: Sulforaphane (SFN) is a dietary component with multiple bioactivities; however, its role in obesity-related metabolic derangement remains unclear. Here, the effect of SFN on the glucose intolerance of obese mice and the underlying mechanism were ... ...

    Abstract Sulforaphane (SFN) is a dietary component with multiple bioactivities; however, its role in obesity-related metabolic derangement remains unclear. Here, the effect of SFN on the glucose intolerance of obese mice and the underlying mechanism were determined. C57B/6J male mice were randomly divided into two groups, having free access to water and a normal-fat diet (ND, n = 6) or a high-fat diet (HFD, n = 33) for 8 weeks; thereafter twelve mice having the greatest weight gain among the HFD-fed mice were considered as obese mice. These obese mice were randomly divided into two groups and treated orally for 6 weeks with or without SFN (100 μmol per kg bw, 3 times per week). During this period the animals were continuously maintained on a ND or a HFD. Blood glucose and serum insulin were examined; then glucose tolerance and insulin resistance were evaluated. In addition, the expression of insulin signaling pathway-related genes in the muscle was determined. Our data showed that the obese mice presented a marked insulin resistance and glucose intolerance as compared to the control group, while SFN treatment exerted a prominently protective effect. In addition, the SFN-treated obese mice had a significantly increased insulin receptor substrate 1 (IRS-1) protein level (P < 0.05), markedly elevated Akt activation, as well as dramatically enhanced phosphorylation of PDK-1 (P < 0.05) when compared with the SFN-untreated obese mice. Moreover, the SFN-treated obese mice exhibited a significantly enhanced translocation of GLUT4 (P < 0.05) to the plasma membrane in the muscle compared to the obese mice without SFN treatment. In conclusion, our results support the notion that SFN acts as a promising agent to improve glucose tolerance through the up-regulation of insulin signaling mainly involving the IRS-1/Akt/GLUT4 pathway in the muscle.
    Keywords animal disease models ; blood glucose ; blood serum ; genes ; glucose ; glucose tolerance ; glucose transporters ; high fat diet ; insulin ; insulin receptor substrate proteins ; insulin resistance ; males ; mice ; muscles ; obesity ; phosphorylation ; plasma membrane ; protective effect ; protein content ; signal transduction ; sulforaphane ; weight gain
    Language English
    Dates of publication 2018-0919
    Size p. 4695-4701.
    Publishing place The Royal Society of Chemistry
    Document type Article ; Online
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/c8fo00763b
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  6. Article ; Online: Sulforaphane ameliorates glucose intolerance in obese mice via the upregulation of the insulin signaling pathway.

    Xu, Yan / Fu, Jian-Fei / Chen, Jia-Hui / Zhang, Zhuang-Wei / Zou, Zu-Quan / Han, Li-Yuan / Hua, Qi-Hang / Zhao, Jin-Shun / Zhang, Xiao-Hong / Shan, Yu-Juan

    Food & function

    2018  Volume 9, Issue 9, Page(s) 4695–4701

    Abstract: Sulforaphane (SFN) is a dietary component with multiple bioactivities; however, its role in obesity-related metabolic derangement remains unclear. Here, the effect of SFN on the glucose intolerance of obese mice and the underlying mechanism were ... ...

