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  1. Book ; Online ; E-Book: Analyzing high-dimensional gene expression and DNA methylation data with R

    Zhang, Hongmei

    (Chapman & Hall/CRC computational biology series)

    2020  

    Author's details Hongmei Zhang
    Series title Chapman & Hall/CRC computational biology series
    Keywords Gene expression/Statistical methods ; Gene expression/Data processing ; DNA/Methylation ; Epigenetics/Statistical methods ; R (Computer program language)
    Subject code 572.865015195
    Language English
    Size 1 Online-Ressource (xii, 190 Seiten), Illustrationen, Diagramme
    Edition First edition
    Publisher CRC Press, Taylor & Francis Group
    Publishing place Boca Raton
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020472824
    ISBN 978-0-429-15519-2 ; 9781498772594 ; 9780367495169 ; 0-429-15519-0 ; 1498772595 ; 0367495163
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Preparation, Characterization, and Lubrication Performances of Water-Based Nanolubricant for Micro Rolling Strips.

    Zhu, Yuchuan / Zhang, Hongmei / Li, Na / Jiang, Zhengyi

    Materials (Basel, Switzerland)

    2024  Volume 17, Issue 2

    Abstract: Water-based nanolubricants are widely used in rolling processes due to their unique characteristics. As a common additive, nanoparticles could significantly improve the tribological properties of the lubricant. However, the effect of the physical ... ...

    Abstract Water-based nanolubricants are widely used in rolling processes due to their unique characteristics. As a common additive, nanoparticles could significantly improve the tribological properties of the lubricant. However, the effect of the physical properties of the particles on the anti-friction behavior is unclear. In this study, the effect of Fe
    Language English
    Publishing date 2024-01-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17020516
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Gbdmr: identifying differentially methylated CpG regions in the human genome via generalized beta regressions.

    Wu, Chengzhou / Mou, Xichen / Zhang, Hongmei

    BMC bioinformatics

    2024  Volume 25, Issue 1, Page(s) 97

    Abstract: Background: DNA methylation is a biochemical process in which a methyl group is added to the cytosine-phosphate-guanine (CpG) site on DNA molecules without altering the DNA sequence. Multiple CpG sites in a certain genome region can be differentially ... ...

    Abstract Background: DNA methylation is a biochemical process in which a methyl group is added to the cytosine-phosphate-guanine (CpG) site on DNA molecules without altering the DNA sequence. Multiple CpG sites in a certain genome region can be differentially methylated across phenotypes. Identifying these differentially methylated CpG regions (DMRs) associated with the phenotypes contributes to disease prediction and precision medicine development.
    Results: We propose a novel DMR detection algorithm, gbdmr. In contrast to existing methods under a linear regression framework, gbdmr assumes that DNA methylation levels follow a generalized beta distribution. We compare gbdmr to alternative approaches via simulations and real data analyses, including dmrff, a new DMR detection approach that shows promising performance among competitors, and the traditional EWAS that focuses on single CpG sites. Our simulations demonstrate that gbdmr is superior to the other two when the correlation between neighboring CpG sites is strong, while dmrff shows a higher power when the correlation is weak. We provide an explanation of these phenomena from a theoretical perspective. We further applied the three methods to multiple real DNA methylation datasets. One is from a birth cohort study undertaken on the Isle of Wight, United Kingdom, and the other two are from the Gene Expression Omnibus database repository. Overall, gbdmr identifies more DMR CpGs linked to phenotypes than dmrff, and the simulated results support the findings.
    Conclusions: Gbdmr is an innovative method for detecting DMRs based on generalized beta regression. It demonstrated notable advantages over dmrff and traditional EWAS, particularly when adjacent CpGs exhibited moderate to strong correlations. Our real data analyses and simulated findings highlight the reliability of gbdmr as a robust DMR detection tool. The gbdmr approach is accessible and implemented by R on GitHub: https://github.com/chengzhouwu/gbdmr .
    MeSH term(s) Humans ; Genome, Human ; Phosphates ; Cohort Studies ; Reproducibility of Results ; Cytosine ; Guanine
    Chemical Substances Phosphates ; Cytosine (8J337D1HZY) ; Guanine (5Z93L87A1R)
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041484-5
    ISSN 1471-2105 ; 1471-2105
    ISSN (online) 1471-2105
    ISSN 1471-2105
    DOI 10.1186/s12859-024-05711-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Moral Dilemmas Regarding Physical Restraints in Intensive Care Units: Understanding Autonomy, Beneficence, Non-Maleficence and Justice in the Use of Physical Restraints.

