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Article ; Online: New progress in research and prevention of respiratory syncytial virus infection in children

REN Shaolong / ZHAO Genming

Shanghai yufang yixue, Vol 34, Iss 11, Pp 1158-

2022 Volume 1164

Abstract: Respiratory syncytial virus （RSV） is the most important viral pathogen causing acute lower respiratory tract infections in children under 5 years of age and poses a serious threat to infant health. After more than 60 years， the development of RSV ... ...

Abstract	Respiratory syncytial virus （RSV） is the most important viral pathogen causing acute lower respiratory tract infections in children under 5 years of age and poses a serious threat to infant health. After more than 60 years， the development of RSV vaccines and monoclonal antibodies has been moving forward amid bumps. Recently， several RSV vaccines and monoclonal antibodies have entered phase Ш clinical trials， which brings light to the prevention of RSV. We reviewed the new progress in research and prevention of RSV， so as to provide help for the prevention and control of RSV.
Keywords	respiratory syncytial virus ; vaccine ; monoclonal antibody ; surveillance ; Medicine ; R
Language	Chinese
Publishing date	2022-11-01T00:00:00Z
Publisher	Shanghai Preventive Medicine Association
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Association of Surrogates of Insulin Resistance with Hyperuricemia among Middle-Aged and Older Individuals: A Population-Based Nationwide Cohort Study.

Han, Yutong / Zhou, Zonglei / Zhang, Yuge / Zhao, Genming / Xu, Biao

Nutrients

2023 Volume 15, Issue 14

Abstract: The triglyceride-glucose (TyG) index, triglyceride-to-high-density-lipoprotein-cholesterol (TG/HDL-C) ratio, metabolic score for insulin resistance (METS-IR) and TyG with body mass index (TyG-BMI) have been proposed as indicators of insulin resistance ( ... ...

Abstract	The triglyceride-glucose (TyG) index, triglyceride-to-high-density-lipoprotein-cholesterol (TG/HDL-C) ratio, metabolic score for insulin resistance (METS-IR) and TyG with body mass index (TyG-BMI) have been proposed as indicators of insulin resistance (IR). This study aimed to explore the association between these IR surrogates and their longitudinal variation with the development of hyperuricemia in a middle-aged and older Chinese population. Data from the China Health and Retirement Longitudinal Study (CHARLS) was used to identify 5269 participants aged ≥45 years. Logistic regression was used to assess the effect of IR surrogates and their variations on the risk of hyperuricemia. After four years of follow-up, 517 (9.81%) participants developed incident hyperuricemia. Increased baseline values of TyG, TG/HDL, METS-IR, and TyG-BMI were all significantly associated with higher risks of hyperuricemia. Compared to individuals with maintained low levels of IR surrogates, those with low-to-high and maintained high variation patterns had a significantly higher risk of hyperuricemia. These four IR surrogates have comparable predictive ability for hyperuricemia. This study provides evidence of the associations between IR and hyperuricemia. Early intervention among middle-aged and elderly Chinese individuals with high IR levels may effectively reduce the burden of hyperuricemia.
MeSH term(s)	Middle Aged ; Aged ; Humans ; Insulin Resistance ; Hyperuricemia/epidemiology ; Longitudinal Studies ; Cohort Studies ; Blood Glucose/metabolism ; Biomarkers ; Glucose ; Triglycerides ; Cholesterol, HDL
Chemical Substances	Blood Glucose ; Biomarkers ; Glucose (IY9XDZ35W2) ; Triglycerides ; Cholesterol, HDL
Language	English
Publishing date	2023-07-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15143139
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Disease Burden of Meningitis Caused by Streptococcus pneumoniae Among Under-Fives in China: A Systematic Review and Meta-analysis.

Wang, Biying / Lin, Wanjing / Qian, Chen / Zhang, Youyi / Zhao, Genming / Wang, Weibing / Zhang, Tao

Infectious diseases and therapy

2023 Volume 12, Issue 11, Page(s) 2567–2580

Abstract: Introduction: Streptococcus pneumoniae is the leading cause of meningitis, with a case fatality of up to about 50%. Children younger than 5 years are at greater risk for pneumococcal meningitis compared with other populations. It is of significant ... ...

