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Article ; Online: Spatial-temporal distribution and source analysis of atmospheric particulate-bound cadmium from 1998 to 2021 in China.

Huang, Wei / Sun, Donglei / Zhao, Tianhe / Long, Keyan / Zhang, Zunzhen

2024 Volume 46, Issue 2, Page(s) 44

Abstract: Cadmium (Cd) is one of the most serious atmospheric heavy metal pollutants in China. ... ...

Abstract	Cadmium (Cd) is one of the most serious atmospheric heavy metal pollutants in China. PM
MeSH term(s)	Cadmium ; China ; Coal ; Dust ; Environmental Pollutants
Chemical Substances	Cadmium (00BH33GNGH) ; Coal ; Dust ; Environmental Pollutants
Language	English
Publishing date	2024-01-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	52039-1
ISSN	1573-2983 ; 0142-7245 ; 0269-4042
ISSN (online)	1573-2983
ISSN	0142-7245 ; 0269-4042
DOI	10.1007/s10653-023-01788-1
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Zs.A 4723: Show issues

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Article ; Online: Bacterial Contamination in the Different Parts of Household Washing Machine: New Insights from Chengdu, Western China.

Sun, Donglei / Sun, Weilian / Tang, Li / Huang, Wei / Zhang, Zunzhen

Current microbiology

2024 Volume 81, Issue 5, Page(s) 114

Abstract: The moist and warm environment in the household washing machine provides ideal living conditions for the growth and survival of various microorganisms. However, the biodiversity of bacterial community in the different parts of washing machine from ... ...

Abstract	The moist and warm environment in the household washing machine provides ideal living conditions for the growth and survival of various microorganisms. However, the biodiversity of bacterial community in the different parts of washing machine from Chinese households has not been clarified. In this study, we assessed the bacterial communities in sealing strip, detergent drawer, inner drum, water filter and greywater of ten domestic washing machines quantitatively and qualitatively in Chengdu, southwestern China. The microbial cultivation results indicated that the washing machines from Chengdu had a severe microbial contamination reflected by large counts on bacteria, fungi and coliform. Furthermore, the sequencing data showed that the different parts displayed distinctive bacterial compositions. At the level of genus, the anaerobic bacteria of Caproiciproducens and Acidipropionibacterium were predominant in sealing strip. Barnesiella, Shinella and Sellimonas were detected as the characteristic bacteria in detergent drawer. The pathogens of Luteibacter and Corynebacterium at the genus level were the dominant bacteria in inner drum and water filter, respectively. The genera of Azospira, Roseococcus, Elstera and Aquicella, which belonged to the pathogenic phylum of Proteobacteria, were identified as bioindicators for the greywater. Gene function analysis on the sequencing data illustrated that the bacteria from washing machines were potentially associated with bacterial infectious diseases and antimicrobial resistance. This study shows the bacterial diversity in the different parts of washing machines, providing new clues for bacterial contamination in washing machines from Chinese households.
MeSH term(s)	Detergents ; Bacteria ; Proteobacteria ; Bacteroidetes ; Water
Chemical Substances	Detergents ; Water (059QF0KO0R)
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-024-03630-y
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Zs.A 1446: Show issues

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Article ; Online: Triclosan targeting of gut microbiome ameliorates hepatic steatosis in high fat diet-fed mice.

Sun, Donglei / Zuo, Chao / Huang, Wei / Wang, Jingjing / Zhang, Zunzhen

The Journal of antibiotics

2022 Volume 75, Issue 6, Page(s) 341–353

Abstract: Antibiotic use provides a promising strategy for the treatment of non-alcoholic fatty liver disease (NAFLD) by regulating the gut microbiota composition. Triclosan, a widely used antibiotic, may improve gut microbiome dysbiosis associated with NAFLD ... ...