    Abstract Sulforaphane (SFN) is a dietary component with multiple bioactivities; however, its role in obesity-related metabolic derangement remains unclear. Here, the effect of SFN on the glucose intolerance of obese mice and the underlying mechanism were determined. C57B/6J male mice were randomly divided into two groups, having free access to water and a normal-fat diet (ND, n = 6) or a high-fat diet (HFD, n = 33) for 8 weeks; thereafter twelve mice having the greatest weight gain among the HFD-fed mice were considered as obese mice. These obese mice were randomly divided into two groups and treated orally for 6 weeks with or without SFN (100 μmol per kg bw, 3 times per week). During this period the animals were continuously maintained on a ND or a HFD. Blood glucose and serum insulin were examined; then glucose tolerance and insulin resistance were evaluated. In addition, the expression of insulin signaling pathway-related genes in the muscle was determined. Our data showed that the obese mice presented a marked insulin resistance and glucose intolerance as compared to the control group, while SFN treatment exerted a prominently protective effect. In addition, the SFN-treated obese mice had a significantly increased insulin receptor substrate 1 (IRS-1) protein level (P < 0.05), markedly elevated Akt activation, as well as dramatically enhanced phosphorylation of PDK-1 (P < 0.05) when compared with the SFN-untreated obese mice. Moreover, the SFN-treated obese mice exhibited a significantly enhanced translocation of GLUT4 (P < 0.05) to the plasma membrane in the muscle compared to the obese mice without SFN treatment. In conclusion, our results support the notion that SFN acts as a promising agent to improve glucose tolerance through the up-regulation of insulin signaling mainly involving the IRS-1/Akt/GLUT4 pathway in the muscle.
    MeSH term(s) Animals ; Blood Glucose/metabolism ; Diet, High-Fat/adverse effects ; Glucose Intolerance/drug therapy ; Glucose Intolerance/genetics ; Glucose Intolerance/metabolism ; Glucose Transporter Type 4/genetics ; Glucose Transporter Type 4/metabolism ; Humans ; Insulin/genetics ; Insulin/metabolism ; Insulin Receptor Substrate Proteins/genetics ; Insulin Receptor Substrate Proteins/metabolism ; Isothiocyanates/administration & dosage ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Pyruvate Dehydrogenase Acetyl-Transferring Kinase ; Signal Transduction/drug effects ; Up-Regulation/drug effects
    Chemical Substances Blood Glucose ; Glucose Transporter Type 4 ; Insulin ; Insulin Receptor Substrate Proteins ; Isothiocyanates ; Pyruvate Dehydrogenase Acetyl-Transferring Kinase ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; sulforaphane (GA49J4310U)
    Language English
    Publishing date 2018-08-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/c8fo00763b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Sulforaphane protects MLE-12 lung epithelial cells against oxidative damage caused by ambient air particulate matter

    Wang, An-Shi / Xu, Yan / Zhang, Zhuang-Wei / Lu, Bei-Bei / Yin, Xuan / Yao, An-Jun / Han, Li-Yuan / Zou, Zu-Quan / Li, Zhen / Zhang, Xiao-Hong

    Food & function. 2017 Dec. 13, v. 8, no. 12 p.4555-4562

    2017  

    Abstract: Ambient air particulate matter with aerodynamic diameters ≤2.5 μm (PM₂.₅) can cause pulmonary injury. Oxidative stress is thought to be an important mechanism of PM₂.₅-mediated toxicity. Sulforaphane (SFN), a compound derived from cruciferous vegetables, ...

    Abstract Ambient air particulate matter with aerodynamic diameters ≤2.5 μm (PM₂.₅) can cause pulmonary injury. Oxidative stress is thought to be an important mechanism of PM₂.₅-mediated toxicity. Sulforaphane (SFN), a compound derived from cruciferous vegetables, is a well-known potent antioxidant; however, its protective effect on lung epithelial cells exposed to PM₂.₅ is unclear. The results showed that SFN pre-treatment markedly inhibited PM₂.₅-induced apoptosis of the type II alveolar epithelial cell line MLE-12 by elevating glutathione S-transferase levels and decreasing reactive oxygen species. SFN pre-treatment down-regulated the expression of the pro-apoptotic proteins Bax and Bad, and reduced the activity of caspase-3, while it up-regulated the expression of the anti-apoptotic protein Bcl-2. Moreover, SFN induced the activation of the Akt and ERK pathways, and up-regulated the expression of Nrf2 and its downstream antioxidant genes NQO-1 and HO-1. This is the first study to demonstrate that SFN could protect MLE-12 cells against PM₂.₅-induced oxidative damage via activation of the Nrf2 pathway and inhibition of the mitochondrial apoptotic pathway; therefore, SFN may be a promising compound for preventing PM₂.₅-triggered pulmonary cell damage.
    Keywords Brassicaceae ; aerodynamics ; air ; antioxidant genes ; apoptosis ; caspase-3 ; cell lines ; epithelial cells ; gene expression regulation ; glutathione transferase ; lungs ; mitochondria ; mitogen-activated protein kinase ; oxidative stress ; particulates ; pro-apoptotic proteins ; protective effect ; reactive oxygen species ; sulforaphane ; toxicity ; vegetables
    Language English
    Dates of publication 2017-1213
    Size p. 4555-4562.
    Publishing place The Royal Society of Chemistry
    Document type Article ; Online
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/c7fo00969k
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  8. Article ; Online: Sulforaphane protects MLE-12 lung epithelial cells against oxidative damage caused by ambient air particulate matter.