    Zhou, Junya / Qin, Qingzhu / Chen, Songge / Zhang, Hongmei

    Journal of multidisciplinary healthcare

    2024  Volume 17, Page(s) 1619–1627

    Abstract: In intensive care units, patients are often restrained to ensure their safety, with physical restraints being the most commonly used method. However, physical restraints compromises the patient's freedom, health and comfort, and nurses often face moral ... ...

    Abstract In intensive care units, patients are often restrained to ensure their safety, with physical restraints being the most commonly used method. However, physical restraints compromises the patient's freedom, health and comfort, and nurses often face moral dilemmas when deciding whether to use physical restraints. This article examines physical restraints through the four universal principles of autonomy, beneficence, non-maleficence and justice. Through these principles, the authors will critically explore whether the physical restraints of patients by nurses is ethical in practice and what moral issues exist. This paper also explores conflicts and moral dilemmas for nurses in this context. Finally, suggestions are made on changes to education and clinical practice.
    Language English
    Publishing date 2024-04-12
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2453343-9
    ISSN 1178-2390
    ISSN 1178-2390
    DOI 10.2147/JMDH.S455910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Sugar-coated bullets: Unveiling the enigmatic mystery 'sweet arsenal' in osteoarthritis.

    Liu, Hong-Zhi / Song, Xin-Qiu / Zhang, Hongmei

    Heliyon

    2024  Volume 10, Issue 6, Page(s) e27624

    Abstract: Glycosylation is a crucial post-translational modification process where sugar molecules (glycans) are covalently linked to proteins, lipids, or other biomolecules. In this highly regulated and complex process, a series of enzymes are involved in adding, ...

    Abstract Glycosylation is a crucial post-translational modification process where sugar molecules (glycans) are covalently linked to proteins, lipids, or other biomolecules. In this highly regulated and complex process, a series of enzymes are involved in adding, modifying, or removing sugar residues. This process plays a pivotal role in various biological functions, influencing the structure, stability, and functionality of the modified molecules. Glycosylation is essential in numerous biological processes, including cell adhesion, signal transduction, immune response, and biomolecular recognition. Dysregulation of glycosylation is associated with various diseases. Glycation, a post-translational modification characterized by the non-enzymatic attachment of sugar molecules to proteins, has also emerged as a crucial factor in various diseases. This review comprehensively explores the multifaceted role of glycation in disease pathogenesis, with a specific focus on its implications in osteoarthritis (OA). Glycosylation and glycation alterations wield a profound influence on OA pathogenesis, intertwining with disease onset and progression. Diverse studies underscore the multifaceted role of aberrant glycosylation in OA, particularly emphasizing its intricate relationship with joint tissue degradation and inflammatory cascades. Distinct glycosylation patterns, including N-glycans and O-glycans, showcase correlations with inflammatory cytokines, matrix metalloproteinases, and cellular senescence pathways, amplifying the degenerative processes within cartilage. Furthermore, the impact of advanced glycation end-products (AGEs) formation in OA pathophysiology unveils critical insights into glycosylation-driven chondrocyte behavior and extracellular matrix remodeling. These findings illuminate potential therapeutic targets and diagnostic markers, signaling a promising avenue for targeted interventions in OA management. In this comprehensive review, we aim to thoroughly examine the significant impact of glycosylation or AGEs in OA and explore its varied effects on other related conditions, such as liver-related diseases, immune system disorders, and cancers, among others. By emphasizing glycosylation's role beyond OA and its implications in other diseases, we uncover insights that extend beyond the immediate focus on OA, potentially revealing novel perspectives for diagnosing and treating OA.
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The causal relationship between psoriasis and artificial joint re-operation after arthroplasty: A two-sample Mendelian randomization study.