Abstract	Antibiotic use provides a promising strategy for the treatment of non-alcoholic fatty liver disease (NAFLD) by regulating the gut microbiota composition. Triclosan, a widely used antibiotic, may improve gut microbiome dysbiosis associated with NAFLD through the suppression of pathogenic gram-negative bacteria. However, the effects of triclosan on gut microbiota and hepatic steatosis and have not been explored in NAFLD mouse model. In this study, C57BL/6J mice were fed with high fat diet (HFD) for continuous 20 weeks and treated with triclosan at 400 mg/kg/d for 8 weeks from week 13. We explored the effects of triclosan on hepatic lipid accumulation and gut microbiome in HFD-fed mice by histological examination and 16 S ribosomal RNA sequencing, respectively. Analysis on the composition of gut microbiota indicated that triclosan suppressed pathogenic gram-negative bacteria, including Helicobacter, Erysipelatoclostridium and Citrobacter, and increased the ratio of Bacteroidetes/Firmicutes in HFD-fed mice. Meanwhile, triclosan increased the relative abundance of beneficial gut microbiomes including Lactobacillus, Bifidobacterium and Lachnospiraceae, which protected against metabolic abnormality. The results of alpha-diversity and beta-diversity also showed the improvement of triclosan on bacterial diversity and richness in HFD-fed mice. Pathway analysis further confirmed that triclosan can regulate nutrient and energy metabolism through the elimination of deleterious bacteria. As a result, triclosan intervention significantly reduced lipid accumulation and alleviated hepatic steatosis in HFD-fed mice. In conclusion, our results suggest that triclosan can alleviate liver steatosis in HFD-fed mice by targeting the gut microbiome.
MeSH term(s)	Animals ; Anti-Bacterial Agents/metabolism ; Anti-Bacterial Agents/pharmacology ; Bacteria/genetics ; Diet, High-Fat/adverse effects ; Gastrointestinal Microbiome/genetics ; Lipids ; Liver/metabolism ; Liver/pathology ; Mice ; Mice, Inbred C57BL ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/metabolism ; Non-alcoholic Fatty Liver Disease/microbiology ; Triclosan/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Lipids ; Triclosan (4NM5039Y5X)
Language	English
Publishing date	2022-04-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390800-8
ISSN	1881-1469 ; 0021-8820 ; 0368-3532
ISSN (online)	1881-1469
ISSN	0021-8820 ; 0368-3532
DOI	10.1038/s41429-022-00522-w
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Zs.A 207: Show issues

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Article ; Online: Oxidative Stress Induced by Arsenite is Involved in YTHDF2 Phase Separation.

Man, Jin / Zhang, Qian / Zhao, Tianhe / Sun, Donglei / Sun, Weilian / Long, Keyan / Zhang, Zunzhen

Biological trace element research

2023 Volume 202, Issue 3, Page(s) 885–899

Abstract: ... YTH ... ...

Abstract	YTH N
MeSH term(s)	Humans ; Acetylcysteine/pharmacology ; Arsenites/toxicity ; Phase Separation ; Oxidative Stress ; RNA-Binding Proteins/genetics
Chemical Substances	Acetylcysteine (WYQ7N0BPYC) ; arsenite (N5509X556J) ; Arsenites ; YTHDF2 protein, human ; RNA-Binding Proteins
Language	English
Publishing date	2023-06-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-023-03728-7
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Zs.B 2323: Show issues

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Article ; Online: N

Zhao, Tianhe / Sun, Donglei / Long, Keyan / Xiong, Wenxiao / Man, Jin / Zhang, Qian / Zhang, Zunzhen

Journal of hazardous materials

2023 Volume 465, Page(s) 133329

Abstract: ... ...

Abstract	N
MeSH term(s)	Humans ; Antioxidants/metabolism ; Arsenic/toxicity ; Reactive Oxygen Species/metabolism ; Superoxide Dismutase-1/metabolism ; Carcinogenesis/chemically induced ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Oxidation-Reduction ; Homeostasis ; Methyltransferases/metabolism ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/metabolism ; Adenosine/analogs & derivatives
Chemical Substances	Antioxidants ; Arsenic (N712M78A8G) ; Reactive Oxygen Species ; Superoxide Dismutase-1 (EC 1.15.1.1) ; N-methyladenosine (CLE6G00625) ; METTL3 protein, human (EC 2.1.1.62) ; Methyltransferases (EC 2.1.1.-) ; FTO protein, human (EC 1.14.11.33) ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO (EC 1.14.11.33) ; Adenosine (K72T3FS567)
Language	English
Publishing date	2023-12-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2023.133329
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Article ; Online: China's drinking water sanitation from 2007 to 2018: A systematic review

Wang, Ting / Sun, Donglei / Zhang, Qian / Zhang, Zunzhen

Science of the Total Environment. 2021 Feb., v. 757 p.143923-

2021

Abstract: Regular monitoring of drinking water in China is carried out by the Centers for Disease Control and Prevention at all levels and some articles were published for the public to understand the status of drinking water. However, these published articles ... ...