    Wang, An-Shi / Xu, Yan / Zhang, Zhuang-Wei / Lu, Bei-Bei / Yin, Xuan / Yao, An-Jun / Han, Li-Yuan / Zou, Zu-Quan / Li, Zhen / Zhang, Xiao-Hong

    Food & function

    2017  Volume 8, Issue 12, Page(s) 4555–4562

    Abstract: Ambient air particulate matter with aerodynamic diameters ≤2.5 μm ( ... ...

    Abstract Ambient air particulate matter with aerodynamic diameters ≤2.5 μm (PM
    MeSH term(s) Animals ; Antioxidants/pharmacology ; Apoptosis/drug effects ; Caspase 3/genetics ; Caspase 3/metabolism ; Cell Line ; Epithelial Cells/cytology ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Glutathione Transferase/genetics ; Glutathione Transferase/metabolism ; Isothiocyanates/pharmacology ; Lung/cytology ; Lung/drug effects ; Lung/metabolism ; Mice ; Mitochondria/drug effects ; Mitochondria/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress/drug effects ; Particulate Matter/toxicity ; Protective Agents/pharmacology ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects
    Chemical Substances Antioxidants ; Isothiocyanates ; NF-E2-Related Factor 2 ; Particulate Matter ; Protective Agents ; Glutathione Transferase (EC 2.5.1.18) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Caspase 3 (EC 3.4.22.-) ; sulforaphane (GA49J4310U)
    Language English
    Publishing date 2017-11-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/c7fo00969k
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  9. Article: [Trends of overweight and obesity in aged 7 to 18 Mongolian ethnic children and adolescents from 1985-2010].

    Huang, Ze-yu / Buren, Ba-tu / Hasen, Gao-wa / Lin, Zhe / Li, Yong-shan / Zhang, Zhuang-wei / Tong, Wei-jun

    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

    2012  Volume 33, Issue 2, Page(s) 201–206

    Abstract: Objective: To study the overweight and obesity situation among Mongolian ethnic children and adolescents in the last 25 years and to provide a basis on related prevention and control measures.: Methods: A cross-sectional study was used, with 18 366 ... ...

    Abstract Objective: To study the overweight and obesity situation among Mongolian ethnic children and adolescents in the last 25 years and to provide a basis on related prevention and control measures.
    Methods: A cross-sectional study was used, with 18 366 aged 7 to 18 Mongolian ethnic children and adolescents involved. Surveys on their physical health, in 1985, 2000 and 2010 were carried out. Comparison on the mean of BMI and the prevalence rates of overweight and obesity in different years, genders, location of residence (urban or rural) was also made.
    Results: Over the past 25 years, among the aged 7 to 18 Mongolian ethnic children and adolescents, the overall trend on their means of BMI was increasing. The prevalence rates of overweight and obesity in Mongolian ethnic children and adolescents were 2.1%, 0.5% in 1985, and 6.3%, 2.4% in 2000, with an increase of 2 to 4 times during the last 15 years. The prevalence rates of overweight and obesity were substantially increasing in the year 2010, to have reached 9.1% and 6.6%, which were 4 to 12 times of the figures in 1985. The detection rates of overweight and obesity in urban boys were 1.2%, 0 in 1985, 7.9%, 3.4% in 2000 and 11.0%, 11.8% in 2010. However, the rate of obesity in the rural boys were 0.6% and 0.6% in 1985, 2.8%, 2.1% in 2000 and 9.0%, 3.4% in 2010. In 1985 the rates of overweight and obesity in urban girls were 1.8%, 0.3%, 8.1%, 4.3% in 2000 and 9.4%, 8.4% in 2010. However, among the rural girls, the prevalence rates of overweight and obesity prevalence was 8.8%, 2.2% in 1985, 4.5%, 0.9%, in 2000 and 10.2%, 4.5% in 2010. The rates of overweight and obesity among groups in different years showed significant differences (P < 0.05).
    Conclusion: Over the past 25 years, the prevalence rates on overweight and obesity increased significantly in Mongolian ethnic children and adolescents, and continued to rise, which called for reasonable and effective measures to be taken to prevent and control the occurrence of the problem.
    MeSH term(s) Adolescent ; Body Mass Index ; Child ; China/epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Male ; Minority Groups/statistics & numerical data ; Obesity/epidemiology ; Overweight/epidemiology ; Rural Population ; Urban Population
    Language Chinese
    Publishing date 2012-02
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 645026-x
    ISSN 0254-6450
    ISSN 0254-6450
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