    Liu, Hongzhi / Song, Xinqiu / Li, Chuiqing / Zhang, Hongmei

    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)

    2024  Volume 30, Issue 1, Page(s) e13560

    Abstract: Background: Psoriasis is observationally associated with a higher risk of complications of arthroplasty; however, the causal effects of psoriasis on complications of arthroplasty are yet to be established. This study was to explore the causal effect of ... ...

    Abstract Background: Psoriasis is observationally associated with a higher risk of complications of arthroplasty; however, the causal effects of psoriasis on complications of arthroplasty are yet to be established. This study was to explore the causal effect of psoriasis on artificial joint re-operation after arthroplasty through two-sample Mendelian randomization (MR).
    Methods: In the MR analysis, psoriasis was selected as the exposure in this study while single-nucleotide polymorphisms (SNPs) from a genome-wide association study (GWAS) were selected as the instrumental variables (IVs). Summary statistics data on artificial joint re-operation was extracted from publicly available GWAS data, including 218 792 European descent individuals. MR analysis was performed using the standard inverse variance weighted method (IVW). Furthermore, MR Egger, weighted median, simple mode, weighted mode, and the MR-PRESSO (Mendelian Randomization Pleiotropy Residual Sum and Outlier) test were also done to verify the results. Finally, the sensitivity analysis was executed.
    Results: The IVW showed that psoriasis increases the risk of artificial joint re-operation (OR = 1.12; 95% CI = (1.01, 1.25); p = 0.036). This outcome was also verified by other methods including weighted median (OR = 1.16; 95% CI = (1.03, 1.31); p = 0.015), MR Egger (OR = 1.22; 95% CI = (1.03, 1.44); p = 0.038), and weighted mode (OR = 1.16; 95% CI = (1.03, 1.30); p = 0.025). No heterogeneity and directional pleiotropy were observed upon sensitivity analysis.
    Conclusion: The present study showed that psoriasis has a potential causal effect on artificial joint re-operation after arthroplasty. Further studies are warranted to elucidate the underlying mechanisms of causal associations between psoriasis on re-operation.
    MeSH term(s) Humans ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Arthroplasty ; Psoriasis/genetics ; Psoriasis/surgery
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1229160-2
    ISSN 1600-0846 ; 0909-752X ; 1397-1344
    ISSN (online) 1600-0846
    ISSN 0909-752X ; 1397-1344
    DOI 10.1111/srt.13560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4278: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Humanistic quality teaching reform of material science

    Ma Zhuang / Cheng Zhifang / Gao Lihong / Zhang Hongmei

    SHS Web of Conferences, Vol 153, p

    2023  Volume 01022

    Abstract: How to play the role of humanistic quality education in Material major courses? This paper discusses the design ideas and specific implementation methods of integrating Curriculum humanistic quality into the teaching of material science from three ... ...

    Abstract How to play the role of humanistic quality education in Material major courses? This paper discusses the design ideas and specific implementation methods of integrating Curriculum humanistic quality into the teaching of material science from three aspects: curriculum knowledge objectives and ability objective, strategies of curriculum teaching methods, course expected learning results. After humanistic quality teaching reform of the basic course of material science, professional knowledge points and ideological and political elements are integrated, and the teaching platform, students' real feelings and the power of humanistic quality elements are coordinated.
    Keywords Social Sciences ; H
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: COVID-19 Infection May Cause Thyroid Dysfunction

    Zhang, Hongmei

    SSRN Electronic Journal ; ISSN 1556-5068

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.2139/ssrn.3670913
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Recent advances in primary resistance mechanisms against immune checkpoint inhibitors.