Abstract	Regular monitoring of drinking water in China is carried out by the Centers for Disease Control and Prevention at all levels and some articles were published for the public to understand the status of drinking water. However, these published articles were limited to small areas and reported almost exclusively in Chinese. In order to give the public a comprehensive understanding of the situation of drinking water sanitation in China and provide specific directions for ensuring drinking water safety in the future, we review the sanitation status of drinking water in different regions of China from 2007 to 2018, the changes over time and the factors affecting drinking water quality by means of systematic review for the first time. Our results show that the quality of drinking water in China has shown an upward trend from 2007 to 2018. The qualification rate of urban drinking water (85.51%) was much higher than that of rural drinking water (51.12%), and the dry season (56.93%) was higher than the wet season (50.54%), and the terminal tap water (59.88%) was higher than the outlet water of waterworks (55.87%). In addition, the regions with low qualification rate of water quality in China were mainly distributed in several southern provinces, such as Yunnan, Guizhou, Hainan, etc. What's more, the qualified rate of the three microbiological indicators was the lowest, all below 85%. All the results indicate that the sanitation status of drinking water in China is unsatisfactory, and the biggest risk affecting water safety is microbial pollution. The central and local governments should work hard to improve people's drinking water quality and continue to strengthen the treatment and supervision of drinking water, especially in rural areas and undeveloped southern areas.
Keywords	dry season ; environment ; pollution ; risk ; sanitation ; systematic review ; tap water ; water quality ; water utilities ; wet season ; China ; Drinking water ; Sanitation status
Language	English
Dates of publication	2021-02
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2020.143923
Database	NAL-Catalogue (AGRICOLA)

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Z 74/341: Show issues

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Article ; Online: N6-methyladenosine upregulates ribosome biogenesis in environmental carcinogenesis

Zhao, Tianhe / Sun, Donglei / Long, Keyan / Lemos, Bernardo / Zhang, Qian / Man, Jin / Zhao, Manyu / Zhang, Zunzhen

Science of the Total Environment. 2023 July, v. 881 p.163428-

2023

Abstract: Many trace metal pollutants in surface water, the atmosphere, and soil are carcinogenic, and ribosome biogenesis plays an important role in the carcinogenicity of heavy metals. However, the contradiction between upregulated ribosome biogenesis and ... ...

Abstract	Many trace metal pollutants in surface water, the atmosphere, and soil are carcinogenic, and ribosome biogenesis plays an important role in the carcinogenicity of heavy metals. However, the contradiction between upregulated ribosome biogenesis and decreased ribosomal DNA copy number in environmental carcinogenesis is not fully understood. Here, from a perspective of the most predominant and abundant RNA epigenetic modification, N⁶-methyladenosine (m⁶A), we explored the reason behind this contradiction at the post-transcriptional level using arsenite-induced skin carcinogenesis models both in vitro and in vivo. Based on the m⁶A microarray assay and a series of experiments, we found for the first time that the elevated m⁶A in arsenite-induced transformation is mainly enriched in the genes regulating ribosome biogenesis. m⁶A upregulates ribosome biogenesis post-transcriptionally by stabilizing ribosomal proteins and modulating non-coding RNAs targeting ribosomal RNAs and proteins, leading to arsenite-induced skin carcinogenesis. Using multi-omics analysis of human subjects and experimental validation, we identified an unconventional role of a well-known key proliferative signaling node AKT1 as a vital mediator between m⁶A and ribosome biogenesis in arsenic carcinogenesis. m⁶A activates AKT1 and transmits proliferative signals to ribosome biogenesis, exacerbating the upregulation of ribosome biogenesis in arsenite-transformed keratinocytes. Similarly, m⁶A promotes cell proliferation by upregulating ribosome biogenesis in cell transformation induced by carcinogenic heavy metals (chromium and nickel). Importantly, inhibiting m⁶A reduces ribosome biogenesis. Targeted inhibition of m⁶A-upregulated ribosome biogenesis effectively prevents cell transformation induced by trace metals (arsenic, chromium, and nickel). Our results reveal the mechanism of ribosome biogenesis upregulated by m⁶A in the carcinogenesis of trace metal pollutants. From the perspective of RNA epigenetics, our study improves our understanding of the contradiction between upregulated ribosome biogenesis and decreased ribosomal DNA copy number in the carcinogenesis of environmental carcinogens.
Keywords	RNA ; arsenic ; biogenesis ; carcinogenesis ; carcinogenicity ; cell proliferation ; chromium ; environment ; epigenetics ; humans ; keratinocytes ; microarray technology ; multiomics ; nickel ; ribosomal DNA ; ribosomes ; soil ; surface water ; Heavy metal contaminants ; m6A ; Ribosomal proteins ; AKT1
Language	English
Dates of publication	2023-07
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.163428
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Article ; Online: Linc-ROR promotes arsenite-transformed keratinocyte proliferation by inhibiting P53 activity.