Abstract	Introduction: Streptococcus pneumoniae is the leading cause of meningitis, with a case fatality of up to about 50%. Children younger than 5 years are at greater risk for pneumococcal meningitis compared with other populations. It is of significant importance to provide a comprehensive understanding of the burden of pneumococcal meningitis among under-fives in the low pneumococcal conjugate vaccine (PCV) coverage period in China. Methods: A systematic review was conducted. We searched both English (PubMed, Ovid-EMBASE, Biosis, Web of Science, and Cochrane) and Chinese (CNKI, Wanfang, and ViP) databases for studies on bacterial meningitis in China published between January 1980 and July 2022. Ineligible studies were excluded based on study design and data integrity. Heterogeneity was assessed with I Results: A total of 13,082 studies were identified in the literature, and 56 studies were finally included for data analysis. The estimated incidence of pneumococcal meningitis was 2.10 cases per 100,000 children younger than 5 years each year (95% CI: 0.59-7.46), with a pooled case fatality rate of 24.59% (95%CI: 19.35-30.28%) in China. It was estimated that 1617.16 (95% CI: 454.35-5744.78) pneumococcal meningitis cases and 548.86 (95% CI: 474.80-627.62) deaths occurred among under-fives in China in 2020. Streptococcus pneumoniae played an important role in the etiology of confirmed bacterial meningitis cases, with a pooled proportion of 22.05% (95% CI: 17.83-26.27%). The most prevalent serotypes were 6B, 14, 19F, 19A, and 23F, which were preventable with a vaccine. Conclusions: Pneumococcal meningitis remains one of the most important health problems among children younger than 5 years in China. Immunization programs should be promoted to avoid preventable cases and deaths.
Language	English
Publishing date	2023-10-14
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2701611-0
ISSN	2193-6382 ; 2193-8229
ISSN (online)	2193-6382
ISSN	2193-8229
DOI	10.1007/s40121-023-00878-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Analysis of Dietary Patterns Associated with Kidney Stone Disease Based on Data-Driven Approaches: A Case-Control Study in Shanghai.

Wang, Yifei / Liu, Shaojie / Zhao, Qi / Wang, Na / Liu, Xing / Zhang, Tiejun / He, Gengsheng / Zhao, Genming / Jiang, Yonggen / Chen, Bo

Nutrients

2024 Volume 16, Issue 2

Abstract: The main objective of this study was to analyze dietary patterns using data-driven approaches and to explore preventive or risk dietary factors for kidney stone disease (KSD). A case-control matching study was conducted in adults ( ...

Abstract	The main objective of this study was to analyze dietary patterns using data-driven approaches and to explore preventive or risk dietary factors for kidney stone disease (KSD). A case-control matching study was conducted in adults (
MeSH term(s)	Adult ; Female ; Male ; Humans ; Case-Control Studies ; Dietary Patterns ; China/epidemiology ; Kidney Calculi/epidemiology ; Kidney Calculi/etiology ; Kidney Calculi/prevention & control ; Meat
Language	English
Publishing date	2024-01-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16020214
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Article ; Online: Epidemiological characteristics and risk factors of hypertension in residents in Songjiang District， Shanghai： a cohort based cross-sectional study

WU Yiling / LI Jing / WANG Wei / GUAN Ying / JIANG Yonggen / ZHAO Genming

Shanghai yufang yixue, Vol 34, Iss 4, Pp 371-

2022 Volume 375

Abstract: ObjectiveTo determine the epidemiological characteristics and risk factors of hypertension in residents in Songjiang District of Shanghai， and provide evidence for prevention and control of hypertension.MethodsLocal residents aged between 20 and 74 years ...