    Li, Yi-Ze / Zhang, Hong-Mei

    Current opinion in oncology

    2022  Volume 34, Issue 1, Page(s) 95–106

    Abstract: Purpose of review: The resistance of immune checkpoint inhibitors (ICIs) has become an obstacle to further improve the survival of patients with advanced cancer. This review provides an overview of recent advances in primary resistance mechanisms of ... ...

    Abstract Purpose of review: The resistance of immune checkpoint inhibitors (ICIs) has become an obstacle to further improve the survival of patients with advanced cancer. This review provides an overview of recent advances in primary resistance mechanisms of ICIs.
    Recent findings: With the improvement of study approach, new characteristics and trends have emerged in the classification of tumor immune subtypes. The effects of germline genetic on tumor microenvironment and the efficacy of immunotherapy have been further studied. Exosomal programmed death-ligand 1 (PD-L1) is an increasing focus of research in primary resistance mechanisms of ICIs. In addition to antibiotics and steroids, the influence of other concomitant medications on the efficacy of ICIs has recently gained more attention.
    Summary: Exploring the resistance mechanisms of ICIs is one of the great challenges in the field of tumor immunotherapy. Continued work to understand the resistance mechanism of ICIs is ongoing.
    MeSH term(s) Humans ; Immune Checkpoint Inhibitors ; Immunotherapy ; Neoplasms/drug therapy ; Programmed Cell Death 1 Receptor ; Tumor Microenvironment
    Chemical Substances Immune Checkpoint Inhibitors ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2022-06-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1049384-0
    ISSN 1531-703X ; 1040-8746
    ISSN (online) 1531-703X
    ISSN 1040-8746
    DOI 10.1097/CCO.0000000000000802
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3046: Show issues Location:
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  10. Article ; Online: Resistance analysis of grape Botrytis cinerea based on PCR and sequencing technology.

    Zhang, Hongmei / Jiang, Huimin

    Cellular and molecular biology (Noisy-le-Grand, France)

    2022  Volume 67, Issue 6, Page(s) 181–190

    Abstract: Resistance of grape Botrytis cinerea was analyzed based on PCR and sequencing technology, which provided a reasonable basis for guiding the species and usage of grape Botrytis cinerea. 104 monospora strains of grape B. cinerea were collected from the ... ...

    Abstract Resistance of grape Botrytis cinerea was analyzed based on PCR and sequencing technology, which provided a reasonable basis for guiding the species and usage of grape Botrytis cinerea. 104 monospora strains of grape B. cinerea were collected from the main grape-producing areas of China. After isolation and purification, the grape B. cinerea DNA was extracted, and PCR primers were designed according to the resistance mechanism of pyrimethene to pyrimethamines, pyridamines and diformolines. Sequence analysis showed that the resistance frequency of B. cinerea to pyrimidine was 22.22%-62.5%, the high-resistant strain frequency was 44.23%, and the mid-temperature zone was 62.5%. The total resistance rate of B. cinerea to pyrimidine was 42.60%. The resistance rate of B. cinerea to pyrimidine was 42.60%. Resistance frequencies of grape gray mold strains were significantly different. The resistance frequencies of grape gray mold strains to pyridimide were significant. The highest resistance frequencies of grape gray mold strains were 53.42% in the cool temperature zone. Only 3.85% of grape gray mold strains showed resistance to pyridimide. Therefore, the resistance of Grape B. cinerea to pyrimidine and pyrimidine is relatively common, and the resistance to enoylmorpholine is still in the initial stage.
    MeSH term(s) Botrytis ; Plant Diseases/genetics ; Polymerase Chain Reaction ; Pyrimidines ; Sequence Analysis ; Technology ; Vitis
    Chemical Substances Pyrimidines
    Language English
    Publishing date 2022-02-27
    Publishing country France
    Document type Journal Article
    ZDB-ID 1161779-2
    ISSN 1165-158X ; 0145-5680
    ISSN (online) 1165-158X
    ISSN 0145-5680
    DOI 10.14715/cmb/2021.67.6.25
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3812: Show issues Location:
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