Li, Xinyang / Zuo, Chao / Wu, Mei / Zhang, Zunzhen

Metallomics : integrated biometal science

2020 Volume 12, Issue 6, Page(s) 963–973

Abstract: Linc-ROR is an oncogenic long non-coding RNA over-expressed in many kinds of cancer that promotes cancer cell proliferation. Arsenite is a determined carcinogen that increases the risk of skin cancer, but the carcinogenic mechanism of arsenite remains ... ...

Abstract	Linc-ROR is an oncogenic long non-coding RNA over-expressed in many kinds of cancer that promotes cancer cell proliferation. Arsenite is a determined carcinogen that increases the risk of skin cancer, but the carcinogenic mechanism of arsenite remains unclear. To explore whether and how linc-ROR plays a role in arsenite-induced carcinogenesis of skin cancer, we established arsenite-transformed keratinocyte HaCaT cells by exposing them to 1 μM arsenite for 50 passages. Then we examined the linc-ROR expression during the transformation and explored the effect of linc-ROR on the cell proliferation of arsenite-transformed HaCaT cells. We found that the linc-ROR level in HaCaT cells was gradually increased during arsenite-induced malignant transformation, and the activity of P53 was decreased, but the P53 expression was not significantly altered, indicating that linc-ROR may play a role in arsenite-induced HaCaT cell transformation that is associated with P53 activity but not P53 expression. We further demonstrated that linc-ROR down-regulation by siRNA significantly inhibited the cellular proliferation and restored P53 activity in arsenite-transformed HaCaT cells, suggesting that linc-ROR promotes proliferation of arsenite-transformed HaCaT cells by inhibiting P53 activity. Moreover, linc-ROR siRNA also down-regulated the PI3K/AKT pathway in arsenite-transformed HaCaT cells, and treatment with AKT inhibitor wortmannin restored P53 activity, implying that linc-ROR inhibits P53 activity by activating the PI3K/AKT pathway. Taken together, the present study shows that linc-ROR promotes arsenite-transformed keratinocyte proliferation by inhibiting P53 activity through activating PI3K/AKT, providing a novel carcinogenic mechanism of arsenite-induced skin cancer.
MeSH term(s)	Arsenites/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Humans ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; RNA, Small Interfering/metabolism ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism
Chemical Substances	Arsenites ; RNA, Small Interfering ; Tumor Suppressor Protein p53 ; arsenite (N5509X556J)
Language	English
Publishing date	2020-05-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2474317-3
ISSN	1756-591X ; 1756-5901
ISSN (online)	1756-591X
ISSN	1756-5901
DOI	10.1039/d0mt00076k
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Article ; Online: China's drinking water sanitation from 2007 to 2018: A systematic review.