Abstract	ObjectiveTo determine the epidemiological characteristics and risk factors of hypertension in residents in Songjiang District of Shanghai， and provide evidence for prevention and control of hypertension.MethodsLocal residents aged between 20 and 74 years were recruited from four towns in Songjiang District from 2016 to 2017 by using a multistage sampling strategy. Questionnaire surveys were conducted， and then physical examination， blood pressure measurement， glucose test and lipid test were performed. The data was analyzed by SPSS 16.0 software. Chi-square test was used to compare the differences in the prevalence of hypertension in residents， stratified by demographics and health conditions. Risk factors were determined by multivariate logistic regression.ResultsAmong 35 759 residents with a median age of 58 years and the proportion of male being 40.67%， crude prevalence of hypertension was 54.24% （19 395/35 759） and standardized prevalence was 31.69%. In the hypertensive patients， proportion of hypertension awareness was 61.09%， with 63.67% in male and 59.10% in female. Proportion of receiving treatment was 49.00%， with 50.91% in male and 47.51% in female. Furthermore， in the hypertensive patients with treatment， proportion of effectively controlling hypertension was 40.50%， with 44.46% in male and 37.21% in female. Multivariate logistic regression showed that male （OR=1.272）， senior age （40‒59 years old： OR=4.353， 60‒74 years old： OR=9.802）， overweight （OR=1.823）， obesity （OR=3.070）， central obesity （OR=1.380）， diabetes （OR=1.923）， dyslipidemia （OR=1.452）， and drinking （OR=1.338） were risk factors associated with hypertension.ConclusionPrevalence of hypertension is high， while the proportions of receiving treatment and effective control remain low in residents in Songjiang District. It warrants strengthening prevention and control of hypertension in targeted and young residents.
Keywords	hypertension ; prevalence ; awareness rate ; treatment ; risk factor ; Medicine ; R
Subject code	610
Language	Chinese
Publishing date	2022-04-01T00:00:00Z
Publisher	Shanghai Preventive Medicine Association
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prevalence and influencing factors of diabetes mellitus among a community population aged from 20 to 74 in Songjiang District， Shanghai

WU Yiling / ZHANG Yu / ZHU Yinfeng / JIANG Yonggen / HE Jingyi / ZHAO Genming

Shanghai yufang yixue, Vol 34, Iss 5, Pp 475-

2022 Volume 480

Abstract: ObjectiveTo investigate the prevalence and influencing factors of diabetes mellitus among community population in Songjiang District of Shanghai， and to provide scientific basis for prevention and treatment of diabetes mellitus.MethodsBased on the ... ...

Abstract	ObjectiveTo investigate the prevalence and influencing factors of diabetes mellitus among community population in Songjiang District of Shanghai， and to provide scientific basis for prevention and treatment of diabetes mellitus.MethodsBased on the baseline data of the Shanghai Suburban Adult Cohort （2016‒2017） and local medication database， the prevalence of diabetes in the cohort was described， and the influencing factors for the prevalence of diabetes in different genders were analyzed.ResultsAmong 35 928 participants， males accounted for 40.57%， and the median age was 58 years old. There were 5 342 diabetic patients with a crude prevalence rate of 14.87% and the standardized prevalence rate of diabetes mellitus was 7.57%. The prevalence rate of diabetes in males （15.81%） was significantly higher than that in females （14.23%， P<0.001）. Multivariate logistic regression analysis showed that the following factors were associated with high risk of diabetes mellitus in males： 40‒59 age group （OR=7.111，95%CI：4.900‒10.320）， 60‒74 age group （OR=8.994，95%CI：6.154‒13.144）， family history of diabetes （OR=3.369，95%CI：2.963‒3.83）， overweight （OR=1.272，95%CI：1.123‒1.439）， obesity （OR=1.912，95%CI：1.623‒2.252）， hypertension （OR=1.685，95%CI：1.512‒1.877）， and dyslipidemia （OR=1.396，95%CI：1.263‒1.542）. In females， the high risk of diabetes was associated with： 40‒59 age group （OR=2.718，95%CI：1.838‒4.02）， 60‒74 age group （OR=3.517，95%CI：2.34‒5.286）， family history of diabetes （OR=3.071，95%CI：2.761‒3.416）， overweight （OR=1.254，95%CI：1.125‒1.398）， obesity （OR=2.018，95%CI：1.764‒2.308）， central obesity （OR=1.515，95%CI：1.357‒1.692）， hypertension （OR=2.128，95%CI：1.929‒2.347）， dyslipidemia （OR=1.506，95%CI：1.379‒1.644）， exercise （OR=1.241，95%CI：1.137‒1.355）， and menopause （OR=1.967，95%CI：1.693‒2.286）.ConclusionThe prevalence rate of diabetes is high in Shanghai， and the related factors are different in different gender groups.
Keywords	cohort ; cross-sectional study ; diabetes mellitus ; prevalence ; influencing factor ; Medicine ; R
Subject code	571
Language	Chinese
Publishing date	2022-05-01T00:00:00Z
Publisher	Shanghai Preventive Medicine Association
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Rotavirus Infection in Children <5 Years of Age in Suzhou, China, 2013-2019: Disease Burden, Genotype Distribution and Seasonality.

