Article: Rapid Access to Fluorinated Anilides via DAST-Mediated Deoxyfluorination of Arylhydroxylamines
Organic letters. 2021 Nov. 19, v. 23, no. 23
2021
Abstract: A new strategy for the synthesis of fluorinated anilides in the absence of metals and oxidants has been developed. This deoxyfluorination of N-arylhydroxylamines with diethylaminosulfur trifluoride (DAST) proceeded smoothly under mild conditions, and the ...
| Abstract | A new strategy for the synthesis of fluorinated anilides in the absence of metals and oxidants has been developed. This deoxyfluorination of N-arylhydroxylamines with diethylaminosulfur trifluoride (DAST) proceeded smoothly under mild conditions, and the ortho- or para-fluorinated aromatic amine products were prepared in moderate to good yields. Structurally diverse fluorinated anilides, including heterocyclic and pharmaceutically relevant molecules, can be efficiently constructed by this protocol. |
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| Keywords | anilides ; aromatic amines ; heterocyclic compounds ; metals ; oxidants |
| Language | English |
| Dates of publication | 2021-1119 |
| Size | p. 9332-9336. |
| Publishing place | American Chemical Society |
| Document type | Article |
| ISSN | 1523-7052 |
| DOI | 10.1021/acs.orglett.1c03779 |
| Database | NAL-Catalogue (AGRICOLA) |
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