Wang, Ting / Sun, Donglei / Zhang, Qian / Zhang, Zunzhen

The Science of the total environment

2020 Volume 757, Page(s) 143923

Abstract	Regular monitoring of drinking water in China is carried out by the Centers for Disease Control and Prevention at all levels and some articles were published for the public to understand the status of drinking water. However, these published articles were limited to small areas and reported almost exclusively in Chinese. In order to give the public a comprehensive understanding of the situation of drinking water sanitation in China and provide specific directions for ensuring drinking water safety in the future, we review the sanitation status of drinking water in different regions of China from 2007 to 2018, the changes over time and the factors affecting drinking water quality by means of systematic review for the first time. Our results show that the quality of drinking water in China has shown an upward trend from 2007 to 2018. The qualification rate of urban drinking water (85.51%) was much higher than that of rural drinking water (51.12%), and the dry season (56.93%) was higher than the wet season (50.54%), and the terminal tap water (59.88%) was higher than the outlet water of waterworks (55.87%). In addition, the regions with low qualification rate of water quality in China were mainly distributed in several southern provinces, such as Yunnan, Guizhou, Hainan, etc. What's more, the qualified rate of the three microbiological indicators was the lowest, all below 85%. All the results indicate that the sanitation status of drinking water in China is unsatisfactory, and the biggest risk affecting water safety is microbial pollution. The central and local governments should work hard to improve people's drinking water quality and continue to strengthen the treatment and supervision of drinking water, especially in rural areas and undeveloped southern areas.
MeSH term(s)	China ; Drinking Water ; Humans ; Rural Population ; Sanitation ; Water Quality ; Water Supply
Chemical Substances	Drinking Water
Language	English
Publishing date	2020-12-03
Publishing country	Netherlands
Document type	Journal Article ; Systematic Review
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2020.143923
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Zs.A 949: Show issues

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Article ; Online: Long non-coding RNA ROR confers arsenic trioxide resistance to HepG2 cells by inhibiting p53 expression.

Li, Xinyang / Sun, Donglei / Zhao, Tianhe / Zhang, Zunzhen

European journal of pharmacology

2020 Volume 872, Page(s) 172982

Abstract: Arsenic trioxide is an effective drug in the treatment of hematologic malignancies, but it has no obvious therapeutic effect on liver cancer. Long non-coding RNA ROR is a newly found long-noncoding RNA that has been reported to get involved in the ... ...

Abstract	Arsenic trioxide is an effective drug in the treatment of hematologic malignancies, but it has no obvious therapeutic effect on liver cancer. Long non-coding RNA ROR is a newly found long-noncoding RNA that has been reported to get involved in the regulation of chemo-resistance in multiple cancers. However, whether and how long non-coding RNA ROR gets involved in the resistance to arsenic trioxide in liver cancer has not been explored. In this study, We found that cellular apoptosis was increased by arsenic trioxide in liver cancer HepG2 cells; P53 expression was also increased by arsenic trioxide at both mRNA level and protein level, indicating that P53-dependent apoptosis is the main mechanism for arsenic trioxide to induce cytotoxicity in liver cancer HepG2 cells. Meanwhile, we found an obvious increase in the level of long non-coding RNA ROR in arsenic trioxide-treated HepG2 cells. By measuring the level of reactive oxygen species, glutathione, superoxide dismutase, and malondialdehyde, the product of lipid peroxidation, we further demonstrated that oxidative stress was a potential factor for both the activation of P53 expression and the increase in long non-coding RNA ROR expression. Through the knock-down of long non-coding RNA ROR by siRNA, we revealed that the activated long non-coding RNA ROR ameliorated arsenic trioxide-induced apoptosis by inhibiting P53 expression. Together, our study reported that long non-coding RNA ROR conferred arsenic trioxide resistance to liver cancer cells through inhibiting P53 expression, and long non-coding RNA ROR might be a novel sensitizing target for liver cancer treatment.
MeSH term(s)	Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Apoptosis/genetics ; Arsenic Trioxide/pharmacology ; Arsenic Trioxide/therapeutic use ; Drug Resistance, Neoplasm/genetics ; Gene Knockdown Techniques ; Hep G2 Cells ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; RNA, Small Interfering/metabolism ; Tumor Suppressor Protein p53/genetics
Chemical Substances	Antineoplastic Agents ; Linc-RNA-RoR, human ; RNA, Long Noncoding ; RNA, Small Interfering ; TP53 protein, human ; Tumor Suppressor Protein p53 ; Arsenic Trioxide (S7V92P67HO)
Language	English
Publishing date	2020-02-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2020.172982
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