Shen, Si / Ren, Shaolong / Chen, Liling / Xue, Jian / Shao, Xuejun / Zhang, Tao / Zhao, Genming

The Pediatric infectious disease journal

2022 Volume 41, Issue 5, Page(s) 375–380

Abstract: Background: This study aimed to determine the disease burden and strain distribution of rotavirus in children with diarrhea <5 years old in Suzhou, China.: Methods: The study was conducted among children with diarrhea <5 years old at Suzhou ... ...

Abstract	Background: This study aimed to determine the disease burden and strain distribution of rotavirus in children with diarrhea <5 years old in Suzhou, China. Methods: The study was conducted among children with diarrhea <5 years old at Suzhou University Affiliated Children's Hospital from 2013 to 2019. Rotavirus antigen was detected in clinical laboratory and then sent to Suzhou Centers for Disease Control and Prevention for further molecular analysis. Group A rotavirus (RVA) was detected through enzyme-linked immunosorbent assays, and G-genotype and P-genotype of RVA were tested using reverse transcription-polymerase chain reaction. Results: Of a total of 198,130 children with diarrhea, 70,813 (35.7%) were positive for RVA; RVA-related diarrhea was detected in 7798 (20.7%, n = 7798/37,710) inpatients and 63,015 (39.3%, n = 63,015/160,420) outpatients. Most children (92.0%, n = 65,171/70,813) positive for RVA were found as children <3 years old. Children 12-35 months old were reported as the highest prevalence among all age groups. The seasonal peak of RVA was in the autumn and winter. Among all 673 RVA strains genotyped, the G9P[8] strain was reported to be persistently predominant in the pediatric population from 2013 to 2019. Conclusions: The burden of diarrhea disease due to rotavirus infection remains high in Suzhou.
MeSH term(s)	Child ; Child, Preschool ; China/epidemiology ; Cost of Illness ; Diarrhea/epidemiology ; Feces ; Genotype ; Humans ; Infant ; Phylogeny ; Rotavirus/genetics ; Rotavirus Infections/prevention & control
Language	English
Publishing date	2022-01-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000003463
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Enhanced Predictive Value of Lipid Accumulation Product for Identifying Metabolic Syndrome in the General Population of China.

Shao, Qi / Li, Jing / Wu, Yiling / Liu, Xing / Wang, Na / Jiang, Yonggen / Zhao, Qi / Zhao, Genming

Nutrients

2023 Volume 15, Issue 14

Abstract: The purpose of this research was to evaluate the lipid accumulation product (LAP)'s accuracy and predictive value for identifying metabolic syndrome (MS) in the general Chinese population compared with other obesity indicators. Baseline survey ... ...

Abstract	The purpose of this research was to evaluate the lipid accumulation product (LAP)'s accuracy and predictive value for identifying metabolic syndrome (MS) in the general Chinese population compared with other obesity indicators. Baseline survey information from a population-based cohort study carried out in Shanghai's Songjiang District was used in this research. Odds ratios (OR) and a 95% confidence interval (CI) were obtained by logistic regression. The ability of each variable to detect MS was assessed using the receiver operating characteristic curve (ROC). The optimum cut-off point for each indicator was selected using Youden's index. The survey involved 35,446 participants in total. In both genders, the prevalence of MS rose as the LAP increased (
MeSH term(s)	Humans ; Lipid Accumulation Product ; Predictive Value of Tests ; Metabolic Syndrome/diagnosis ; China/epidemiology ; Obesity/epidemiology ; Male ; Female ; Adult ; Middle Aged ; Aged
Language	English
Publishing date	2023-07-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15143168
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Article ; Online: The Effect of Dietary Pattern on Metabolic Syndrome in a Suburban Population in Shanghai, China.

Wei, Lanxin / Fan, Jing / Dong, Ruihua / Zhang, Mei / Jiang, Yonggen / Zhao, Qi / Zhao, Genming / Chen, Bo / Li, Jing / Liu, Shaojie

Nutrients

2023 Volume 15, Issue 9

Abstract: Metabolic syndrome (MetS) is recognized as one of the most severe non-communicable chronic diseases. Diet plays an essential role in the development and exacerbation of MetS. Thus, this study aimed to investigate the relationship between dietary patterns ...

Abstract	Metabolic syndrome (MetS) is recognized as one of the most severe non-communicable chronic diseases. Diet plays an essential role in the development and exacerbation of MetS. Thus, this study aimed to investigate the relationship between dietary patterns and MetS in a suburban population in Shanghai, China. Data were collected on the Zhongshan community from the Shanghai Suburban Adult Cohort and Biobank (SSACB) study between May and September 2017. A total of 5426 participants who completed the questionnaire investigation, physical measurements, and biological sample collection were effectively enrolled in this study. Both posteriori and priori methods were utilized to generate different dietary patterns, including the dietary approaches to stop hypertension (DASH) and Mediterranean diet (MD). The prevalence of MetS in this study was 22.47%. Compared to the reference, dietary patterns with a higher intake of "dairy and fruits" and "coarse cereals and soy products" had protective effects on MetS (
MeSH term(s)	Adult ; Humans ; Suburban Population ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/prevention & control ; China/epidemiology ; Diet, Mediterranean ; Dietary Approaches To Stop Hypertension ; Edible Grain
Language	English
Publishing date	2023-05-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15092185
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Unneglectable Disease Burden of Otitis Media Among Children in China: A Systematic Review and Meta-analysis.

Lin, Wanjing / Wang, Biying / Wang, Mengzhen / Wang, Yujie / Tuerdibieke, Yelina / Qian, Chen / Zhao, Genming / Zhang, Tao

The Pediatric infectious disease journal

2023 Volume 43, Issue 5, Page(s) 403–409

Abstract: Background: Otitis media (OM) is one of the most commonly diagnosed infections among children yet with obscure disease burden.: Methods: The literature published from 1980 to 2022 was retrieved in PubMed, Ovid-EMBASE, Web of Science, CNKI, Wanfang ... ...

Abstract	Background: Otitis media (OM) is one of the most commonly diagnosed infections among children yet with obscure disease burden. Methods: The literature published from 1980 to 2022 was retrieved in PubMed, Ovid-EMBASE, Web of Science, CNKI, Wanfang and VIP. Literature screening, quality assessment and data extraction were conducted by 2 independent reviewers. Heterogeneity and publication bias were detected by I2 , Egger's and Begg's tests. The data were pooled using the random-effects model. The number of OM cases was estimated by the multiplied model based on pooled results and the 2020 China census data. Results: A total of 28,378 literatures were identified with 67 finally included for data analysis. The OM incidence among children was 7.89% [95% confidence interval (CI): 5.43%-11.33%] and the prevalence of OM was 5.13% (95% CI: 3.49%-7.49%). The most common pathogen of the OM cases was Streptococcus pneumoniae ( S. pneumoniae ), with a positive rate of 33.52% (95% CI: 26.55%-41.29%). The most common serotypes of S. pneumoniae isolated from OM cases were serotypes 19F, 19A, 6B, 23F and 3, with 85.8% covered by the PCV13. We estimated that there were 8,950,797 (95% CI: 6,080,533-12,928,051) OM cases among under-fives in China in 2020, of which 3,374,451 (95% CI: 1,698,901-6,277,862) cases of OM were caused by S. pneumoniae . Conclusions: The burden of OM in China was considerable yet neglected. To date, S. pneumoniae was the most frequently detected bacterial pathogen of OM. Vaccination may be effective to protect young children from OM.
MeSH term(s)	Child ; Humans ; Infant ; Child, Preschool ; Otitis Media/microbiology ; Streptococcus pneumoniae ; Serogroup ; Vaccination ; China/epidemiology ; Pneumococcal Infections/prevention & control ; Pneumococcal Vaccines
Chemical Substances	Pneumococcal Vaccines
Language	English
Publishing date	2023-12-28
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000004239
Database	MEDical Literature Analysis and Retrieval System OnLINE

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